Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Tim T Chiu; Thomas Elbenhardt Jensen; Lykke Sylow; Erik Richter; Amira Klip

doi:10.1016/j.cellsig.2011.05.022

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Tim T Chiu, Thomas Elbenhardt Jensen, Lykke Sylow, Erik Richter, Amira Klip

97 Citations (Scopus)

Abstract

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

Original language	English
Journal	Cellular Signalling
Volume	23
Issue number	10
Pages (from-to)	1546-1554
Number of pages	9
ISSN	0898-6568
DOIs	https://doi.org/10.1016/j.cellsig.2011.05.022
Publication status	Published - Oct 2011

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title = "Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle",

abstract = "Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.",

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AU - Richter, Erik

AU - Klip, Amira

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AB - Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.

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Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Abstract

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