Research output per year
Research output per year
Research output
Search results
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2019
19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR
Christensen, M. V., Kongstad, K. T., Sondergaard, T. E., Stærk, D., Nielsen, H. M., Franzyk, H. & Wimmer, R., Apr 2019, In: Journal of Biomolecular N M R. 73, p. 167-182Research output: Contribution to journal › Journal article › Research › peer-review
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Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients
Molchanova, N., Wang, H., Hansen, P. R., Høiby, N., Nielsen, H. M. & Franzyk, H., Feb 2019, In: Frontiers in Microbiology. 10, 9 p., 275.Research output: Contribution to journal › Journal article › Research › peer-review
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Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery
Thanki, K., Papai, S., Lokras, A., Rose, F., Falkenberg, E., Franzyk, H. & Foged, C., 1 Mar 2019, In: Pharmaceutical Research. 36, 3, p. 37Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration
Tandrup Schmidt, S., Line Olsen, C., Franzyk, H., Wørzner, K., Smith Korsholm, K., Rades, T., Andersen, P., Foged, C. & Christensen, D., Jul 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 140, p. 29-39 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency.
Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A. S. J., Berg, J. O., Thulstrup, P. W., Franzyk, H., Edvinsson, L., Sams, A., Sheykhzade, M. & Hansen, P. R., 20 Dec 2019, (Submitted) In: International Journal of Molecular Sciences (Online).Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation
Dormenval, C., Lokras, A., Cano-Garcia, G., Wadhwa, A., Thanki, K., Rose, F., Thakur, A., Franzyk, H. & Foged, C., 1 Oct 2019, In: Pharmaceutical Research. 36, 10, p. 142Research output: Contribution to journal › Journal article › Research › peer-review
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Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model
Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, H., Nielsen, H. M., van Eden, W., Dong, M., Broere, F., Foged, C. & Zeng, X., Sept 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.Research output: Contribution to journal › Journal article › Research › peer-review
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Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling
Hansen, M., Peltier, J., Killy, B., Amin, B., Bodendorfer, B., Härtlova, A., Uebel, S., Bosmann, M., Hofmann, J., Büttner, C., Ekici, A. B., Kuttke, M., Franzyk, H., Foged, C., Beer-Hammer, S., Schabbauer, G., Trost, M. & Lang, R., Apr 2019, In: Molecular and Cellular Proteomics. 18, 4, p. 669-685Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration
Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, H., Nielsen, H. M., Braeckmans, K., Lehr, C.-M., Ogris, M. & Foged, C., 28 Sept 2019, In: Journal of controlled release : official journal of the Controlled Release Society.Research output: Contribution to journal › Journal article › Research › peer-review
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Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae
Hansen, A. M., Bonke, G., Hogendorf, W. F. J., Björkling, F., Nielsen, J., Kongstad, K. T., Zabicka, D., Tomczak, M., Urbas, M., Nielsen, P. E. & Franzyk, H., 15 Apr 2019, In: European Journal of Medicinal Chemistry. 168, p. 134-145 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, P. R., Björkling, F. & Franzyk, H., 4 Dec 2019, In: Molecules (Print Archive Edition). 24, 18 p., 4429.Research output: Contribution to journal › Journal article › Research › peer-review
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Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency
Kachel, H. S., Franzyk, H. & Mellor, I. R., 5 Jun 2019, In: Journal of Medicinal Chemistry. 62, 13, p. 6214-6222Research output: Contribution to journal › Journal article › Research › peer-review
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Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators
Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, H. M., Franzyk, H. & Guardabassi, L., Jun 2019, In: International Journal of Antimicrobial Agents. 53, p. 868-872 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics
Baker, K. R., Jana, B., Hansen, A. M., Nielsen, H. M., Franzyk, H. & Guardabassi, L., 2 Jul 2019, In: Frontiers in Cellular and Infection Microbiology. 9Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function
