Kim Theilgaard-Mønch

2019

Identification of two distinct pathways of human myelopoiesis

Drissen, R., Thongjuea, S., Theilgaard-Mönch, K. & Nerlov, C., 2019, In: Science immunology. 4, 35, eaau7148.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

Jakobsen, J. S., Laursen, L. G., Schuster, M. B., Pundhir, S., Schoof, E., Ge, Y., d'Altri, T., Vitting-Seerup, K., Rapin, N., Gentil, C., Jendholm, J., Theilgaard-Mönch, K., Reckzeh, K., Bullinger, L., Döhner, K., Hokland, P., Fitzgibbon, J. & Porse, B. T., 2019, In: Science Advances. 5, 7, p. 1-16 17 p., eaaw4304.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

9 Downloads (Pure)

2018

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

Reckzeh, K., Kizilkaya, H., Helbo, A. S., Alrich, M. E., Deslauriers, A. G., Grover, A., Rapin, N., Asmar, F., Grønbæk, K., Porse, B., Borregaard, N., Vestweber, D., Nerlov, C. & Theilgaard-Mönch, K., 10 Jul 2018, In: Blood advances. 2, 13, p. 1628-1632 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2017

Gut microbiota sustains hematopoiesis

Theilgaard-Mönch, K., 9 Feb 2017, In: Blood. 129, 6, p. 662-663 2 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

5 Citations (Scopus)

2016

Low-molecular-weight carbohydrate Pentaisomaltose may replace dimethyl sulfoxide as a safer cryoprotectant for cryopreservation of peripheral blood stem cells

Svalgaard, J. D., Haastrup, E. K., Reckzeh, K., Holst, B., Glovinski, P. V., Gørløv, J. S., Hansen, M. B., Moench, K. T., Clausen, C. & Fischer-Nielsen, A., 1 May 2016, In: Transfusion. 56, 5, p. 1088-95 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

2015

Cellular origin of prognostic chromosomal aberrations in AML patients

Mora-Jensen, H., Jendholm, L. J., Rapin, N. P. J-P., Andersen, M. K., Roug, A. S., Bagger, F. O., Bullinger, L., Winther, O., Borregaard, N., Porse, B. T. & Theilgaard-Mönch, K., 7 Aug 2015, In: Leukemia. 29, p. 1785-1789 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

Knudsen, K. J., Rehn, M. C., Hasemann, M. S., Rapin, N. P. J-P., Bagger, F. O., Ohlsson, E. K., Willer, A., Frank, A-K., Søndergaard, E., Jendholm, L. J., Thorén, L. A. M., Lee, J., Rak, J., Theilgaard-Mønch, K. & Porse, B. T., 15 Sept 2015, In: Genes & Development. 29, p. 1915-1929 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

2014

Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

Rapin, N. P. J-P., Bagger, F. O., Jendholm, L. J., Mora-Jensen, H., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Mönch, K. & Porse, B. T., 6 Feb 2014, In: Blood (online). 123, 6, p. 894-904 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

67 Citations (Scopus)

Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177

Hu, N., Mora-Jensen, H., Theilgaard-Mønch, K., Doornbos-van der Meer, B., Huitema, M. G., Stegeman, C. A., Heeringa, P., Kallenberg, C. G. M. & Westra, J., 13 Jun 2014, In: PLOS ONE. 9, 6, p. e99671 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2013

HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

Bagger, F. O., Rapin, N. P. J-P., Theilgaard-Mønch, K., Kaczkowski, B., Thorén, L. A. M., Jendholm, L. J., Winther, O. & Porse, B. T., 1 Jan 2013, In: Nucleic Acids Research. 41, Database issue, p. D1034-D1039 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

60 Citations (Scopus)

2220 Downloads (Pure)

Improving The Analysis Of Gene Expression Profiles By Comparing AML Blasts With Their Nearest Normal Counterparts

