Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate

E.C. dos Santos; Z. Rozynek; E.L. Hansen; Rasmus Hartmann-Petersen; R.N. Klitgaard; Anders Løbner-Olesen; L. Michels; A. Mikkelsen; null Plivelic; Heloisa Nunes Bordallo; J.O. Fossum

doi:10.1039/c7ra01384a

Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate

E.C. dos Santos, Z. Rozynek, E.L. Hansen, Rasmus Hartmann-Petersen, R.N. Klitgaard, Anders Løbner-Olesen, L. Michels, A. Mikkelsen, Plivelic, Heloisa Nunes Bordallo, J.O. Fossum

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Abstract

Different natural clay minerals, including halloysite, montmorillonite and kaolinite, have been proven to be efficient drug carriers providing for high and long lasting drug concentrations owing to their adsorption capacity and ion exchange property. Synthetic clays, however, are advantageous over the natural clay minerals in terms of purity of composition and controllable cation exchange capacity, factors that contribute to improve reproducibility of the host system. Here we studied a synthetic smectite clay as a candidate for high adsorption and controlled release rate. Via X-ray powder diffraction we verified that, under acidic conditions, the antibiotic ciprofloxacin was successfully incorporated in the synthetic clay fluorohectorite, while via UV-VIS spectroscopy we showed that the degree of the drug incorporation is at least 25% higher than for other systems reported in the literature. Furthermore, temperature dependent release studies allowed us to show that the release process is thermally activated and diffusion-controlled. Finally, via bacterial and toxicological tests, we demonstrated that the effectiveness and toxicity of pure ciprofloxacin is unaffected in the clay-drug complex.

Original language	English
Journal	R S C Advances
Volume	7
Issue number	43
Pages (from-to)	26537-26545
ISSN	2046-2069
DOIs	https://doi.org/10.1039/c7ra01384a
Publication status	Published - 17 May 2017

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dos Santos, E. C., Rozynek, Z., Hansen, E. L., Hartmann-Petersen, R., Klitgaard, R. N., Løbner-Olesen, A., Michels, L., Mikkelsen, A., Plivelic, Nunes Bordallo, H., & Fossum, J. O. (2017). Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate. R S C Advances, 7(43), 26537-26545. https://doi.org/10.1039/c7ra01384a

dos Santos, EC, Rozynek, Z, Hansen, EL, Hartmann-Petersen, R, Klitgaard, RN, Løbner-Olesen, A, Michels, L, Mikkelsen, A, Plivelic, , Nunes Bordallo, H & Fossum, JO 2017, 'Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate', R S C Advances, vol. 7, no. 43, pp. 26537-26545. https://doi.org/10.1039/c7ra01384a

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title = "Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate",

abstract = "Different natural clay minerals, including halloysite, montmorillonite and kaolinite, have been proven to be efficient drug carriers providing for high and long lasting drug concentrations owing to their adsorption capacity and ion exchange property. Synthetic clays, however, are advantageous over the natural clay minerals in terms of purity of composition and controllable cation exchange capacity, factors that contribute to improve reproducibility of the host system. Here we studied a synthetic smectite clay as a candidate for high adsorption and controlled release rate. Via X-ray powder diffraction we verified that, under acidic conditions, the antibiotic ciprofloxacin was successfully incorporated in the synthetic clay fluorohectorite, while via UV-VIS spectroscopy we showed that the degree of the drug incorporation is at least 25% higher than for other systems reported in the literature. Furthermore, temperature dependent release studies allowed us to show that the release process is thermally activated and diffusion-controlled. Finally, via bacterial and toxicological tests, we demonstrated that the effectiveness and toxicity of pure ciprofloxacin is unaffected in the clay-drug complex.",

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AU - dos Santos, E.C.

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AU - Hartmann-Petersen, Rasmus

AU - Klitgaard, R.N.

AU - Løbner-Olesen, Anders

AU - Michels, L.

AU - Mikkelsen, A.

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AU - Nunes Bordallo, Heloisa

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N2 - Different natural clay minerals, including halloysite, montmorillonite and kaolinite, have been proven to be efficient drug carriers providing for high and long lasting drug concentrations owing to their adsorption capacity and ion exchange property. Synthetic clays, however, are advantageous over the natural clay minerals in terms of purity of composition and controllable cation exchange capacity, factors that contribute to improve reproducibility of the host system. Here we studied a synthetic smectite clay as a candidate for high adsorption and controlled release rate. Via X-ray powder diffraction we verified that, under acidic conditions, the antibiotic ciprofloxacin was successfully incorporated in the synthetic clay fluorohectorite, while via UV-VIS spectroscopy we showed that the degree of the drug incorporation is at least 25% higher than for other systems reported in the literature. Furthermore, temperature dependent release studies allowed us to show that the release process is thermally activated and diffusion-controlled. Finally, via bacterial and toxicological tests, we demonstrated that the effectiveness and toxicity of pure ciprofloxacin is unaffected in the clay-drug complex.

AB - Different natural clay minerals, including halloysite, montmorillonite and kaolinite, have been proven to be efficient drug carriers providing for high and long lasting drug concentrations owing to their adsorption capacity and ion exchange property. Synthetic clays, however, are advantageous over the natural clay minerals in terms of purity of composition and controllable cation exchange capacity, factors that contribute to improve reproducibility of the host system. Here we studied a synthetic smectite clay as a candidate for high adsorption and controlled release rate. Via X-ray powder diffraction we verified that, under acidic conditions, the antibiotic ciprofloxacin was successfully incorporated in the synthetic clay fluorohectorite, while via UV-VIS spectroscopy we showed that the degree of the drug incorporation is at least 25% higher than for other systems reported in the literature. Furthermore, temperature dependent release studies allowed us to show that the release process is thermally activated and diffusion-controlled. Finally, via bacterial and toxicological tests, we demonstrated that the effectiveness and toxicity of pure ciprofloxacin is unaffected in the clay-drug complex.

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M3 - Journal article

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Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate

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