Research output per year
Research output per year
Personal profile
CV
EDUCATION
- PhD (pharm.), 1995
- MSc (pharm.), 1990
- Apoteksassistent, 1986
EMPLOYMENT
- Associate professor at the Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 2000-
- Assistant professor at the Department of Pharmacy, the Danish University of Pharmaceutical Sciences, 1996-2000
- Research and teaching assistant at the Department of Pharmacy, Royal Danish School of Pharmacy, 1995-1996
- PhD student at the Department of Pharmacy, Royal Danish School of Pharmacy, 1991-1995
- Apoteksassistentelev, Næstved Løve Apotek, 1983-1986
Short presentation
RESEARCH INTERESTS AND EXPERIENCES
The research gains fundamental knowledge about drug delivery in the oral cavity to alleviate local disorders or for systemic drug administration. Elucidation of oromucosal absorption barrier properties and development of biorelevant in vitro methods to study oromucosal toxicity and permeability of drugs and excipients: I) mechanistic understanding of bioadhesivness, drug release and drug absorption, II) in vitro-in vivo correlation of toxicity and permeability of drugs (cell culture, modified Ussing chamber, bioavailability studies in animals); III) development of aqueous gel for alleviation of mucosal disorders or food lubricant
Key words: Oromucosal drug delivery – adhesion – anti-adhesion - biorelevant in vitro models (cell culture, Ussing chamber) - permeability – bioavailability – IVIVC - toxicity of drugs and formulated drugs/excipients – mucus - absorption barrier - absorption enhancement – absorption retardment - surfactants –- lubrication - humectants
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Dive into the research topics where Jette Jacobsen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers
Stie, M. B., Jones, M., Sørensen, H. O., Jacobsen, J., Chronakis, I. S. & Nielsen, H. M., 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262Research output: Contribution to journal › Journal article › Research › peer-review
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Polymeric Lids for Microcontainers for Oral Protein Delivery
Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, J. R., Vaut, L., Jacobsen, J., Gundlach, C., Müllertz, A., Nielsen, L. H. & Boisen, A., May 2019, In: Macromolecular Bioscience. 19, 5, 1900004.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery
Handler, A. M., Marxen, E., Jacobsen, J. & Janfelt, C., 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analytical aspects of printed oral dosage forms
Edinger, M., Jacobsen, J., Bar-Shalom, D., Rantanen, J. & Genina, N., 20 Dec 2018, In: International Journal of Pharmaceutics. 553, 1-2, p. 97-108Research output: Contribution to journal › Journal article › Research › peer-review
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Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa
Hansen, S. E., Marxen, E., Janfelt, C. & Jacobsen, J., Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging
Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A., 1 Mar 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.Research output: Contribution to journal › Journal article › Research › peer-review
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Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging
Marxen, E., Jacobsen, J., Hyrup, B. & Janfelt, C., 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526Research output: Contribution to journal › Journal article › Research › peer-review
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Polymer coated liposomes for use in the oral cavity - A study of the in vitro toxicity, effect on cell permeability and interaction with mucin
Klemetsrud, T., Kjøniksen, A.-L., Hiorth, M., Jacobsen, J. & Smistad, G., 2 Jan 2018, In: Journal of Liposome Research. 28, 1, p. 62–73 12 p.Research output: Contribution to journal › Journal article › Research › peer-review