Jesper Christensen

2019

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

Poeta, L., Padula, A., Attianese, B., Valentino, M., Verrillo, L., Filosa, S., Shoubridge, C., Barra, A., Schwartz, C. E., Christensen, J., van Bokhoven, H., Helin, K., Lioi, M. B., Collombat, P., Gecz, J., Altucci, L., Di Schiavi, E. & Miano, M. G., 15 Dec 2019, In: Human Molecular Genetics.

Research output: Contribution to journal › Journal article › Research › peer-review

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

Rasmussen, K. D., Berest, I., Kessler, S., Nishimura, K., Simon-Carrasco, L., Vassiliou, G. S., Pedersen, M. T., Christensen, J., Zaugg, J. & Helin, K., Apr 2019, In: Genome Research. 29, 4, p. 564-575 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

24 Downloads (Pure)

The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

Miyagi, S., Sroczynska, P., Kato, Y., Nakajima-Takagi, Y., Oshima, M., Rizq, O., Takayama, N., Saraya, A., Mizuno, S., Sugiyama, F., Takahashi, S., Matsuzaki, Y., Christensen, J., Helin, K. & Iwama, A., 6 Jun 2019, In: Blood. 133, 23, p. 2495-2506

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

2018

Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner

Dimopoulos, K., Søgaard Helbo, A., Fibiger Munch-Petersen, H., Sjö, L., Christensen, J., Sommer Kristensen, L., Asmar, F., Hermansen, N. E. U., O'Connel, C., Gimsing, P., Liang, G. & Grønbaek, K., 1 Feb 2018, In: Molecular Oncology. 12, 2, p. 180-195

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

59 Downloads (Pure)

2015

H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans

Vandamme, J., Sidoli, S., Mariani, L., Friis, C., Christensen, J., Helin, K., Jensen, O. N. & Salcini, A. E., 1 Oct 2015, In: Nucleic Acids Research. 43, 20, p. 9694-710 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J. & Helin, K., 1 May 2015, In: Genes & Development. p. 910-922 13 p., 29.

Research output: Contribution to journal › Journal article › Research › peer-review

144 Citations (Scopus)

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

Wu, X., Bekker-Jensen, I. H., Christensen, J., Rasmussen, K. D., Sidoli, S., Qi, Y., Kong, Y., Wang, X., Cui, Y., Xiao, Z., Xu, G., Williams, K., Rappsilber, J., Sønderby, C. K., Winther, O., Jensen, O. N. & Helin, K., 1 Nov 2015, In: Cell Research. 25, p. 1205-1218 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

2014

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells

Langlois, T., da Costa Reis Monte Mor, B., Lenglet, G., Droin, N., Marty, C., Le Couédic, J-P., Almire, C., Auger, N., Mercher, T., Delhommeau, F., Christensen, J. A., Helin, K., Debili, N., Fuks, F., Bernard, O. A., Solary, E., Vainchenker, W. & Plo, I., Aug 2014, In: Stem Cells.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

The Demethylase JMJD2C Localizes to H3K4me3 Positive Transcription Start Sites and Is Dispensable for Embryonic Development

Pedersen, M. T., Agger, K., Laugesen, A., Johansen, J. V., Cloos, P. A. C., Christensen, J. A. & Helin, K., Mar 2014, In: Molecular and Cellular Biology.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner

Williams, K., Christensen, J., Rappsilber, J., Nielsen, A. L., Johansen, J. V. & Helin, K., 5 May 2014, In: PLOS ONE. 9, 5, p. e96545

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

2607 Downloads (Pure)

2013

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

Asmar, F., Punj, V., Christensen, J. A., Pedersen, M. T., Pedersen, A., Nielsen, A. B., Hother, C., Ralfkiaer, U., Brown, P., Ralfkiaer, E., Helin, K. & Grønbæk, K., 1 Dec 2013, In: Haematologica. 98, 12, p. 1912-20 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

de la Rica, L., Rodríguez-Ubreva, J., García, M., Islam, A. B., Urquiza, J. M., Hernando, H., Christensen, J. A., Helin, K., Gómez-Vaquero, C. & Ballestar, E., 12 Sept 2013, In: Genome Biology (Online Edition). 14, 9, p. R99

Research output: Contribution to journal › Journal article › Research › peer-review

119 Citations (Scopus)

Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells

Vella, P., Scelfo, A., Jammula, S., Chiacchiera, F., Williams, K., Cuomo, A., Roberto, A., Christensen, J., Bonaldi, T., Helin, K. & Pasini, D., 21 Feb 2013, In: Molecular Cell.

Research output: Contribution to journal › Journal article › Research › peer-review

203 Citations (Scopus)

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia

Arteaga, M. F., Mikesch, J-H., Qiu, J., Christensen, J. A., Helin, K., Kogan, S. C., Dong, S. & So, C. W. E., 18 Mar 2013, In: Cancer Cell. 23, 3, p. 376-89 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

63 Citations (Scopus)

2012

DNA methylation: TET proteins-guardians of CpG islands?

