Adam Frederik Sander Bertelsen
20092019

Research activity per year

Personal profile

Primary fields of research

At Centre for Medical Parasitology, University of Copenhagen, I have been involved with the development of anti-malaria vaccines. During this work I have been involved with the development of a generic and easy-to-use technology for making efficient vaccines against both infectious- and noncommunicable chronic diseases. The technology employs “virus-like particles” (VLPs) which are enabled to bind efficiently to various vaccine antigens via a genetically engineered binding-tag on the VLP surface. By simply mixing the tagged VLPs with an antigen of choice (genetically fused to a complementary peptide tag) – VLPs are (within minutes) decorated by the antigen, which is displayed at high density on the VLP surface. This very versatile and cost-effective way of making a VLP based vaccine from any complex antigen could present a paradigm shift in future vaccine design. Three patent applications have currently been filed based on this technology.

                      Recently, the VLP technology has been further developed to also allow for delivery of different cargos. Specifically, cargo molecules (toxin, siRNA, CRISPR, fluorophores etc.) are efficiently delivered in the “stomach” of VLPs where they are protected against enzymes, and the multivalent display of a specific cell-targeting molecule on the VLP surface provides unprecedented specificity in the delivering of cargos to cells in vivo. Therefore, the ability to efficiently package cargos inside VLPs in combination with the unique ability to decorate VLPs with different targeting molecules, together, provide a state-of-the-art system for in vivo delivery of cargos and has great potential for e.g. treatment of cancer.

CV

Curriculum vitae

Personal information

Name: Adam Frederik Sander Pedersen

Address: Ulspilsager 73, 2791, Dragør

Mobile: +45 30111529

Mail: [email protected]

Birth date: 25/12 - 1978

 

 

Education

2007 – 2011  PhD-student at Center for Medical Parasitology (CMP), Copenhagen

University, financed by the Niels Bohr Visiting Professorship.

Date of registration: 01-09-07. Date of acceptance: 27-05-11

Contact: Professor David Arnot. ([email protected])

2000 – 2007 M.Sc. in Biology at Copenhagen University.

Master project title: Characterization of the DBL2x domain of the VAR2CSA protein.

Carried out at Center for Medical Parasitology (CMP), Department of International

Health, Immunology and Microbiology, Faculty of Medicine, University of

Copenhagen, Denmark. Grade: 12

Main courses: - Immunology, Proteins Chemistry, Cellular Biology and Genetics.

1995– 1998   Mathematical student of Christianshavns Gymnasium.

 

Courses:    Leading Research course.

 

Employment:

2017-            Associate Professor.

2012 – 2016  Postdoctoral fellow (Leader of VLP-team containing: 3 PhD-stud., 1 Ms-stud., 1 Bachelor stud., 1 Sc.assistant, 2 Lab. Tech., 1 Bachelor stud.) at Centre for Medical Parasitology.

2011 – 2012 Postdoc at the National History Museum, under Prof. M. Thomas P Gilbert.

2011              Research assistant at Centre for Medical Parasitology (CMP), Copenhagen University.

 

Teaching:

 

2016              Lectures and execution of an experimental vaccine development workshop at the Faculty of Medicine, Chulalongkorn, Bangkok, Thailand September 19-23, 2016.

2015              Seminar at Klinisk Forskningscenter, Hvidovre Hospital “Development of a novel Virus-like particle based vaccine platform”.

2014              Execution of seminar addressed to laboratory technicians and students concerning various PCR techniques (Quantitative real-time PCR, Taqman probes, Multiplex, touchdown PCR, PCR Assembly)

2013 – now   Supervision of PhD-students Susan Thrane and Sungwa Matondo, Ms.-student Christoph Janitzek and Bachelor Stud. Philip Carlsen.

2013              Lectures and experimental supervision in the course: “Experimental

Immunology” for students studying Medicine at Copenhagen University. (Duration: 6 weeks).

2008 – 2012 Practical supervision of Two Technicians and one Master Student and a Bachelor student.

2007              Experimental supervision in “Immunology Course” for students studying Medicine and Human biology at Copenhagen University. (Duration: 8 weeks).

 

Reviewer for: Small, Virus Research, Malaria Journal, Parasitology Journal, Microbial Cell factories Journal.

