Claudia Lukas

Research output

Research output per year 2000 2012 2013 2016 2019

• 25 Journal article
• 1 Review

Research output per year

Research output per year

Search results

• 2019

  53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

  Spies, J., Lukas, C., Somyajit, K., Rask, M-B., Lukas, J. & Neelsen, K. J., 1 Apr 2019, In: Nature Cell Biology. 21, p. 487-497

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Damage 100%
  • DNA 64%
  • Genome 31%
  • Mutagens 27%
  • Interphase 26%
  26 Citations (Scopus)

• Stabilization of chromatin topology safeguards genome integrity

  Ochs, F., Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M-B., Lampe, M., Buckle, V., Schermelleh, L., Lukas, J. & Lukas, C., 24 Oct 2019, In: Nature. 574, 7779, p. 571-574 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatin 100%
  • Genome 76%
  • DNA 63%
  • DNA Repair 34%
  • cohesins 26%
  39 Citations (Scopus)
• 2018

  Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

  Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J., & 1 othersGorgoulis, V. G., 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • genetic instability 100%
  • Genomic Instability 80%
  • genomics 72%
  • repair 70%
  • annealing 31%
  28 Citations (Scopus)

  97 Downloads (Pure)
• 2016

  53BP1 fosters fidelity of homology-directed DNA repair

  Ochs, F., Somyajit, K., Altmeyer, M., Rask, M-B. D., Lukas, J. & Lukas, C., 1 Aug 2016, In: Nature Structural and Molecular Biology. 23, 8, p. 714-21 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Repair 100%
  • Chromatin 63%
  • Gene Conversion 48%
  • Double-Stranded DNA Breaks 41%
  • Genomic Instability 39%
  115 Citations (Scopus)

• Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

  Sotiriou, S. K., Kamileri, I., Lugli, N., Evangelou, K., Da-Ré, C., Huber, F., Padayachy, L., Tardy, S., Nicati, N. L., Barriot, S., Ochs, F., Lukas, C., Lukas, J., Gorgoulis, V. G., Scapozza, L. & Halazonetis, T. D., 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1127-1134 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Replication 100%
  • Oncogenes 37%
  • Rad52 DNA Repair and Recombination Protein 36%
  • Small Interfering RNA 33%
  • Neoplasms 25%
  129 Citations (Scopus)

• Profiling DNA damage response following mitotic perturbations

  Pedersen, R. S., Karemore, G., Gudjonsson, T., Rask, M-B., Neumann, B., Hériché, J-K., Pepperkok, R., Ellenberg, J., Gerlich, D. W., Lukas, J. & Lukas, C., 15 Dec 2016, In: Nature Communications. 7, 12 p., 13887.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • deoxyribonucleic acid 100%
  • DNA Damage 96%
  • Error 82%
  • damage 78%
  • perturbation 73%
  24 Citations (Scopus)
• 2015

  Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining

  Zong, D., Callén, E., Pegoraro, G., Lukas, C., Lukas, J. & Nussenzweig, A., 1 Apr 2015, In: Nucleic Acids Research. 43, 10, p. 4950-61 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ectopic Gene Expression 100%
  • Genetic Recombination 87%
  • Homologous Recombination 68%
  • S Phase 59%
  • Tumor Suppressor p53-Binding Protein 1 53%
  17 Citations (Scopus)
• 2014

  The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

  Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M-B., Grøfte, M., Lukas, C., Nielsen, M. L., Smerdon, S. J., Lukas, J. & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nijmegen Breakage Syndrome 100%
  • Ribosomal RNA 79%
  • DNA Damage 54%
  • Chromosome Breakage 42%
  • Mandibulofacial Dysostosis 24%
  78 Citations (Scopus)
• 2013

  ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

  Toledo Lazaro, L. I., Altmeyer, M., Rask, M-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J. & Lukas, J., 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Single-Stranded DNA 100%
  • Cell Nucleus 48%
  • Reduction 42%
  • DNA Damage 41%
  • Hypersensitivity 38%
  420 Citations (Scopus)

• Molecular biology. Shielding broken DNA for a quick fix

  Lukas, J. & Lukas, C., 8 Feb 2013, In: Science (New York, N.Y.). 339, 6120, p. 652-3 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  10 Citations (Scopus)

• Shielding broken DNA for a quick fix

  Lukas, J. & Lukas, C., 8 Feb 2013, In: Science. 339, 6120, p. 652-653 2 p.

  Research output: Contribution to journal › Review › peer-review

  • DNA Repair 100%
  • DNA 60%
  • Proteins 39%
  10 Citations (Scopus)

• The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling

  Altmeyer, M., Toledo Lazaro, L. I., Gudjonsson, T., Grøfte, M., Rask, M-B., Lukas, C., Akimov, V., Blagoev, B., Bartek, J. & Lukas, J., 24 Oct 2013, In: Molecular Cell. 52, 2, p. 206-220

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatin 100%
  • DNA Damage 98%
  • Cell Cycle Checkpoints 44%
  • Proteins 41%
  • Poly Adenosine Diphosphate Ribose 31%
  46 Citations (Scopus)

• The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

  Mosbech, A., Lukas, C., Bekker-Jensen, S. & Mailand, N., 7 Jun 2013, In: Journal of Biological Chemistry. 288, p. 16579-16587 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ligases 95%
  • Histone 93%
  • Ubiquitin 87%
  • Enzymes 47%
  82 Citations (Scopus)
• 2012

  DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

  Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, C., Hartmann-Petersen, R., Lukas, J., Choudhary, C. R., Pocock, R. D. J., Bekker-Jensen, S. & Mailand, N., Nov 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin 100%
  • DNA Damage 86%
  • Proliferating Cell Nuclear Antigen 80%
  • Anaphase-Promoting Complex-Cyclosome 36%
  • DNA-Directed DNA Polymerase 27%
  120 Citations (Scopus)

• LEDGF (p75) promotes DNA-end resection and homologous recombination

  Daugaard, M., Baude, A., Fugger, K., Povlsen, L. K., Beck, H., Sørensen, C. S., Petersen, N. H. T., Sorensen, P. H. B., Lukas, C., Bartek, J., Lukas, J., Rohde, M. & Jaattela, M., Aug 2012, In: Nature Structural & Molecular Biology. 19, 8, p. 803-810 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • lens epithelium-derived growth factor 100%
  • Homologous Recombination 66%
  • Double-Stranded DNA Breaks 33%
  • DNA 32%
  • Chromatin 25%
  107 Citations (Scopus)

• TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

  Gudjónsson, T., Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, S., Mailand, N., Neumann, B., Heriche, J-K., Shearer, R., Saunders, D., Bartek, J., Lukas, J. & Lukas, C., 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • Histone 98%
  • Spreading 97%
  • Chromatin 81%
  • Chromosomes 72%
  204 Citations (Scopus)

• Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

  Moudry, P., Lukas, C., Macurek, L., Hanzlikova, H., Hodny, Z., Lukas, J. & Bartek, J., 15 Apr 2012, In: Cell Cycle. 11, 8, p. 1573-82 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin-Activating Enzymes 100%
  • Ubiquitination 65%
  • Ionizing Radiation 62%
  • DNA Damage 52%
  • Ubiquitin 40%
  46 Citations (Scopus)
• 2011

  53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

  Lukas, C., Savic, V., Bekker-Jensen, S., Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, I. D., Bartek, J. & Lukas, J., 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromosomes 100%
  • Genome 85%
  • Chromatin 74%
  • DNA 70%
  • condensin complexes 67%
  426 Citations (Scopus)
• 2009

  RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

  Doil, C., Mailand, N., Bekker-Jensen, S., Menard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, J. & Lukas, C., 2009, In: Cell. 136, 3, p. 435-46 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitin 100%
  • Lysine 94%
  • Ubiquitination 80%
  • Chromosomes 78%
  • Chromatin 66%
  629 Citations (Scopus)
• 2007

  RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

  Mailand, N., Bekker-Jensen, S., Faustrup, H., Melander, F., Bartek, J., Lukas, C. & Lukas, J., 2007, In: Cell. 131, 5, p. 887-900 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Double-Stranded DNA Breaks 100%
  • Ubiquitination 94%
  • Histone 93%
  • Histones 81%
  • BRCA1 Protein 43%
  848 Citations (Scopus)
• 2006

  Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

  Liu, S., Bekker-Jensen, S., Mailand, N., Lukas, C., Bartek, J. & Lukas, J., 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Damage 100%
  • Phosphorylation 33%
  • RNA Interference 31%
  • Checkpoint Kinase 1 25%
  • Down-Regulation 11%
  129 Citations (Scopus)
• 2004

  Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

  Krämer, A., Mailand, N., Lukas, C., Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, J., Sept 2004, In: Nature Cell Biology. 6, 9, p. 884-91 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CDC2 Protein Kinase 100%
  • Cyclin B 96%
  • Centrosome 87%
  • Checkpoint Kinase 1 17%
  • Mitosis 11%
  261 Citations (Scopus)
• 2003

  Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

  Celis, J. E., Gromov, P., Gromova, I., Moreira, J. M. A., Cabezón, T., Ambartsumian, N., Grigorian, M., Lukanidin, E., Thor Straten, P., Guldberg, P., Bartkova, J., Bartek, J., Lukas, J., Lukas, C., Lykkesfeldt, A., Jäättelä, M., Roepstorff, P., Bolund, L., Ørntoft, T. F., Brünner, N., & 5 othersOvergaard, J., Sandelin, K., Blichert-Toft, M., Mouridsen, H. & Rank, F. E., 2003, In: Molecular and Cellular Proteomics. 2, 6, p. 369-377 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Biological Property 100%
  • Proteomics 94%
  • Biological Marker 92%
  • Technology 67%
  • Breast Neoplasms 65%
  45 Citations (Scopus)
• 2002

  Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

  Mailand, N., Lukas, C., Kaiser, B. K., Jackson, P. K., Bartek, J. & Lukas, J., Apr 2002, In: Nature Cell Biology. 4, 4, p. 317-22 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Centrosome 100%
  • Chromosome Segregation 98%
  • Phosphoric Monoester Hydrolases 81%
  • Nuclear Export Signals 59%
  • Down-Regulation 28%
  174 Citations (Scopus)
• 2001

  DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

  Lukas, C., Bartkova, J., Latella, L., Falck, J., Mailand, N., Schroeder, T., Sehested, M., Lukas, J. & Bartek, J., 1 Jul 2001, In: Cancer Research. 61, 13, p. 4990-3 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Damage 100%
  • Phosphotransferases 88%
  • Checkpoint Kinase 1 44%
  • Retinoblastoma Protein 36%
  • Gamma Rays 33%
  106 Citations (Scopus)
• 2000

  Rapid destruction of human Cdc25A in response to DNA damage

  Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, J., 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Damage 100%
  • Ultraviolet Rays 78%
  • S Phase 75%
  • cdc25 Phosphatases 62%
  • Checkpoint Kinase 1 58%
  623 Citations (Scopus)