Thomas Svava Nielsen

2019

Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle

de Guia, R. M., Agerholm, M., Nielsen, T. S., Consitt, L. A., Sogaard, D., Helge, J. W., Larsen, S., Brandauer, J., Houmard, J. A. & Treebak, J. T., Jul 2019, In: Physiological Reports. 7, 12, 15 p., e14139.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

40 Downloads (Pure)

Assessment of mouse liver [1-¹³C]pyruvate metabolism by dynamic hyperpolarized MRS

Faarkrog Høyer, K., Laustsen, C., Ringgaard, S., Qi, H., Mariager, C. Ø., Nielsen, T. S., Sundekilde, U. K., Treebak, J. T., Jessen, N. & Stødkilde-Jørgensen, H., Sept 2019, In: Journal of Endocrinology. 242, 3, p. 251-260 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans

Ramshanker, N., Jessen, N., Voss, T. S., Pedersen, S. B., Jørgensen, J. O. L., Nielsen, T. S., Frystyk, J. & Møller, N., Oct 2019, In: Metabolism: Clinical and Experimental. 99, p. 1-10

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals

Park, S., Turner, K. D., Zheng, D., Brault, J. J., Zou, K., Chaves, A. B., Nielsen, T. S., Tanner, C. J., Treebak, J. T. & Houmard, J. A., 15 Jan 2019, In: The Journal of Physiology. 597, 2, p. 449-466

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes

Sharma, V. M., Vestergaard, E. T., Jessen, N., Kolind-Thomsen, P., Nellemann, B., Nielsen, T. S., Vendelbo, M. H., Møller, N., Sharma, R., Lee, K. Y., Kopchick, J. J., Jørgensen, J. O. L. & Puri, V., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 1, p. E34-E42

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis

Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, T. S., Johannsen, M., Svart, M. V., Jessen, N. & Møller, N., 1 Mar 2019, In: Diabetologia. 62, 3, p. 494-503

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2018

Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo

Høyer, K. F., Nielsen, T. S., Risis, S., Treebak, J. T. & Jessen, N., Dec 2018, In: Basic & Clinical Pharmacology & Toxicology. 123, 6, p. 732-738

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

Shi, H., Munk, A., Nielsen, T. S., Daughtry, M. R., Larsson, L., Li, S., Høyer, K. F., Geisler, H. W., Sulek, K., Kjøbsted, R., Fisher, T., Andersen, M. M., Shen, Z., Hansen, U. K., England, E. M., Cheng, Z., Højlund, K., Wojtaszewski, J., Yang, X., Hulver, M. W., & 3 othersHelm, R. F., Treebak, J. T. & Gerrard, D. E., May 2018, In: Molecular Metabolism. 11, p. 160-177 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

57 Downloads (Pure)

2017

Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study

Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, T. S., Johannsen, M., Svart, M. V., Jessen, N. & Møller, N., 1 Jan 2017, In: Diabetologia. 60, 1, p. 143-52 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

2016

Combined insulin deficiency and endotoxin exposure stimulate lipid mobilization and alter adipose tissue signaling in an experimental model of ketoacidosis in subjects with type 1 diabetes: A randomized, controlled, cross over trial

Svart, M., Kampmann, U., Voss, T., Pedersen, S. B., Johannsen, M., Rittig, N., Poulsen, P. L., Nielsen, T. S., Jessen, N. & Møller, N., May 2016, In: Diabetes. 65, 5, p. 1380-6 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

Jensen, B. A. H., Nielsen, T. S., Fritzen, A. M., Holm, J. B., Fjære, E., Serup, A. K. L., Borkowski, K., Risis, S., Pærregaard, S. I., Søgaard, I., Poupeau, A. A. G., Poulsen, M., Ma, T., Sina, C., Kiens, B., Madsen, L., Kristiansen, K. & Treebak, J. T., 1 Dec 2016, In: Metabolism. 65, 12, p. 1706-1719 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

79 Downloads (Pure)

Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast

Bak, A. M., Møller, A. B., Vendelbo, M. H., Nielsen, T. S., Viggers, R., Rungby, J., Pedersen, S. B., Jørgensen, J. O. L., Jessen, N. & Møller, N., 1 Jul 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 1, p. E224-35 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Pronounced expression of the lipolytic inhibitor G0/G1 Switch Gene 2 (G0S2) in adipose tissue from brown bears (Ursus arctos) prior to hibernation

Jessen, N., Nielsen, T. S., Vendelbo, M. H., Viggers, R., Støen, O-G., Evans, A. & Frøbert, O., 1 Apr 2016, In: Physiological Reports. 4, 8, p. 1-7 7 p., e12781.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial

