Bo Torben Porse

Research output

Research output per year 1995 1999 2008 2010 2012 2013 2014 2015 2016 2018 2019 2019

• 93 Journal article
• 2 Comment/debate
• 2 Review
• 1 Conference abstract in journal
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2019

  A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

  Morgan, M., Kabayama, Y., Much, C., Ivanova, I., Di Giacomo, M., Auchynnikava, T., Monahan, J. M., Vitsios, D. M., Vasiliauskaitė, L., Comazzetto, S., Rappsilber, J., Allshire, R. C., Porse, B. T., Enright, A. J. & O'Carroll, D., 1 Mar 2019, In: Cell Research.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA Stability 100%
  • Spermatogenesis 98%
  • Spermatocytes 57%
  • Messenger RNA 51%
  • Transcriptome 41%
  10 Citations (Scopus)

• ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

  Søndergaard, E., Rauch, A., Michaut, M., Rapin, N., Rehn, M., Wilhelmson, A. S., Camponeschi, A., Hasemann, M. S., Bagger, F. O., Jendholm, J., Knudsen, K. J., Mandrup, S., Mårtensson, I. L. & Porse, B. T., 26 Nov 2019, In: Cell Reports. 29, 9, p. 2756-2769.e6 21 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genetic Recombination 100%
  • Pre-B Cell Receptors 89%
  • B-Lymphocytes 80%
  • B-Lymphoid Precursor Cells 62%
  • Reduction 47%
  3 Citations (Scopus)

• Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes

  D'Altri, T., Schuster, M. B., Wenzel, A. & Porse, B. T., 1 Oct 2019, In: European Journal of Haematology. 103, 4, p. 319-328 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Signal Recognition Particle 100%
  • Phenotype 47%
  • Hematopoietic System 34%
  • Proteins 28%
  • Hematologic Neoplasms 26%
  2 Citations (Scopus)

• Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

  Johnson, J. L., Stoica, L., Liu, Y., Zhu, P. J., Bhattacharya, A., Buffington, S., Huq, R., Eissa, N. T., Larsson, O., Porse, B. T., Domingo, D., Nawaz, U., Carroll, R., Jolly, L., Scerri, T. S., Kim, H-G., Brignell, A., Coleman, M. J., Braden, R., Kini, U., & 11 othersJackson, V., Baxter, A., Bahlo, M., Scheffer, I. E., Amor, D. J., Hildebrand, M. S., Bonnen, P. E., Beeton, C., Gecz, J., Morgan, A. T. & Costa-Mattioli, M., 20 Nov 2019, In: Neuron.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Psychological Inhibition 100%
  • Neurodevelopmental Disorders 95%
  • Long-Term Potentiation 92%
  • Encephalitis 87%
  • Communication 61%
  11 Citations (Scopus)

• Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

  Jakobsen, J. S., Laursen, L. G., Schuster, M. B., Pundhir, S., Schoof, E., Ge, Y., d'Altri, T., Vitting-Seerup, K., Rapin, N., Gentil, C., Jendholm, J., Theilgaard-Mönch, K., Reckzeh, K., Bullinger, L., Döhner, K., Hokland, P., Fitzgibbon, J. & Porse, B. T., 2019, In: Science Advances. 5, 7, p. 1-16 17 p., eaaw4304.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Myeloid Leukemia 100%
  • Protein Isoforms 33%
  • Neoplasms 33%
  • Transcription Factors 31%
  • Chromatin Immunoprecipitation Sequencing 27%
  8 Citations (Scopus)

  9 Downloads (Pure)

• The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

  Ge, Y., Schuster, M. B., Pundhir, S., Rapin, N., Bagger, F. O., Sidiropoulos, N., Hashem, N. & Porse, B. T., 1 Dec 2019, In: Nature Communications. 10, 1, 14 p., 172.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • leukemias 100%
  • Small Interfering RNA 95%
  • RNA Splicing Factors 92%
  • regulators 88%
  • splicing 88%
  7 Citations (Scopus)