Rapin, N., Bagger, F. O., Jendholm, J., Mora-Jensen, H. I., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Moench, K. & Porse, B., 2013, In: Blood. 122, 21

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

MicroRNA profiling in human neutrophils during bone marrow granulopoiesis and in vivo exudation

Larsen, M. T., Hother, C., Häger, M., Pedersen, C. C., Theilgaard-Mönch, K., Borregaard, N. & Cowland, J. B., 12 Mar 2013, In: P L o S One. 8, 3, 13 p., e58454.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

2012

HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

Bagger, F. O., Rapin, N. P. J-P., Theilgaard-Mønch, K., Kaczkowski, B., Jendholm, L. J., Winther, O. & Porse, B. T., 28 Jun 2012, In: Blood. 119, 26, p. 6394-6395 2 p.

Research output: Contribution to journal › Comment/debate › Research

26 Citations (Scopus)

Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

Hasemann, M. S., Schuster, M. B., Frank, A-K., Theilgaard-Mönch, K., Pedersen, T. Å., Nerlov, C. & Porse, B. T., 8 Jun 2012, In: P L o S One. 7, 6, p. e38841

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2011

Gene expression profiling in MDS and AML: potential and future avenues

Theilgaard-Mönch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J. M., Kohlmann, A., Morgan, M., Porse, B., Tagliafico, E., Zwaan, C. M., Wainscoat, J., Van den Heuvel-Eibrink, M. M., Mills, K., Bullinger, L., Theilgaard-Mönch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J. M., Kohlmann, A., & 8 othersMorgan, M., Porse, B. T., Tagliafico, E., Zwaan, C. M., Wainscoat, J., Van den Heuvel-Eibrink, M. M., Mills, K. & Bullinger, L., Jun 2011, In: Leukemia. 25, 6, p. 909-20 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

Immunophenotypical characterization of human neutrophil differentiation

Jensen, H. M., Jendholm, J., Fossum, A., Porse, B., Borregaad, N. & Theilgaard-Mönch, K., Sept 2011, In: Journal of Leukocyte Biology. p. 629-634 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

2010

A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia

Marstrand, T. T., Borup, R., Willer, A., Borregaard, N., Sandelin, A. G., Porse, B. T. & Theilgaard-Mönch, K., Jul 2010, In: Leukemia. 24, 7, p. 1265-75 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

2008

High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO).

Kirkeby, A., Torup, L., Bochsen, L., Kjalke, M., Abel, K., Theilgaard-Mønch, K., Johansson, P. I., Bjørn, S. E., Gerwien, J. & Leist, M., 2008, In: Thrombosis and Haemostasis. 99, 4, p. 720-8 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

Kirstetter, P., Schuster, M. B., Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Mönch, K., Månsson, R., Pedersen, T. A., Pabst, T., Schrock, E., Porse, B. T., Jacobsen, S. E. W., Bertone, P., Tenen, D. G. & Nerlov, C., 2008, In: Cancer Cell. 13, 4, p. 299-310 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

173 Citations (Scopus)

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.

Hasemann, M. S., Damgaard, I., Schuster, M. B., Theilgaard-Mönch, K., Sørensen, A. B., Mrsic, A., Krugers, T., Ylstra, B., Pedersen, F. S., Nerlov, C. & Porse, B. T., 2008, In: Blood. 111, 8, p. 4309-21 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.

Weischelfeldt, J. L., Damgaard, I., Bryder, D., Theilgaard-Mönch, K., Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C. & Porse, B. T., 2008, In: Genes & Development. 22, 10, p. 1381-96 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

178 Citations (Scopus)

The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils.

Jacobsen, L. C., Sørensen, O. E., Cowland, J. B., Borregaard, N. & Theilgaard-Mönch, K., 2008, In: Journal of Leukocyte Biology. 83, 5, p. 1155-64 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

2007

Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.

