Department of Drug Design and Pharmacology

2014

Standardized testing with chlorhexidine in perioperative allergy – a large single-centre evaluation

Schjørring Opstrup, M., Malling, H-J., Krøigaard, M., Mosbech, H., Skov, P. S., Poulsen, L. K. & Garvey, L. H., 24 Jun 2014, In: Allergy. 69, 10, p. 1390–1396 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

89 Citations (Scopus)

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel γ-aminobutyric acidA receptor agonists

Petersen, J. G., Sørensen, T. E., Damgaard, M., Nielsen, B., Jensen, A. A., Balle, T., Bergmann, R. & Frølund, B., 12 Sept 2014, In: European Journal of Medicinal Chemistry. 84, p. 404-416 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Synthesis and SAR study of a novel series of dopamine receptor agonists

Risgaard, R., Jensen, M., Jørgensen, M., Bang-Andersen, B., Christoffersen, C. T., Jensen, K. G., Kristensen, J. L. & Püschl, A., 1 Jan 2014, In: Bioorganic and Medicinal Chemistry. 22, 1, p. 381-392

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H. & Kristensen, J. L., 19 Mar 2014, In: A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

75 Citations (Scopus)

Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, H. M., Frimodt-Møller, N. & Franzyk, H., 10 Apr 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

The prognosis of incurable cachectic cancer patients on home parenteral nutrition: a multi-centre observational study with prospective follow-up of 414 patients

Bozzetti, F., Santarpia, L., Pironi, L., Thul, P., Klek, S., Gavazzi, C., Tinivella, M., Joly, F., Jonkers, C., Baxter, J., Gramlich, L., Chicharro, L., Staun, M., Van Gossum, A., Lo Vullo, S. & Mariani, L., Feb 2014, In: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 25, 2, p. 487-493 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition

Welling, S. H., Hubálek, F., Jacobsen, J., Brayden, D. J., Rahbek, U. L. & Buckley, S. T., Apr 2014, In: European Journal of Pharmaceutics and Biopharmaceutics. 86, 3, p. 544-51 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Topotecan Monotherapy in Heavily Pretreated Patients with Progressive Advanced Stage Neuroendocrine Carcinomas

Olsen, I. M. H., Knigge, U., Federspiel, B., Hansen, C. P., Skov, A., Kjær, A. & Langer, S. W., 2014, In: Journal of Cancer. 5, 8, p. 628-632 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Disease

Mylotte, D., Lefevre, T., Søndergaard, L., Watanabe, Y., Modine, T., Dvir, D., Bosmans, J., Tchetche, D., Kornowski, R., Sinning, J-M., Thériault-Lauzier, P., O'Sullivan, C. J., Barbanti, M., Debry, N., Buithieu, J., Codner, P., Dorfmeister, M., Martucci, G., Nickenig, G., Wenaweser, P., & 6 othersTamburino, C., Grube, E., Webb, J. G., Windecker, S., Lange, R. & Piazza, N., 9 Dec 2014, In: Journal of the American College of Cardiology. 64, 22, p. 2330-2339 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

194 Citations (Scopus)

6 Downloads (Pure)

Transcatheter treatment of heart failure with preserved or mildly reduced ejection fraction using a novel interatrial implant to lower left atrial pressure

Søndergaard, L., Reddy, V., Kaye, D., Malek, F., Walton, A., Mates, M., Franzen, O., Neuzil, P., Ihlemann, N. & Gustafsson, F., Jul 2014, In: European Journal of Heart Failure. 16, 7, p. 796-801 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

Transkateterlukning af venstre atriums aurikel til forebyggelse af apoplexia cerebri

Translated title of the contribution: Percutaneous closure of the left atrial appendage for stroke prevention.Loupis, A. M., De Backer, O., Ihlemann, N., Rosenberg, T. S., Franzen, O. W. & Søndergaard, L., 15 Sept 2014, In: Ugeskrift for Laeger. 176, 38, p. 1759-1762 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Treatment of aortic stenosis with a self-expanding transcatheter valve: the International Multi-centre ADVANCE Study

