Biomolecular Sciences

2017

A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)

Hendus-Altenburger, R., Lambrughi, M., Terkelsen, T. B., Pedersen, S. H. F., Papaleo, E., Lindorff-Larsen, K. & Kragelund, B. B., Sept 2017, In: Cellular Signalling. 37, p. 40-51 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

109 Downloads (Pure)

Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness

Olsen, J. G., Teilum, K. & Kragelund, B. B., 1 Sept 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3175-3183 9 p.

Research output: Contribution to journal › Review › peer-review

48 Citations (Scopus)

118 Downloads (Pure)

Biomolecular conformational changes and ligand binding: from kinetics to thermodynamics

Wang, Y., Martins, J. & Lindorff-Larsen, K., Sept 2017, In: Chemical Science. 8, 9, p. 6466-6473 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

84 Downloads (Pure)

Blocking protein quality control to counter hereditary cancers

Kampmeyer, C., Nielsen, S. V., Clausen, L., Stein, A., Gerdes, A-M. A., Lindorff-Larsen, K. & Hartmann-Petersen, R., Dec 2017, In: Genes, Chromosomes & Cancer. 56, 12, p. 823-831 9 p.

Research output: Contribution to journal › Review › peer-review

10 Citations (Scopus)

Choreography by Structural Disorder in Membrane Proteins

Kragelund, B. B., 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, suppl. 1, p. 12A 1 p., 65-Subg.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate

dos Santos, E. C., Rozynek, Z., Hansen, E. L., Hartmann-Petersen, R., Klitgaard, R. N., Løbner-Olesen, A., Michels, L., Mikkelsen, A., Plivelic, Nunes Bordallo, H. & Fossum, J. O., 17 May 2017, In: R S C Advances. 7, 43, p. 26537-26545

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

50 Downloads (Pure)

Class I Cytokine Receptors: Towards the Inside

Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, K., Brooks, A. & Kragelund, B. B., 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Class I Cytokine Receptors: Interactions in the membrane

Steinocher, H., 2017, Department of Biology, Faculty of Science, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

Cold denaturation of the HIV-1 protease monomer

Rösner, H. I., Caldarini, M., Prestel, A., Vanoni, M. A., Broglia, R. A., Aliverti, A., Tiana, G. & Kragelund, B. B., 28 Feb 2017, In: Biochemistry. 56, 8, p. 1029-1032 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Computational Studies of Drug Resistance. Investigating Binding Affinities and Structural Ensembles of Proteins

da Silva Martins, J. M., 2017, Department of Biology, Faculty of Science, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery

Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., Lindorff-Larsen, K., Page, R. & Peti, W., 16 Feb 2017, In: Molecular Cell. 65, 4, p. 644-658 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-mediated inhibition of replication

Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira, M-F. U., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C. & Nielsen, O., May 2017, In: Genes. 8, 5, 14 p., 128.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

311 Downloads (Pure)

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

Erlendsson, S., Gotfryd, K., Larsen, F. H., Mortensen, J. S., Geiger, M-A., van Rossum, B-J., Oschkinat, H., Gether, U., Teilum, K. & Løland, C. J., 24 Jan 2017, In: eLife. 6, 9 p., e19314.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

99 Downloads (Pure)

Diversity-oriented peptide stapling: a third generation copper-catalysed azide–alkyne cycloaddition stapling and functionalisation strategy

Tran, T. P., Larsen, C. Ø., Røndbjerg, T., de Foresta, M., Kunze, M. B. A., Marek, A., Hartvig Løper, J., Boyhus, L-E., Knuhtsen, A., Lindorff-Larsen, K. & Pedersen, D. S., 8 Mar 2017, In: Chemistry: A European Journal. 23, 14, p. 3490-3495 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip

Ponsero, A. J., Igbaria, A., Darch, M. A., Miled, S., Outten, C. E., Winther, J. R., Palais, G., D'Autréaux, B., Delaunay-Moisan, A. & Toledano, M. B., 21 Sept 2017, In: Molecular Cell. 67, 6, p. 962-973.e5 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

Eukaryotic transcription factors: paradigms of protein intrinsic disorder

Staby, L., O'Shea, C., Willemoës, M., Theisen, F., Kragelund, B. B. & Skriver, K., 1 Aug 2017, In: Biochemical Journal. 474, 15, p. 2509-2532 24 p.

Research output: Contribution to journal › Review › peer-review

50 Citations (Scopus)

Evolution i overhalingsbanen

Abildgaard, A. B., Hartmann-Petersen, R., Lindorff-Larsen, K. & Winther, J. R., 15 Dec 2017, In: Weekendavisen. 2017, 50, p. Ideer: 13 1 p.

Research output: Contribution to journal › Contribution to newspaper - Feature article

Exploring the antigenic response to multiplexed immunizations in a chicken model of antibody production

Kousted, T. M., Kalliokoski, O., Christensen, S. K., Winther, J. R. & Hau, J., 1 Mar 2017, In: Heliyon. 3, 3, 19 p., e00267.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

66 Downloads (Pure)

Functions of intrinsic disorder in transmembrane proteins

Kjærgaard, M. & Kragelund, B. B., 1 Sept 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3205-3224 20 p.

