Publikationer pr. år
Publikationer pr. år
Personlig profil
Kommentarer til publikationsliste
Se Hjemmeside for fuld publikationsliste (inkl. alle publikationer fra før 2007)CV
Education
Cand. pharm. 1985
PhD pharm. 1989. Royal Danish School of Pharmacy (RDSP), Department of Organic Chemistry (X-ray crystallography and molecular modelling).
Appointments
- Research Scholarship, Department of Organic Chemistry, RDSP, 1985 - 1988.
- Assistant professor, Department of Organic Chemistry, RDSP, 1989 - 1990.
- Research Fellowship, Department of Organic Chemistry, RDSP, 1990 - 1994.
- Alfred Benzon Research Fellowship, 1994 - 1997.
- Research Fellowship, Department of Medicinal Chemistry, RDSP, 1997 - 1999.
- Bøje Benzon Research Fellowship, 1999 - 2002.
- Associate Professor, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, 2002 -
Research
Membrane bound ionotropic glutamate receptors play a central role in research. The extracellular ligand-binding domain has been expressed and purified from E.Coli. The domain is analyzed in complex with agonist, antagonists and positive allosteric modulators in order to achieve an understanding for differences in binding affinity and especially in selectivity and specificity. X-ray crystallographic studies are performed on the protein – ligand complexes in order to obtain detailed three dimensional structure, where interactions between the igand and the protein can be analyzed.
91 publications in peer reviewed journals and many poster presentations at conferences and symposia.
Teaching
Participating in regular teaching programs for pharmacy students. Lectures, seminars, practical courses and setting examinations in basic organic chemistry and philosophy of science. Furthermore, participating in the planning of two elective courses: “Structural and Computational Medicinal Chemistry” for pharmacy students and “Medicines: Design, Development, Delivery and Use” for Ph.D.-students.
Advisor for external and internal master students during their final research projects.
Advisor and external examiner for Ph.D.-students.
Memberships
Member of the Danish National committee for crystallographers
Chairman of the committee for teaching at the department (2009-2012)
Emneord
- Det tidligere Farmaceutiske Fakultet
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Karla Andrea Frydenvang er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 12 Lignende profiler
Publikation
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Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor
Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, K. & Kastrup, J. S., 14 mar. 2019, I: ACS Medicinal Chemistry Letters. 10, 3, s. 243-247 5 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters
Poulie, C. B. M., Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, W. E., Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, B., Frydenvang, K. A., Jensen, A. A., Hansen, K. B., Pickering, D. S. & Bunch, L., 19 jun. 2019, I: A C S Chemical Neuroscience. 10, 6, s. 2989-3007 19 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 jun. 2019, I: Journal of Medicinal Chemistry. 62, 12, s. 5797-5809Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Functionalized Helical beta-Peptoids
Wellhofer, I., Frydenvang, K., Kotesova, S., Christiansen, A. M., Laursen, J. S. & Olsen, C. A., 5 apr. 2019, I: Journal of Organic Chemistry. 84, 7, s. 3762-3779Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology
Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, P., Pasini, D., Bornholdt, J., Nielsen, B., Mamedova, E., Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen, J. T., Frydenvang, K., Kastrup, J. S., Johansen, T. N. & Pickering, D. S., 2019, I: ACS Chemical Neuroscience. 10, s. 4685-4695 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology
Pallesen, J. S., Møllerud, S., Frydenvang, K. A., Pickering, D. S., Bornholt, J., Nielsen, B., Pasini, D., Han, L., Marconi, L., Kastrup, J. S. J. & Johansen, T. N., 20 mar. 2019, I: A C S Chemical Neuroscience. 10, s. 1841-1853 13 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors
Dawe, G. B., Kadir, M. F., Venskutonyte, R., Perozzo, A. M., Yan, Y., Alexander, R. P. D., Navarrete, C., Santander, E. A., Arsenault, M., Fuentes, C., Aurousseau, M. R. P., Frydenvang, K., Barrera, N. P., Kastrup, J. S., Edwardson, J. M. & Bowie, D., 5 jun. 2019, I: Neuron. 102, 5, s. 976-+Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
Frydenvang, K., Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, O., Jørgensen, F. S. & Geerke, D. P., maj 2019, I: PLoS ONE. 14, 5, 15 s., e0217292.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Aktiviteter
- 1 Medlemskab af udvalg, råd og nævn
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Danmarks Nationalkomité for Krystallografi (Ekstern organisation)
Frydenvang, K. A. (Medlem)
1 jun. 1999 → …Aktivitet: Medlemsskab - typer › Medlemskab af udvalg, råd og nævn