 

Communication:

2017              Invited speaker at “Inspirationsdagen 2017/Gymnasielærernes Dag”

2016              Speaker at TRF Senior Research Scholar Seminar, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Sept. 21-23, 2016

2016              Interviewed by “Weekend Avisen”, “Videnskab.dk”, “Politiken”, ”Information”, ”Pharma”, ”Berlingske Tidende”.

2014              Speaker at VIRUS-LIKE PARTICLE & NANO-PARTICLE VACCINES, Salk Institute for Biological Studies, La Jolla, California, USA. 4-6 June 2014. “Development of a versatile virus-like particle based vaccine delivery platform

2012              Interview by ‘Discovery Channel’ regarding the new biodiversity screening method

of using DNA from leeches.

2010              Speaker at seminar at John A. Burns Medical School of Medicine, Honololu, Hawaii.

Title: Malaria in Pregnancy

2009              Speaker at the ‘Welcome Trust’ conference at Cambridge University.

Title: Duplicated var2csa genes in Plasmodium falciparum placental parasites.

 

Publications: 17 peer-reviewed papers. I10-index= 8.

 

Five selected publications:

 

2018                  Palladini A, Thrane S, Janitzek CM, Pihl J, Clemmensen SB, de Jongh WA, Clausen TM, Nicoletti G, Landuzzi L, Penichet ML, Balboni T, Ianzano ML, Giusti V, Theander TG, Nielsen MA, Salanti A, Lollini PL, Nanni P, Sander AF.

Virus-like particle display of HER2 induces potent anti-cancer responses.

Oncoimmunology. 2018 Jan.

 

2016                  Susan Thrane, Christoph M. Janitzek, Sungwa Matondo, Mafalda Resende, Tobias Gustavsson, Wian de Jongh, Stine Clemmensen, Will Roeffen, Marga van de Vegte‑Bolmer, Geert Jan van Gemert, Robert Sauerwein, John T. Schiller, Morten A. Nielsen, Thor G. Theander, Ali Salanti, Adam F. Sander#

                          Bacterial superglue enables easy development of efficient Virus-like particle based Vaccines

                          J Nanobiotechnology. 2016 Apr 27;14:30. doi: 10.1186/s12951-016-0181-1.

 

2015                  Susan Thrane, Christoph Mikkel Janitzek, Mette Ø. Agerbæk, Morten A. Nielsen, Thor Theander, Ali Salanti, Adam F. Sander*

A novel versatile virus-like particle based vaccine platform

PLoS One. 2015 Nov 23;10(11):e0143071. doi: 10.1371/journal.pone.0143071.

 

2015                  Salanti A, Clausen TM, Agerbæk MØ, Al Nakouzi N, Dahlbäck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M.

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.

Cancer Cell. 2015 Oct 12;28(4):500-14.

 

2013                  Adam F. Sander, Thomas Lavstsen, Thomas S. Rask, Michael Lisby, , Ali Salanti,

Sarah L. Fordyce, Jakob S. Jespersen, Richard Carter, Thor G. Theander, Anders Gorm

Pedersen & David E. Arnot.

DNA secondary structures are associated with recombination in major

Plasmodium falciparum variable surface antigen gene families.

Nucleic Acids Res. 2014 Feb;42(4):2270-81. doi: 10.1093/nar/gkt1174. Epub 2013 Nov 18.

 

Patents:           

 

2015                  Adam F. Sander, Ali Salanti, Thor Theander, Susan Thrane, Christoph Mikkel Janitzek, Mette Ørskov Agerbæk, Morten Agertoug Nielsen, Tobias Gustavson.Virus-like particle based Vaccine delivery. ID: P3710DK01. Filing date: 28 April 2015

 

2015                  Adam F. Sander, Ali Salanti, Thor Theander, Susan Thrane, Christoph Mikkel Janitzek, Mette Ørskov Agerbæk, Morten Agertoug Nielsen, Tobias Gustavson. Virus-like particle with efficient epitope display. ID: P3710DK01. Filing date: 15 January 2015

 

2014                  Adam F. Sander, Ali Salanti, Thor Theander, Susan Thrane, Christoph Mikkel Janitzek, Mette Ørskov Agerbæk, Morten Agertoug Nielsen, Tobias Gustavson.Virus-like particle platform. ID: P3596DK00.

Filing date: November 2014.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Characterization of the VAR2CSA DBL2x domain, Centre for Medical Parasitology

Award Date: 1 Aug 2007

External positions

1 Jan 201231 Dec 2031

Keywords

  • Faculty of Health and Medical Sciences
  • Vaccine Development
  • Vaccines

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