Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

Julio E Celis; Pavel Gromov; Irina Gromova; José Manuel Alfonso Moreira; Teresa Cabezón; Noona Ambartsumian; Mariam Grigorian; Eugene Lukanidin; Per Thor Straten; Per Guldberg; Jirina Bartkova; Jiri Bartek; Jiri Lukas; Claudia Lukas; Anne Lykkesfeldt; Marja Jäättelä; Peter Roepstorff; Lars Bolund; Torben Falck Ørntoft; Nils Brünner; Jens Overgaard; Kerstin Sandelin; Mogens Blichert-Toft; Henning Mouridsen; Fritz E Rank

doi:10.1074/mcp.R300007-MCP200

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

Julio E Celis, Pavel Gromov, Irina Gromova, José Manuel Alfonso Moreira, Teresa Cabezón, Noona Ambartsumian, Mariam Grigorian, Eugene Lukanidin, Per Thor Straten, Per Guldberg, Jirina Bartkova, Jiri Bartek, Jiri Lukas, Claudia Lukas, Anne Lykkesfeldt, Marja Jäättelä, Peter Roepstorff, Lars Bolund, Torben Falck Ørntoft, Nils BrünnerJens Overgaard, Kerstin Sandelin, Mogens Blichert-Toft, Henning Mouridsen, Fritz E Rank

45 Citations (Scopus)

Abstract

The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.

Original language	English
Journal	Molecular and Cellular Proteomics
Volume	2
Issue number	6
Pages (from-to)	369-377
Number of pages	9
ISSN	1535-9476
DOIs	https://doi.org/10.1074/mcp.R300007-MCP200
Publication status	Published - 2003

Keywords

Academies and Institutes
Biomedical Research
Biopsy
Body Fluids
Breast Neoplasms
Denmark
Electrophoresis, Gel, Two-Dimensional
Female
Gene Expression Profiling
Genomics
Humans
Mammary Glands, Human
Pilot Projects
Proteomics
Specimen Handling
Tumor Markers, Biological

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1074/mcp.R300007-MCP200

http://www.mcponline.org

Cite this

Celis, J. E., Gromov, P., Gromova, I., Moreira, J. M. A., Cabezón, T., Ambartsumian, N., Grigorian, M., Lukanidin, E., Thor Straten, P., Guldberg, P., Bartkova, J., Bartek, J., Lukas, J., Lukas, C., Lykkesfeldt, A., Jäättelä, M., Roepstorff, P., Bolund, L., Ørntoft, T. F., ... Rank, F. E. (2003). Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. Molecular and Cellular Proteomics, 2(6), 369-377. https://doi.org/10.1074/mcp.R300007-MCP200

Celis, JE, Gromov, P, Gromova, I, Moreira, JMA, Cabezón, T, Ambartsumian, N, Grigorian, M, Lukanidin, E, Thor Straten, P, Guldberg, P, Bartkova, J, Bartek, J, Lukas, J , Lukas, C, Lykkesfeldt, A, Jäättelä, M, Roepstorff, P, Bolund, L, Ørntoft, TF, Brünner, N, Overgaard, J, Sandelin, K, Blichert-Toft, M, Mouridsen, H & Rank, FE 2003, 'Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research', Molecular and Cellular Proteomics, vol. 2, no. 6, pp. 369-377. https://doi.org/10.1074/mcp.R300007-MCP200

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AU - Grigorian, Mariam

AU - Lukanidin, Eugene

AU - Thor Straten, Per

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AU - Bartkova, Jirina

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AU - Ørntoft, Torben Falck

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KW - Gene Expression Profiling

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EP - 377

JO - Molecular and Cellular Proteomics

JF - Molecular and Cellular Proteomics

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ER -

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

Abstract

Keywords

UN SDGs

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