Carolyn F. Deacon

Research output

Research output per year 1995 2003 2004 2005 2006 2007 2008 2009 2010 2011 2014 2015 2016 2018 2019

• 198 Journal article
• 12 Review
• 4 Book chapter
• 1 Conference abstract in journal
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2019

  Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study

  Clarke, S. J., Pettit, S., Giblett, J. P., Zhao, T., Kydd, A. C., Albrechtsen, N. J. W., Deacon, C. F., Parameshwar, J. & Hoole, S. P., Jan 2019, In: Clinical Therapeutics. 41, 1, p. 118-127 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Hemodynamics 62%
  • Heart Failure 62%
  • Lung 45%
  • Thermodilution 33%
  1 Citation (Scopus)

• Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

  Jepsen, S. L., Grunddal, K. V., Wewer Albrechtsen, N. J., Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, C., Poulsen, S. S., Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, C. F., Schwartz, T. W., Christ, A. D., Martin, R. E. & Holst, J. J., Dec 2019, In: A J P: Endocrinology and Metabolism (Online).

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Enteroendocrine Cells 100%
  • Somatostatin-Secreting Cells 91%
  • Glucagon-Like Peptide 1 82%
  • Somatostatin 36%
  • somatostatin receptor 2 10%
  12 Citations (Scopus)

• Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes

  Deacon, C. F., 2019, In: Frontiers in Endocrinology. 10, 14 p., 80.

  Research output: Contribution to journal › Review › peer-review

  1 Citation (Scopus)

  10 Downloads (Pure)

• Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men

  Wewer Albrechtsen, N. J., Mark, P. D., Terzic, D., Hansen, L. H., Andersen, U. Ø., Hartmann, B., Carr, R. D., Gustafsson, F., Deacon, C. F., Holst, J. J., Goetze, J. P. & Plomgaard, P., 1 Sept 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 9, p. 3868-3876

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sacubitril 100%
  • Sitagliptin 82%
  • LCZ 696 81%
  • Glucagon-Like Peptide 1 79%
  • Valsartan 76%
• 2018

  A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients

  Samkani, A., Skytte, M. G. J., Kandel, D., Kjaer, S., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Rehfeld, J. F., Haugaard, S. B. & Krarup, T., 28 Apr 2018, In: British Journal of Nutrition. 119, 8, p. 910-917 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • High-Protein Diet 100%
  • Carbohydrates 61%
  • Type 2 Diabetes Mellitus 53%
  • Diet 48%
  • Glucose 44%
  20 Citations (Scopus)

• Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice

  Christiansen, C. B., Lind, S. J., Svendsen, B., Balk-Møller, E., Dahlby, T., Kuhre, R. E., Hartmann, B., Mandrup-Poulsen, T., Deacon, C. F., Albrechtsen, N. J. W. & Holst, J. J., Jul 2018, In: Physiological Reports. 6, 13, p. 1-8 e13788.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Interleukin-6 65%
  • Glucagon 38%
  • Insulin Secretion 36%
  • Glucose 30%
  2 Citations (Scopus)

  46 Downloads (Pure)

• Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects

  Samkani, A. A., Skytte, M. J., Thomsen, M. N., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Rehfeld, J. F., Krarup, T. & Haugaard, S. B., Sept 2018, In: Nutrients. 10, 9, p. 1-14 14 p., 1285.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dietary Carbohydrates 100%
  • breakfast 91%
  • acute effects 90%
  • dietary carbohydrate 88%
  • hyperlipidemia 85%
  4 Citations (Scopus)

  114 Downloads (Pure)

• A review of dipeptidyl peptidase-4 inhibitors: Hot topics from randomized controlled trials

  Deacon, C. F., Feb 2018, In: Diabetes, Obesity and Metabolism. 20, p. 34-46 13 p.