  57 Downloads (Pure)
• 2018

  A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines

  Gonzalez, J. M., Baudet, A., Abelechian, S., Bonderup, K., d'Altri, T., Porse, B., Brakebusch, C., Juliusson, G. & Cammenga, J., Sept 2018, In: Genesis: The Journal of Genetics and Development (Print). 56, 9, p. 1-7 7 p., e23238.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Embryonic Stem Cells 92%
  • Hematopoietic Stem Cells 86%
  • Inbred NOD Mouse 53%
  • Cell Line 51%

• Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

  Lauridsen, F. KB., Jensen, T. L., Rapin, N., Aslan, D., Wilhelmson, A. S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M. S., Serup, P., Amit, I. & Porse, B. T., 17 Jul 2018, In: Cell Reports. 24, 3, p. 766-780 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA Sequencing 100%
  • Retinoic Acid 78%
  • Hematopoietic Stem Cells 59%
  • Heterogeneity 55%
  • Tretinoin 52%
  16 Citations (Scopus)

  83 Downloads (Pure)

• Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

  Pundhir, S., Bratt Lauridsen, F. K., Schuster, M. B., Jakobsen, J. S., Ge, Y., Schoof, E. M., Rapin, N. P. J-P., Waage, J., Hasemann, M. S. & Porse, B. T., 29 May 2018, In: Cell Reports. 23, 9, p. 2744-2757 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Enhancer 100%
  • Transcription Factors 63%
  • Block Like Crystal 56%
  • proto-oncogene protein Spi-1 46%
  • Cytidine Monophosphate 41%
  9 Citations (Scopus)

  56 Downloads (Pure)

• Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

  Reckzeh, K., Kizilkaya, H., Helbo, A. S., Alrich, M. E., Deslauriers, A. G., Grover, A., Rapin, N., Asmar, F., Grønbæk, K., Porse, B., Borregaard, N., Vestweber, D., Nerlov, C. & Theilgaard-Mönch, K., 10 Jul 2018, In: Blood advances. 2, 13, p. 1628-1632 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  3 Citations (Scopus)

• Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

  Gu, X., Ebrahem, Q., Mahfouz, R. Z., Hasipek, M., Enane, F., Radivoyevitch, T., Rapin, N., Przychodzen, B., Hu, Z., Balusu, R., Cotta, C. V., Wald, D., Argueta, C., Landesman, Y., Martelli, M. P., Falini, B., Carraway, H., Porse, B. T., Maciejewski, J., Jha, B. K., & 1 othersSaunthararajah, Y., 1 Oct 2018, In: The Journal of Clinical Investigation. 128, 10, p. 4260-4279 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • nucleophosmin 100%
  • Co-Repressor Proteins 57%
  • Monocytes 55%
  • Transcription Factors 50%
  • Granulocytes 44%
  48 Citations (Scopus)

• SinaPlot: an enhanced chart for simple and truthful representation of single observations over multiple classes

  Sidiropoulos, N., Sohi, S. H., Pedersen, T. L., Porse, B. T., Winther, O., Rapin, N. & Bagger, F. O., 3 Jul 2018, In: Journal of Computational and Graphical Statistics. 27, 3, p. 673-676 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chart 100%
  • Charts 88%
  • Observation 65%
  • Jitter 49%
  • Sample Size 45%
  12 Citations (Scopus)

• Testosterone is an endogenous regulator of BAFF and splenic B cell number

  Wilhelmson, A. S., Lantero Rodriguez, M., Stubelius, A., Fogelstrand, P., Johansson, I., Buechler, M. B., Lianoglou, S., Kapoor, V. N., Johansson, M. E., Fagman, J. B., Duhlin, A., Tripathi, P., Camponeschi, A., Porse, B. T., Rolink, A. G., Nissbrandt, H., Turley, S. J., Carlsten, H., Mårtensson, I-L., Karlsson, M. C. I., & 1 othersTivesten, Å., 1 Dec 2018, In: Nature Communications. 9, p. 1-13 13 p., 2067.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • regulators 100%
  • Testosterone 91%
  • B-Lymphocytes 60%
  • Cell Count 58%
  • serums 46%
  22 Citations (Scopus)