Williams, K., Christensen, J. & Helin, K., Jan 2012, In: E M B O Reports. 13, 1, p. 28-35 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

216 Citations (Scopus)

Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells

Kallin, E. M., Rodríguez-Ubreva, J., Christensen, J. A., Cimmino, L., Aifantis, I., Helin, K., Ballestar, E. & Graf, T., 26 Oct 2012, In: Molecular Cell. 48, 2, p. 266-76 11 p.

Research output: Contribution to journal › Journal article › Research

67 Citations (Scopus)

2011

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J. & Helin, K., 19 May 2011, In: Nature. 473, 7347, p. 343-8 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

723 Citations (Scopus)

The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma

Anderton, J. A., Bose, S., Vockerodt, M., Vrzalikova, K., Wei, W., Kuo, M., Helin, K., Christensen, J. A., Rowe, M., Murray, P. G. & Woodman, C. B., 28 Apr 2011, In: Oncogene. 30, 17, p. 2037-43 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

2010

A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation

Kleine-Kohlbrecher, D., Christensen, J., Vandamme, J., Abarrategui, I., Bak, M., Tommerup, N., Shi, X., Gozani, O., Rappsilber, J., Salcini, A. E. & Helin, K., 23 Apr 2010, In: Molecular Cell. 38, 2, p. 165-78 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

148 Citations (Scopus)

2009

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors

Ciró, M., Prosperini, E., Quarto, M., Grazini, U., Walfridsson, J., McBlane, F., Nucifero, P., Pacchiana, G., Capra, M., Christensen, J. & Helin, K., 2009, In: Cancer Research. 69, 21, p. 8491-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

150 Citations (Scopus)

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

Agger, K., Cloos, P. A. C., Rudkjaer, L., Williams, K., Andersen, G., Christensen, J. & Helin, K., 2009, In: Genes & Development. 23, 10, p. 1171-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

317 Citations (Scopus)

2008

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.

Pasini, D., Hansen, K. H., Christensen, J., Agger, K., Cloos, P. A. C. & Helin, K., 2008, In: Genes & Development. 22, 10, p. 1345-55 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

243 Citations (Scopus)

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

Cloos, P. A. C., Christensen, J., Agger, K. & Helin, K., 2008, In: Genes & Development. 22, 9, p. 1115-40 25 p.

Research output: Contribution to journal › Review › peer-review

501 Citations (Scopus)

Regulation of Stem Cell Differentiation by Histone Methyltransferases and Demethylases

Pasini, D., Bracken, A. P., Agger, K., Christensen, J. A., Hansen, K., Cloos, P. A. C. & Helin, K., 2008, In: Cold Spring Harbor Symposia on Quantitative Biology. 73, p. 253-63 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

The emerging functions of histone demethylases.

Agger, K., Christensen, J., Cloos, P. A. & Helin, K., 2008, In: Current Opinion in Genetics & Development. 18, 2, p. 159-68 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

176 Citations (Scopus)

2007

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

Christensen, J., Agger, K., Cloos, P. A. C., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K., Salcini, A. E. & Helin, K., 2007, In: Cell. 128, 6, p. 1063-76 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

390 Citations (Scopus)

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Agger, K., Cloos, P. A. C., Christensen, J., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E. & Helin, K., 2007, In: Nature. 449, 7163, p. 731-4 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

891 Citations (Scopus)

2006

Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV.

Bjelke, J. R., Christensen, J., Nielsen, P. F., Branner, S., Kanstrup, A. B., Wagtmann, N. & Rasmussen, H. B., 2006, In: Biochemical Journal. 396, 2, p. 391-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

89 Citations (Scopus)

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.

Cloos, P. A. C., Christensen, J., Agger, K., Maiolica, A., Rappsilber, J., Antal, T., Hansen, K. H. & Helin, K., 2006, In: Nature. 442, 7100, p. 307-11 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

566 Citations (Scopus)

2005

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.

Christensen, J., Cloos, P., Toftegaard, U., Klinkenberg, D., Bracken, A. P., Trinh, E., Heeran, M., Di Stefano, L. & Helin, K., 2005, In: Nucleic Acids Research. 33, 17, p. 5458-70 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

116 Citations (Scopus)

Human XPC-hHR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks.

Thoma, B. S., Wakasugi, M., Christensen, J., Reddy, M. C. & Vasquez, K. M., 2005, In: Nucleic Acids Research. 33, 9, p. 2993-3001 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

Interplay between human high mobility group protein 1 and replication protein A on psoralen-cross-linked DNA.

