Andreas Mæchel Fritzen

Research output

Research output per year 2013 2015 2016 2017 2019 2020

• 17 Journal article
• 3 Review
• 1 Ph.D. thesis
• 1 Book chapter

Research output per year

Research output per year

Search results

• 2020

  Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation

  Lundsgaard, A-M., Fritzen, A. M., Nicolaisen, T. S., Carl, C. S., Sjøberg, K. A., Raun, S. H., Klein, A. B., Sanchez-Quant, E., Langer, J., Ørskov, C., Clemmensen, C., Tschöp, M. H., Richter, E., Kiens, B. & Kleinert, M., 2020, In: Journal of Lipid Research.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fatty Acids 100%
  • Fatty Acid 94%
  • etomoxir 86%
  • Glucose 86%
  • Insulin Derivative 59%
  9 Citations (Scopus)

• Growth factor-dependent and -independent activation of mTORC2

  Knudsen, J. R., Fritzen, A. M., James, D. E., Jensen, T. E., Kleinert, M. & Richter, E., Jan 2020, In: Trends in Endocrinology and Metabolism.

  Research output: Contribution to journal › Review › peer-review

  • Mechanistic Target of Rapamycin Complex 2 100%
  • Intercellular Signaling Peptides and Proteins 56%
  • Insulin 13%
  • Saccharomycetales 12%
  • Phosphotransferases 7%
  6 Citations (Scopus)
• 2019

  Adaptations in mitochondrial enzymatic activity occurs independent of genomic dosage in response to aerobic exercise training and deconditioning in human skeletal muscle

  Fritzen, A. M., Thøgersen, F. B., Thybo, K., Vissing, C. R., Krag, T. O., Ruiz-Ruiz, C., Risom, L., Wibrand, F., Høeg, L. D., Kiens, B., Duno, M., Vissing, J. & Jeppesen, T. D., Mar 2019, In: Cells. 8, 3, 16 p., 237.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mitochondrial DNA 100%
  • Enzyme Activity 78%
  • Skeletal Muscle 75%
  • Citrate (si)-Synthase 64%
  • Cardiolipin 62%
  49 Downloads (Pure)

• Dietary fuels in athletic performance

  Fritzen, A. M., Lundsgaard, A. & Kiens, B., 21 Aug 2019, In: Annual Review of Nutrition. 39, p. 45-73 29 p.

  Research output: Contribution to journal › Review › peer-review

  • Athletic Performance 100%
  • Exercise 51%
  • Skeletal Muscle 37%
  • Athletes 28%
  • Endurance Training 19%
  8 Citations (Scopus)

• Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle

  Fritzen, A. M., Lundsgaard, A., Jeppesen, J. F., Sjøberg, K. A., Høeg, L. D., Deleuran, H. H., Wojtaszewski, J., Richter, E. & Kiens, B., 2019, In: F A S E B Journal. 33, 4, p. 5510-5519 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Saturated Fatty Acid 100%
  • Insulin Derivative 84%
  • Fatty Acids 70%
  • Insulin Resistance 67%
  • Fatty Acid 66%
  2 Citations (Scopus)

• Human Paneth cell α-defensin-5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice

  Larsen, I. S., Fritzen, A. M., Carl, C. S., Agerholm, M., Damgaard, M. T. F., Holm, J. B., Marette, A., Nordkild, P., Kiens, B., Kristiansen, K., Wehkamp, J. & Jensen, B. A. H., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 1, p. E42-E52 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Paneth Cells 100%
  • Defensins 95%
  • Obese Mice 83%
  • Dyslipidemias 67%
  • Diet 47%
  8 Citations (Scopus)

• Insulin tolerance test under anaesthesia to measure tissue-specific insulin-stimulated glucose disposal

  Fazakerley, D. J., Fritzen, A. M., Nelson, M. E., Thorius, I. H., Cooke, K. C., Humphrey, S. J., Cooney, G. J. & James, D. E., 20 Jan 2019, In: Bio-protocol. 9, 2, 13 p., e3146.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • insulin tolerance test 100%
  • anesthesia 56%
  • insulin 50%
  • insulin resistance 42%
  • glucose 34%
  50 Downloads (Pure)
• 2018

  Molecular regulation of fatty acid oxidation in skeletal muscle during aerobic exercise

  Lundsgaard, A., Fritzen, A. M. & Kiens, B., Jan 2018, In: Trends in Endocrinology and Metabolism. 29, 1, p. 18-30 13 p.