Linke, A., Wenaweser, P., Gerckens, U., Tamburino, C., Bosmans, J., Bleiziffer, S., Blackman, D., Schäfer, U., Müller, R., Sievert, H., Søndergaard, L., Klugmann, S., Hoffmann, R., Tchétché, D., Colombo, A., Legrand, V. M., Bedogni, F., lePrince, P., Schuler, G., Mazzitelli, D., & 10 othersEftychiou, C., Frerker, C., Boekstegers, P., Windecker, S., Mohr, F-W., Woitek, F., Lange, R., Bauernschmitt, R., Brecker, S. & ADVANCE study Investigators, 7 Oct 2014, In: European Heart Journal. 35, 38, p. 2672-2684 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

164 Citations (Scopus)

2013

[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice

Jensen, M. M., Erichsen, K. D., Johnbeck, C. B., Björkling, F., Madsen, J., Jensen, P. B., Sehested, M., Højgaard, L. & Kjær, A., 1 Apr 2013, In: B M C Cancer. 13, p. 1-9 10 p., 168.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

A characterization of the current communication patterns in Danish community pharmacies - an observational study

Kaae, S., Mygind, A. & Saleem, S., Nov 2013, In: Research in Social and Administrative Pharmacy. 9, 6, p. 958-64 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Adductor canal block versus femoral nerve block for analgesia after total knee arthroplasty: A Randomized, Double-blind Study

Jaeger, P., Zaric, D., Fomsgaard, J. S., Hilsted, K. L., Bjerregaard, J., Gyrn, J., Mathiesen, O., Larsen, T. & Dahl, J. B., Nov 2013, In: Regional Anesthesia and Pain Medicine. 38, 6, p. 526-532 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

207 Citations (Scopus)

An aromatic substituted pentadienoic acid amides as potentiators of the bioefficacy of drugs

Koul, S., Mallepally Venkat, R., Thota, N., Koul Jawahir, L. & Sangwan Payare. et.al, L., 2013, Patent No. Denmark

Research output: Patent

A unified model of the GABAA receptor comprising agonsit and benzodiazepine binding sites

Bergmann, R., Kongsbak, K. G., Sørensen, P. L., Sander, T. & Balle, T., 7 Jan 2013, In: P L o S One. 8, 1, p. e52323 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

84 Citations (Scopus)

Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures

Dadsetan, S., Kukolj, E., Bak, L. K., Sørensen, M., Ott, P., Vilstrup, H., Schousboe, A., Keiding, S. & Waagepetersen, H. S., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1235-41 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Central Hypothyroidism and Its Replacement Have a Significant Influence on Cardiovascular Risk Factors in Adult Hypopituitary Patients

Klose, M., Marina, D., Hartoft-Nielsen, M-L., Klefter, O., Gavan, V., Hilsted, L., Rasmussen, Å. K. & Feldt-Rasmussen, U., Sept 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 9, p. 3802-3810 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Characterization of a proteolytically stable multifunctional host defense peptidomimetic

Jahnsen, R. D., Haney, E. F., Franzyk, H. & Hancock, R. E. W., 24 Oct 2013, In: Chemistry & Biology. 20, 10, p. 1286-1295 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry

Müller, M. S., Obel, L. L. F., Waagepetersen, H. S., Schousboe, A. & Bak, L. K., Jun 2013, In: Neurochemical Research. 38, 6, p. 1260-5 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Contextualising migrants’ health behaviour – Transnational ties and their implications for participation in mammography screening

Lue Kessing, L., Nørredam, M. L., Kvernrød, A-B., Mygind, A. & Kristiansen, M., 2013, In: B M C Public Health. 13, 431.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Control of the ambident reactivity of the nitrite ion

Dong, H., Rahm, M., Thota, N., Deng, L., Brinck, T. & Ramström, O., 28 Jan 2013, In: Organic & Biomolecular Chemistry. 11, 4, p. 648-53 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

CPC-056 Evolution in Drug Related Problems Identified in Pharmacist Notes at the Emergency Department, Hillerød Hospital Denmark

