Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR

TY - JOUR

T1 - Resistance exercise-induced hypertrophy

T2 - A potential role for rapamycin-insensitive mTOR

AU - Ogasawara, Riki

AU - Jensen, Thomas Elbenhardt

AU - Goodman, Craig A

AU - Hornberger, Troy A

N1 - CURIS 2019 NEXS 249

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.

AB - The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.

KW - Faculty of Science

KW - Exercise

KW - Hypertrophy

KW - Protein synthesis

KW - mTOR

KW - mTORC1

KW - mTORC2

KW - Rapamycin

U2 - 10.1249/JES.0000000000000189

DO - 10.1249/JES.0000000000000189

M3 - Review

C2 - 30870215

SN - 0091-6331

VL - 47

SP - 188

EP - 194

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 3

ER -