  Research output: Contribution to journal › Review › peer-review

  • Dipeptidyl-Peptidase IV Inhibitors 100%
  • Randomized Controlled Trials 51%
  • Hypoglycemia 20%
  • Type 2 Diabetes Mellitus 16%
  • Dipeptidyl Peptidase 4 14%
  34 Citations (Scopus)

• A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomised controlled trials

  Deacon, C. F., 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, Suppl. 1, p. 34-46

  Research output: Contribution to journal › Review › peer-review

  • Dipeptidyl-Peptidase IV Inhibitors 100%
  • Randomized Controlled Trials 51%
  • Hypoglycemia 29%
  • Type 2 Diabetes Mellitus 22%
  • Phase III Clinical Trials 18%

• Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

  Kuhre, R. E., Albrechtsen, N. J. W., Larsen, O., Jepsen, S. L., Balk-Møller, E., Andersen, D. B., Deacon, C. F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, R., Hartmann, B., Rosenkilde, M. & Holst, J. J., 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ghrelin 100%
  • Bile Acids and Salts 87%
  • Pancreas 71%
  • GTP-Binding Proteins 47%
  • Glucagon-Like Peptide 1 42%
  60 Citations (Scopus)

  60 Downloads (Pure)

• Do we know the true mechanism of action of the DPP-4 inhibitors?

  Andersen, E. S., Deacon, C. F. & Holst, J. J., 2018, In: Diabetes, Obesity and Metabolism. 20, 1, p. 34-41 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dipeptidyl-Peptidase IV Inhibitors 100%
  • Incretins 65%
  • Neural Pathways 32%
  • Glucose 31%
  • Glucagon-Like Peptide 1 29%
  37 Citations (Scopus)

• Ghrelin secretion in humans - a role for the vagus nerve?

  Veedfald, S., Plamboeck, A., Hartmann, B., Vilsbøll, T., Knop, F. K., Deacon, C. F., Svendsen, L. B. & Holst, J. J., Jun 2018, In: Neurogastroenterology and Motility. 30, 6, e13295.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vagus Nerve 100%
  • Ghrelin 98%
  • Glucagon-Like Peptide 1 48%
  • Meals 18%
  • Endocrine Cells 12%
  9 Citations (Scopus)

• GLP-1 Is a Coronary Artery Vasodilator in Humans

  Clarke, S. J., Giblett, J. P., Yang, L. L., Hubsch, A., Zhao, T., Aetesam-ur-Rahman, M., West, N. E. J., O'Sullivan, M., Figg, N., Bennett, M., Albrechtsen, N. J. W., Deacon, C. F., Cheriyan, J. & Hoole, S. P., 1 Nov 2018, In: Journal of the American Heart Association. 7, 22, 14 p., e010321.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Vasodilator Agents 86%
  • Coronary Vessels 69%
  • Peptides 54%
  • Forearm 32%
  6 Citations (Scopus)

  43 Downloads (Pure)

• Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men

  Veedfald, S., Wu, T., Bound, M., Grivell, J., Hartmann, B., Rehfeld, J. F., Deacon, C. F., Horowitz, M., Holst, J. J. & Rayner, C. K., 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4409-4418

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gastrointestinal Hormone 100%
  • Ghrelin 97%
  • Gastrointestinal Hormones 80%
  • Peptide YY 42%
  • Neurotensin 36%
  11 Citations (Scopus)

• Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?

  Andersen, E. S., Lund, A., Bagger, J. I., Andreasen, C., Grøndahl, MF., Deacon, C. F., Hartmann, B., Holst, J. J., Knop, F. K. & Lauritsen, T. V., Aug 2018, In: Diabetes, Obesity and Metabolism. 20, 8, p. 1937-1943

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sitagliptin Phosphate 100%
  • Dipeptidyl-Peptidase IV Inhibitors 92%
  • Glucagon-Like Peptide 1 68%
  • Type 2 Diabetes Mellitus 52%
  • Dipeptidyl Peptidase 4 47%
  2 Citations (Scopus)

• Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes

  Deacon, C. F., Feb 2018, In: Peptides. 100, p. 150-157 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Dipeptidyl Peptidase IV Inhibitor 98%
  • Dipeptidyl-Peptidase IV Inhibitors 83%
  • Dipeptidyl Peptidase 4 56%
  • Metabolic 51%
  27 Citations (Scopus)

• The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

  Samkani, A., Skytte, M. G. J., Anholm, C., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Boston, R., Krarup, T. & Haugaard, S. B., 27 Dec 2018, In: Lipids in Health and Disease. 17, 9 p., 295.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dietary Carbohydrates 100%
  • Triglyceride 73%
  • Carbohydrates 61%
  • Fatty Acids 59%
  • Lunch 58%
  3 Citations (Scopus)

