Louise Turner

2019

Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria

Rambhatla, J. S., Turner, L., Manning, L., Laman, M., Davis, T. M. E., Beeson, J. G., Mueller, I., Warrel, J., Theander, T. G., Lavstsen, T. & Rogerson, S. J., 15 Feb 2019, In: The Journal of Infectious Diseases. 219, 5, p. 808-818 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

Derkach, A., Otim, I., Pfeiffer, R. M., Onabajo, O. O., Legason, I. D., Nabalende, H., Ogwang, M. D., Kerchan, P., Talisuna, A. O., Ayers, L. W., Reynolds, S. J., Nkrumah, F., Neequaye, J., Bhatia, K., Theander, T. G., Prokunina-Olsson, L., Turner, L., Goedert, J. J., Lavstsen, T. & Mbulaiteye, S. M., 2019, In: EBioMedicine. 39, p. 358-368 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

69 Downloads (Pure)

Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination

Fougeroux, C., Turner, L., Bojesen, A. M., Laystsen, T. & Holst, P. J., 15 Apr 2019, In: Journal of Immunology. 202, 8, p. 2320-2331

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Plasmodium falciparum-CD36 structure-function relationships defined by ortholog scanning mutagenesis

Cabrera, A., Neculai, D., Tran, V., Lavstsen, T., Turner, L. & Kain, K. C., 23 Feb 2019, In: The Journal of Infectious Diseases. 219, 6, p. 945-954 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2018

Immunization with Recombinant Plasmodium falciparum Erythrocyte Membrane Protein 1 CIDRα1 Domains Induces Domain Subtype Inhibitory Antibodies

Turner, L., Theander, T. G. & Lavstsen, T., 2018, In: Infection and Immunity. 86, 11, 11 p., e00435-18.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

2017

PROFILES OF PFEMP1-SPECIFIC IGG ANTIBODIES FROM BIRTH TO 12 MONTHS OF AGE IN BENINESE INFANTS

Moussiliou, A., Cottrell, G., Turner, L., Lavstsen, T., Fievet, N., Massougbodji, A., Theander, T., Deloron, P. & Ndam, N., Nov 2017, In: American Journal of Tropical Medicine and Hygiene. 95, 5 Suppl. , p. 302-302

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., Ecklu-Mensah, G. D., Moussiliou, A., Ofori, M. F., Gamain, B., Lusingu, J. P., Petersen, J. E. V., Wang, C. W., Nunes-Silva, S., Jespersen, J. S., Lau, C. K. Y., Theander, T. G., Lavstsen, T., Hviid, L., Higgins, M. K., & 1 othersJensen, A. T. R., 8 Mar 2017, In: Cell Host & Microbe. 21, 3, p. 403-414 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

441 Downloads (Pure)

2016

Cytoadhesion to gC1qR through Plasmodium falciparum erythrocyte membrane protein 1 in severe malaria

Magallón-Tejada, A., Machevo, S., Cisteró, P., Lavstsen, T., Aide, P., Rubio, M., Jiménez, A., Turner, L., Valmaseda, A., Gupta, H., De Las Salas, B., Mandomando, I., Wang, C. W., Petersen, J. E. V., Muñoz, J., Gascón, J., Macete, E., Alonso, P. L., Chitnis, C. E., Bassat, Q., & 1 othersMayor, A., 1 Nov 2016, In: PLOS Pathogens. 12, 11, 22 p., e1006011.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

92 Downloads (Pure)

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

Duffy, M. F., Noviyanti, R., Tsuboi, T., Feng, Z-P., Trianty, L., Sebayang, B. F., Takashima, E., Sumardy, F., Lampah, D. A., Turner, L., Lavstsen, T., Fowkes, F. J. I., Siba, P., Rogerson, S. J., Theander, T. G., Marfurt, J., Price, R. N., Anstey, N. M., Brown, G. V. & Papenfuss, A. T., 5 May 2016, In: Malaria Journal. 15, 12 p., 258.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

70 Downloads (Pure)

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

Jespersen, J. S., Wang, C. W., Mkumbaye, S. I., Minja, D. T., Petersen, B., Turner, L., Petersen, J. E., Lusingu, J. P., Theander, T. G. & Lavstsen, T., 1 Aug 2016, In: EMBO Molecular Medicine. 8, 8, p. 839-850 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

118 Downloads (Pure)

The structural basis for CD36 binding by the malaria parasite

Hsieh, F-L., Turner, L., Bolla, J. R., Robinson, C. V., Lavstsen, T. & Higgins, M. K., 26 Sept 2016, In: Nature Communications. 7, 11 p., 12837.