  55 Downloads (Pure)
• 2017

  EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

  Mohammad, F., Weissmann, S., Leblanc, B. O., Pandey, D. P., Højfeldt, J. W., Comet, I., Zheng, C., Johansen, J. V., Rapin, N. P. J-P., Porse, B. T., Tvardovskiy, A., Jensen, O. N., Olaciregui, N. G., Lavarino, C., Suñol, M., de Torres, C., Mora, J., Carcaboso, A. M. & Helin, K., 1 Apr 2017, In: Nature Medicine. 23, 4, p. 483-492 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • H3K27Me3 100%
  • Diffuse Intrinsic Pontine Glioma 87%
  • Polycomb Repressive Complex 2 60%
  • Glioma 48%
  • Pediatrics 33%
  206 Citations (Scopus)
• 2016

  BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

  Bagger, F. O., Sasivarevic, D., Hadi Sohi, S., Laursen, L. G., Pundhir, S., Sønderby, C. K., Winther, O., Rapin, N. & Porse, B. T., 4 Jan 2016, In: Nucleic Acids Research. 44, D1, p. D917-24 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hematopoiesis 100%
  • Transcriptome 84%
  • Databases 55%
  • Datasets 43%
  • Gene Expression 32%
  141 Citations (Scopus)

  102 Downloads (Pure)

• C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4

  Di Stefano, B., Collombet, S., Jakobsen, J. S., Wierer, M., Sardina, J. L., Lackner, A., Stadhouders, R., Segura-Morales, C., Francesconi, M., Limone, F., Mann, M., Porse, B., Thieffry, D. & Graf, T., 30 Mar 2016, In: Nature Cell Biology. 18, 4, p. 371-81 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cellular Reprogramming 100%
  • Induced Pluripotent Stem Cells 88%
  • B-Lymphocytes 60%
  • Chromatin 34%
  • Granulocyte-Macrophage Progenitor Cells 24%
  49 Citations (Scopus)

• Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality

  Pundhir, S., Bagger, F. O., Lauridsen, F. K. B., Rapin, N. P. J-P. & Porse, B. T., 19 May 2016, In: Nucleic Acids Research. 44, 9, p. 4037-4051 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Code 100%
  • Nucleosomes 68%
  • histone H3 trimethyl Lys4 41%
  • Chromatin Immunoprecipitation Sequencing 37%
  • Histones 27%
  11 Citations (Scopus)

  161 Downloads (Pure)

• The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

  Stunnenberg, H. G., Hirst, M., International Human Epigenome Consortium, Helin, K. & Porse, B. T., 17 Nov 2016, In: Cell. 167, 5, p. 1145-1149 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Epigenome 100%
  • Epigenomics 28%
  • Catalogs 19%
  • Datasets 12%
  • Health 7%
  158 Citations (Scopus)

• The multifaceted functions of C/EBPα in normal and malignant haematopoiesis

  Ohlsson, E., Schuster, M. B., Hasemann, M. & Porse, B. T., 1 Apr 2016, In: Leukemia. 30, 4, p. 767-75 9 p.

  Research output: Contribution to journal › Review › peer-review

  • CCAAT-Enhancer-Binding Proteins 100%
  • Hematopoiesis 78%
  • Hematopoietic Stem Cells 30%
  • Acute Myeloid Leukemia 19%
  • Transcription Factors 15%
  29 Citations (Scopus)

• The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia

  O'Connor, C., Lohan, F., Campos, J., Ohlsson, E., Salomè, M., Forde, C., Artschwager, R., Liskamp, R. M., Cahill, M. R., Kiely, P. A., Porse, B. & Keeshan, K., 6 Oct 2016, In: Oncogene. 35, 40, p. 5272-5281 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Myeloid Leukemia 100%
  • Leukemia 85%
  • Proteasome Inhibitors 17%
  • Ubiquitination 16%
  • Myeloid Cells 15%
  22 Citations (Scopus)