Jacobsen, L. C., Theilgaard-Mönch, K., Christensen, E. I. & Borregaard, N., 2007, In: Blood. 109, 7, p. 3084-7 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

82 Citations (Scopus)

Neutrophil granules: a library of innate immunity proteins.

Borregaard, N., Sørensen, O. E. & Theilgaard-Mönch, K., 2007, In: Trends in Immunology. 28, 8, p. 340-5 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

451 Citations (Scopus)

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.

Nilsson, L., Edén, P., Olsson, E., Månsson, R., Astrand-Grundström, I., Strömbeck, B., Theilgaard-Mönch, K., Anderson, K., Hast, R., Hellström-Lindberg, E., Samuelsson, J., Bergh, G., Nerlov, C., Johansson, B., Sigvardsson, M., Borg, A. & Jacobsen, S. E. W., 2007, In: Blood. 110, 8, p. 3005-14 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

87 Citations (Scopus)

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J-C., Hansen, K. H. & Helin, K., 2007, In: Genes & Development. 21, 5, p. 525-30 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

668 Citations (Scopus)

2006

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.

Theilgaard-Mönch, K., Jacobsen, L. C., Nielsen, M. J., Rasmussen, T., Udby, L., Gharib, M., Arkwright, P. D., Gombart, A. F., Calafat, J., Moestrup, S. K., Porse, B. T. & Borregaard, N., 2006, In: Blood. 108, 1, p. 353-61 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

97 Citations (Scopus)

Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation.

Wynn, R. F., Sood, M., Theilgaard-Mönch, K., Jones, C. J., Gombart, A. F., Gharib, M., Koeffler, H. P., Borregaard, N. & Arkwright, P. D., 2006, In: Gut. 55, 2, p. 292-3 1 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

2005

Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils.

Theilgaard-Mönch, K., Jacobsen, L. C., Rasmussen, T., Niemann, C. U., Udby, L., Borup, R., Gharib, M., Arkwright, P. D., Gombart, A. F., Calafat, J., Porse, B. T. & Borregaard, N., 2005, In: Journal of Leukocyte Biology. 78, 2, p. 462-70 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

Identification of ID-1 as a potential target gene of MMSET in multiple myeloma.

Hudlebusch, HR., Theilgaard-Mønch, K., Lodahl, M., Johnsen, HE. & Rasmussen, T., 2005, In: British Journal of Haematology.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

Porse, B. T., Bryder, D., Theilgaard-Mönch, K., Hasemann, M. S., Anderson, K., Damgaard, I., Jacobsen, S. E. W. & Nerlov, C., 2005, In: Journal of Experimental Medicine. 202, 1, p. 85-96 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

83 Citations (Scopus)

Systems biology of neutrophil differentiation and immune response.

Theilgaard-Mönch, K., Porse, B. T. & Borregaard, N., 2005, In: Current Opinion in Immunology. 18, 1, p. 54-60 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

60 Citations (Scopus)

2004

Neutrophils and keratinocytes in innate immunity--cooperative actions to provide antimicrobial defense at the right time and place.

Borregaard, N., Theilgaard-Mönch, K., Cowland, J. B., Ståhle, M. & Sørensen, O. E., 2004, In: Journal of Leukocyte Biology. 77, 4, p. 439-43 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing.

Theilgaard-Mönch, K., Knudsen, S., Follin, P. & Borregaard, N., 2004, In: Journal of Immunology. 172, 12, p. 7684-93 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

149 Citations (Scopus)

The transcriptional program of terminal granulocytic differentiation.

Theilgaard-Mönch, K., Jacobsen, L. C., Borup, R., Rasmussen, T., Bjerregaard, M. D., Nielsen, F. C., Cowland, J. B. & Borregaard, N., 2004, In: Blood. 105, 4, p. 1785-96 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

205 Citations (Scopus)

2003

Occurrence of dysregulated oncogenes in primary plasma cells representing consecutive stages of myeloma pathogenesis: indications for different disease entities.