Research output: Contribution to journal › Journal article › Research › peer-review

81 Citations (Scopus)

103 Downloads (Pure)

2015

Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania

Hansson, H. H., Turner, L., Møller, L., Wang, C. W., Minja, D., Gesase, S., Mmbando, B., Bygbjerg, I. C., Theander, T. G., Lusingu, J. P. A., Alifrangis, M. & Lavstsen, T., 1 Dec 2015, In: Malaria Journal. 14, 9 p., 474.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

IgG antibodies to endothelial protein C receptor-binding Cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria

Turner, L., Lavstsen, T., Mmbando, B. P., Wang, C. W., Magistrado, P. A., Vestergaard, L. S., Ishengoma, D. S., Minja, D. T. R., Lusingu, J. P. & Theander, T. G., Aug 2015, In: Infection and Immunity. 83, 8, p. 3096-103 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Multiple Plasmodium falciparum erythrocyte membrane protein 1 variants per genome can bind IgM via its Fc fragment Fcμ

Jeppesen, A., Ditlev, S. B., Soroka, V., Stevenson, E. K., Turner, L., Dzikowski, R., Hviid, L. & Barfod, L., 2015, In: Infection and Immunity. 83, 10, p. 3972-81 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

1030 Downloads (Pure)

Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant

Petersen, J. E. V., Bouwens, E. A. M., Tamayo, I., Turner, L., Wang, C. W., Stins, M., Theander, T. G., Hermida, J., Mosnier, L. O. & Lavstsen, T., Nov 2015, In: Thrombosis and Haemostasis. 114, 5, p. 1038-48 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

Lau, C. K. Y., Turner, L., Jespersen, J. S., Lowe, E. D., Petersen, B., Wang, C. W., Petersen, J. E. V., Lusingu, J., Theander, T. G., Lavstsen, T. & Higgins, M. K., 14 Jan 2015, In: Cell Host & Microbe. 17, 1, p. 118-29 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

98 Citations (Scopus)

2014

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

Zhang, Q., Siegel, T. N., Martins, R. M., Wang, F., Cao, J., Gao, Q., Cheng, X., Jiang, L., Hon, C-C., Scheidig-Benatar, C., Sakamoto, H., Turner, L., Jensen, A. T. R., Claes, A., Guizetti, J., Malmquist, N. A. & Scherf, A., 29 Jun 2014, In: Nature. 531, p. 431-435

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Modeling malaria infection and immunity against variant surface antigens in Príncipe island, West Africa

Bandeiras, C., Trovoada, M. J., Gonçalves, L. A., Marinho, C. R. F., Turner, L., Hviid, L., Penha-Gonçalves, C. & Gomes, M. G. M., 10 Feb 2014, In: PloS one. 9, 2, p. e88110

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

1091 Downloads (Pure)

2013

A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, L., Theander, T. G., Hviid, L., Higgins, M. K., Craig, A., Brown, A. & Jensen, A. T. R., 1 Jan 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

23 Downloads (Pure)

Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surface

Tibúrcio, M., Silvestrini, F., Bertuccini, L., Sander, A. F., Turner, L., Lavstsen, T. & Alano, P., Apr 2013, In: Cellular Microbiology Online. 15, 4, p. 647-659

Research output: Contribution to journal › Journal article › Research › peer-review

46 Citations (Scopus)

Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1

Brown, A., Turner, L., Christoffersen, S., Andrews, K. A., Szestak, T., Zhao, Y., Larsen, S., Craig, A. G. & Higgins, M. K., 22 Feb 2013, In: Journal of Biological Chemistry. 288, 8, p. 5992-6003 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

Jiang, L., Mu, J., Zhang, Q., Ni, T., Srinivasan, P., Rayavara, K., Yang, W., Turner, L., Lavstsen, T., Theander, T. G., Peng, W., Wei, G., Jing, Q., Wakabayashi, Y., Bansal, A., Luo, Y., Ribeiro, J. M. C., Scherf, A., Aravind, L., Zhu, J., & 2 othersZhao, K. & Miller, L. H., 11 Jul 2013, In: Nature. 499, 7457, p. 223-7 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

