Thomas Mandrup-Poulsen

Research output

Research output per year 1985 2005 2007 2008 2009 2010 2011 2012 2013 2014 2016 2018 2019 2019

• 158 Journal article
• 4 Review
• 3 Book chapter
• 3 Conference abstract for conference
• 13 More
  • 3 Poster
  • 3 Comment/debate
  • 2 Letter
  • 2 Other contribution
  • 1 Article in proceedings
  • 1 Conference abstract in journal
  • 1 Conference article

Research output per year

Research output per year

Search results

• 2014

  Iron: the hard player in diabetes pathophysiology

  Hansen, J. B., Moen, I. W. & Mandrup-Poulsen, T., Apr 2014, In: Acta Physiologica (Print). 210, 4, p. 717-32 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Iron 100%
  • Reactive Oxygen Species 24%
  • solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2 16%
  • Cell Death 15%
  • Chelation Therapy 13%
  65 Citations (Scopus)

• JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis

  Prause, M., Christensen, D. P., Billestrup, N. & Mandrup-Poulsen, T., 24 Jan 2014, In: PLOS ONE. 9, 1, p. 1-11 11 p., e87067.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apoptosis 100%
  • Cell death 97%
  • apoptosis 88%
  • Glucose 74%
  • Palmitates 56%
  30 Citations (Scopus)

• Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial

  Hadley, D., Cheung, R. K., Becker, D. J., Girgis, R., Palmer, J. P., Cuthbertson, D., Krischer, J. P., Dosch, H-M., TRIGR North America Investigators & Mandrup-Poulsen, T., Feb 2014, In: Clinical and Vaccine Immunology (Online). 21, 2, p. 203-11 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Multicenter Studies 100%
  • Proliferative 76%
  • T-Lymphocytes 71%
  • Toxin 54%
  • Quality Control 52%
  2 Citations (Scopus)

• Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

  Christensen, D. P., Gysemans, C., Lundh, M., Dahllöf, M. S., Noesgaard, D., Schmidt, S. F., Mandrup, S., Birkbak, N., Workman, C., Piemonti, L., Blaabjerg, L., Monzani, V., Fossati, G., Mascagni, P., Paraskevas, S., Aikin, R. A., Billestrup, N., Grunnet, L. G., Dinarello, C. A., Mathieu, C., & 1 othersMandrup-Poulsen, T., 21 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. 1055-9 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • givinostat 100%
  • Cytoprotection 78%
  • Vorinostat 70%
  • Lysine 64%
  • Inbred NOD Mouse 61%
  42 Citations (Scopus)

• Need for Reclassification of Diabetes Secondary to Iron Overload in the ADA and WHO Classifications

  Ellervik, C., Birgens, H. & Mandrup-Poulsen, T., Jun 2014, In: Diabetes Care. 37, 6, p. e137-e138 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  4 Citations (Scopus)

• Recruitment and retention of participants for an international type 1 diabetes prevention trial: a coordinators' perspective

  Franciscus, M., Nucci, A., Bradley, B., Suomalainen, H., Greenberg, E., Laforte, D., Kleemola, P., Hyytinen, M., Salonen, M., Martin, M. J., Catte, D., Catteau, J., TRIGR Investigators & Mandrup-Poulsen, T., Apr 2014, In: Clinical Trials. 11, 2, p. 150-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Type 1 Diabetes Mellitus 100%
  • HLA Antigens 32%
  • Milk Proteins 21%
  • Mothers 20%
  • Privacy 19%
  6 Citations (Scopus)

• Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation

  Bartels, E. D., Ploug, T., Størling, J., Mandrup-Poulsen, T. & Nielsen, L. B., Jun 2014, In: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 4, p. 351-7 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins B 100%
  • Triglyceride 94%
  • Insulin Derivative 91%
  • Triglycerides 72%
  • Skeletal Muscle 71%
  5 Citations (Scopus)

• Total and cause-specific mortality by elevated transferrin saturation and hemochromatosis genotype in individuals with diabetes - two general population studies

  Ellervik, C., Mandrup-Poulsen, T., Tybjærg-Hansen, A. & Nordestgaard, B. G., Feb 2014, In: Diabetes Care. 37, 2, p. 444-452 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hemochromatosis 100%
  • Transferrin 85%
  • Genotype 56%
  • Mortality 40%
  • Population 31%
  11 Citations (Scopus)

• Use of vitamin D supplements during infancy in an international feeding trial

  Lehtonen, E., Ormisson, A., Nucci, A., Cuthbertson, D., Sorkio, S., Hyytinen, M., Alahuhta, K., Berseth, C., Salonen, M., Taback, S., Franciscus, M., González-Frutos, T., Korhonen, T. E., Lawson, M. L., Becker, D. J., Krischer, J. P., Knip, M., Virtanen, S. M., TRIGR Investigators & Mandrup-Poulsen, T., Apr 2014, In: Public Health Nutrition. 17, 4, p. 810-22 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vitamin D 100%
  • supplement 97%
  • infant 90%
  • Canada 41%
  • chronic illness 35%
  5 Citations (Scopus)
• 2013