Rasmussen, T., Theilgaard-Mønch, K., Hudlebusch, HR., Lodahl, M., Johnsen, HE. & Dahl, IM., 2003, In: British Journal of Haematology.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Occurrence of dysregulated oncogenes in primary plasma cells representing consecutive stages of myeloma pathogenesis: indications for different disease entities.

Rasmussen, T., Theilgaard-Mønch, K., Hudlebusch, H. R., Lodahl, M., Johnsen, H. E. & Dahl, I. M. S., 2003, In: British Journal of Haematology. 123, 2, p. 253-62 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Pluripotent and myeloid-committed CD34+ subsets in hematopoietic stem cell allografts.

Theilgaard-Mönch, K., Raaschou-Jensen, K., Schjødt, K., Heilmann, C., Vindeløv, L., Jacobsen, N. & Dickmeiss, E., 2003, In: Bone Marrow Transplantation. 32, 12, p. 1125-33 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors.

Sørensen, O. E., Cowland, J. B., Theilgaard-Mönch, K., Liu, L., Ganz, T. & Borregaard, N., 2003, In: Journal of Immunology. 170, 11, p. 5583-9 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

292 Citations (Scopus)

2002

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

Sitnicka, E., Bryder, D., Theilgaard-Mönch, K., Buza-Vidas, N., Adolfsson, J. & Jacobsen, S. E. W., 2002, In: Immunity. 17, 4, p. 463-72 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

203 Citations (Scopus)

2001

Flow cytometric assessment of lymphocyte subsets, lymphoid progenitors, and hematopoietic stem cells in allogeneic stem cell grafts.

Theilgaard-Mönch, K., Raaschou-Jensen, K., Palm, H., Schjødt, K., Heilmann, C., Vindeløv, L., Jacobsen, N. & Dickmeiss, E., 2001, In: Bone Marrow Transplantation. 28, 11, p. 1073-82 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

Profiling of gene expression in individual hematopoietic cells by global mRNA amplification and slot blot analysis.

Theilgaard-Mönch, K., Cowland, J. & Borregaard, N., 2001, In: Journal of Immunological Methods. 252, 1-2, p. 175-89 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Regulation of human neutrophil granule protein expression.

Borregaard, N., Theilgaard-Mönch, K., Sørensen, O. E. & Cowland, J. B., 2001, In: Current Opinion in Hematology. 8, 1, p. 23-7 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation.

Bryder, D., Ramsfjell, V., Dybedal, I., Theilgaard-Mönch, K., Högerkorp, C. M., Adolfsson, J., Borge, O. J. & Jacobsen, S. E., 2001, In: Journal of Experimental Medicine. 194, 7, p. 941-52 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

82 Citations (Scopus)

Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.

Adolfsson, J., Borge, O. J., Bryder, D., Theilgaard-Mönch, K., Astrand-Grundström, I., Sitnicka, E., Sasaki, Y. & Jacobsen, S. E., 2001, In: Immunity. 15, 4, p. 659-69 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

504 Citations (Scopus)

1999

A comparative study of CD34+ cells, CD34+ subsets, colony forming cells and cobblestone area forming cells in cord blood and bone marrow allografts.

Theilgaard-Mönch, K., Raaschou-Jensen, K., Heilmann, C., Andersen, H., Bock, J., Russel, C. A., Vindeløv, L., Jacobsen, N. & Dickmeiss, E., 1999, In: European Journal of Haematology. 62, 3, p. 174-83 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Single leukapheresis products collected from healthy donors after the administration of granulocyte colony-stimulating factor contain ten-fold higher numbers of long-term reconstituting hematopoietic progenitor cells than conventional bone marrow allografts.

Theilgaard-Mönch, K., Raaschou-Jensen, K., Andersen, H., Russell, C. A., Vindeløv, L., Jacobsen, N. & Dickmeiss, E., 1999, In: Bone Marrow Transplantation. 23, 3, p. 243-9 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Kim Theilgaard-Mønch

Research output

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