Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Matthias Manfred Herth; Valdemar L.  Andersen; Szabolcs Lehel; Jacob Madsen; Gitte Moos Knudsen; Jesper Langgaard Kristensen

doi:10.1039/c3cc41027g

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Matthias Manfred Herth, Valdemar L. Andersen, Szabolcs Lehel, Jacob Madsen, Gitte Moos Knudsen, Jesper Langgaard Kristensen

Department of Drug Design and Pharmacology

49 Citations (Scopus)

Abstract

Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

Original language	English
Journal	Chemical Communications
Volume	49
Pages (from-to)	3805-3807
Number of pages	3
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c3cc41027g
Publication status	Published - 9 Apr 2013

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10.1039/c3cc41027g

Cite this

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abstract = "Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.",

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AU - Herth, Matthias Manfred

AU - Andersen, Valdemar L.

AU - Lehel, Szabolcs

AU - Madsen, Jacob

AU - Knudsen, Gitte Moos

AU - Kristensen, Jesper Langgaard

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AB - Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

U2 - 10.1039/c3cc41027g

DO - 10.1039/c3cc41027g

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JO - Chemical Communications

JF - Chemical Communications

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