Protecting the mitochondrial powerhouse

Morten Scheibye-Knudsen; Evandro F. Fang; Deborah L. Croteau; David M. Wilson; Vilhelm A. Bohr

doi:10.1016/j.tcb.2014.11.002

Protecting the mitochondrial powerhouse

Morten Scheibye-Knudsen, Evandro F. Fang, Deborah L. Croteau, David M. Wilson, Vilhelm A. Bohr^*

^*Corresponding author for this work

156 Citations (Scopus)

Abstract

Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.

Original language	English
Journal	Trends in Cell Biology
Volume	25
Issue number	3
Pages (from-to)	158-170
Number of pages	13
ISSN	0962-8924
DOIs	https://doi.org/10.1016/j.tcb.2014.11.002
Publication status	Published - 1 Mar 2015
Externally published	Yes

Keywords

Disease
DNA repair
Mitochondria
Mitophagy
Reactive oxygen species

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2014.11.002

Cite this

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title = "Protecting the mitochondrial powerhouse",

abstract = "Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.",

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T1 - Protecting the mitochondrial powerhouse

AU - Scheibye-Knudsen, Morten

AU - Fang, Evandro F.

AU - Croteau, Deborah L.

AU - Wilson, David M.

AU - Bohr, Vilhelm A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.

AB - Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.

KW - Disease

KW - DNA repair

KW - Mitochondria

KW - Mitophagy

KW - Reactive oxygen species

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JO - Trends in Cell Biology

JF - Trends in Cell Biology

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Protecting the mitochondrial powerhouse

Abstract

Keywords

UN SDGs

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