Tim Holm Jakobsen

Research output

Research output per year 2009 2010 2011 2012 2013 2017 2018 2019

• 24 Journal article
• 3 Book chapter
• 1 Review
• 1 Patent

Research output per year

Research output per year

Search results

• 2019

  Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms

  Nilsson, M., Jakobsen, T. H., Givskov, M., Twetman, S. & Tolker-Nielsen, T., Mar 2019, In: Microbiology-Sgm. 165, 3, p. 334-342

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Streptococcus mutans 100%
  • Biofilms 81%
  • Oxidative Stress 61%
  • Anti-Bacterial Agents 54%
  • Glutathione 21%
  9 Citations (Scopus)
• 2018

  Imaging N-acyl homoserine lactone quorum sensing in vivo

  Hultqvist, L. D., Alhede, M., Jakobsen, T. H., Givskov, M. & Bjarnsholt, T., 2018, Quorum Sensing: Methods and Protocols. Leoni, L. & Rampion, G. (eds.). Humana Press, Vol. 1673. p. 203-212 10 p. (Methods in Molecular Biology; No. 1673).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • Acyl-Butyrolactones 100%
  • Quorum Sensing 81%
  • Green Fluorescent Proteins 46%
  • Escherichia coli 45%
  • Pseudomonas aeruginosa 40%
  2 Citations (Scopus)

• Implants induce a new niche for microbiomes

  Jakobsen, T. H., Eickhardt, S. R., Gheorghe, A. G., Stenqvist, C., Sønderholm, M., Stavnsberg, C., Jensen, P., Odgaard, A., Whiteley, M., Moser, C., Hvolris, J., Hougen, H. P. & Bjarnsholt, T., 1 Aug 2018, In: APMIS - Journal of Pathology, Microbiology and Immunology. 126, 8, p. 685-692 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Microbiota 100%
  • Fungi 90%
  • Bacteria 68%
  • Infections 48%
  • Denmark 35%
  14 Citations (Scopus)

• Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro

  Jakobsen, T. H., Alhede, M., Hultqvist, L. D., Bjarnsholt, T. & Givskov, M., 2018, Quorum Sensing: Methods and Protocols. Springer, Vol. 1673. p. 275-285 11 p. (Methods in molecular biology (Clifton, N.J.)).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • Quorum Sensing 100%
  • Biofilms 38%
  • Pseudomonas aeruginosa 36%
  • Evaluation Studies 35%
  • In Vitro Techniques 34%
  1 Citation (Scopus)
• 2017

  A broad range quorum sensing inhibitor working through sRNA inhibition

  Jakobsen, T. H., Warming, A. N., Vejborg, R. M., Moscoso, J. A., Stegger, M., Lorenzen, F., Rybtke, M., Andersen, J. B., Petersen, R., Andersen, P. S., Nielsen, T. E., Tolker-Nielsen, T., Filloux, A., Ingmer, H. & Givskov, M., 2017, In: Scientific Reports. 7, 1, 12 p., 9857.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ajoene 100%
  • Quorum Sensing 68%
  • Staphylococcus aureus RNAIII 38%
  • RNA 37%
  • Virulence Factors 33%
  30 Citations (Scopus)

  81 Downloads (Pure)

• Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

  Jakobsen, T. H., Tolker-Nielsen, T. & Givskov, M., 13 Sept 2017, In: International Journal of Molecular Sciences. 18, 9, 27 p., 1970.

  Research output: Contribution to journal › Review › peer-review

  • Bacterial Physiological Phenomena 100%
  • biofilms 92%
  • Biofilms 91%
  • Guanosine 74%
  • perturbation 45%
  29 Citations (Scopus)

  196 Downloads (Pure)

• Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

  Fong, J., Yuan, M., Jakobsen, T. H., Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, T. E. & Givskov, M., 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ajoene 100%
  • Antipathogenic 95%
  • Pyocyanin 91%
  • Virulence Factor 74%
  • Allyl Group 69%
  38 Citations (Scopus)

• Fusaric acid and analogues as gram-negative bacterial quorum sensing inhibitors

  Thanh Tung, T., Jakobsen, T. H., Dao, T. T., Fuglsang, A. T., Givskov, M., Christensen, S. B. & Nielsen, J., 2017, In: European Journal of Medicinal Chemistry. 126, p. 1011-1020 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fusaric Acid 100%
  • Quorum Sensing 69%
  • Aliivibrio fischeri 22%
  • Microwave Assisted Synthesis 21%
  • Microwaves 16%
  29 Citations (Scopus)

• Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

  Belstrøm, D., Constancias, F., Liu, Y., Yang, L., Drautz-Moses, D. I., Schuster, S. C., Kohli, G. S., Jakobsen, T. H., Holmstrup, P. & Givskov, M., 1 Dec 2017, In: npj Biofilms and Microbiomes. 3, 8 p., 23.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Metagenomics 100%
  • Dental Caries 88%
  • Periodontitis 88%
  • Microbiota 80%
  • Saliva 79%
  41 Citations (Scopus)

  75 Downloads (Pure)

• Pseudomonas aeruginosa aggregate formation in an alginate bead model system exhibits In Vivo-like characteristics

  Sønderholm, M., Kragh, K. N., Koren, K., Jakobsen, T. H., Darch, S., Alhede, M., Jensen, P. Ø., Whiteley, M., Kühl, M. & Bjarnsholt, T., 1 May 2017, In: Applied and Environmental Microbiology. 83, 9, 15 p., e00113-17.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • alginate 100%
  • Alginates 96%
  • Pseudomonas 93%
  • alginates 88%
  • Pseudomonas aeruginosa 68%
  57 Citations (Scopus)

  108 Downloads (Pure)
• 2015

  Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

  Hansen, M. R., Jakobsen, T. H., Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, T., Givskov, M. & Nielsen, T., 1 Apr 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-Acyl Homoserine Lactone 100%
  • homoserine lactone 97%
  • Homoserine Lactone 94%
  • Acyl-Butyrolactones 91%
  • Triazoles 80%
  21 Citations (Scopus)
• 2014

  Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa

  Tan, S. Y-Y., Liu, Y., Chua, S. L., Vejborg, R. M., Jakobsen, T. H., Chew, S. C., Li, Y., Nielsen, T. E., Tolker-Nielsen, T., Yang, L. & Givskov, M., 1 Nov 2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6648-59 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • iberin 100%
  • isothiocyanic acid 59%
  • Systems Biology 57%
  • Pseudomonas aeruginosa 44%
  • Virulence Factors 21%
  21 Citations (Scopus)

• Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

  Hansen, M. R., Le Quement, S. T., Jakobsen, T. H., Skovstrup, S., Taboureau, O., Tolker-Nielsen, T., Givskov, M. & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • L-Homoserine Lactone 100%
  • homoserine lactone 82%
  • Solid-Phase Synthesis Techniques 80%
  • Quorum Sensing 63%
  • Signalling Molecule 63%
  5 Citations (Scopus)
• 2013

  Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes

  Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J., & 2 othersHøiby, N. & Bjarnsholt, T., 22 Jul 2013, In: P L o S One. 8, 7, 17 p., e68484.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Achromobacter denitrificans 100%
  • Fibrosis 93%
  • Achromobacter xylosoxidans 93%
  • Antibiotics 85%
  • cystic fibrosis 79%
  50 Citations (Scopus)

  2657 Downloads (Pure)

• Identification of LasR ligands through a virtual screening approach

  Skovstrup, S., Le Quement, S. T., Hansen, T., Jakobsen, T. H., Harmsen, M., Tolker-Nielsen, T., Nielsen, T. E., Givskov, M. & Taboureau, O., Jan 2013, In: ChemMedChem. 8, 1, p. 157-63 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-(3-Oxododecanoyl)-L-Homoserine Lactone 100%
  • N-(3-oxododecanoyl)homoserine lactone 86%
  • Bacterial Drug Resistance 70%
  • Ligands 69%
  • Antimicrobial Agent 68%
  14 Citations (Scopus)

• Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

  Claussen, A., Jakobsen, T. H., Bjarnsholt, T., Givskov, M., Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Regulon 100%
  • regulators 96%
  • Quorum Sensing 95%
  • Dimerization 85%
  • Molecules 73%
  4 Citations (Scopus)

• Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

  Jakobsen, T. H., Bjarnsholt, T., Jensen, P. Ø., Givskov, M. & Høiby, N., Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Quorum Sensing 100%
  • Biofilms 77%
  • Pseudomonas aeruginosa 73%
  • Microbial Drug Resistance 19%
  • Cystic Fibrosis 19%
  60 Citations (Scopus)
• 2012

  Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

  Jakobsen, T. H., van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, L. D., Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, P. Ø., Moser, C., Nielsen, K. F., Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, N., Bjarnsholt, T., Givskov, M. & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ajoene 100%
  • Garlic 70%
  • Quorum Sensing 68%
  • Sulfur 63%
  • Pseudomonas aeruginosa 50%
  269 Citations (Scopus)

• Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa

  Jakobsen, T. H., Bragason, S. K., Phipps, R. K., Christensen, L. D., van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, N., Bjarnsholt, T. & Givskov, M., Apr 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • iberin 100%
  • Armoracia 84%
  • horseradish 67%
  • Quorum Sensing 60%
  • quorum sensing 57%
  131 Citations (Scopus)

• Process for the manufacture of ajoene derivatives

  Translated title of the contribution: PROCESS FOR THE MANUFACTURE OF AJOENE DERIVATIVESBjarnsholt, T., Hoeiby, N., Jensen, P. Ø., Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, L. D., Jakobsen, T. H., Tanner, D., Larsen, Thomas, O. & Givskov, M., 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154

  Research output: Patent

  • (Z)-Ajoene 100%
  • Allicin 15%
  • Compound E 14%
  • Antimicrobial Agent 6%
  • Solvent 4%

• Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.

  Hultqvist, L. D., van Gennip, M., Jakobsen, T. H., Alhede, M., Hougen, H. P., Høiby, N., Bjarnsholt, T. & Givskov, M., May 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tobramycin 100%
  • Foreign Bodies 83%
  • Pseudomonas aeruginosa 73%
  • Infections 38%
  • Biofilms 34%
  119 Citations (Scopus)

• Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

  Christensen, L., van Gennip, M., Jakobsen, T. H., Alhede, M., Hougen, H. P., Høiby, N., Bjarnsholt, T., Givskov, M. & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Quorum Sensing 100%
  • Tobramycin 99%
  • Foreign Bodies 83%
  • Pseudomonas aeruginosa 73%
  • Infections 37%
  119 Citations (Scopus)
• 2011

  Imaging N-acyl homoserine lactone quorum sensing in vivo

  Christensen, L. D., van Gennip, M., Jakobsen, T. H., Givskov, M. & Bjarnsholt, T., 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acyl-Butyrolactones 100%
  • Quorum Sensing 81%
  • Green Fluorescent Proteins 46%
  • Escherichia coli 45%
  • Alginates 25%
  5 Citations (Scopus)

• Novel and future treatment strategies

  Alhede, M., Jakobsen, T. H. & Givskov, M., 1 Dec 2011, Biofilm Infections. Springer, p. 231-249 19 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • tolerance 100%
  • survival strategy 69%
  • evidence 22%
  1 Citation (Scopus)

• Qualitative and quantitative determination of quorum sensing inhibition in vitro

  Jakobsen, T. H., van Gennip, M., Christensen, L. D., Bjarnsholt, T. & Givskov, M., 1 Jan 2011, In: Methods in Molecular Biology. 692, 3, p. 253-263 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Quorum Sensing 100%
  • In Vitro Techniques 34%
  • Biofilms 19%
  • Pseudomonas aeruginosa 18%
  • Evaluation Studies 17%
  4 Citations (Scopus)
• 2010

  In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

  Bjarnsholt, T., van Gennip, M., Jakobsen, T. H., Christensen, L. D., Jensen, P. Ø. & Givskov, M., Feb 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Quorum Sensing 100%
  • Antimicrobial Agent 55%
  • Lethal 47%
  • Drug 41%
  • Biofilms 38%
  53 Citations (Scopus)

• Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

  Bjarnsholt, T., Jensen, P. Ø., Jakobsen, T. H., Phipps, R., Nielsen, A. K., Rybtke, M. T., Tolker-Nielsen, T., Givskov, M., Høiby, N., Ciofu, O. & Scandinavian Cystic Fibrosis Study Consortium, 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Quorum Sensing 100%
  • Fibrosis 96%
  • cystic fibrosis 82%
  • virulence 80%
  • Lung 79%
  153 Citations (Scopus)

• Quorum sensing regulation in Aeromonas hydrophila

  Garde, C., Bjarnsholt, T., Givskov, M., Jakobsen, T. H., Hentzer, M., Claussen, A., Sneppen, K., Ferkinghoff-Borg, J. & Sams, T., 2010, In: Journal of Molecular Biology. 396, 4, p. 849-57 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Aeromonas hydrophila 100%
  • Quorum Sensing 89%
  • N-butyrylhomoserine lactone 55%
  • Kinetics 14%
  • Gram-Negative Bacteria 10%
  33 Citations (Scopus)
• 2009

  Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

  Yang, L., Rybtke, M. T., Jakobsen, T. H., Hentzer, M., Bjarnsholt, T., Givskov, M. & Tolker-Nielsen, T., 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2432-43 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Quorum Sensing 100%
  • Pseudomonas aeruginosa 73%
  • Pharmaceutical Preparations 32%
  • nifuroxazide 21%
  • Chlorzoxazone 18%
  150 Citations (Scopus)