  59 Downloads (Pure)
• 2017

  Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide: A randomized controlled trial in patients with type 2 diabetes

  Nauck, M. A., Kahle, M., Baranov, O., Deacon, C. F. & Holst, J. J., 1 Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 200-207 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sitagliptin Phosphate 100%
  • Liraglutide 98%
  • Dipeptidyl-Peptidase IV Inhibitors 92%
  • Glucagon-Like Peptide-1 Receptor 90%
  • Type 2 Diabetes Mellitus 52%
  28 Citations (Scopus)

• A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite

  Wewer Albrechtsen, N. J., Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, R. E., Asmar, M., Veedfald, S., Plamboeck, A., Knop, F. K., Vilsbøll, T., Madsbad, S., Nauck, M. A., Deacon, C. F., Bülow, J., Holst, J. J. & Hartmann, B., 1 Sept 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Enzyme-Linked Immunosorbent Assay 60%
  • Type 2 Diabetes Mellitus 12%
  • Dipeptidyl Peptidase 4 11%
  • Dipeptidyl-Peptidase IV Inhibitors 11%
  6 Citations (Scopus)

• Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

  Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N., & 9 othersIdorn, T., Deacon, C. F., Knop, F. K., Rosenkilde, M. M., Hartmann, B., Feldt-Rasmussen, B., Mann, M., Madsbad, S. & Holst, J. J., 7 Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proglucagon 100%
  • Glucagon 85%
  • Insulin Derivative 64%
  • Insulin Secretion 62%
  • Blood Glucose 52%
  13 Citations (Scopus)

  119 Downloads (Pure)

• Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia

  Craig, C. M., Liu, L-F., Deacon, C. F., Holst, J. J. & McLaughlin, T. L., 1 Mar 2017, In: Diabetologia. 60, 3, p. 531-540

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bariatrics 100%
  • Glucagon-Like Peptide 1 93%
  • Hypoglycemia 76%
  • Glucagon-Like Peptide-1 Receptor 30%
  • Glucose Tolerance Test 16%
  59 Citations (Scopus)

• Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men

  Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, J. J., Deacon, C. F., Rehfeld, J. F., Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 1 Apr 2017, In: European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bread 100%
  • Triticum 94%
  • Glucagon-Like Peptide 1 91%
  • Particle Size 81%
  • Kinetics 56%
  11 Citations (Scopus)

  39 Downloads (Pure)

• Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

  Ten Kulve, J. S., Veltman, D. J., Gerdes, V. E. A., van Bloemendaal, L., Barkhof, F., Deacon, C. F., Holst, J. J., Drent, M. L., Diamant, M. & IJzerman, R. G., 1 Nov 2017, In: Diabetes Care. 40, 11, p. 1522-1529 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Gastric Bypass 97%
  • Cues 74%
  • Food 59%
  • Central Nervous System 35%
  30 Citations (Scopus)

• Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men

  Matikainen, N., Söderlund, S., Björnson, E., Bogl, L. H., Pietiläinen, K. H., Hakkarainen, A., Lundbom, N., Eliasson, B., Räsänen, S. M., Rivellese, A., Patti, L., Prinster, A., Riccardi, G., Després, J-P., Alméras, N., Holst, J. J., Deacon, C. F., Borén, J. & Taskinen, M-R., Jun 2017, In: Nutrition, Metabolism & Cardiovascular Diseases. 27, 6, p. 534-542 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Incretins 100%
  • Fructose 87%
  • Meals 69%
  • Hormones 54%
  • Glucagon-Like Peptide 1 48%
  11 Citations (Scopus)

• Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

  Windeløv, J. A., Wewer Albrechtsen, N. J., Kuhre, R. E., Jepsen, S. L., Hornburg, D., Pedersen, J., Jensen, E. P., Galsgaard, K. D., Winther-Sørensen, M., Ørgaard, A., Deacon, C. F., Mann, M., Kissow, H., Hartmann, B. & Holst, J. J., 1 Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Enzyme-Linked Immunosorbent Assay 26%
  • candoxatril 21%
  • Dipeptidyl Peptidase 4 14%
  • Peptide Fragments 7%
  22 Citations (Scopus)
• 2016