  Research output: Contribution to journal › Review › peer-review

  • Fatty Acids 100%
  • Skeletal Muscle 92%
  • Exercise 76%
  • Carnitine 63%
  • Acetyl Coenzyme A 56%
  42 Citations (Scopus)
• 2017

  Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

  Lundsgaard, A., Fritzen, A. M., Sjøberg, K. A., Myrmel, L. S., Madsen, L., Wojtaszewski, J., Richter, E. & Kiens, B., 1 Jan 2017, In: Molecular Metabolism. 6, 1, p. 22-29 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • fibroblast growth factor 21 100%
  • Carbohydrates 60%
  • Diet 41%
  • Dietary Carbohydrates 21%
  • Dietary Proteins 19%
  50 Citations (Scopus)

  244 Downloads (Pure)

• Exercise physiology in men and women

  Lundsgaard, A., Fritzen, A. M. & Kiens, B., 15 May 2017, Principles of Gender-Specific Medicine: Gender in the Genomic Era. Legato, M. J. (ed.). 3. ed. Amsterdam: Academic Press, p. 526-542 18 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education › peer-review

  • Exercise 100%
  • Musculoskeletal System 47%
  • Multifactorial Inheritance 47%
  • Physical Functional Performance 42%
  • Cardiovascular System 37%
  3 Citations (Scopus)

• FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis

  Mottillo, E. P., Desjardins, E. M., Fritzen, A. M., Zou, V. Z., Crane, J. D., Yabut, J. M., Kiens, B., Erion, D. M., Lanba, A., Granneman, J. G., Talukdar, S. & Steinberg, G. R., Jun 2017, In: Molecular Metabolism. 6, 6, p. 471-481 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • fibroblast growth factor 21 100%
  • Acetyl-CoA Carboxylase 93%
  • AMP-Activated Protein Kinases 82%
  • Adipocytes 65%
  • Homeostasis 50%
  24 Citations (Scopus)

  28 Downloads (Pure)

• Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

  Kleinert, M., Parker, B. L., Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M. A., James, D. E. & Richter, E., 15 Jul 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mechanistic Target of Rapamycin Complex 2 100%
  • TOR Serine-Threonine Kinases 77%
  • Glucose 43%
  • Muscles 41%
  • Running 27%
  23 Citations (Scopus)

• Opposite regulation of insulin sensitivity by dietary lipid versus carbohydrate excess

  Lundsgaard, A., Sjøberg, K. A., Høeg, L. D., Jeppesen, J., Jordy, A. B., Serup, A. K. L., Fritzen, A. M., Pilegaard, H., Myrmel, L. S., Madsen, L., Wojtaszewski, J., Richter, E. & Kiens, B., 1 Oct 2017, In: Diabetes. 66, 10, p. 2583-2595 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Carbohydrates 100%
  • Insulin Resistance 93%
  • Diet 78%
  • Lipids 74%
  • Glucose 71%
  30 Citations (Scopus)
• 2016

  Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

  Jensen, B. A. H., Nielsen, T. S., Fritzen, A. M., Holm, J. B., Fjære, E., Serup, A. K. L., Borkowski, K., Risis, S., Pærregaard, S. I., Søgaard, I., Poupeau, A. A. G., Poulsen, M., Ma, T., Sina, C., Kiens, B., Madsen, L., Kristiansen, K. & Treebak, J. T., 1 Dec 2016, In: Metabolism. 65, 12, p. 1706-1719 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dietary Fats 100%
  • High Fat Diet 83%
  • Weight Gain 76%
  • Insulin Resistance 68%
  • Body Weight 59%
  18 Citations (Scopus)

  79 Downloads (Pure)

• Emerging Roles of AMP-Activated Protein Kinase: The Role of AMPK in Regulatin of Substrate Utilisation During and After Acute Exercise, Adipose Tissue Metabolism During Weight Loss, and Autophagy in Skeletal Muscle During Acute Exercise

  Fritzen, A. M., 2016, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen. 138 p.

