HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

TY - JOUR

T1 - HemaExplorer

T2 - a database of mRNA expression profiles in normal and malignant haematopoiesis

AU - Bagger, Frederik Otzen

AU - Rapin, Nicolas Philippe Jean-Pierre

AU - Theilgaard-Mønch, Kim

AU - Kaczkowski, Bogumil

AU - Thorén, Lina Anna Maria

AU - Jendholm, Lars Johan

AU - Winther, Ole

AU - Porse, Bo Torben

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The HemaExplorer (http://servers.binf.ku.dk/hema-explorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.

AB - The HemaExplorer (http://servers.binf.ku.dk/hema-explorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.

U2 - 10.1093/nar/gks1021

DO - 10.1093/nar/gks1021

M3 - Journal article

SN - 0305-1048

VL - 41

SP - D1034-D1039

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - Database issue

ER -