Research output: Contribution to journal › Review › peer-review

30 Citations (Scopus)

Genotoxic and inflammatory effects of nanofibrillated cellulose in murine lungs

Catalán, J., Rydman, E., Aimonen, K., Hannukainen, K-S., Suhonen, S., Vanhala, E., Moreno, C., Meyer, V., da Silva Perez, D., Sneck, A., Forsström, U., Højgaard, C., Willemoës, M., Winther, J. R., Vogel, U., Wolff, H., Alenius, H., Savolainen, K. M. & Norppa, H., 1 Jan 2017, In: Mutagenesis. 32, 1, p. 23-31 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

HicA toxin of Escherichia coli derepresses hicAB transcription to selectively produce HicB antitoxin

Turnbull, K. & Gerdes, K., Jun 2017, In: Molecular Microbiology. 104, 5, p. 781-792 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Hormone-like peptides in the venoms of marine cone snails

Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A. W., Norton, R. S. & Safavi-Hemami, H., 1 Apr 2017, In: General and Comparative Endocrinology. 244, p. 11-18 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

In silico evolution of lysis-lysogeny strategies reproduces observed lysogeny propensities in temperate bacteriophages

Sinha, V., Goyal, A., Svenningsen, S. L., Semsey, S. & Krishna, S., 26 Jul 2017, In: Frontiers in Microbiology. 8, 11 p., 1386.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

56 Downloads (Pure)

Involvement of WRKY, MYB and DOF DNA-binding proteins in interaction with a rice germin-like protein gene promoter

Deeba, F., Sultana, T., Mahmood, T., O'Shea, C., Skriver, K. & Naqvi, S. M. S., 1 Aug 2017, In: Acta Physiologiae Plantarum. 39, 10 p., 189.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study

Olivera, B. M., Raghuraman, S., Schmidt, E. W. & Safavi-Hemami, H., Oct 2017, In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 203, 9, p. 717-735 19 p.

Research output: Contribution to journal › Review › peer-review

7 Citations (Scopus)

Looking at Charges in an Uncharged Protein

Højgaard, C., 2017, Department of Biology, Faculty of Science, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

Mapping the universe of RNA tetraloop folds

Bottaro, S. & Lindorff-Larsen, K., 25 Jul 2017, In: Biophysical Journal. 113, 2, p. 257-267 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Occlusion of the ribosome binding site connects the translational initiation frequency, mRNA stability and premature transcription termination

Eriksen, M., Sneppen, K., Pedersen, S. & Mitarai, N., 14 Mar 2017, In: Frontiers in Microbiology. 8, 7 p., 362.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

72 Downloads (Pure)

Peptide-nucleotide antibiotic Microcin C is a potent inducer of stringent response and persistence in both sensitive and producing cells

Piskunova, J., Maisonneuve, E., Germain-Maisonneuve, E., Gerdes, K. & Severinov, K., May 2017, In: Molecular Microbiology. 104, 3, p. 463-471 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Phosphoribosyl diphosphate (PRPP): biosynthesis, enzymology, utilization, and metabolic significance

Hove-Jensen, B., Andersen, K. R., Kilstrup, M., Martinussen, J., Switzer, R. L. & Willemoës, M., 1 Mar 2017, In: Microbiology and Molecular Biology Reviews. 81, 1, 83 p., e00040-16.

Research output: Contribution to journal › Review › peer-review

46 Citations (Scopus)

Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites

Kristensen, L. V., Oppermann, F. S., Rauen, M. J., Hartmann-Petersen, R. & Thirstrup, K., 1 May 2017, In: Neurochemistry International. 105, p. 42-50 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Positive staining for cellulose in oral pulse granuloma

Virkkunen, S., Wolff, H., Haglund, C., Højgaard, C., Winther, J. R., Willemoës, M., Vogel, U. & Hagström, J., 1 Apr 2017, In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123, 4, p. 464-467 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Post-translational modifications of an archaea esterase and rapid analysis and acquisition of NMR relaxation dispersion data

Schwarz-Linnet, T., 2017, Department of Biology, Faculty of Science, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Nielsen, S. V., Stein, A., Dinitzen, A. B., Papaleo, E., Tatham, M. H., Poulsen, E. G., Kassem, M. M., Rasmussen, L. J., Lindorff-Larsen, K. & Hartmann-Petersen, R., 19 Apr 2017, In: PLoS Genetics. 13, 4, 26 p., e1006739.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

187 Downloads (Pure)

Prophages and growth dynamics confound experimental results with antibiotic-tolerant persister cells

Harms, A., Fino, C., Sørensen, M. A., Semsey, S. & Gerdes, K., 12 Dec 2017, In: mBio. 8, 6, 18 p., e01964-17.