  A comparative review of DPP-4 inhibitors and sulphonylureas

  Deacon, C. F. & Lebovitz, HE., 2016, In: Diabetes, Obesity and Metabolism. 18, p. 333-347

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dipeptidyl-Peptidase IV Inhibitors 100%
  • Metformin 81%
  • Hypoglycemia 73%
  • Weight Gain 69%
  • Hypoglycemic Agents 36%

• A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes

  Wu, T., Little, TL., Bound, MJ., Borg, M., Zhang, X., Deacon, C. F., Horowitz, M., Jones, KL. & Rayner, CK., Apr 2016, In: Diabetes Care. 39, 4, p. 511-517 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vildagliptin 100%
  • Gastric Emptying 74%
  • Incretins 72%
  • Type 2 Diabetes Mellitus 48%
  • Glucose 40%
  47 Citations (Scopus)

• Cephalic phase secretion of insulin and other enteropancreatic hormones in humans

  Veedfald, S., Plamboeck, A., Deacon, C. F., Hartmann, B., Knop, F. K., Lauritsen, T. V. & Holst, J. J., 1 Jan 2016, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 1, p. G43-51

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Atropine 100%
  • Insulin Secretion 97%
  • Ghrelin 93%
  • Glucagon 81%
  • Pancreatic Polypeptide 80%
  30 Citations (Scopus)

• Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas.

  Deacon, C. F. & Lebovitz, HE., 1 Apr 2016, In: Diabetes, Obesity and Metabolism. 18, 4, p. 333-347 15 p.

  Research output: Contribution to journal › Review › peer-review

  • Dipeptidyl-Peptidase IV Inhibitors 100%
  • Metformin 32%
  • Hypoglycemia 29%
  • Weight Gain 27%
  • Hypoglycemic Agents 14%
  115 Citations (Scopus)

• DPP-4 inhibitors

  Deacon, C. F., 2016, Handbook of incretin therapies in type 2 diabetes. Gough, S. (ed.). Switzerland: Springer, p. 45-60

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  • Dipeptidyl Peptidase IV Inhibitor 100%
  • Antidiabetic Agent 78%
  • Hormone 63%

• Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.

  Albrechtsen, N. J. W., Kuhre, R. E., Windeløv, J. A., Ørgaard, A., Deacon, C. F., Kissow, H., Hartmann, B. & Holst, J. J., 1 Aug 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 2, p. E302-E309 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon 100%
  • Enzyme-Linked Immunosorbent Assay 67%
  • Arginine 53%
  • Hypnorm 38%
  • Glucose 36%
  16 Citations (Scopus)

• Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition: a randomized, prospective comparison of sitagliptin and vildagliptin treatment

  Baranov, O., Kahle, M., Deacon, C. F., Holst, J. J. & Nauck, M. A., 1 Nov 2016, In: Diabetes, Obesity and Metabolism. 18, 11, p. 1100-1109 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vildagliptin 100%
  • Sitagliptin Phosphate 92%
  • Dipeptidyl Peptidase 4 87%
  • Glucagon-Like Peptide 1 76%
  • Meals 58%
  11 Citations (Scopus)

• Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes

  Albrechtsen, N. J. W., Albrechtsen, R., Bremholm, L., Svendsen, B., Kuhre, R. E., Poulsen, S. S., Christiansen, C. B., Jensen, E. P., Janus, C., Hilsted, L., Deacon, C. F., Hartmann, B. & Holst, J. J., 13 Dec 2016, In: Cell Reports. 17, 11, p. 2845-2856 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Glucagon-Like Peptide-1 Receptor 81%
  • Acinar Cells 74%
  • Exocrine Pancreas 62%
  • Incretins 41%
  15 Citations (Scopus)

  553 Downloads (Pure)

• Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion

  Wewer Albrechtsen, N. J., Veedfald, S., Plamboeck, A., Deacon, C. F., Hartmann, B., Knop, F. K., Lauritsen, T. V. & Holst, J. J., 2016, In: Journal of Diabetes Research. 2016, 5 p., 8352957.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon 100%
  • Technology 20%
  • Health Care Outcome Assessment 13%
  • Spectrophotometry 13%
  • Glucose Clamp Technique 12%
  22 Citations (Scopus)