Rittig, N., Bach, E., Thomsen, H. H., Pedersen, S. B., Nielsen, T. S., Jørgensen, J. O., Jessen, N. & Møller, N., Sept 2016, In: P L o S One. 11, 9, p. 1-13 13 p., e0162167.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Stress hormone release is a key component of the metabolic response to lipopolysaccharide (LPS): studies in hypopituitary and healthy subjects

Bach, E., Møller, A. B., Jorgensen, J. O. L., Vendelbo, M. H., Jessen, N., Pedersen, S. B., Nielsen, T. S. & Møller, N., Nov 2016, In: European Journal of Endocrinology. 175, 5, p. 455-465 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2015

Intact Pituitary Function is Decisive for the Catabolic Response to TNF-α: Studies of Protein, Glucose and Fatty Acid Metabolism in Hypopituitary and Healthy Subjects

Bach, E., Møller, A. B., Jørgensen, J. O. L., Vendelbo, M. H., Jessen, N., Olesen, J. F., Pedersen, S. B., Nielsen, T. S. & Møller, N., 1 Feb 2015, In: The Journal of clinical endocrinology and metabolism. 100, 2, p. 578-86 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2014

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O., & 3 othersNielsen, R., Albrechtsen, A. & Hansen, T., 14 Aug 2014, In: Nature. 512, 7513, p. 190-193 4 p.

Research output: Contribution to journal › Letter › peer-review

211 Citations (Scopus)

Adipose triglyceride lipase and g0/g1 switch gene 2: approaching proof of concept

Nielsen, T. S. & Møller, N., Mar 2014, In: Diabetes. 63, 3, p. 847-9 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

Nielsen, T. S., Jessen, N., Jørgensen, J. O. L., Møller, N. & Lund, S., 27 Feb 2014, In: Journal of Molecular Endocrinology. 52, 3, p. R199-R222 24 p.

Research output: Contribution to journal › Review › peer-review

174 Citations (Scopus)

Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

Nellemann, B., Vendelbo, M. H., Nielsen, T. S., Bak, A. M., Høgild, M., Pedersen, S. B., Biensø, R. S., Pilegaard, H., Møller, N., Jessen, N. & Jørgensen, J. O. L., Feb 2014, In: Acta Physiologica. 210, 2, p. 392-402 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

2012

Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

Christensen, B., Lundby, C., Jessen, N., Nielsen, T. S., Vestergaard, P. F., Møller, N., Pilegaard, H., Pedersen, S. B., Kopchick, J. J. & Jørgensen, J. O. L., 22 Feb 2012, In: P L o S One. 7, 2, 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

644 Downloads (Pure)

Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

Vendelbo, M., Clasen, B. F. F., Treebak, J. T., Møller, L., Krusenstjerna-Hafstrøm, T., Madsen, M., Nielsen, T. S., Stødkilde-Jørgensen, H., Pedersen, S. B., Jørgensen, J. O. L., Goodyear, L. J., Wojtaszewski, J., Møller, N. & Jessen, N., Jan 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 302, 2, p. E190-E200 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes

Nielsen, T. S., Kampmann, U., Nielsen, R. R., Jessen, N., Orskov, L., Pedersen, S. B., Jørgensen, J. O. L., Lund, S. & Møller, N., Jul 2012, In: The Journal of clinical endocrinology and metabolism. 97, 7, p. E1348-52

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

2011

Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue

Nielsen, T. S., Vendelbo, M., Jessen, N., Pedersen, S. B., Jørgensen, J. O. L., Lund, S. & Møller, N., Aug 2011, In: The Journal of clinical endocrinology and metabolism. 96, 8, p. E1293-7

Research output: Contribution to journal › Journal article › Research › peer-review

57 Citations (Scopus)

GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance

Kampmann, U., Christensen, B., Nielsen, T. S., Pedersen, S. B., Ørskov, L., Lund, S., Møller, N. & Jessen, N., 16 Nov 2011, In: PLOS ONE. 6, 11, p. e27854

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

2010

Effects of GH in human muscle and fat

Jørgensen, J. O. L., Rubeck, K. Z., Nielsen, T. S., Clasen, B. F. F., Vendelboe, M., Hafstrøm, T. K., Madsen, M. & Lund, S., Apr 2010, In: Pediatric nephrology (Berlin, Germany). 25, 4, p. 705-9 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Reduced cannabinoid receptor 1 protein in subcutaneous adipose tissue of obese

Bennetzen, M. F., Nielsen, T. S., Paulsen, S. K., Bendix, J., Fisker, S., Jessen, N., Lund, S., Richelsen, B. & Pedersen, S. B., Feb 2010, In: European Journal of Clinical Investigation. 40, 2, p. 121-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Thomas Svava Nielsen

Research output

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