  Research output: Book/Report › Ph.D. thesis

• mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

  Kleinert, M., Parker, B. L., Chaudhuri, R., Fazakerley, D. J., Serup, A. K. L., Thomas, K. C., Krycer, J. R., Sylow, L., Fritzen, A. M., Hoffman, N. J., Jeppesen, J. F., Schjerling, P., Ruegg, M. A., Kiens, B., James, D. E. & Richter, E., 1 Aug 2016, In: Molecular Metabolism. 5, 8, p. 646-655 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Perilipin-3 100%
  • Mechanistic Target of Rapamycin Complex 2 75%
  • Triglycerides 42%
  • Muscles 31%
  • Lipids 19%
  31 Citations (Scopus)

  208 Downloads (Pure)

• Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation

  Fritzen, A. M., Madsen, A. L. B., Kleinert, M., Treebak, J. T., Lundsgaard, A., Jensen, T. E., Richter, E., Wojtaszewski, J., Kiens, B. & Frøsig, C., 1 Feb 2016, In: Journal of Physiology. 594, 3, p. 745-761 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Autophagy 100%
  • Skeletal Muscle 82%
  • Insulin 70%
  • Exercise 67%
  • Light 64%
  45 Citations (Scopus)

• Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle

  Fritzen, A. M., Frøsig, C., Jeppesen, J. F., Jensen, T. E., Lundsgaard, A., Serup, A. K. L., Schjerling, P., Proud, C. G., Richter, E. & Kiens, B., 1 Jun 2016, In: Cellular Signalling. 28, 6, p. 663-674 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Autophagy 100%
  • Fasting 83%
  • Skeletal Muscle 82%
  • Autophagy-Related Protein-1 Homolog 45%
  • Phosphotransferases 40%
  42 Citations (Scopus)
• 2015

  5´AMP activated protein kinase α2 controls substrate metabolism during post-exercise recovery via regulation of pyruvate dehydrogenase kinase 4

  Fritzen, A. M., Lundsgaard, A., Jeppesen, J., Christiansen, M. L. B., Biensø, R. S., Dyck, J. R. B., Pilegaard, H. & Kiens, B., 1 Nov 2015, In: Journal of Physiology. 593, 21, p. 4765-4780 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • pyruvate dehydrogenase kinase 4 100%
  • Protein Kinases 54%
  • Muscles 35%
  • Pyruvate Dehydrogenase (Lipoamide) 27%
  • Malonyl Coenzyme A 22%
  26 Citations (Scopus)

• New Nordic Diet induced weight loss is accompanied by changes in metabolism and AMPK signalling in adipose tissue

  Fritzen, A. M., Lundsgaard, A., Jordy, A. B., Poulsen, S. K., Stender, S., Pilegaard, H., Astrup, A., Larsen, T. M., Wojtaszewski, J., Richter, E. & Kiens, B., 1 Sept 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 9, p. 3509-3519 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Reducing Diet 100%
  • Abdominal Subcutaneous Fat 67%
  • Adipose Tissue 59%
  • Pharmacological Metabolism 55%
  • Diet 49%
  28 Citations (Scopus)

• SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

  Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, A. M., Foretz, M., Campbell, D. G., Sakamoto, K., Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O., 2015, In: Journal of Cell Science. 128, 3, p. 472-486 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Deacetylases 100%
  • Adipocytes 81%
  • Salts 75%
  • Phosphotransferases 66%
  • Glucose 54%
  56 Citations (Scopus)
• 2013

  LKB1 regulates lipid oxidation during exercise independently of AMPK

  Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, A. M., Pehmøller, C., Sylow, L., Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, C., Qvortrup, K., Dyck, J. R. B., Hunter, R. W., Sakamoto, K., Thomson, D. M., Schjerling, P., Wojtaszewski, J., Richter, E. & Kiens, B., May 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • AMP-Activated Protein Kinases 100%
  • Mouse Stk11 protein 77%
  • Fatty Acids 71%
  • Phosphotransferases 64%
  • Lipids 54%
  54 Citations (Scopus)