Research output per year
Research output per year
Personal profile
Short presentation
Palle Serup and his research group have during recent years focused on the role of cell to cell signalling in the control of pancreatic endocrine development and on the role of key transcription factors in the regulation of beta cell specification. Also, he has, as the principal investigator of both EU and NIH sponsored projects, together with teams of European and American scientists been instrumental in expanding our knowledge of intercellular signalling events and cell-autonomous transcription factors in pancreatic development.
For more information please visit the following webpages:
About Palle Serup: http://danstem.ku.dk/people/serup_staff/serup/
Serup lab: http://danstem.ku.dk/research1/serup_laboratory/
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Notch signalling
- pancreas
- embryonic stem cells
- endocrine development
- Diabetes
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Mesodermal induction of pancreatic fate commitment
Seymour, P. A. & Serup, P., Aug 2019, In: Seminars in Cell and Developmental Biology. 92, p. 77-88Research output: Contribution to journal › Review › peer-review
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Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment
Lauridsen, F. KB., Jensen, T. L., Rapin, N., Aslan, D., Wilhelmson, A. S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M. S., Serup, P., Amit, I. & Porse, B. T., 17 Jul 2018, In: Cell Reports. 24, 3, p. 766-780 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dll1 and Jag1 are differentially required to specify proximal and distal pancreatic duct compartments.
Seymour, P. A., Collin, C. A., Jorgensen, M. C., Imayoshi, I., Kageyama, R. & Serup, P., 2018, (E-pub ahead of print) In: bioRxiv, Developmental Biology. p. 1-36 36 p.Research output: Contribution to journal › Journal article › Research
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Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors
Liu, K-C., Leuckx, G., Sakano, D., Seymour, P. A., Mattsson, C. L., Rautio, L., Staels, W., Verdonck, Y., Serup, P., Kume, S., Heimberg, H. & Andersson, O., 1 Jan 2018, In: Diabetes. 67, 1, p. 58-70 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanosignalling via integrins directs fate decisions of pancreatic progenitors
Mamidi, A., Prawiro, C., Seymour, P. A., de Lichtenberg, K. H., Jackson, A., Serup, P. & Semb, H., 6 Dec 2018, In: Nature. 564, 7734, p. 114-118 5 p.Research output: Contribution to journal › Letter › peer-review
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Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice
Jørgensen, M. C., de Lichtenberg, K. H., Collin, C. A., Klinck, R., Ekberg, J. H., Engelstoft, M. S., Lickert, H. & Serup, P., Sept 2018, In: Development (Cambridge, England). 145, 17, p. 1-11 11 p., dev163568.Research output: Contribution to journal › Journal article › Research › peer-review
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Notch controls multiple pancreatic cell fate regulators through direct hes1-mediated repression.
de Lichtenberg, K. H., Seymour, P. A., Joergensen, M. C., Kim, Y-H., Grapin-Botton, A., Magnuson, M. A., Nakic, N., Ferrer, J. & Serup, P., 2018, (E-pub ahead of print) In: bioRxiv, Developmental Biology. p. 1-30 30 p.Research output: Contribution to journal › Journal article › Research
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Anteroposterior polarity and elongation in the absence of extraembryonic tissues and of spatially localised signalling in gastruloids: Mammalian embryonic organoids
Turner, D. A., Girgin, M., Alonso-Crisostomo, L., Trivedi, V., Baillie-Johnson, P., Glodowski, C. R., Hayward, P. C., Collignon, J., Gustavsen, C., Serup, P., Steventon, B., Lutolf, M. P. & Arias, A. M., Nov 2017, In: Development (Cambridge). 144, 21, p. 3894-3906 13 p.Research output: Contribution to journal › Journal article › Research › peer-review