Tomsen, DV., Jensen, MB., Gammelgaard, LG. & Christrup, L., 2013, In: European Journal of Hospital Pharmacy - Science and Practice. 20, p. A185-A185

Research output: Contribution to journal › Journal article › Research › peer-review

Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

Crestey, F., Jensen, A. A., Borch, M., Andreasen T., J., Andersen, J., Balle, T. & Kristensen, J. L., 12 Dec 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9673-9682

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Design and characterization of core-shell mPEG-PLGA composite microparticles for development of cell-scaffold constructs

Wen, Y., Gallego, M. R., Nielsen, L. F., Jorgensen, L., Møller, E. H. & Nielsen, H. M., Sept 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 1, p. 87-98 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Herth, M. M., Andersen, V. L., Lehel, S., Madsen, J., Knudsen, G. M. & Kristensen, J. L., 9 Apr 2013, In: Chemical Communications. 49, p. 3805-3807 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Diagnose og behandling af binyrebarkkarcinom

Abildgaard, J., Pappot, H., Petersen, P. M., Rørth, M., Rasmussen, Å. K., Toft, B. G., Sommer, P. & Daugaard, G., Apr 2013, In: Ugeskrift for Laeger. 175, 17, p. 1181-1185 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of a subtype-selective of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile

Kragholm, B., Kvist, T., Madsen, K. K., Jørgensen, L., Vogensen, S. B., Schousboe, A., Clausen, R. P., Jensen, A. A. & Bräuner-Osborne, H., 2013, In: Biochemical Pharmacology. 86, p. 521-528

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Diversity Oriented Approach toTriazole Based Peptidomimetics as Mammalian Sterile 20 Kinase Inhibitors

Kotha, S., Goyal, D., Bitra, A., Thota, N., Kruger, G. & Anand, R., 14 Dec 2013, In: R S C Advances. 3, p. 24447-24454 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper

Aabye, M. G., Latorre, I., Diaz, J., Maldonado, J., Mialdea, I., Eugen-Olsen, J., Ravn, P., Dominguez, J. & Ruhwald, M., 1 Aug 2013, In: European Respiratory Journal. 42, 2, p. 495-503 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

Early clinical outcome of aortic transcatheter valve-in-valve implantation in the Nordic countries

Ihlberg, L., Nissen, H. H., Nielsen, N. E., Rück, A., Busund, R., Klaarborg, K-E., Soendergaard, L., Harnek, J., Miettinen, H., Eskola, M., Wahba, A. & Laine, M., Nov 2013, In: Journal of Thoracic and Cardiovascular Surgery. 146, 5, p. 1047-1054 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Echocardiographic and clinical outcomes of central versus noncentral percutaneous edge-to-edge repair of degenerative mitral regurgitation

Estévez-Loureiro, R., Franzen, O., Winter, R., Sondergaard, L., Jacobsen, P., Cheung, G., Moat, N., Ihlemann, N., Ghione, M., Price, S., Duncan, A., Streit Rosenberg, T., Barker, S., Di Mario, C. & Settergren, M., 24 Dec 2013, In: Journal of the American College of Cardiology. 62, 25, p. 2370-2377 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Enhanced voluntary wheel running in GPRC6A receptor knockout mice

Clemmensen, C., Pehmøller, C., Klein, A. B., Ratner, C., Wojtaszewski, J. & Bräuner-Osborne, H., 3 Jun 2013, In: Physiology & Behavior. 118, p. 144-151 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation

Krall, J., Jensen, C. H., Sørensen, T. E., Nielsen, B., Jensen, A. A., Sander, T., Balle, T. & Frølund, B., 22 Aug 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6536−6540 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease

Jensen, A. S., Johansson, P. I., Bochsen, L., Idorn, L., Sørensen, K. E., Thilén, U., Nagy, E., Furenäs, E. & Søndergård, L., 1 Sept 2013, In: International Journal of Cardiology. 167, 5, p. 2210-2014 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

How should I treat severe paravalvular leakage after TAVI?

