5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

Nis Stride; Steen Larsen; Jonas Thue Treebak; Christina Neigaard Hansen; Martin Hey-Mogensen; Tobias Speerschneider; Thomas Elbenhardt Jensen; Jacob Jeppesen; Jørgen Wojtaszewski; Erik Richter; Lars Køber; Flemming Dela

doi:10.3389/fphys.2012.00033

5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

Nis Stride, Steen Larsen, Jonas Thue Treebak, Christina Neigaard Hansen, Martin Hey-Mogensen, Tobias Speerschneider, Thomas Elbenhardt Jensen, Jacob Jeppesen, Jørgen Wojtaszewski, Erik Richter, Lars Køber, Flemming Dela

Abstract

5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKa2 (AMPKa2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P¿

Original language	English
Article number	00033
Journal	Frontiers in Physiology
Volume	3
Number of pages	7
ISSN	1664-042X
DOIs	https://doi.org/10.3389/fphys.2012.00033
Publication status	Published - 22 Feb 2012

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Stride, N., Larsen, S., Treebak, J. T., Hansen, C. N., Hey-Mogensen, M., Speerschneider, T., Jensen, T. E., Jeppesen, J., Wojtaszewski, J., Richter, E., Køber, L., & Dela, F. (2012). 5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice. Frontiers in Physiology, 3, Article 00033. https://doi.org/10.3389/fphys.2012.00033

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title = "5'-AMP activated protein kinase is involved in the regulation of myocardial {\ss}-oxidative capacity in mice",

abstract = "5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKa2 (AMPKa2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P¿",

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doi = "10.3389/fphys.2012.00033",

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T1 - 5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

AU - Stride, Nis

AU - Larsen, Steen

AU - Treebak, Jonas Thue

AU - Hansen, Christina Neigaard

AU - Hey-Mogensen, Martin

AU - Speerschneider, Tobias

AU - Jensen, Thomas Elbenhardt

AU - Jeppesen, Jacob

AU - Wojtaszewski, Jørgen

AU - Richter, Erik

AU - Køber, Lars

AU - Dela, Flemming

N1 - CURIS 2012 5200 070

PY - 2012/2/22

Y1 - 2012/2/22

N2 - 5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKa2 (AMPKa2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P¿

AB - 5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKa2 (AMPKa2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P¿

U2 - 10.3389/fphys.2012.00033

DO - 10.3389/fphys.2012.00033

M3 - Journal article

C2 - 22371704

SN - 1664-042X

VL - 3

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 00033

ER -

5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice

Abstract

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