141 Citations (Scopus)

Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1

Berger, S. S., Turner, L., Wang, C. W., Petersen, J. E. V., Kraft, M., Lusingu, J. P. A., Mmbando, B., Marquard, A. M., Bengtsson, D. B. A. C., Hviid, L., Nielsen, M. A., Theander, T. G. & Lavstsen, T., 9 Jul 2013, In: PloS one. 8, 7, p. e69117

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

Severe malaria is associated with parasite binding to endothelial protein C receptor

Turner, L., Lavstsen, T., Berger, S. S., Wang, C. W., Petersen, J. E. V., Avril, M., Brazier, A. J., Freeth, J., Jespersen, J. S., Nielsen, M. A., Magistrado, P., Lusingu, J., Smith, J. D., Higgins, M. K. & Theander, T. G., 27 Jun 2013, In: Nature. 498, 7455, p. 502-5 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

314 Citations (Scopus)

2012

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells

Claessens, A., Adams, Y., Ghumra, A., Lindergard, G., Buchan, C. C., Andisi, C., Bull, P. C., Mok, S., Gupta, A. P., Wang, C. W., Turner, L., Arman, M., Raza, A., Bozdech, Z. & Rowe, J. A., 26 Jun 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. E1772-81

Research output: Contribution to journal › Journal article › Research › peer-review

142 Citations (Scopus)

Evidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1

Wang, C. W., Lavstsen, T., Bengtsson, D. C., Magistrado, P. A., Berger, S. S., Marquard, A. M., Alifrangis, M., Lusingu, J. P., Theander, T. G. & Turner, L., 2012, In: Malaria Journal. 11, 1, p. 129

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes

Mwakalinga, S. B., Wang, C. W., Bengtsson, D. C., Turner, L., Dinko, B., Lusingu, J. P., Arnot, D. E., Sutherland, C. J., Theander, T. G. & Lavstsen, T., 2012, In: Malaria Journal. 11, 1, p. 429

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

Lavstsen, T., Turner, L., Saguti, F., Magistrado, P. A., Rask, T. S., Jespersen, J. S., Wang, C. W., Berger, S. S., Baraka, V., Marquard, A. M., Seguin-Orlando, A., Willerslev, E., Gilbert, T., Lusingu, J. P. A. & Theander, T. G., 26 Jun 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. E1791-E1800 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

173 Citations (Scopus)

2011

Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers

Turner, L., Wang, C. W., Lavstsen, T., Mwakalinga, S. B., Sauerwein, R. W., Hermsen, C. C. & Theander, T. G., 2011, In: P L o S One. 6, 12, p. e29025

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites

Bejon, P., Turner, L., Lavstsen, T., Cham, G., Olotu, A., Drakeley, C. J., Lievens, M., Vekemans, J., Savarese, B., Lusingu, J., von Seidlein, L., Bull, P. C., Marsh, K. & Theander, T. G., 1 Jan 2011, In: P L o S One. 6, 6, p. e21711

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

2010

Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children

Cham, G. K. K., Turner, L., Kurtis, J. D., Mutabingwa, T., Fried, M., Jensen, A. T. R., Lavstsen, T., Hviid, L., Duffy, P. E. & Theander, T. G., Nov 2010, In: Infection and Immunity. 78, 11, p. 4653-9 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

11 Downloads (Pure)

Surface co-expression of two different PfEMP1 antigens on single Plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1

Joergensen, L., Bengtsson, D. C., Bengtsson, A., Ronander, E., Berger, S. S., Turner, L., Dalgaard, M. B., Cham, G. K. K., Victor, M. E., Lavstsen, T., Theander, T. G., Arnot, D. E. & Jensen, A. T. R., Sept 2010, In: PLoS Pathogens. 6, 9, p. e1001083

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

18 Downloads (Pure)

2009

Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites

Resende, M., Ditlev, S. B., Nielsen, M. A., Bodevin, S., Bruun, S., Pinto, V. V., Clausen, H., Turner, L., Theander, T. G., Salanti, A. & Dahlbäck, M., 2009, In: International Journal for Parasitology. 39, 11, p. 1195-204 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains

Cham, G. K. K., Turner, L., Lusingu, J., Vestergaard, L., Mmbando, B. P., Kurtis, J. D., Jensen, A. T. R., Salanti, A., Lavstsen, T. & Theander, T. G., 2009, In: Journal of Immunology. 183, 5, p. 3356-63 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

84 Citations (Scopus)

2008

A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes

Bengtsson, D., Sowa, K. M., Salanti, A., Jensen, A. T., Joergensen, L., Turner, L., Theander, T. G. & Arnot, D. E., 2008, In: Malaria Journal. 7, p. 101

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma

Cham, G. K. K., Kurtis, J., Lusingu, J., Theander, T. G., Jensen, A. T. R. & Turner, L., 2008, In: Malaria Journal. 7, p. 108

Research output: Contribution to journal › Journal article › Research › peer-review

46 Citations (Scopus)

2007

3D7-derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensity

Joergensen, L., Vestergaard, L. S., Turner, L., Magistrado, P., Lusingu, J. P., Lemnge, M., Theander, T. G. & Jensen, A. T. R., 2007, In: Journal of Immunology. 178, 1, p. 428-35 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

6 Downloads (Pure)

Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA

Barfod, L., Bernasconi, N. L., Dahlbäck, M., Jarrossay, D., Andersen, P. H., Salanti, A., Ofori, M. F., Turner, L., Resende, M., Nielsen, M. A., Theander, T. G., Sallusto, F., Lanzavecchia, A. & Hviid, L., 2007, In: Molecular Microbiology. 63, 2, p. 335-47 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

76 Citations (Scopus)

Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria

Magistrado, P. A., Lusingu, J., Vestergaard, L. S., Lemnge, M., Lavstsen, T., Turner, L., Hviid, L., Jensen, A. T. R. & Theander, T. G., 2007, In: Infection and Immunity. 75, 5, p. 2415-20 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsin

Nielsen, M. A., Resende, M., Alifrangis, M., Turner, L., Hviid, L., Theander, T. G. & Salanti, A., 2007, In: Experimental Parasitology. 117, 1, p. 1-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2006

Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes

Barfod, L., Nielsen, M. A., Turner, L., Dahlbäck, M., Jensen, A. T. R., Hviid, L., Theander, T. G. & Salanti, A., 2006, In: Infection and Immunity. 74, 7, p. 4357-60 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Dynamics of anti-VAR2CSA immunoglobulin G response in a cohort of senegalese pregnant women

Tuikue Ndam, N. G., Salanti, A., Le-Hesran, J-Y., Cottrell, G., Fievet, N., Turner, L., Sow, S., Dangou, J-M., Theander, T. & Deloron, P., 2006, In: Journal of Infectious Diseases. 193, 5, p. 713-20 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

69 Citations (Scopus)

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration

Dahlbäck, M., Rask, T. S., Andersen, P. H., Nielsen, M. A., Ndam, N. T., Resende, M., Turner, L., Deloron, P., Hviid, L., Lund, O., Pedersen, A. G., Theander, T. G. & Salanti, A., 2006, In: PLoS Pathogens. 2, 11, p. e124

Research output: Contribution to journal › Journal article › Research › peer-review

69 Citations (Scopus)

Limited cross-reactivity among domains of the Plasmodium falciparum clone 3D7 erythrocyte membrane protein 1 family

Joergensen, L., Turner, L., Magistrado, P., Dahlbäck, M. A., Vestergaard, L. S., Lusingu, J. P., Lemnge, M., Salanti, A., Theander, T. G. & Jensen, A. T. R., 2006, In: Infection and Immunity. 74, 12, p. 6778-84 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

2005

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta

Tuikue Ndam, N. G., Salanti, A., Bertin, G., Dahlbäck, M., Fievet, N., Turner, L., Gaye, A., Theander, T. & Deloron, P., 2005, In: Journal of Infectious Diseases. 192, 2, p. 331-5 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

127 Citations (Scopus)

2004

Evidence for the involvement of VAR2CSA in pregnancy-associated malaria

Salanti, A., Dahlbäck, M., Turner, L., Nielsen, M. A., Barfod, L., Magistrado, P., Jensen, A. T. R., Lavstsen, T., Ofori, M. F., Marsh, K., Hviid, L. & Theander, T. G., 2004, In: Journal of Experimental Medicine. 200, 9, p. 1197-203 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

406 Citations (Scopus)

Louise Turner

Research output

Search results