Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

Kaushik Thanki; Aneesh Thakur; A. M. de Groot; A. Geyer; Juan Fraire; Emily Falkenberg; Hannelore Van Eygen; Emma Putteman; Djai C. J. Van Bijnen; Xianghui Zeng; H. Sami; S.  Gehrig; Sarah Justesen; Henrik Franzyk; Femke Broere; Willem van Eden; Alice J A M Sijts; M. Ogris; Hanne Mørck Nielsen; Kevin Braeckmans; Camilla Foged

Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

Kaushik Thanki, Aneesh Thakur, A. M. de Groot, A. Geyer, Juan Fraire, Emily Falkenberg, Hannelore Van Eygen, Emma Putteman, Djai C. J. Van Bijnen, Xianghui Zeng, H. Sami, S. Gehrig, Sarah Justesen, Henrik Franzyk, Femke Broere, Willem van Eden, Alice J A M Sijts, M. Ogris, Hanne Mørck Nielsen, Kevin BraeckmansCamilla Foged

Original language	English
Publication date	2018
Publication status	Published - 2018
Event	Controlled Release Society Annual Meeting & Exposition (CRS 2018) - New York, United States Duration: 22 Jul 2018 → 24 Jul 2018

Conference

Conference	Controlled Release Society Annual Meeting & Exposition (CRS 2018)
Country/Territory	United States
City	New York
Period	22/07/2018 → 24/07/2018

Cite this

Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., ... Foged, C. (2018). Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. / Thanki, Kaushik; Thakur, Aneesh; de Groot, A. M. et al.

2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Thanki, K, Thakur, A, de Groot, AM, Geyer, A, Fraire, J, Falkenberg, E, Van Eygen, H, Putteman, E, Van Bijnen, DCJ, Zeng, X, Sami, H, Gehrig, S, Justesen, S, Franzyk, H, Broere, F, van Eden, W, Sijts, AJAM, Ogris, M, Nielsen, HM, Braeckmans, K & Foged, C 2018, 'Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies', Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States, 22/07/2018 - 24/07/2018.

Thanki K, Thakur A, de Groot AM, Geyer A, Fraire J, Falkenberg E et al.. Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. 2018. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

Thanki, Kaushik ; Thakur, Aneesh ; de Groot, A. M. et al. / Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies. Abstract from Controlled Release Society Annual Meeting & Exposition (CRS 2018), New York, United States.

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title = "Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies",

author = "Kaushik Thanki and Aneesh Thakur and {de Groot}, {A. M.} and A. Geyer and Juan Fraire and Emily Falkenberg and {Van Eygen}, Hannelore and Emma Putteman and {Van Bijnen}, {Djai C. J.} and Xianghui Zeng and H. Sami and S. Gehrig and Sarah Justesen and Henrik Franzyk and Femke Broere and {van Eden}, Willem and Sijts, {Alice J A M} and M. Ogris and Nielsen, {Hanne M{\o}rck} and Kevin Braeckmans and Camilla Foged",

year = "2018",

language = "English",

note = "Controlled Release Society Annual Meeting & Exposition (CRS 2018) ; Conference date: 22-07-2018 Through 24-07-2018",

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TY - ABST

T1 - Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

AU - Thanki, Kaushik

AU - Thakur, Aneesh

AU - de Groot, A. M.

AU - Geyer, A.

AU - Fraire, Juan

AU - Falkenberg, Emily

AU - Van Eygen, Hannelore

AU - Putteman, Emma

AU - Van Bijnen, Djai C. J.

AU - Zeng, Xianghui

AU - Sami, H.

AU - Gehrig, S.

AU - Justesen, Sarah

AU - Franzyk, Henrik

AU - Broere, Femke

AU - van Eden, Willem

AU - Sijts, Alice J A M

AU - Ogris, M.

AU - Nielsen, Hanne Mørck

AU - Braeckmans, Kevin

AU - Foged, Camilla

PY - 2018

Y1 - 2018

M3 - Conference abstract for conference

T2 - Controlled Release Society Annual Meeting & Exposition (CRS 2018)

Y2 - 22 July 2018 through 24 July 2018

ER -