Mitophagy and Neuroprotection

Guofeng Lou; Konstantinos Palikaras; Sofie Lautrup; Morten Scheibye-Knudsen; Nektarios Tavernarakis; Evandro F. Fang

doi:10.1016/j.molmed.2019.07.002

Mitophagy and Neuroprotection

Guofeng Lou, Konstantinos Palikaras, Sofie Lautrup, Morten Scheibye-Knudsen, Nektarios Tavernarakis, Evandro F. Fang^*

^*Corresponding author for this work

64 Citations (Scopus)

Abstract

Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.

Original language	English
Journal	Trends in Molecular Medicine
ISSN	1471-4914
DOIs	https://doi.org/10.1016/j.molmed.2019.07.002
Publication status	Published - Jan 2020

Keywords

ageing
Alzheimer's disease
amyotrophic lateral sclerosis
energy homeostasis
mitochondria
mitophagy
neurodegeneration
Parkinson's disease

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10.1016/j.molmed.2019.07.002

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title = "Mitophagy and Neuroprotection",

abstract = "Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.",

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author = "Guofeng Lou and Konstantinos Palikaras and Sofie Lautrup and Morten Scheibye-Knudsen and Nektarios Tavernarakis and Fang, {Evandro F.}",

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doi = "10.1016/j.molmed.2019.07.002",

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T1 - Mitophagy and Neuroprotection

AU - Lou, Guofeng

AU - Palikaras, Konstantinos

AU - Lautrup, Sofie

AU - Scheibye-Knudsen, Morten

AU - Tavernarakis, Nektarios

AU - Fang, Evandro F.

PY - 2020/1

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N2 - Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.

AB - Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms. In neurons, efficient clearance of damaged mitochondria, through the highly evolutionary conserved cellular process termed mitophagy, plays a fundamental role in mitochondrial and metabolic homeostasis, energy supply, neuronal survival, and health. Conversely, defective mitophagy leads to accumulation of damaged mitochondria and cellular dysfunction, contributing to ageing and age-predisposed neurodegeneration. Here, we discuss the contribution of defective mitophagy in these diseases, and underlying molecular mechanisms, and highlight novel therapeutics based on new discovered mitophagy-inducing strategies.

KW - ageing

KW - Alzheimer's disease

KW - amyotrophic lateral sclerosis

KW - energy homeostasis

KW - mitochondria

KW - mitophagy

KW - neurodegeneration

KW - Parkinson's disease

U2 - 10.1016/j.molmed.2019.07.002

DO - 10.1016/j.molmed.2019.07.002

M3 - Review

C2 - 31375365

AN - SCOPUS:85069854565

SN - 1471-4914

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

ER -

Mitophagy and Neuroprotection

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Keywords

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