Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

Guido Keijzers; Daniela Bakula; Michael Angelo Petr; Nils Gedsig Kirkelund Madsen; Amanuel Teklu; Garik Mkrtchyan; Brenna Osborne; Morten Scheibye-Knudsen

doi:10.3390/ijms20010074

Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

Guido Keijzers^*, Daniela Bakula, Michael Angelo Petr, Nils Gedsig Kirkelund Madsen, Amanuel Teklu, Garik Mkrtchyan, Brenna Osborne, Morten Scheibye-Knudsen

^*Corresponding author for this work

13 Citations (Scopus)

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Abstract

Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.

Original language	English
Article number	74
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	1
Number of pages	15
ISSN	1661-6596
DOIs	https://doi.org/10.3390/ijms20010074
Publication status	Published - 2019

Keywords

DNA repair
Double strand break repair
EXO1
Exonuclease 1
Mismatch repair
MMR
NER
Nucleotide excision repair
Strand displacements
TLS
Translesion DNA synthesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in CancerFinal published version, 989 KBLicence: CC BY

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abstract = "Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.",

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author = "Guido Keijzers and Daniela Bakula and Petr, {Michael Angelo} and Madsen, {Nils Gedsig Kirkelund} and Amanuel Teklu and Garik Mkrtchyan and Brenna Osborne and Morten Scheibye-Knudsen",

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T1 - Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

AU - Keijzers, Guido

AU - Bakula, Daniela

AU - Petr, Michael Angelo

AU - Madsen, Nils Gedsig Kirkelund

AU - Teklu, Amanuel

AU - Mkrtchyan, Garik

AU - Osborne, Brenna

AU - Scheibye-Knudsen, Morten

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N2 - Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.

AB - Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.

KW - DNA repair

KW - Double strand break repair

KW - EXO1

KW - Exonuclease 1

KW - Mismatch repair

KW - MMR

KW - NER

KW - Nucleotide excision repair

KW - Strand displacements

KW - TLS

KW - Translesion DNA synthesis

U2 - 10.3390/ijms20010074

DO - 10.3390/ijms20010074

M3 - Review

C2 - 30585186

AN - SCOPUS:85059116556

SN - 1424-6783

VL - 20

JO - International Journal of Molecular Sciences (CD-ROM)

JF - International Journal of Molecular Sciences (CD-ROM)

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ER -

Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

Abstract

Keywords

UN SDGs

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