  65 Downloads (Pure)

• Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

  Matikainen, N., Björnson, E., Söderlund, S., Borén, C., Eliasson, B., Pietiläinen, K. H., Bogl, L. H., Hakkarainen, A., Lundbom, N., Rivellese, A., Riccardi, G., Després, J-P., Alméras, N., Holst, J. J., Deacon, C. F., Borén, J. & Taskinen, M-R., 11 Jan 2016, In: PLOS ONE. 11, 1, p. 1-15 15 p., e0145890.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • glucagon-like peptide 2 100%
  • Glucagon-Like Peptide 2 93%
  • glucagon-like peptide 1 86%
  • gastric inhibitory polypeptide 85%
  • Peptides 83%
  13 Citations (Scopus)

• Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

  Wewer Albrechtsen, N. J., Hornburg, D., Albrechtsen, R., Svendsen, B., Toräng, S., Jepsen, S. L., Kuhre, R. E., Hansen, M., Janus, C., Floyd, A., Lund, A., Lauritsen, T. V., Knop, F. K., Vestergaard, H., Deacon, C. F., Meissner, F., Mann, M., Holst, J. J. & Hartmann, B., 1 May 2016, In: EBioMedicine. 7, p. 112-120 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oxyntomodulin 100%
  • Gastrointestinal Hormone 67%
  • Glucagon-Like Peptide 1 62%
  • Gastric Bypass 60%
  • Mass Spectrometry 47%
  37 Citations (Scopus)

• Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon

  Larger, E., Albrechtsen, N. J. W., Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, C. F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, J. J. & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon 100%
  • Hyperplasia 84%
  • Mutation 53%
  • Glucagon Receptors 42%
  • Amino Acids 38%
  35 Citations (Scopus)

• Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.

  Kuhre, R. E., Albrechtsen, N. J. W., Deacon, C. F., Balk-Møller, E., Rehfeld, J. F., Relman, F., Gribble, F. M. & Holst, J. J., Apr 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211

  Research output: Contribution to journal › Journal article › Research › peer-review

  • L Cells 100%
  • Glucagon-Like Peptide 1 89%
  • Proprotein Convertase 1 50%
  • Peptides 48%
  • Cell Line 36%
  48 Citations (Scopus)

• Quantification of the contribution of GLP-1 to mediating insulinotropic effects of DPP-4 inhibition with vildagliptin in healthy subjects and type 2-diabetic patients using exendin [9-39] as a GLP-1 receptor antagonist.

  Nauck, M. A., Kind, J., Köthe, L. D., Holst, J. J., Deacon, C. F., Broschag, M., He, YL., Kjems, L. & Foley, J., 1 Aug 2016, In: Diabetes. 65, 8, p. 2440-2447 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • exendin (9-39) 100%
  • Vildagliptin 91%
  • Dipeptidyl Peptidase 4 80%
  • Glucagon-Like Peptide-1 Receptor 76%
  • Glucagon-Like Peptide 1 69%
  35 Citations (Scopus)

• Small intestinal glucose delivery affects the glucose-lowering effect of acute vildagliptin in type 2 diabetes

  Wu, T., Zhang, X., Trahair, LG., Bound, MJ., Little, TL., Deacon, C. F., Horowitz, M., Jones, KL. & Rayner, CK., 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4769-4778

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vildagliptin 100%
  • Glucagon-Like Peptide 1 44%
  • Type 2 Diabetes Mellitus 42%
  • Glucose 41%
  • Insulinotropic 37%
  11 Citations (Scopus)

• The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs

  Veedfald, S., Hansen, M., Christensen, L. W., Larsen, S. A. H., Hjøllund, K. R., Plamboeck, A., Hartmann, B., Deacon, C. F. & Holst, J. J., 1 Jul 2016, In: Experimental Physiology. 101, 7, p. 895-912 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vagotomy 100%
  • Glucagon-Like Peptide 1 96%
  • Swine 65%
  • Truncal Vagotomy 19%
  • Glucose 13%
  3 Citations (Scopus)
• 2015

  Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow

  Jensen, E. P., Poulsen, S. S., Kissow, H., Holstein-Rathlou, N-H., Deacon, C. F., Jensen, B. L., Holst, J. J. & Sorensen, C. M., 15 Apr 2015, In: A J P: Renal Physiology (Online). 308, 8, p. F867-F877 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide-1 Receptor 100%
  • Renal Circulation 90%
  • Arterioles 84%
  • Vascular Smooth Muscle 76%
  • Smooth Muscle Myocytes 68%
  63 Citations (Scopus)

• Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients

  Yabe, D., Kuroe, A., Watanabe, K., Iwasaki, M., Hamasaki, A., Hamamoto, Y., Harada, N., Yamane, S., Lee, S., Murotani, K., Deacon, C. F., Holst, J. J., Hirano, T., Inagaki, N., Kurose, T. & Seino, Y., 1 Apr 2015, In: Journal of Diabetes and its Complications. 29, p. 413-421 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Incretins 100%
  • Glucagon 80%
  • Hyperglycemia 70%
  • Nutrients 65%
  • Eating 58%
  30 Citations (Scopus)

• Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in type 2 diabetes

  Wu, T., Trahair, LG., Bound, MJ., Deacon, C. F., Horowitz, M., Rayner, CK. & Jones, KL., 2015, In: Diabetic Medicine. 32, 5, p. 595-600 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  4 Citations (Scopus)

• Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

  Ten Kulve, J. S., Veltman, D. J., van Bloemendaal, L., Barkhof, F., Deacon, C. F., Holst, J. J., Konrad, R. J., Sloan, J. H., Drent, M. L., Diamant, M. & IJzerman, R. G., 1 Dec 2015, In: Diabetologia. 58, 12, p. 2688-98 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Reward 82%
  • Type 2 Diabetes Mellitus 64%
  • Central Nervous System 63%
  • Food 33%
  51 Citations (Scopus)

• Important species differences regarding lymph contribution to gut hormone responses

  Hansen, M., Hjøllund, K. R., Hartmann, B., Plamboeck, A., Deacon, C. F., Albrechtsen, N. J. W. & Holst, J. J., 24 Jun 2015, In: Peptides. 71, p. 28-31 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vildagliptin 100%
  • Gastrointestinal Hormone 96%
  • Neuromedin C 72%
  • Glucagon-Like Peptide 1 65%
  • Lymph 61%
  3 Citations (Scopus)

• Incretin effect after oral amino Acid ingestion in humans

  Lindgren, O., Pacini, G., Tura, A., Holst, J. J., Deacon, C. F. & Ahrén, B., 1 Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. 1172-6 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Incretins 100%
  • Insulin Derivative 64%
  • Eating 58%
  • Amino Acids 53%
  • Insulinotropic 46%
  41 Citations (Scopus)

• Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

  Kuhre, R. E., Wewer Albrechtsen, N. J., Hartmann, B., Deacon, C. F. & Holst, J. J., 1 Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gastric Inhibitory Polypeptide 100%
  • Incretins 88%
  • Glucagon-Like Peptide 1 79%
  • Hormones 47%
  • Insulin Secretion 22%
  42 Citations (Scopus)

• Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors

  Aaboe, K., Akram, S., Deacon, C. F., Holst, J. J., Madsbad, S. & Krarup, T., 1 Jan 2015, In: Diabetes, Obesity and Metabolism. 17, 1, p. 74-81 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dipeptidyl-Peptidase IV Inhibitors 100%
  • Sitagliptin Phosphate 92%
  • Hypoglycemic Agents 72%
  • Glucagon-Like Peptide 1 50%
  • Peptides 48%
  31 Citations (Scopus)

• Stability of glucagon-like peptide-1 and glucagon in human plasma

  Albrechtsen, N. J. W., Bak, M. J., Hartmann, B., Christensen, L. W., Kuhre, R. E., Deacon, C. & Holst, J. J., 16 Jan 2015, In: Endocrine Connections. 4, 1, p. 50-57 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Glucagon 88%
  • Ice 51%
  • Dipeptidyl-Peptidase IV Inhibitors 42%
  • Freezing 21%