Thomas Elbenhardt Jensen

2020

Growth factor-dependent and -independent activation of mTORC2

Knudsen, J. R., Fritzen, A. M., James, D. E., Jensen, T. E., Kleinert, M. & Richter, E., Jan 2020, In: Trends in Endocrinology and Metabolism.

Research output: Contribution to journal › Review › peer-review

6 Citations (Scopus)

2019

Adaptations to high-intensity interval training in skeletal muscle require NADPH oxidase 2

Henríquez-Olguín, C., Baghersad Renani, L., Arab-Ceschia, L., Raun, S. H., Bhatia, A., Li, Z., Knudsen, J. R., Holmdahl, R. & Jensen, T. E., Jun 2019, In: Redox Biology. 24, 12 p., 101188.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

38 Downloads (Pure)

Chemical denervation using botulinum toxin increases Akt expression and reduces submaximal insulin-stimulated glucose transport in mouse muscle

Li, Z., Näslund-Koch, L., Henriquez Olguín, C., Knudsen, J. R., Li, J., Madsen, A. L. B., Ato, S., Wienecke, J., Ogasawara, R., Nielsen, J. B. & Jensen, T. E., Jan 2019, In: Cellular Signalling. 53, p. 224-233 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

Ducommun, S., Deak, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, T. E., Viollet, B., Foretz, M., Gut, P., Sumpton, D. & Sakamoto, K., May 2019, In: Cellular Signalling. 57, p. 45-57 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

Henríquez-Olguin, C., Knudsen, J. R., Raun, S. H., Li, Z., Dalbram, E., Treebak, J. T., Sylow, L., Holmdahl, R., Richter, E., Jaimovich, E. & Jensen, T. E., 1 Dec 2019, In: Nature Communications. 10, 11 p., 4623.

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

16 Downloads (Pure)

Electroporated GLUT4-7myc-GFP detects in vivo glucose transporter 4 translocation in skeletal muscle without discernible changes in GFP patterns

Knudsen, J. R., Henriquez-Olguín, C., Li, Z. & Jensen, T. E., 1 May 2019, In: Experimental Physiology. 104, 5, p. 704-714 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

Han, X., Møller, L. L. V., De Groote, E., Bojsen-Møller, K. N., Davey, J., Henríquez-Olguin, C., Li, Z., Knudsen, J. R., Jensen, T. E., Madsbad, S., Gregorevic, P., Richter, E. & Sylow, L., 1 Dec 2019, In: Journal of Cachexia, Sarcopenia and Muscle.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR

Ogasawara, R., Jensen, T. E., Goodman, C. A. & Hornberger, T. A., 1 Jul 2019, In: Exercise and Sport Sciences Reviews. 47, 3, p. 188-194 7 p.

Research output: Contribution to journal › Review › peer-review

15 Citations (Scopus)

Skeletal muscle-specific activation of G_q signaling maintains glucose homeostasis

Bone, D. B. J., Meister, J., Knudsen, J. R., Dattaroy, D., Cohen, A., Lee, R., Lu, H., Metzger, D., Jensen, T. E. & Wess, J., 1 Jun 2019, In: Diabetes. 68, 6, p. 1341-1352 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism

Henríquez-Olguín, C., Boronat, S., Cabello-Verrugio, C., Jaimovich, E., Hidalgo, E. & Jensen, T. E., 20 Dec 2019, In: Antioxidants & Redox Signaling. 31, 8, p. 1371-1410 40 p.

Research output: Contribution to journal › Review › peer-review

15 Citations (Scopus)

11 Downloads (Pure)

The gut microbiome on a periodized low-protein diet is associated with improved metabolic health

Li, Z., Rasmussen, T. S., Rasmussen, M. L., Li, J., Olguín, C. H., Kot, W., Nielsen, D. S. & Jensen, T. E., 2019, In: Frontiers in Microbiology. 10, 10 p., 709.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

135 Downloads (Pure)

The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training: [The original title and the article is written in Persian!]

Baghersad Renani, L., Ravasi, A. A., Shabkhiz, F. & Jensen, T. E., 2019, In: Iranian Journal of Endocrinology and Metabolism. 20, 5, p. 263-272 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

2018

Lactate administration activates the ERK1/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse

Cerda-Kohler, H., Henríquez Olguín, C. F., Casas, M., Jensen, T. E., Llanos, P. & Jaimovich, E., Sept 2018, In: Physiological Reports. 6, 18, 9 p., e13800.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

63 Downloads (Pure)

Low- and high-protein diets do not alter ex vivo insulin action in skeletal muscle

Li, Z., Rasmussen, M. L., Li, J., Olguín, C. H., Knudsen, J. R., Søgaard, O., Madsen, A. L. B. & Jensen, T. E., Jul 2018, In: Physiological Reports. 6, 13, 12 p., e13798.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

90 Downloads (Pure)

Periodized low protein-high carbohydrate diet confers potent, but transient, metabolic improvements

Li, Z., Rasmussen, M. L., Li, J., Henriquez-Olguin, C., Knudsen, J. R., Madsen, A. B., Sanchez-Quant, E., Kleinert, M. & Jensen, T. E., Nov 2018, In: Molecular Metabolism. 17, p. 112-121 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

