ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Elisabeth Søndergaard; Alexander Rauch; Magali Michaut; Nicolas Rapin; Matilda Rehn; Anna S. Wilhelmson; Alessandro Camponeschi; Marie S. Hasemann; Frederik O. Bagger; Johan Jendholm; Kasper J. Knudsen; Susanne Mandrup; Inga Lill Mårtensson; Bo T. Porse

doi:10.1016/j.celrep.2019.10.098

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Elisabeth Søndergaard, Alexander Rauch, Magali Michaut, Nicolas Rapin, Matilda Rehn, Anna S. Wilhelmson, Alessandro Camponeschi, Marie S. Hasemann, Frederik O. Bagger, Johan Jendholm, Kasper J. Knudsen, Susanne Mandrup, Inga Lill Mårtensson, Bo T. Porse^*

^*Corresponding author for this work

3 Citations (Scopus)

Abstract

Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.

Original language	English
Journal	Cell Reports
Volume	29
Issue number	9
Pages (from-to)	2756-2769.e6
Number of pages	21
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2019.10.098
Publication status	Published - 26 Nov 2019

Keywords

B cell development
ERG
ETS-related gene
immunoglobulin heavy-chain gene
pre-BCR
transcriptional control
V(D)J recombination

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10.1016/j.celrep.2019.10.098Licence: CC BY-NC-ND

ERG Controls B Cell Development by Promoting Igh V-to-DJ RecombinationFinal published version, 5.16 MBLicence: CC BY-NC-ND

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@article{f9c82e371773444092db18481db881d1,

title = "ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination",

abstract = "S{\o}ndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.",

keywords = "B cell development, ERG, ETS-related gene, immunoglobulin heavy-chain gene, pre-BCR, transcriptional control, V(D)J recombination",

author = "Elisabeth S{\o}ndergaard and Alexander Rauch and Magali Michaut and Nicolas Rapin and Matilda Rehn and Wilhelmson, {Anna S.} and Alessandro Camponeschi and Hasemann, {Marie S.} and Bagger, {Frederik O.} and Johan Jendholm and Knudsen, {Kasper J.} and Susanne Mandrup and M{\aa}rtensson, {Inga Lill} and Porse, {Bo T.}",

year = "2019",

month = nov,

day = "26",

doi = "10.1016/j.celrep.2019.10.098",

language = "English",

volume = "29",

pages = "2756--2769.e6",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "9",

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TY - JOUR

T1 - ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

AU - Søndergaard, Elisabeth

AU - Rauch, Alexander

AU - Michaut, Magali

AU - Rapin, Nicolas

AU - Rehn, Matilda

AU - Wilhelmson, Anna S.

AU - Camponeschi, Alessandro

AU - Hasemann, Marie S.

AU - Bagger, Frederik O.

AU - Jendholm, Johan

AU - Knudsen, Kasper J.

AU - Mandrup, Susanne

AU - Mårtensson, Inga Lill

AU - Porse, Bo T.

PY - 2019/11/26

Y1 - 2019/11/26

N2 - Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.

AB - Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.

KW - B cell development

KW - ERG

KW - ETS-related gene

KW - immunoglobulin heavy-chain gene

KW - pre-BCR

KW - transcriptional control

KW - V(D)J recombination

U2 - 10.1016/j.celrep.2019.10.098

DO - 10.1016/j.celrep.2019.10.098

M3 - Journal article

C2 - 31775043

AN - SCOPUS:85075512481

SN - 2211-1247

VL - 29

SP - 2756-2769.e6

JO - Cell Reports

JF - Cell Reports

IS - 9

ER -

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

Abstract

Keywords

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