Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

Shravankumar Kankala; Ranjith Kumar Kankala; Prasad Gundepaka; Niranjan Thota; Srinivas Nerella; Mohan Rao Gangula; Hanmanthu Guguloth; Mukkanti Kagga; Ravinder Vadde; Chandra Sekhar Vasam

doi:10.1016/j.bmcl.2012.12.101

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

Shravankumar Kankala, Ranjith Kumar Kankala, Prasad Gundepaka, Niranjan Thota, Srinivas Nerella, Mohan Rao Gangula, Hanmanthu Guguloth, Mukkanti Kagga, Ravinder Vadde, Chandra Sekhar Vasam

Department of Drug Design and Pharmacology

80 Citations (Scopus)

Abstract

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their efficiency in in vivo analgesic and anti-inflammatory activity was described. A comparison of structure-activity relationship for there compounds was also emphasized.

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	23
Issue number	5
Pages (from-to)	1306-9
Number of pages	4
ISSN	0960-894X
DOIs	https://doi.org/10.1016/j.bmcl.2012.12.101
Publication status	Published - 1 Mar 2013

Keywords

Analgesics
Anti-Inflammatory Agents
Benzimidazoles
Isoxazoles
Structure-Activity Relationship
Journal Article

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10.1016/j.bmcl.2012.12.101

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Kankala, S., Kankala, R. K., Gundepaka, P., Thota, N., Nerella, S., Gangula, M. R., Guguloth, H., Kagga, M., Vadde, R., & Vasam, C. S. (2013). Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies. Bioorganic & Medicinal Chemistry Letters, 23(5), 1306-9. https://doi.org/10.1016/j.bmcl.2012.12.101

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies. / Kankala, Shravankumar; Kankala, Ranjith Kumar; Gundepaka, Prasad et al.
In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 5, 01.03.2013, p. 1306-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Kankala, S, Kankala, RK, Gundepaka, P, Thota, N, Nerella, S, Gangula, MR, Guguloth, H, Kagga, M, Vadde, R & Vasam, CS 2013, 'Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies', Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 5, pp. 1306-9. https://doi.org/10.1016/j.bmcl.2012.12.101

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abstract = "Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their efficiency in in vivo analgesic and anti-inflammatory activity was described. A comparison of structure-activity relationship for there compounds was also emphasized.",

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AU - Kankala, Shravankumar

AU - Kankala, Ranjith Kumar

AU - Gundepaka, Prasad

AU - Thota, Niranjan

AU - Nerella, Srinivas

AU - Gangula, Mohan Rao

AU - Guguloth, Hanmanthu

AU - Kagga, Mukkanti

AU - Vadde, Ravinder

AU - Vasam, Chandra Sekhar

PY - 2013/3/1

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N2 - Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their efficiency in in vivo analgesic and anti-inflammatory activity was described. A comparison of structure-activity relationship for there compounds was also emphasized.

AB - Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their efficiency in in vivo analgesic and anti-inflammatory activity was described. A comparison of structure-activity relationship for there compounds was also emphasized.

KW - Analgesics

KW - Anti-Inflammatory Agents

KW - Benzimidazoles

KW - Isoxazoles

KW - Structure-Activity Relationship

KW - Journal Article

U2 - 10.1016/j.bmcl.2012.12.101

DO - 10.1016/j.bmcl.2012.12.101

M3 - Journal article

C2 - 23357631

SN - 0960-894X

VL - 23

SP - 1306

EP - 1309

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 5

ER -

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

Abstract

Keywords

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