Kasper Harpsøe

Publikation

Publikationer pr. år 2007 2007 2012 2016 2019

• 34 Tidsskriftartikel
• 3 Konferenceabstrakt i tidsskrift
• 1 Patent

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2019

  Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

  Krall, J., Bavo, F., Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Y., Anglani, V., Kongstad, K. T., Piilgaard, L., Nielsen, B., Gloriam, D. E., Kehler, J., Jensen, A. A., Harpsøe, K., Wellendorph, P. & Frølund, B., 14 mar. 2019, I: Journal of Medicinal Chemistry. 62, 5, s. 2798-2813

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Hydroxybutyrates 100%
  • gabazine 87%
  • Acetic Acid 68%
  • Binding Sites 48%
  • Aminobutyrates 46%
  3 Citationer (Scopus)

• Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

  Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 jun. 2019, I: Journal of Medicinal Chemistry. 62, 12, s. 5797-5809

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  • GABA Receptors 100%
  • Gamma-Aminobutyric Acid 98%
  • GABA-A Receptors 88%
  • gamma-Aminobutyric Acid 78%
  • Receptor Binding Affinity 28%
  7 Citationer (Scopus)

• Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

  Malfacini, D., Patt, J., Annala, S., Harpsøe, K., Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, D. E., Bräuner-Osborne, H., Strømgaard, K., König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 apr. 2019, I: The Journal of Biological Chemistry. 294, 15, s. 5747-5758

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  • FR900359 100%
  • Heterotrimeric GTP-Binding Proteins 64%
  • Protein Subunits 54%
  • Protein 19%
  • Psychological Inhibition 19%
  10 Citationer (Scopus)

  18 Downloads (Pure)
• 2018

  5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

  Peng, Y., McCorvy, J. D., Harpsøe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, W. E., Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, A. A., & 6 flereHanson, M. A., Zhao, S., Gloriam, D. E., Roth, B. L., Stevens, R. C. & Liu, Z., 8 feb. 2018, I: Cell. 172, 4, s. 719-730 P719-730.E14.

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  • Polypharmacology 100%
  • Receptor, Serotonin, 5-HT2C 85%
  • G-Protein-Coupled Receptors 60%
  • Drug Design 45%
  • Drug 31%
  93 Citationer (Scopus)

• GPCRdb in 2018: adding GPCR structure models and ligands

  Pándy-Szekeres, G., Munk, C., Tsonkov, T. M., Mordalski, S., Harpsøe, K., Hauser, A. S., Bojarski, A. J. & Gloriam, D. E., 1 jan. 2018, I: Nucleic Acids Research. 46, D1, 7 s., gkx1109.

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  • Ligands 100%
  • G-Protein-Coupled Receptors 35%
  • GTP-Binding Proteins 35%
  • Information Storage and Retrieval 32%
  • Publications 29%
  214 Citationer (Scopus)

  102 Downloads (Pure)

• Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

  Zhang, H., Nielsen, A. L., Boesgaard, M. W., Harpsøe, K., Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner-osborne, H., Gloriam, D. E. & Strømgaard, K., 5 aug. 2018, I: European Journal of Medicinal Chemistry. 156, s. 847-860

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  • FR900359 100%
  • YM-254890 92%
  • Depsipeptides 77%
  • Depsipeptide 65%
  • GTP-Binding Proteins 47%
  7 Citationer (Scopus)
• 2017

  Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide

  Di Giglio, M. G., Muttenthaler, M., Harpsøe, K., Liutkeviciute, Z., Keov, P., Eder, T., Rattei, T., Arrowsmith, S., Wray, S., Marek, A., Elbert, T., Alewood, P. F., Gloriam, D. E. & Gruber, C. W., 1 feb. 2017, I: Scientific Reports. 7, 15 s., 41002.

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  • Antidiuretic Hormone Receptor Antagonists 100%
  • Vasopressin Receptors 91%
  • Human Development 75%
  • Insecta 73%
  • Neuropeptides 71%
  22 Citationer (Scopus)

  70 Downloads (Pure)

• Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

  Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, K. T., Gloriam, D. E., Clausen, R. P., Harpsøe, K., Wellendorph, P. & Frølund, B., 9 nov. 2017, I: Journal of Medicinal Chemistry. 60, 21, s. 9022-9039 18 s.

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  • trans-hydroxycrotonic acid 100%
  • 3-hydroxycyclopent-1-enecarboxylic acid 93%
  • Hydroxybutyrates 63%
  • trans-4-hydroxycrotonic acid 51%
  • Molecular Modeling 36%
  8 Citationer (Scopus)

• Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

  Harpsøe, K., Boesgaard, M. W., Munk, C., Bräuner-Osborne, H. & Gloriam, D. E., 15 apr. 2017, I: Bioinformatics (Oxford, England). 33, 8, s. 1116-1120 5 s., btw784.