• UPF2-dependent nonsense-mediated mRNA decay pathway is essential for spermatogenesis by selectively eliminating longer 3'UTR transcripts

  Bao, J., Vitting-Seerup, K., Waage, J. E., Tang, C., Ge, Y., Porse, B. T. & Yan, W., May 2016, In: P L o S Genetics. 12, 5, 24 p., e1005863.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nonsense Mediated mRNA Decay 100%
  • germ cell 80%
  • Spermatogenesis 71%
  • 3' untranslated regions 71%
  • 3' Untranslated Regions 68%
  38 Citations (Scopus)

  139 Downloads (Pure)
• 2015

  Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq

  Jakobsen, J. S., Bagger, F. O., Hasemann, M. S., Schuster, M. B., Frank, A-K., Waage, J., Vitting-Seerup, K. & Porse, B. T., 5 Feb 2015, In: BMC Genomics. 16, p. 46

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bacterial DNA 100%
  • Chromatin Immunoprecipitation Sequencing 99%
  • Transcription Factors 58%
  • Cell Count 57%
  • DNA 43%
  19 Citations (Scopus)

  133 Downloads (Pure)

• Cellular origin of prognostic chromosomal aberrations in AML patients

  Mora-Jensen, H., Jendholm, L. J., Rapin, N. P. J-P., Andersen, M. K., Roug, A. S., Bagger, F. O., Bullinger, L., Winther, O., Borregaard, N., Porse, B. T. & Theilgaard-Mönch, K., 7 Aug 2015, In: Leukemia. 29, p. 1785-1789 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  7 Citations (Scopus)

• Disease evolution and outcomes in familial AML with germline CEBPA mutations

  Tawana, K., Wang, J., Renneville, A., Bödör, C., Hills, R., Loveday, C., Savic, A., Van Delft, F. W., Treleaven, J., Georgiades, P., Uglow, E., Asou, N., Uike, N., Debeljak, M., Jazbec, J., Ancliff, P., Gale, R., Thomas, X., Mialou, V., Döhner, K., & 21 othersBullinger, L., Mueller, B., Pabst, T., Stelljes, M., Schlegelberger, B., Wozniak, E., Iqbal, S., Okosun, J., Araf, S., Frank, A-K., Lauridsen, F. B., Porse, B., Nerlov, C., Owen, C., Dokal, I., Gribben, J., Smith, M., Preudhomme, C., Chelala, C., Cavenagh, J. & Fitzgibbon, J., 3 Sept 2015, In: Blood. 126, 10, p. 1214-23 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Familial Acute Myeloid Leukemia with Mutated Cebpa 100%
  • Germ-Line Mutation 54%
  • Mutation 40%
  • Recurrence 27%
  • High-Throughput Nucleotide Sequencing 19%
  79 Citations (Scopus)

• ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

  Knudsen, K. J., Rehn, M. C., Hasemann, M. S., Rapin, N. P. J-P., Bagger, F. O., Ohlsson, E. K., Willer, A., Frank, A-K., Søndergaard, E., Jendholm, L. J., Thorén, L. A. M., Lee, J., Rak, J., Theilgaard-Mønch, K. & Porse, B. T., 15 Sept 2015, In: Genes & Development. 29, p. 1915-1929 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hematopoietic Stem Cells 100%
  • Maintenance 70%
  • Genes 40%
  • Cell Self Renewal 31%
  • Cell Differentiation 30%
  32 Citations (Scopus)

• Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

  Xu, M-J., Feng, D., Wu, H., Wang, H., Chan, Y., Kolls, J., Borregaard, N., Porse, B., Berger, T., Mak, T. W., Cowland, J. B., Kong, X. & Gao, B., 1 Feb 2015, In: Hepatology. 61, 2, p. 692-702 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lipocalin-2 100%
  • Hepatectomy 80%
  • Bacterial Infections 70%
  • Interleukin-6 57%
  • Liver 38%
  88 Citations (Scopus)

• Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

  Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J. & Helin, K., 1 May 2015, In: Genes & Development. p. 910-922 13 p., 29.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Myeloid Leukemia 100%
  • CpG Islands 84%
  • Tumor Suppressor Genes 69%
  • DNA Methylation 68%
  • DNA 58%
  144 Citations (Scopus)

• TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

  Willer, A., Jakobsen, J. S., Ohlsson, E., Rapin, N., Waage, J., Billing, M., Bullinger, L., Karlsson, S. & Porse, B. T., 11 May 2015, In: Leukemia. 29, p. 1018-31 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Myeloid Leukemia 100%
  • Leukemia 85%
  • Maintenance 44%
  • Amino Acids 44%
  • Myeloid-Lymphoid Leukemia Protein 37%
  12 Citations (Scopus)

• Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

  Paul, F., Arkin, Y., Giladi, A., Jaitin, D. A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., David, E., Cohen, N., Lauridsen, F. K. B., Haas, S., Schlitzer, A., Mildner, A., Ginhoux, F., Jung, S., Trumpp, A., Porse, B. T., & 2 othersTanay, A. & Amit, I., 17 Dec 2015, In: Cell. 163, 7, p. 1663-77 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Plastic Property 100%
  • Hematopoiesis 94%
  • Histone 92%
  • Regulator Genes 89%
  • Bone Marrow Cells 81%
  463 Citations (Scopus)

• UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome

  Bao, J., Tang, C., Yuan, S., Porse, B. T. & Yan, W., 15 Jan 2015, In: Development (Cambridge, England). 142, p. 352-362 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nonsense Mediated mRNA Decay 100%
  • Sertoli Cells 78%
  • Fertility 62%
  • Transcriptome 60%
  • Nonsense Codon 30%
  16 Citations (Scopus)
• 2014

  C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner

  Norrie, I. C., Ohlsson, E., Nielsen, O., Hasemann, M. S. & Porse, B. T., 3 Jan 2014, In: P L o S One. 9, 1, p. 1-9 9 p., e84728.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ontogeny 100%
  • T-cells 84%
  • ontogeny 65%
  • T-lymphocytes 51%
  • Immunosenescence 41%
  5 Citations (Scopus)

  1451 Downloads (Pure)

• C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

  Hasemann, M. S., Lauridsen, F. K. B., Waage, J., Jakobsen, J. S., Frank, A-K., Schuster, M. B., Rapin, N. P. J-P., Bagger, F. O., Hoppe, P. S., Schroeder, T. & Porse, B. T., Jan 2014, In: P L o S Genetics (Online). 10, 1, p. 1-10 10 p., e1004079.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • hematopoietic stem cells 100%
  • Hematopoietic Stem Cells 70%
  • epigenetics 70%
  • stem 64%
  • Epigenomics 62%
  58 Citations (Scopus)

  2007 Downloads (Pure)

• Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

  Rapin, N. P. J-P., Bagger, F. O., Jendholm, L. J., Mora-Jensen, H., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Mönch, K. & Porse, B. T., 6 Feb 2014, In: Blood (online). 123, 6, p. 894-904 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Myeloid Leukemia 100%
  • Transcriptome 96%
  • Neoplasms 33%
  • Karyotype 26%
  • Stem Cells 19%
  67 Citations (Scopus)

• Initiation of MLL-rearranged AML is dependent on C/EBPα

  Ohlsson, E., Hasemann, M. S., Willer, A., Lauridsen, F. K. B., Rapin, N. P. J-P., Jendholm, L. J. & Porse, B. T., 13 Jan 2014, In: The Journal of Experimental Medicine. 211, 1, p. 5-13 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Myeloid Leukemia 100%
  • Proteins 38%
  • Neoplasms 25%
  • Transcriptome 24%
  • Maintenance 18%
  45 Citations (Scopus)

• Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models

  Klein, H-U., Schäfer, M., Porse, B. T., Hasemann, M. S., Ickstadt, K. & Dugas, M., 22 Jan 2014, In: Bioinformatics.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transcription 100%
  • Chromatin Immunoprecipitation Sequencing 95%
  • Chip 94%
  • Bayesian Model 83%
  • Histone 79%
  20 Citations (Scopus)

• Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML

  Rapin, N. & Porse, B. T., 9 Jun 2014, In: Oncogenesis. 3, p. 1-5 5 p., e106.