Reinthaler, M., Empen, K., Busch, M., Könemann, R., Ince, H., Felix, S. B., Jilaihawi, H., Chakravarty, T., Makkar, R. R., Franzen, O., Loh, P. H., Ihlemann, N. & Søndergaard, L., Sept 2013, In: EuroIntervention. 9, 5, p. 650-653 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide

Petersen, I. N., Tortzen, C., Kristensen, J. L., Pedersen, D. S. & Breindahl, T., Jun 2013, In: Journal of Analytical Toxicology. 37, 5, p. 291-7 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

Clemmensen, C., Smajilovic, S., Madsen, A. N., Klein, A. B., Holst, B. & Bräuner-Osborne, H., May 2013, In: Journal of Endocrinology. 217, 2, p. 151-60 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Infective endocarditis following percutaneous pulmonary valve replacement: Diagnostic challenges and application of intra-cardiac echocardiography

Cheung, G., Vejlstrup, N., Ihlemann, N., Arnous, S., Franzen, O., Bundgaard, H. & Søndergaard, L., 30 Nov 2013, In: International Journal of Cardiology. 169, 6, p. 425–429 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Organ culture of C57BL/6 mouse arteries with LPS as an in vitro model of vascular inflammation

Outzen, E. M., Mehryar, R., Boonen, H. C. M., Nielsen, A. S. & Sheykhzade, M., 28 Aug 2013. 1 p.

Research output: Contribution to conference › Poster › Research

Patients' preferences for patient-centered communication: a survey from an outpatient department in rural Sierra Leone

Lau, S. R., Christensen, S. T. & Andreasen T., J., Nov 2013, In: Patient Education and Counseling. 93, 2, p. 312-8 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Percutaneous pulmonary valve replacement after different duration of free pulmonary regurgitation in a porcine model effects on the right and left ventricle

Ersboell, M., Vejlstrup, N., Nilsson, J. C., Kjaergaard, J., Norman, W., Lange, T., Taylor, A., Bonhoeffer, P. & Sondergaard, L., 2013, In: International Journal of Cardiology. 167, 6, p. 2944-51 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Perspectives in Implementing Standardized Case Definitions for Tuberculosis Research Involving Children in a Low-Income, High-Burden Setting

Holm, L. L., Rose, M. V. & Ravn, P., 1 Mar 2013, In: Journal of Infectious Diseases. 207, 5, p. 870-871 2 p.

Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)

Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro

Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, J. L. & Clausen, R. P., 2 Jul 2013, In: P L o S One. 8, 7, p. e67653

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Quality of life and cognitive function in Fontan patients, a population-based study

Idorn, L., Jensen, A. S., Juul, K., Overgaard, D., Nielsen, N. P., Sørensen, K. E., Reimers, J. I. & Søndergaard, L., 9 Oct 2013, In: International Journal of Cardiology. 168, 4, p. 3230-3235 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

Kankala, S., Kankala, R. K., Gundepaka, P., Thota, N., Nerella, S., Gangula, M. R., Guguloth, H., Kagga, M., Vadde, R. & Vasam, C. S., 1 Mar 2013, In: Bioorganic & Medicinal Chemistry Letters. 23, 5, p. 1306-9 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

80 Citations (Scopus)

Response to GH treatment in adult GH deficiency is predicted by gender, age, and IGF1 SDS but not by stimulated GH-peak

Feldt-Rasmussen, U., Brabant, G., Maiter, D., Jonsson, B., Toogood, A., Koltowska-Haggstrom, M., Rasmussen, Å. K., Buchfelder, M., Saller, B. & Biller, B. M. K., May 2013, In: European Journal of Endocrinology. 168, 5, p. 733-743 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal nicotine-evoked glutamatergic transients in rats

Grupe, M., Paolone, G., Jensen, A. A., Sandager-Nielsen, K., Sarter, M. & Grunnet, M., 2013, In: Biochemical Pharmacology. 86, 10, p. 1487-1496

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Short-acting sulfonamides near term and neonatal jaundice

Klarskov, P., Andersen, J. T., Jimenez-Solem, E., Torp-Pedersen, C. & Poulsen, H. E., Jul 2013, In: Obstetrics and Gynecology International. 122, 1, p. 105-110 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Department of Drug Design and Pharmacology

Research output

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