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  • G Protein 100%
  • Modulator 88%
  • Allosteric Site 85%
  • Receptor 77%
  • Modulators 61%
  8 Citationer (Scopus)

  77 Downloads (Pure)
• 2016

  GPCRdb: an information system for G protein-coupled receptors

  Isberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsøe, K., Hauser, A. S., Vroling, B., Bojarski, A. J., Vriend, G. & Gloriam, D. E., 4 jan. 2016, I: Nucleic Acids Research. 44, D1, s. D356-64

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  • Information Systems 100%
  • G-Protein-Coupled Receptors 91%
  • Ligands 42%
  • Snakes 39%
  • Drug Design 34%
  155 Citationer (Scopus)

  165 Downloads (Pure)

• GPCRdb: The G protein-coupled receptor database - an introduction

  Munk, C., Isberg, V., Mordalski, S., Harpsøe, K., Rataj, K., Hauser, A. S., Kolb, P., Bojarski, A. J., Vriend, G. & Gloriam, D. E., jul. 2016, I: British Journal of Pharmacology. 173, 14, s. 2195-207 13 s.

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  • G-Protein-Coupled Receptors 100%
  • Crystallography 71%
  • Light Signal Transduction 71%
  • Ligands 70%
  • Databases 59%
  99 Citationer (Scopus)

• Integrating structural and mutagenesis data to elucidate GPCR ligand binding

  Munk, C., Harpsøe, K., Hauser, A. S., Isberg, V. & Gloriam, D. E., 1 okt. 2016, I: Current Opinion in Pharmacology. 30, s. 51-58 8 s.

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  • G-Protein-Coupled Receptors 100%
  • Mutagenesis 98%
  • Ligands 70%
  • Binding Site 70%
  • Drug Target 56%
  27 Citationer (Scopus)

• Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

  Shehata, M. A., Jensen, A. C. N., Lissa, D., Bisig, C., Isberg, V., Andersen, K. B., Harpsøe, K., Björkling, F., Bräuner-Osborne, H. & Gloriam, D. E., 10 nov. 2016, I: Scientific Reports. 6, s. 1-13 13 s., 36681.

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  • Triazines 100%
  • benzamide 94%
  • Aromatic Amino Acids 91%
  • Structure-Activity Relationship 75%
  • Glycine 65%
  13 Citationer (Scopus)

  134 Downloads (Pure)

• Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

  Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, K., Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, D. E., Bräuner-osborne, H. & Strømgaard, K., 1 nov. 2016, I: Nature Chemistry. 8, 11, s. 1035-1041 7 s.

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  • Proteins 100%
  • Total Synthesis 95%
  • Occurrence in Nature 60%
  • Depsipeptide 49%
  • Protein 45%
  33 Citationer (Scopus)
• 2015

  Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants

  Harpsøe, K., Isberg, V., Tehan, B. G., Weiss, D., Arsova, A., Marshall, F. H., Bräuner-Osborne, H. & Gloriam, D. E., 11 sep. 2015, I: Scientific Reports. 5, s. 1-11 11 s., 13869.

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  • Metabotropic Glutamate Receptors 100%
  • Ligands 56%
  • Drug Design 30%
  • Pharmaceutical Preparations 22%
  • Binding Sites 20%
  32 Citationer (Scopus)
• 2014

  mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

  Mølck, C., Harpsøe, K., Gloriam, D. E., Mathiesen, J. M., Nielsen, S. M. & Bräuner-Osborne, H., 24 sep. 2014, I: Neurochemical Research. 39, 10, s. 1862-1875 14 s.

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  • Drug Discovery 100%
  • Ligands 68%
  • Drug 51%
  • Ligand 42%
  • Application 30%
  21 Citationer (Scopus)

• Revision of the Classical Dopamine D2 Agonist Pharmacophore Based on an Integrated Medicinal Chemistry, Homology Modelling and Computational Docking Approach

  Krogsgaard-Larsen, N., Harpsøe, K., Kehler, J., Christoffersen, C. T., Brøsen, P. & Balle, T., 24 sep. 2014, I: Neurochemical Research. 39, 10, s. 1997-2007 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Dopamine 2 Receptor Stimulating Agent 100%
  • Ergolines 96%
  • Ergoline 91%
  • Pharmaceutical Chemistry 77%
  • Dopamine Agonists 63%
  2 Citationer (Scopus)
• 2013

  Covalent Trapping of Methyllycaconitine at the α4-α4 Interface of the α4β2 Nicotinic Acetylcholine Receptor: ANTAGONIST BINDING SITE AND MODE OF RECEPTOR INHIBITION REVEALED

  Absalom, N. L., Quek, G., Lewis, T. M., Qudah, T., von Arenstorff, I., Ambrus, J. I., Harpsøe, K., Karim, N., Balle, T., McLeod, M. D. & Chebib, M., 13 sep. 2013, I: The Journal of Biological Chemistry. 288, 37, s. 26521-32 12 s.