Research output: Contribution to journal › Journal article › Research › peer-review

104 Citations (Scopus)

111 Downloads (Pure)

Quantification of the abundance and charging levels of transfer RNAs in Escherichia coli

Stenum, T. S., Sørensen, M. A. & Svenningsen, S. L., 22 Aug 2017, In: Journal of Visualized Experiments. 126, e56212.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB

Fazli, M., Rybtke, M. L., Steiner, E., Weidel, E., Berthelsen, J., Groizeleau, J. D. D., Bin, W., Zhi, B. Z., Yaming, Z., Kaever, V., Givskov, M., Hartmann, R. W., Eberl, L. & Tolker-Nielsen, T., Aug 2017, In: MicrobiologyOpen. 6, 4, 13 p., e00480.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

99 Downloads (Pure)

Single methyl groups can act as toggle switches to specify transmembrane protein-protein interactions

He, L., Steinocher, H., Shelar, A., Cohen, E. B., Heim, E. N., Kragelund, B. B., Grigoryan, G. & DiMaio, D., 4 Sept 2017, In: eLife. 6, 28 p., e27701.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

49 Downloads (Pure)

SLiMming the fuzz in gene-regulating interactomes

Staby, L., O'Shea, C., Kragelund, B. B. & Skriver, K., 7 Nov 2017, 1 p.

Research output: Other contribution › Net publication - Internet publication › Research

Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae

Muschiol, S., Erlendsson, S., Aschtgen, M-S., Oliveira, V., Schmieder, P., de Lichtenberg, C., Teilum, K., Boesen, T., Akbey, U. & Henriques-Normark, B., 25 Aug 2017, In: Journal of Biological Chemistry. 292, 34, p. 14134-14146 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

51 Downloads (Pure)

Structures and short linear motif of disordered transcription factor regions provide clues to the interactome of the cellular hub radical-induced cell death1

O'Shea, C., Staby, L., Bendsen, S. K., Tidemand, F. G., Redsted, A., Willemoës, M., Kragelund, B. B. & Skriver, K., 13 Jan 2017, In: Journal of Biological Chemistry. 292, 2, p. 512-527 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

The exocyst subunit Sec3 is regulated by a protein quality control pathway

Kampmeyer, C., Karakostova, A., Schenstrøm, S. M., Abildgaard, A. B., Lauridsen, A. M., Jourdain, I. & Hartmann-Petersen, R., 15 Sept 2017, In: Journal of Biological Chemistry. 292, 37, p. 15240-15253 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications

Stiefler-Jensen, D., Schwarz-Linnet, T., de Lichtenberg, C., Nguyen, T. T. T. N., Rand, K. D., Huang, L., She, Q. & Teilum, K., Sept 2017, In: Protein Science. 26, 9, p. 1819-1827 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu²⁺-Aβ Complex

Somavarapu, A. K., Shen, F., Teilum, K., Zhang, J., Mossin, S., Thulstrup, P. W., Bjerrum, M. J., Tiwari, M. K., Szunyogh, D., Søtofte, P. M., Kepp, K. P. & Hemmingsen, L., 4 Oct 2017, In: Chemistry - A European Journal. 23, 55, p. 13591-13595 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

The polyketide components of waxes and the Cer-cqu gene cluster encoding a novel polyketide synthase, the β-diketone synthase, DKS

von Wettstein, P., Sept 2017, In: Plants. 6, 3, 18 p., 28.

Research output: Contribution to journal › Review › peer-review

3 Citations (Scopus)

72 Downloads (Pure)

Tracking dehydration mechanisms in crystalline hydrates with molecular dynamics simulations

Larsen, A. S., Ruggiero, M. T., Johansson, K. E., Zeitler, J. A. & Rantanen, J., 4 Oct 2017, In: Crystal Growth & Design. 17, 10, p. 5017-5022 6 p.

Research output: Contribution to journal › Letter › peer-review

15 Citations (Scopus)

Transfer RNA is highly unstable during early amino acid starvation in Escherichia coli

Svenningsen, S. L., Kongstad, M., Stenum, T. S., Muñoz Gomez, A. J. & Sørensen, M. A., 1 Jan 2017, In: Nucleic Acids Research. 45, 2, p. 793-804 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

76 Downloads (Pure)

UBL/BAG-domain co-chaperones cause cellular stress upon overexpression through constitutive activation of Hsf1

Poulsen, E. G., Kampmeyer, C., Kriegenburg, F., Johansen, J. V., Hofmann, K., Holmberg, C. & Hartmann-Petersen, R., 1 Jan 2017, In: Cell Stress & Chaperones. 22, 1, p. 143-154 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

2016

A combined computational and structural model of the full-length human prolactin receptor

Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, J. G., Lindorff-Larsen, K. & Kragelund, B. B., 13 May 2016, In: Nature Communications. 7, 11 p., 11578.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

125 Downloads (Pure)

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C. A., Chou, D. H-C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R. S., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In: Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

Biomolecular Sciences

Research output

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