Research output per year
Research output per year
Personal profile
Short presentation
In my PhD thesis work I studied different aspects of hypoxia and the transcription factor HIF-1 in hematopoietic stem cell (HSC) biology. My work led to findings that support a role for hypoxic regulation of HSCs via VEGFA-induction and Cripto/GRP78 signaling. After joining the lab of Bo porse, I have been working on projects characterizing the role of the transcription factor Erg and alternative splicing in hematopoiesis.
CV
Education
2006–2011
PhD in Stem Cell Biology. Lund University, Sweden.
2001–2005
MSc in Medical Science. Biomedicine program, Lund University, Sweden.
Career
Oct 2011–present
Postdoc, laboratory of Bo Porse, Biotech Research and Innovation Centre (BRIC) and the Finsen Laboratory, Copenhagen, Denmark.
Feb 2006–Sept 2011
PhD student, Lund Stem Cell Center, Lund University, Sweden. Supervisor: Jörg Cammenga.
Title of thesis: The Hypoxic Hematopoietic Stem Cell Niche–Consequences of Hypoxia-induced Transcription on Stem Cell Fate.
Sept 2004–June 2005
Master student, Division of Molecular Medicine and Gene therapy, laboratory of Stefan Karlsson, Lund University.
Title of thesis: Generation of lentiviral vectors expressing siRNA against p21 and Pre-B-cell leukemia factor 1 for expansion of hematopoeitic stem cells.
Primary fields of research
- Hematopoiesis
- Hematopoietic stem cells
- Alternative splicing
- RNA-binding proteins
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Dive into the research topics where Matilda Carolina Rehn is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 6 Similar Profiles
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ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
Søndergaard, E., Rauch, A., Michaut, M., Rapin, N., Rehn, M., Wilhelmson, A. S., Camponeschi, A., Hasemann, M. S., Bagger, F. O., Jendholm, J., Knudsen, K. J., Mandrup, S., Mårtensson, I. L. & Porse, B. T., 26 Nov 2019, In: Cell Reports. 29, 9, p. 2756-2769.e6 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment
Lauridsen, F. KB., Jensen, T. L., Rapin, N., Aslan, D., Wilhelmson, A. S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M. S., Serup, P., Amit, I. & Porse, B. T., 17 Jul 2018, In: Cell Reports. 24, 3, p. 766-780 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
Knudsen, K. J., Rehn, M. C., Hasemann, M. S., Rapin, N. P. J-P., Bagger, F. O., Ohlsson, E. K., Willer, A., Frank, A-K., Søndergaard, E., Jendholm, L. J., Thorén, L. A. M., Lee, J., Rak, J., Theilgaard-Mønch, K. & Porse, B. T., 15 Sept 2015, In: Genes & Development. 29, p. 1915-1929 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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HIF-1α can act as a tumor suppressor gene in murine acute myeloid leukemia
Velasco-Hernandez, T., Hyrenius-Wittsten, A., Rehn, M., Bryder, D. & Cammenga, J., 4 Dec 2014, In: Blood. 124, 24, p. 3597-607 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypoxic induction of vascular endothelial growth factor regulates erythropoiesis but not hematopoietic stem cell function in the fetal liver
Rehn, M., Kertész, Z. & Cammenga, J., 1 Nov 2014, In: Experimental Hematology. 42, 11, p. 941-4.e1Research output: Contribution to journal › Journal article › Research › peer-review
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Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche
Miharada, K., Karlsson, G., Rehn, M., Rörby, E., Siva, K., Cammenga, J. & Karlsson, S., Aug 2012, In: Annals of the New York Academy of Sciences. 1266, p. 55-62 8 p.Research output: Contribution to journal › Review › peer-review
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(H)if blood stem cells gO2 sleep: what can wake them up?
Rehn, M. & Cammenga, J., 31 Oct 2011, In: Cell Cycle. 10, 20, p. 3419-20 2 p.Research output: Contribution to journal › Journal article › Communication
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Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78
Miharada, K., Karlsson, G., Rehn, M., Rörby, E., Siva, K., Cammenga, J. & Karlsson, S., 4 Oct 2011, In: Cell Stem Cell. 9, 4, p. 330-44 15 p.Research output: Contribution to journal › Journal article › Research › peer-review