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  • Methyllycaconitine 100%
  • methyllycaconitine 90%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 63%
  • Nicotinic Receptors 63%
  • Acetylcholine 61%
  12 Citationer (Scopus)

• Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

  Harpsøe, K., Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, M., Kastrup, J. S. J. & Ahring, P. K., 25 jan. 2013, I: Journal of Biological Chemistry. 288, 4, s. 2559-2570 12 s.

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  • 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene 100%
  • cytisine 65%
  • Cytisine 64%
  • Nicotinic Receptors 44%
  • Acetylcholine 42%
  19 Citationer (Scopus)

• Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

  Krintel, C., Harpsøe, K., Zachariassen, L. G., Peters, D., Frydenvang, K., Pickering, D. S., Gajhede, M. & Kastrup, J. S., sep. 2013, I: Acta crystallographica. Section D, Biological crystallography. 69, Pt 9, s. 1645-52 8 s.

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  • 1-(quinoxalin-6-ylcarbonyl)piperidine 100%
  • AMPA Receptors 59%
  • Glutamate Receptors 54%
  • varespladib methyl 52%
  • Ligands 35%
  8 Citationer (Scopus)
• 2012

  A robust force field based method for calculating conformational energies of charged drug-like molecules

  Pøhlsgaard, J., Harpsøe, K., Jørgensen, F. S. & Olsen, L., 27 feb. 2012, I: Journal of Chemical Information and Modeling. 52, 2, s. 409-419

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  • Conformations 100%
  • Molecules 77%
  • energy 54%
  • drug 53%
  • Force 53%
  5 Citationer (Scopus)

• Covalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

  Ambrus, J. I., Halliday, J. I., Kanizaj, N., Absalom, N., Harpsøe, K., Balle, T., Chebib, M. & McLeod, M. D., 6 jun. 2012, I: Chemical Communications. 48, 53, s. 6699-6701 3 s.

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  • Methyllycaconitine 100%
  • Maleimides 75%
  • Acetylcholine 61%
  • Antagonist 52%
  • Cysteine 49%
  10 Citationer (Scopus)

• Discovery of a novel allosteric modulator of 5-HT3 receptor: Inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site

  Trattnig, S. M., Harpsøe, K., Thygesen, S. B., Rahr, L. M., Ahring, P. K., Balle, T. & Jensen, A. A., 20 jul. 2012, I: Journal of Biological Chemistry. 287, 30, s. 25241-25254

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  • Cysteine Loop Ligand-Gated Ion Channel Receptors 100%
  • Receptors, Serotonin, 5-HT3 74%
  • Binding Site 39%
  • Allosteric Site 32%
  • Neurotransmitter 31%
  24 Citationer (Scopus)

• Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

  Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Kastrup, J. S. & Balle, T., 3 feb. 2012, I: The Journal of Biological Chemistry. 287, 6, s. 4248-4259

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  • 1,4-diazepane 100%
  • Lymnaea AChBP protein 90%
  • nicotinic receptor alpha4beta2 89%
  • Crystallography 61%
  • Halogens 61%
  39 Citationer (Scopus)

• Nyt bindingssted i nikotine acetylcholinreceptorer: håb om ny behandling af eksempelvis ADHD og Alzheimers sygdom

  Harpsøe, K. & Balle, T., feb. 2012, I: BestPractice Psykiatri/Neurologi. 5, 16, s. 7-10 4 s.

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  700 Downloads (Pure)

• Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

  Mølck, C., Harpsøe, K., Gloriam, D. E., Clausen, R. P., Madsen, U., Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, J. M. & Bräuner-Osborne, H., nov. 2012, I: Molecular Pharmacology. 82, 5, s. 929-37 9 s.