70 Downloads (Pure)

Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

Kleinert, M., Parker, B. L., Jensen, T. E., Raun, S. H., Pham, P., Han, X., James, D. E., Richter, E. & Sylow, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 10723.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

84 Downloads (Pure)

Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt

Raun, S. H., Ali, M. S., Kjøbsted, R., Møller, L. L. V., Federspiel, M. A., Richter, E., Jensen, T. E. & Sylow, L., 15 Jun 2018, In: Journal of Physiology. 596, 12, p. 2283-2299 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

β-actin shows limited mobility and is only required for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle

Madsen, A. L. B., Knudsen, J. R., Henriquez-Olguin, C., Angin, Y., Zaal, K. J., Sylow, L., Schjerling, P., Ralston, E. & Jensen, T. E., Jul 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E110-E125 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

2017

Exercise-stimulated glucose uptake - regulation and implications for glycaemic control

Sylow, L., Kleinert, M., Richter, E. & Jensen, T. E., 1 Mar 2017, In: Nature Reviews Endocrinology. 13, 3, p. 133-148 16 p.

Research output: Contribution to journal › Review › peer-review

149 Citations (Scopus)

Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

Kleinert, M., Parker, B. L., Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M. A., James, D. E. & Richter, E., 15 Jul 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Rac1 and AMPK account for the majority of muscle glucose uptake stimulated by ex vivo contraction but not in vivo exercise

Sylow, L., Møller, L. L. V., Kleinert, M., D'Hulst, G., De Groote, E., Schjerling, P., Steinberg, G. R., Jensen, T. E. & Richter, E., 1 Jun 2017, In: Diabetes. 66, 6, p. 1548-1559 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2016

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

Bultot, L., Jensen, T. E., Lai, Y.-C., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, E. & Sakamoto, K., 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms

Ross, F. A., Jensen, T. E. & Hardie, D. G., 15 Jan 2016, In: Biochemical Journal. 473, 2, p. 189-199 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

80 Citations (Scopus)

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

Sylow, L., Laurent, I., Kleinert, M., Møller, L. L. V., Ploug, T., Schjerling, P., Bilan, P. J., Klip, A., Jensen, T. E. & Richter, E., 1 Sept 2016, In: Journal of Physiology. 594, 17, p. 4997-5008 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

Rac1 in muscle is dispensable for improved insulin action after exercise in mice

Sylow, L., Møller, L. L. V., D'Hulst, G., Schjerling, P., Jensen, T. E. & Richter, E., Aug 2016, In: Endocrinology. 157, 8, p. 3009-3015 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation

Fritzen, A. M., Madsen, A. L. B., Kleinert, M., Treebak, J. T., Lundsgaard, A., Jensen, T. E., Richter, E., Wojtaszewski, J., Kiens, B. & Frøsig, C., 1 Feb 2016, In: Journal of Physiology. 594, 3, p. 745-761 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle

Fritzen, A. M., Frøsig, C., Jeppesen, J. F., Jensen, T. E., Lundsgaard, A., Serup, A. K. L., Schjerling, P., Proud, C. G., Richter, E. & Kiens, B., 1 Jun 2016, In: Cellular Signalling. 28, 6, p. 663-674 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

α-MSH stimulates glucose uptake in mouse muscle and phosphorylates Rab-GTPase-activating protein TBC1D1 independently of AMPK

Møller, C. L., Kjøbsted, R., Enriori, P. J., Jensen, T. E., Garcia-Rudaz, C., Litwak, S. A., Raun, K., Wojtaszewski, J., Wulff, B. S. & Cowley, M. A., Jul 2016, In: P L o S One. 11, 7, 18 p., e0157027.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

103 Downloads (Pure)

2015

Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise-regulated kinases and AMPK substrates

Hoffman, N. J., Parker, B. L., Chaudhuri, R., Fisher-Wellman, K. H., Kleinert, M., Humphrey, S. J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D. J., Stöckli, J., Burchfield, J. G., Jensen, T. E., Jothi, R., Kiens, B., Wojtaszewski, J., Richter, E. & James, D. E., 3 Nov 2015, In: Cell Metabolism. 22, 5, p. 922-935 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

181 Citations (Scopus)

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E., 1 May 2015, In: Biochemical Journal. 467, 3, p. 461-472 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Reply from Lykke Sylow, Lisbeth L. V. Møller, Maximilian Kleinert, Erik A. Richter and Thomas E. Jensen

Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. & Jensen, T. E., 1 May 2015, In: Journal of Physiology. 593, 9, p. 2239-2240 2 p.

