Publikationer pr. år
Publikationer pr. år
Personlig profil
Kort præsentation
The prevalence of obesity and type 2 diabetes is rising at alarming rates worldwide, and urges for the discovery of new therapeutic options. These metabolic disorders are characterized by insulin resistance, i.e. an inappropriate response to insulin in its target tissues, including muscle, adipose tissues and liver.
The main research area of my group is the investigation of the molecular mechanisms involved in the transduction of insulin signalling and the regulation of metabolic processes.
In particular, we are interested in:
- Dissecting the signaling events mediating the various actions of insulin to control metabolic outcomes and cellular differentiation.
- Studying how the complex nature of the insulin signaling network is perturbed in conditions of insulin resistance.
Our molecular interrogation of the insulin signalling cascades aims to identify new avenues for the development of therapeutic strategies to treat insulin resistance with the long-term goal of preventing type 2 diabetes.
Ekspertise relateret til FN’s Verdensmål
I 2015 blev FN-landende enige om 17 Verdensmål til at standse fattigdom, beskytte planeten og sikre velstand for alle. Denne persons arbejde bidrager til følgende verdensmål:
Emneord
- Det Sundhedsvidenskabelige Fakultet
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Brice Emanuelli er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 12 Lignende profiler
-
Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue
Lundh, M., Petersen, P. S., Isidor, M. S., Kazoka-Sørensen, D. N., Plucińska, K., Shamsi, F., Ørskov, C., Tozzi, M., Brown, E. L., Andersen, E., Ma, T., Müller, U. A., Barrès, R., Kristiansen, V. B., Gerhart-Hines, Z., Tseng, Y.-H. & Emanuelli, B., 2019, I: EMBO Reports. 20, 8, e48216.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
Hochreuter, M. Y., Altıntaş, A., Garde, C., Emanuelli, B., Kahn, C. R., Zierath, J. R., Vienberg, S. & Barrès, R., 1 dec. 2019, I: Hepatology Research.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
The brominated flame retardant PBDE 99 promotes adipogenesis via regulating mitotic clonal expansion and PPARγ expression
Wen, Q., Xie, X., Zhao, C., Ren, Q., Zhang, X., Wei, D., Emanuelli, B. & Du, Y., 20 jun. 2019, I: The Science of the Total Environment. 670, s. 67-77 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D. & Keipert, S. & 24 flere, , 3 jul. 2018, I: Cell Metabolism. 28, 1, s. 159-174.e11Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action
Rabiee, A., Krüger, M., Ardenkjær-Larsen, J., Ronald Kahn, C. & Emanuelli, B., jul. 2018, I: Cellular Signalling. 47, s. 1-15Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA
Lundh, M., Pluciñska, K., Isidor, M. S., Petersen, P. S. S. & Emanuelli, B., okt. 2017, I: Molecular Metabolism. 6, 10, s. 1313-1320 8 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5)
Palsgaard, J., Emanuelli, B., Winnay, J. N., Sumara, G., Karsenty, G. & Kahn, C. R., 5 aug. 2016, I: The Journal of Biological Chemistry. 291, 32, s. 16878Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review
-
Interplay between FGF21 and insulin action in the liver regulates metabolism
Emanuelli, B., Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, M., Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., jan. 2015, I: The Journal of Clinical Investigation. 125, 1, s. 458Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review