microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

Eleonora Leucci; Francesca Patella; Johannes Waage; Kim Holmstrøm; Morten Lindow; Bo Porse; Sakari Kauppinen; Anders H. Lund

doi:10.1038/srep02535

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

Eleonora Leucci, Francesca Patella, Johannes Waage, Kim Holmstrøm, Morten Lindow, Bo Porse, Sakari Kauppinen, Anders H. Lund

The Danish Stem Cell Center

167 Citations (Scopus)

Abstract

microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.

Original language	English
Journal	Scientific Reports
Volume	3
Pages (from-to)	2535
ISSN	2045-2322
DOIs	https://doi.org/10.1038/srep02535
Publication status	Published - 29 Aug 2013

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title = "microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus",

abstract = "microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.",

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T1 - microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

AU - Leucci, Eleonora

AU - Patella, Francesca

AU - Waage, Johannes

AU - Holmstrøm, Kim

AU - Lindow, Morten

AU - Porse, Bo

AU - Kauppinen, Sakari

AU - Lund, Anders H.

PY - 2013/8/29

Y1 - 2013/8/29

N2 - microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.

AB - microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.

U2 - 10.1038/srep02535

DO - 10.1038/srep02535

M3 - Journal article

C2 - 23985560

SN - 2045-2322

VL - 3

SP - 2535

JO - Scientific Reports

JF - Scientific Reports

ER -

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

Abstract

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