Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Camilla Foged; Henrik Franzyk; Xianghui Zeng; Hanne Mørck Nielsen; Kaushik Thanki

Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Camilla Foged (Inventor), Henrik Franzyk (Inventor), Xianghui Zeng (Inventor), Hanne Mørck Nielsen (Inventor), Kaushik Thanki (Inventor)

Abstract

The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.

Original language	English
IPC	A61K31/713,A61K47/18,A61K47/34,A61K9/51,A61P25/00,A61P29/00,A61P35/00
Patent number	WO2017158093-A1
Filing date	16/03/2017
Country/Territory	Denmark
Priority date	17/03/2016
Priority number	EP 2016-160931
Publication status	Published - 21 Sept 2017

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Foged, C., Franzyk, H., Zeng, X., Nielsen, H. M., & Thanki, K. (2017). Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA. (Patent No. WO2017158093-A1). https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20170921&CC=WO&NR=2017158093A1&KC=A1

Foged, C , Franzyk, H, Zeng, X, Nielsen, HM & Thanki, K Sept. 21 2017, Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA, Patent No. WO2017158093-A1. <https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20170921&CC=WO&NR=2017158093A1&KC=A1>

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title = "Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA",

abstract = "The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.",

author = "Camilla Foged and Henrik Franzyk and Xianghui Zeng and Nielsen, {Hanne M{\o}rck} and Kaushik Thanki",

year = "2017",

month = sep,

day = "21",

language = "English",

type = "Patent",

note = "WO2017158093-A1; A61K31/713,A61K47/18,A61K47/34,A61K9/51,A61P25/00,A61P29/00,A61P35/00",

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TY - PAT

T1 - Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

AU - Foged, Camilla

AU - Franzyk, Henrik

AU - Zeng, Xianghui

AU - Nielsen, Hanne Mørck

AU - Thanki, Kaushik

PY - 2017/9/21

Y1 - 2017/9/21

N2 - The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.

AB - The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.

M3 - Patent

M1 - WO2017158093-A1

Y2 - 2017/03/16

ER -

Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Abstract

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