GPCRdb: an information system for G protein-coupled receptors

TY - JOUR

T1 - GPCRdb

T2 - an information system for G protein-coupled receptors

AU - Isberg, Vignir

AU - Mordalski, Stefan

AU - Munk, Christian

AU - Rataj, Krzysztof

AU - Harpsøe, Kasper

AU - Hauser, Alexander S

AU - Vroling, Bas

AU - Bojarski, Andrzej J

AU - Vriend, Gert

AU - Gloriam, David E

N1 - FUNDING: European Research Council [639125 to D.E.G]; Lundbeck Foundation [R163-2013-16327 to D.E.G]; Danish Council for Independent Research [1331-00180 to D.E.G]; Polish National Science Centre [DEC-2014/12/T/NZ2/00529 to S.M.]. Funding for open access charge: European Research Council [639125 to D.E.G].

PY - 2016/1/4

Y1 - 2016/1/4

N2 - Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.

AB - Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.

KW - Development of new medicine

U2 - 10.1093/nar/gkv1178

DO - 10.1093/nar/gkv1178

M3 - Journal article

C2 - 26582914

SN - 0305-1048

VL - 44

SP - D356-64

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - D1

ER -