Reddy, M. C., Christensen, J. & Vasquez, K. M., 2005, In: Biochemistry. 44, 11, p. 4188-95 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

2004

Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV

Bjelke, J. R., Christensen, J. A., Branner, S., Wagtmann, N., Olsen, C. & Kanstrup, A. B., 2004, In: Journal of Biological Chemistry. Vol. 279, p. 34691-34697

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV.

Bjelke, J. R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A. B. & Rasmussen, H. B., 2004, In: Journal of Biological Chemistry. 279, 33, p. 34691-7 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

2002

Baculovirus expression of erythrovirus V9 capsids and screening by ELISA: serologic cross-reactivity with erythrovirus B19.

Heegaard, E. D., Qvortrup, K. & Christensen, J., 2002, In: Journal of Medical Virology. 66, 2, p. 246-52 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Detection of parvovirus B19 NS1-specific antibodies by ELISA and western blotting employing recombinant NS1 protein as antigen.

Heegaard, E. D., Rasksen, C. J. & Christensen, J., 2002, In: Journal of Medical Virology. 67, 3, p. 375-83 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Detection of parvovirus B19 NS1 specific antibodies by ELISA and Western blotting using recombinant NS1 protein as antigen

Heegaard, E. D., Rasksen, C. J. & Christensen, J., 2002, In: J. Med. Virol.. 67, p. 375-383

Research output: Contribution to journal › Journal article › Research › peer-review

Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions

Vasquez, K. M., Christensen, J., Li, L., Finch, R. A. & Glazer, P. M., 2002, In: Proceedings of the National Academy of Science of the United States of America. 99, p. 5848-5853

Research output: Contribution to journal › Journal article › Research › peer-review

94 Citations (Scopus)

Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions.

Vasquez, K. M., Christensen, J., Li, L., Finch, R. A. & Glazer, P. M., 2002, In: Proceedings of the National Academy of Science of the United States of America. 99, 9, p. 5848-53 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

94 Citations (Scopus)

Parvovirus initiator protein NS1 and RPA coordinate replication fork progression in a reconstituted DNA replication system.

Christensen, J. & Tattersall, P., 2002, In: Journal of Virology. 76, 13, p. 6518-31 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

74 Citations (Scopus)

The Major Non-Structural Protein of Minute Virus of Mice and Human Single-Stranded DNA binding protein, RPA, coordinate replication fork progression through direct intermolecular interactions

Christensen, J. & Tattersall, P., 2002, In: J. Med. Virol.. 76, p. 6518-6531

Research output: Contribution to journal › Journal article › Research › peer-review

2001

A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters.

Burnett, E., Christensen, J. A. & Tattersall, P., 2001, In: Journal of Molecular Biology. 314, 5, p. 1029-39 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

A novel variable-length transcription factor binding site, sensitive to CpG methylation, is present in a majority of human promoters

Burnett, E., Christensen, J. & Tattersall, P., 2001, In: Journal of Molecular Biology. 314, p. 1029-1039

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Initiation of minute virus of mice DNA replication is regulated at the level of origin unwinding by atypical protein kinase C phosphorylation of NS1.

Nüesch, J. P., Christensen, J. A. & Rommelaere, J., 2001, In: Journal of Virology. 75, 13, p. 5730-9 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Initiation of MVM DNA Replication is Regulated at the Level of Origin Unwinding by atypical PKC Phosphorylation of NS1

Nüesch, J. P. F., Christensen, J. & Rommelaere, J., 2001, In: Journal of Virology. Vol. 75, no. 13, p. 5730-5739

Research output: Contribution to journal › Journal article › Research › peer-review

Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

Ducoux, M., Urbach, S., Baldacci, G., Hübscher, U., Koundrioukoff, S., Christensen, J. A. & Hughes, P., 2001, In: Journal of Biological Chemistry. 276, 52, p. 49258-66 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

76 Citations (Scopus)

Minute virus of mice initiator protein NS1 and a host KDWK family transcription factor must form a precise ternary complex with origin DNA for nicking to occur.

Christensen, J. A., Cotmore, S. F. & Tattersall, P., 2001, In: Journal of Virology. 75, 15, p. 7009-17 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

MVM initiator protein NS1 and a host KDWK family transcription factor must form a precise ternary complex with the origin DNA for nicking to occur

Christensen, J., Cotmore, S. & Tattersall, P., 2001, In: Journal of Virology. Vol. 75, no. 15, p. 7009-7017

Research output: Contribution to journal › Journal article › Research › peer-review

Novel PCR Assay for Differential Detection and Screening of Erythrovirus B19 and Erythrovirus V9

Heegaard, E. D., Jensen, I. P. & Christensen, J., 2001, In: Journal of Medical Virology. 65, p. 362-367

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

Novel PCR assay for differential detection and screening of erythrovirus B19 and erythrovirus V9.

Heegaard, E. D., Panum Jensen, I. & Christensen, J. A., 2001, In: Journal of Medical Virology. 65, 2, p. 362-7 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

Jesper Christensen

Research output

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