  Research output: Contribution to journal › Letter › peer-review

  • Acute Myeloid Leukemia 100%
  • Core Binding Factor alpha Subunits 45%
  • Proteins 38%
  • Acute Promyelocytic Leukemia 32%
  • Genetic Translocation 32%
  3 Citations (Scopus)

• Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

  Rishi, L., Hannon, M., Salomè, M., Hasemann, M., Frank, A-K., Campos, J., Timoney, J., O'Connor, C., Cahill, M. R., Porse, B. & Keeshan, K., 10 Apr 2014, In: Blood. 123, 15, p. 2389-400 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CCAAT-Enhancer-Binding Proteins 100%
  • Myeloid Cells 73%
  • Acute Myeloid Leukemia 68%
  • Cell Proliferation 47%
  • Protein 29%
  38 Citations (Scopus)

• shRNA screening identifies JMJD1C as being required for leukemia maintenance

  Sroczynska, P., Cruickshank, V. A., Bukowski, J-P., Miyagi, S., Bagger, F. O., Walfridsson, J., Schuster, M. B., Porse, B. & Helin, K., 20 Mar 2014, In: Blood (online).

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Small Interfering RNA 100%
  • Drug Target 82%
  • Epigenomics 63%
  • Leukemia 59%
  • Maintenance 50%
  53 Citations (Scopus)

• spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data

  Vitting-Seerup, K., Porse, B. T., Sandelin, A. & Waage, J., 23 Mar 2014, In: B M C Bioinformatics. 15, p. 1-7 7 p., 81.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Alternative Splicing 100%
  • RNA 66%
  • RNA-Seq 64%
  • Coding 54%
  • Prediction 44%
  50 Citations (Scopus)

  3196 Downloads (Pure)

• The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

  Ge, Y. & Porse, B. T., Mar 2014, In: BioEssays.

  Research output: Contribution to journal › Review › peer-review

  • Nonsense Mediated mRNA Decay 100%
  • Alternative Splicing 72%
  • Regulator Genes 68%
  • Introns 63%
  • Hematopoietic System 43%
  96 Citations (Scopus)
• 2013

  HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

  Bagger, F. O., Rapin, N. P. J-P., Theilgaard-Mønch, K., Kaczkowski, B., Thorén, L. A. M., Jendholm, L. J., Winther, O. & Porse, B. T., 1 Jan 2013, In: Nucleic Acids Research. 41, Database issue, p. D1034-D1039 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hematopoiesis 100%
  • Hematopoietic Stem Cells 60%
  • Transcriptome 56%
  • Databases 55%
  • Gene Expression 54%
  60 Citations (Scopus)

  2220 Downloads (Pure)

• Improving The Analysis Of Gene Expression Profiles By Comparing AML Blasts With Their Nearest Normal Counterparts

  Rapin, N., Bagger, F. O., Jendholm, J., Mora-Jensen, H. I., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Moench, K. & Porse, B., 2013, In: Blood. 122, 21

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Lack of the p42 form of C/EBPα leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors

  Schuster, M. B., Frank, A-K., Bagger, F. O., Rapin, N., Vikesaa, J. & Porse, B. T., Oct 2013, In: Experimental Hematology. 41, 10, p. 882-893 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Granulocyte-Macrophage Progenitor Cells 100%
  • Leukemia 85%
  • Acute Myeloid Leukemia 75%
  • T-Lymphocytes 32%
  • Population 30%
  7 Citations (Scopus)

• microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

  Leucci, E., Patella, F., Waage, J., Holmstrøm, K., Lindow, M., Porse, B., Kauppinen, S. & Lund, A. H., 29 Aug 2013, In: Scientific Reports. 3, p. 2535

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA Stability 100%
  • Long Noncoding RNA 98%
  • MicroRNAs 76%
  • Untranslated RNA 41%
  • Gene Targeting 21%
  167 Citations (Scopus)

• PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells

  Thoren, L. A., Fog, C. K., Jensen, K. T., Buza-Vidas, N., Côme, C., Lund, A. H. & Porse, B. T., Nov 2013, In: Stem Cell Research. 11, 3, p. 1129-1136 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hematopoietic Stem Cells 100%
  • Maintenance 70%
  • Granulocyte-Macrophage Progenitor Cells 25%
  • Cell Self Renewal 25%
  • Megakaryocytes 24%
  4 Citations (Scopus)

• Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

  Colak, D., Ji, S-J., Porse, B. T. & Jaffrey, S. R., 6 Jun 2013, In: Cell. 153, 6, p. 1252-65 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Messenger RNA 100%
  • Axon Guidance 96%
  • Nonsense Mediated mRNA Decay 85%
  • RNA Stability 83%
  • Axons 66%
  117 Citations (Scopus)

• Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries

  Jakobsen, J. S., Waage, J., Rapin, N., Bisgaard, H. C., Larsen, F. S. & Porse, B. T., Apr 2013, In: Genome Research. 23, 4, p. 592-603 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • cdc Genes 100%
  • Liver Regeneration 96%
  • Transcription Factors 58%
  • Biological Phenomena 25%
  • CCAAT-Enhancer-Binding Protein-alpha 18%
  43 Citations (Scopus)
• 2012

  Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML

  Treppendahl, M. B., Qiu, X., Søgaard, A., Yang, X., Nandrup-Bus, C., Hother, C., Andersen, M. K., Kjeldsen, L., Möllgård, L., Möllgaard, L., Hellström-Lindberg, E., Jendholm, L. J., Porse, B. T., Jones, P. A., Liang, G. & Grønbæk, K., 5 Jan 2012, In: Blood. 119, 1, p. 206-16 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acute Myeloid Leukemia 100%
  • Methylation 94%
  • Chromosomes 82%
  • Cell Viability 25%
  • eIF-2 Kinase 21%
  67 Citations (Scopus)

• BLUEPRINT to decode the epigenetic signature written in blood

  Adams, D., Altucci, L., Antonarakis, S. E., Ballesteros, J., Beck, S., Bird, A., Bock, C., Boehm, B., Campo, E., Caricasole, A., Dahl, F., Dermitzakis, E. T., Enver, T., Esteller, M., Estivill, X., Ferguson-Smith, A., Fitzgibbon, J., Flicek, P., Giehl, C., Graf, T., & 37 othersGrosveld, F., Guigo, R., Gut, I., Helin, K., Jarvius, J., Küppers, R., Lehrach, H., Lengauer, T., Lernmark, Å., Leslie, D., Loeffler, M., Macintyre, E., Mai, A., Martens, J. H. A., Minucci, S., Ouwehand, W. H., Pelicci, P. G., Pendeville, H., Porse, B., Rakyan, V., Reik, W., Schrappe, M., Schübeler, D., Seifert, M., Siebert, R., Simmons, D., Soranzo, N., Spicuglia, S., Stratton, M., Stunnenberg, H. G., Tanay, A., Torrents, D., Valencia, A., Vellenga, E., Vingron, M., Walter, J. & Willcocks, S., Mar 2012, In: Nature Biotechnology. 30, 3, p. 224-6 3 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  207 Citations (Scopus)

• HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

  Bagger, F. O., Rapin, N. P. J-P., Theilgaard-Mønch, K., Kaczkowski, B., Jendholm, L. J., Winther, O. & Porse, B. T., 28 Jun 2012, In: Blood. 119, 26, p. 6394-6395 2 p.

  Research output: Contribution to journal › Comment/debate › Research

  26 Citations (Scopus)