Research output: Contribution to journal › Comment/debate › Research

Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1

Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. & Jensen, T. E., 1 Feb 2015, In: Journal of Physiology. 593, 3, p. 645-656 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Chang, Y.-J., Pownall, S., Jensen, T. E., Mouaaz, S., Foltz, W., Zhou, L., Liadis, N., Woo, M., Hao, Z., Dutt, P., Bilan, P. J., Klip, A., Mak, T. & Stambolic, V., 29 Oct 2015, In: eLife. 4, 24 p., e06011.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

68 Downloads (Pure)

2014

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

Kleinert, M., Sylow, L., Fazakerley, D. J., Krycer, J. R., Thomas, K. C., Oxbøll, A.-J., Jordy, A. B., Jensen, T. E., Yang, G., Schjerling, P., Kiens, B., James, D. E., Ruegg, M. A. & Richter, E., Sept 2014, In: Molecular Metabolism. 3, 6, p. 630-641 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Akt and Rac1 signalling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Sylow, L., Kleinert, M., Pehmøller, C., Prats Gavalda, C., Chiu, T. T., Klip, A., Richter, E. & Jensen, T. E., 2014, In: Cellular Signalling. 26, 2, p. 323-331 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca²⁺ release

Jensen, T. E., Sylow, L., Rose, A. J., Madsen, A. L. B., Angin, Y., Maarbjerg, S. J. & Richter, E., 1 Oct 2014, In: Molecular Metabolism. 3, 7, p. 742-753 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Is contraction-stimulated glucose transport feedforward regulated by Ca²⁺?

Jensen, T. E., Angin, Y., Sylow, L. & Richter, E., 1 Dec 2014, In: Experimental Physiology. 99, 12, p. 1562-1568 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans

Fink, L. N., Costford, S. R., Lee, Y. S., Jensen, T. E., Bilan, P. J., Oberbach, A., Blüher, M., Olefsky, J. M., Sams, A. & Klip, A., Mar 2014, In: Obesity. 22, 3, p. 747-757 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

100 Citations (Scopus)

Rac1- a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. & Jensen, T. E., 1 Dec 2014, In: Experimental Physiology. 99, 12, p. 1574-1580 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2013

AMPK and insulin action: Responses to ageing and high fat diet

Frøsig, C., Jensen, T. E., Jeppesen, J., Pehmøller, C., Treebak, J. T., Maarbjerg, S. J., Kristensen, J. M., Sylow, L., Alsted, T. J., Schjerling, P., Kiens, B., Wojtaszewski, J. & Richter, E., 6 May 2013, In: P L o S One. 8, 5, p. e62338 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

1693 Downloads (Pure)

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Sylow, L., Jensen, T. E., Kleinert, M., Mouatt, J. R., Maarbjerg, S. J., Jeppesen, J. F., Prats Gavalda, C., Chiu, T. T., Boguslavsky, S., Klip, A., Schjerling, P. & Richter, E., Apr 2013, In: Diabetes. 62, 4, p. 1139-1151 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle

Sylow, L., Jensen, T. E., Kleinert, M., Højlund, K., Kiens, B., Wojtaszewski, J., Prats Gavalda, C., Schjerling, P. & Richter, E., Jun 2013, In: Diabetes. 62, 6, p. 1865-1875 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

114 Citations (Scopus)

2012

5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

Stride, N., Larsen, S., Treebak, J. T., Hansen, C. N., Hey-Mogensen, M., Speerschneider, T., Jensen, T. E., Jeppesen, J., Wojtaszewski, J., Richter, E., Køber, L. & Dela, F., 22 Feb 2012, In: Frontiers in Physiology. 3, 7 p., 00033.

Research output: Contribution to journal › Journal article › Research › peer-review

EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle

Jensen, T. E., Leutert, R., Rasmussen, S. T., Mouatt, J. R., Christiansen, M. L. B., Jensen, B. R. & Richter, E., 8 Feb 2012, In: P L o S One. 7, 2, p. e31054 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

Regulation of glucose and glycogen metabolism during and after exercise

Jensen, T. E. & Richter, E., Feb 2012, In: Journal of Physiology. 590, 5, p. 1069-1076 8 p.

Research output: Contribution to journal › Review › peer-review

138 Citations (Scopus)

TLR2 controls intestinal carcinogen detoxication by CYP1A1

Do, K. N., Fink, L. N., Jensen, T. E., Gautier, L. & Parlesak, A., 19 Mar 2012, In: P L o S One. 7, 3, p. e32309 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2011

Lipid induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling

Høeg, L. D., Sjøberg, K. A., Jeppesen, J., Jensen, T. E., Frøsig, C., Birk, J. B., Bisiani, B., Hiscock, N., Pilegaard, H., Wojtaszewski, J., Richter, E. & Kiens, B., Jan 2011, In: Diabetes. 60, 1, p. 64-73 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

86 Citations (Scopus)

Protein kinase C {alpha} activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle

Thomassen, M., Rose, A. J., Jensen, T. E., Maarbjerg, S. J., Bune, L. T., Leitges, M., Richter, E., Bangsbo, J. & Nordsborg, N. B., Dec 2011, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 301, 6, p. R1808-R1814 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Chiu, T. T., Jensen, T. E., Sylow, L., Richter, E. & Klip, A., Oct 2011, In: Cellular Signalling. 23, 10, p. 1546-1554 9 p.

Research output: Contribution to journal › Review › peer-review

97 Citations (Scopus)

Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes

Gormand, A., Henriksson, E., Ström, K., Jensen, T. E., Sakamoto, K. & Göransson, O., May 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

Thomas Elbenhardt Jensen

Research output

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