Holdfeldt, A., Skovbakke, S. L., Gabl, M., Nielsen, C., Dahlgren, C., Franzyk, H. & Forsman, H., 28 Mar 2019, In: ACS Omega. 4, 3, p. 5968-5982 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies on acid stability and solid-phase block synthesis of peptide-peptoid hybrids: ligands for formyl peptide receptors
Hansen, A. M., Skovbakke, S. L., Christensen, S. B., Perez-Gassol, I. & Franzyk, H., 7 Feb 2019, In: Amino Acids. 51, p. 205-218Research output: Contribution to journal › Journal article › Research › peer-review
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2018
Anchoring of hydrophilic coating polymers onto charged liposomes via attractive electrostatic interactions using charged tags to control the surface charge drainage properties and cellular targeting
Andersen, P. L. (Inventor), Christensen, D. (Inventor), Franzyk, H. (Inventor), Foged, C. (Inventor) & Schmidt, S. T. (Inventor), 2018, (Submitted)Research output: Patent
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Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Kłodzińska, S. N., Molchanova, N., Franzyk, H., Hansen, P. R., Damborg, P. & Nielsen, H. M., Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin
Birch, D., Christensen, M. V., Stærk, D., Franzyk, H. & Nielsen, H. M., 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Fastfase-syntese af Peptider - en visuel guide
Franzyk, H., 2018, 18 p.Research output: Book/Report › Compendium/lecture notes
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Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius
Molchanova, N., Hansen, P. R., Damborg, P. & Franzyk, H., Jul 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction
Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jorgensen, L., Franzyk, H., Cárdenas, M. & Nielsen, H. M., 1 Dec 2018, In: Scientific Reports. 8, 1, 14 p., 6327.Research output: Contribution to journal › Journal article › Research › peer-review
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Guide til Rapportskrivning i Kurset Biopharmaceuticals: Bioorganisk Kemi 2018
Franzyk, H., 2018, 17 p.Research output: Book/Report › Compendium/lecture notes
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High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans
Lima, R. D. C. L., Kongstad, K. T., Kato, L., José das Silva, M., Franzyk, H. & Stærk, D., 2018, In: Molecules. 23, 7, 13 p., 1755.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures
McNair, L. F., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, H. & Stærk, D., 1 Dec 2018, In: F E M S Yeast Research. 18, 9 p., foy094.Research output: Contribution to journal › Journal article › Research › peer-review
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Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein
Rodrigues, L., Raftopoulos, K. N., Tandrup Schmidt, S., Schneider, F., Dietz, H., Rades, T., Franzyk, H., Pedersen, A. E., Papadakis, C. M., Christensen, D., Winter, G., Foged, C. & Hubert, M., 10 Sept 2018, In: Journal of controlled release : official journal of the Controlled Release Society. 285, p. 12-22 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, H., Nielsen, H. M., Broere, F., Gay, N. J., Foged, C. & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists
Hansen, A. M., Peng, P., Baldry, M., Perez-Gassol, I., Christensen, S. B., Vinther, J. M., Ingmer, H. & Franzyk, H., 25 May 2018, In: European Journal of Medicinal Chemistry. 152, p. 370-376 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies
Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M. & Braeckmans, K. & 1 others, , 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Mini-manual: Søgninger i Reaxys
Franzyk, H., 2018, 4 p.Research output: Book/Report › Compendium/lecture notes
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Non-natural Amino Acid and Peptoid Building Blocks for Optimization of the Cell-Penetrating (R-X-R)n Motif
Wester, A., Bjorkling, F., Nieslen, P. & Franzyk, H., Sept 2018, In: Journal of Peptide Science. 24, p. S94-S94Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
107 Downloads (Pure) -
Phorbol Rearrangements
Zimmermann, T., Franzyk, H. & Christensen, S. B., 28 Sept 2018, In: Journal of Natural Products. 81, 9, p. 2134-2137 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis
Zimmermann, T., Christensen, S. B. & Franzyk, H., 15 Jun 2018, In: Molecules. 23, 6, 13 p., 1463.Research output: Contribution to journal › Journal article › Research › peer-review
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Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity
Birch, D., Christensen, M. V., Stærk, D., Franzyk, H. & Nielsen, H. M., 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Study of alpha-Peptoid/alpha-Peptide Peptidomimetics: Influence of Hydrophobicity on Antimicrobial Activity and Cytotoxicity
Frederiksen, N., Bjorkling, F., Nielsen, P. & Franzyk, H., Sept 2018, In: Journal of Peptide Science. 24, s2, p. S120-S120Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
116 Downloads (Pure) -
The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics
Skovbakke, S. L., Holdfeldt , A., Forsman, H., Bylund, J. & Franzyk, H., 2018, In: Current Pharmaceutical Design. 24, 10, p. 1100-1120 21 p.Research output: Contribution to journal › Review › peer-review
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Vejledning til Praktisk Udførelse af Øvelsesdelen i Kurset Biopharmaceuticals: Bioorganisk Kemi 2018
Franzyk, H., 2018, 66 p.Research output: Book/Report › Compendium/lecture notes
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2017
Adjuvants based on synthetic mycobacterial cord factor analogues: Biophysical properties of neat glycolipids and nano-self-assemblies with DDA
Kallerup, R. S., Franzyk, H., Schiøth, M. L., Justesen, S., Martin-Bertelsen, B., Rose, F., Madsen, C. M., Christensen, D., Korsholm, K. S., Yaghmur, A. & Foged, C., 3 Jul 2017, In: Molecular Pharmaceutics. 14, 7, p. 2294-2306 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Advances in development of antimicrobial peptidomimetics as potential drugs
Molchanova, N., Hansen, P. R. & Franzyk, H., Sept 2017, In: Molecules. 22, 9, 60 p., 1430.Research output: Contribution to journal › Review › peer-review
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An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens
Baker, K. R., Jana, B., Nielsen, H. M., Franzyk, H. & Guardabassi, L., 2017. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
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Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization
Skovbakke, S. L. & Franzyk, H., 2017, Methods Molecular Biology: Antimicrobial Peptides. Hansen, P. R. (ed.). Springer, Vol. 1548. p. 369-386 18 p. (Methods in Molecular Biology, Vol. 1548).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
4 Citations (Scopus) -
Antisense PNA antibiotics against multiresistant Gram-negative bacteria
Nielsen, P. E., Björkling, F. & Franzyk, H., 2017, In: International Journal of Molecular Medicine. 40, Suppl. 1, p. S22 1 p., Abstract 169.Research output: Contribution to journal › Conference abstract in journal › Research
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Biopolymer-based nanogels improve the safety profile and antimicrobial activity of a lysine-based peptidomimetic.
Franzyk, H., 2017.Research output: Contribution to conference › Poster › Research › peer-review
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Combining elements from two antagonists of formyl peptide receptor 2 generates more potent peptidomimetic antagonists
Skovbakke, S. L., Holdfeldt, A., Nielsen, C., Hansen, A. M., Perez-Gassol, I., Dahlgren, C., Forsman, H. & Franzyk, H., 24 Aug 2017, In: Journal of Medicinal Chemistry. 60, 16, p. 6991-6997Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, H. M., Franzyk, H. & Foged, C., 2017.Research output: Contribution to conference › Poster › Research
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Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, H. M., Franzyk, H. & Foged, C., Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability
Birch, D., Christensen, M. V., Stærk, D., Franzyk, H. & Nielsen, H. M., Dec 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity
Molchanova, N., Hansen, P. R., Damborg, P. P., Nielsen, H. M. & Franzyk, H., 20 Feb 2017, In: ChemMedChem. 12, p. 312-318 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA
Foged, C. (Inventor), Franzyk, H. (Inventor), Zeng, X. (Inventor), Nielsen, H. M. (Inventor) & Thanki, K. (Inventor), 21 Sept 2017, IPC No. A61K31/713, A61K47/18, A61K47/34, A61K9/51, A61P25/00, A61P29/00, A61P35/00, Patent No. WO2017158093-A1, 16 Mar 2017, Priority date 17 Mar 2016, Priority No. EP 2016-160931Research output: Patent
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On-resin N-formylation of peptides: a head-to-head comparison of reagents in solid-phase synthesis of ligands for formyl peptide receptors
Christensen, S. B., Hansen, A. M. & Franzyk, H., 1 May 2017, In: Journal of Peptide Science. 23, 5, p. 410-415 6 p.Research output: Contribution to journal › Journal article › Research › peer-review