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  • Metabotropic Glutamate 5 Receptor 100%
  • pyridine 86%
  • Benzene 82%
  • Binding Sites 51%
  • Pharmacology 44%
  30 Citationer (Scopus)

• Structure-activity relationships for negative allosteric mGluR5 modulators

  Kaae, B. H., Harpsøe, K., Kvist, T., Mathiesen, J. M., Mølck, C., Gloriam, D. E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, B., Bräuner-Osborne, H., Sauerberg, P., Clausen, R. P. & Madsen, U., 5 mar. 2012, I: ChemMedChem. 7, 3, s. 440-451

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  • pyridine 100%
  • Structure-Activity Relationship 90%
  • Pyridine 54%
  • 2-methyl-6-(phenylethynyl)pyridine 51%
  • 6-methyl-2-(phenylethynyl)pyridine 43%
  15 Citationer (Scopus)
• 2011

  Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene

  Molck, C., Harpsoe, K., Gloriam, D. E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, R. P., Madsen, U., Nielsen, S. M., Mathiesen, J. M. & Brauner-Osborne, H., sep. 2011, I: Current Neuropharmacology. 9, s. 43-43

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• Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors

  Harpsøe, K., Ahring, P. K., Christensen, J. K., Jensen, M. L., Peters, D. & Balle, T., 27 jul. 2011, I: Journal of Neuroscience. 31, 30, s. 10759-10766

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  • Ligand-Gated Ion Channels 100%
  • Cholinergic Agonists 96%
  • Nicotinic Receptors 80%
  • Site-Directed Mutagenesis 78%
  • Occupations 72%
  110 Citationer (Scopus)
• 2009

  Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha₄ß₂ nicotinic ligands

  Tosco, P., Ahring, P. K., Dyhring, T., Peters, D., Harpsøe, K., Liljefors, T. & Balle, T., 2009, I: Journal of Medicinal Chemistry. 52, 8, s. 2311-2316

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  • Quantitative Structure-Activity Relationship 100%
  • QSAR Study 75%
  • Agonist 69%
  • Amino Acid Receptors 56%
  • Kd 55%
  12 Citationer (Scopus)

• Rational design of a-conotoxin analogues targeting a7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives

  Armishaw, C., Jensen, A. A., Balle, T., Clark, R. J., Harpsøe, K., Skonberg, C., Liljefors, T. & Strømgaard, K., 2009, I: Journal of Biological Chemistry. 284, 14, s. 9498-9512

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  • Conotoxins 100%
  • Proline Derivative 94%
  • Nicotinic Receptors 69%
  • Acetylcholine 67%
  • Proline 67%
  43 Citationer (Scopus)
• 2008

  Computeren viser vejen til et nyt potentielt lægemiddel

  Harpsøe, K., Kaae, B. H., Balle, T., Pickering, D. S. & Kastrup, J. S. J., 2008, I: Lægemiddelforskning. s. 28-30

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  1477 Downloads (Pure)

• Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis

  Harpsøe, K., Liljefors, T. & Balle, T., 2008, I: Journal of Molecular Graphics and Modelling. 26, 5, s. 874-883

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  12 Citationer (Scopus)
• 2007

  Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

  Kaae, B. H., Harpsoe, K., Sanz, A. C., Pickering, D. S., Sauerberg, P., Clausen, R. P., Kastrup, J. S., Liljefors, T. & Madsen, U., 19 aug. 2007, I: American Chemical Society. Abstracts of Papers (at the National Meeting). 234

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• Identification of a putative binding site for 5-alkyl-benzothiadiazides in the AMPA receptor dimer interface

  Harpsøe, K., Varming, T., Gouliaev, A. H., Peters, D. & Liljefors, T., 2007, I: Journal of Molecular Graphics and Modelling. 26, 1, s. 213-225 13 s.

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  12 Citationer (Scopus)

• Novel quinoxaline derivatives and their medical use

  Peters, D., Christensen, J. K., Harpsøe, K. & Liljefors, T., 2007, Patentnr. WO/2007/060144, 31 maj 2007

  Publikation: Patent

• Pharmacological characterisation of biarylisopropylalsulphonamide AMPA-R potentiators

  Pickering, D. S., Sanz, C., Harpsøe, K., Clausen, R. P., Sauerberg, P., Liljefors, T., Madsen, U. & Kaae, B. H., 2007, I: Journal of Neurochemistry. 102 (suppl. 1), 41

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• Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

  Kaae, B. H., Harpsøe, K., Kastrup, J. S. J., Sanz, A. C., Pickering, D. S., Metzler, B., Clausen, R. P., Gajhede, M., Sauerberg, P., Liljefors, T. & Madsen, U., 2007, I: Chemistry & Biology. 14, 11, s. 1294-303 10 s.

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  • Stereoisomerism 100%
  • AMPA Receptors 85%
  • cyclothiazide 60%
  • Binding Sites 55%
  • Ionotropic Glutamate Receptors 48%
  46 Citationer (Scopus)