  Anti-cytokine therapies in T1D: Concepts and strategies

  Nepom, G. T., Ehlers, M. & Mandrup-Poulsen, T., Dec 2013, In: Clinical Immunology. 149, 3 Part A, p. 279-85 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cytokines 100%
  • Type 1 Diabetes Mellitus 72%
  • Interleukin-23 51%
  • Interleukin-12 41%
  • Interleukin-1 40%
  46 Citations (Scopus)

• Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes

  Pham, M-L., Kolb, H., Battelino, T., Ludvigsson, J., Pozzilli, P., Zivehe, F., Roden, M., Mandrup-Poulsen, T., Schloot, N. C. & European C-Peptide Trial, Jun 2013, In: Diabetologia. 56, 6, p. 1356-63 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Meals 100%
  • Type 1 Diabetes Mellitus 99%
  • Fasting 89%
  • Anti-Inflammatory Agents 81%
  • Cytokines 69%
  7 Citations (Scopus)

• HDAC3 inhibition rescues pancreatic beta cells from glucolipotoxicity and improves insulin secretion in obese diabetic rats

  Lundh, M., Galbo, T., Wagner, F. F., Christensen, D. P., Walpita, D., Gale, J. P., Zhang, Y-L., Hooker, J., Shulman, G. I., Mandrup-Poulsen, T., Holson, E. B. & Wagner, B. K., Sept 2013, In: Diabetologia. 56, 1 suppl, p. S219-S219

  Research output: Contribution to journal › Journal article › Research › peer-review

• Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

  Moran, A., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., Sanda, S., Schatz, D., Wherrett, D. K., Wilson, D. M., Krischer, J. P., Skyler, J. S., Pickersgill, L., de Koning, E., Ziegler, A-G., Böehm, B., & 12 othersBadenhoop, K., Schloot, N., Bak, J. F., Pozzilli, P., Mauricio, D., Donath, M. Y., Castaño, L., Wägner, A., Lervang, H. H., Perrild, H., Mandrup-Poulsen, T. & Group, T. . D. T. C. S., 1 Jun 2013, In: Lancet. 381, 9881, p. 1905-1915 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • canakinumab 100%
  • Interleukin 1 Receptor Antagonist Protein 95%
  • Interleukin-1 69%
  • Type 1 Diabetes Mellitus 62%
  • Placebos 48%
  218 Citations (Scopus)

• Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

  Moran, A., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., Sanda, S., Schatz, D., Wherrett, D. K., Wilson, D. M., Krischer, J. P., Skyler, J. S., Pickersgill, L., de Koning, E., Ziegler, A-G., Böehm, B., & 12 othersBadenhoop, K., Schloot, N., Bak, J. F., Pozzilli, P., Mauricio, D., Donath, M. Y., Castaño, L., Wägner, A., Lervang, H. H., Perrild, H., Mandrup-Poulsen, T. & Type 1 Diabetes TrialNet Canakinumab Study Group, 1 Jun 2013, In: Lancet. 381, 9881, p. 1905-15 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • canakinumab 100%
  • Interleukin 1 Receptor Antagonist Protein 95%
  • Interleukin-1 69%
  • Type 1 Diabetes Mellitus 62%
  • Placebos 48%
  218 Citations (Scopus)

• Interleukin-1 antagonists for diabetes

  Mandrup-Poulsen, T. & AIDA study group, Aug 2013, In: Expert Opinion on Investigational Drugs. 22, 8, p. 965-79 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interleukin-1 100%
  • Insulin Resistance 54%
  • Insulin Secretion 33%
  • Biological Products 32%
  • Global Health 32%
  9 Citations (Scopus)

• Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

  Pham, M. N., Kolb, H., Mandrup-Poulsen, T., Battelino, T., Ludvigsson, J., Pozzilli, P., Roden, M., Schloot, N. C. & European C-Peptide Trial, Feb 2013, In: Diabetes - Metabolism: Research and Reviews (Online). 29, 2, p. 166-70 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Resistin 100%
  • Adipokines 86%
  • Adiponectin 81%
  • Leptin 75%
  • Type 1 Diabetes Mellitus 67%
  25 Citations (Scopus)

• Small-molecule inhibition of inflammatory β-cell death

  Lundh, M., Scully, S. S., Mandrup-Poulsen, T. & Wagner, B. K., Sept 2013, In: Diabetes, Obesity and Metabolism Online. 15 , 3, p. 176-84 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell Death 100%
  • Apoptosis 26%
  • Insulin Secretion 21%
  • Hypoglycemic Agents 20%
  • Insulin Resistance 17%
  9 Citations (Scopus)

• Total mortality by elevated transferrin saturation in patients with diabetes

  Ellervik, C., Andersen, H. U., Tybjærg-Hansen, A., Frandsen, M. M., Birgens, H., Nordestgaard, B. G. & Mandrup-Poulsen, T., Sept 2013, In: Diabetes Care. 36, 9, p. 2646-54 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transferrin 100%
  • Mortality 46%
  • Genotype 36%
  • Type 1 Diabetes Mellitus 22%
  • Iron Overload 20%
  9 Citations (Scopus)

• Type 2 diabetes mellitus: a metabolic autoinflammatory disease

  Mandrup-Poulsen, T., Jul 2013, In: Dermatologic Clinics. 31, 3, p. 495-506 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inflammasomes 100%
  • Metabolic Diseases 87%
  • Type 2 Diabetes Mellitus 62%
  • Life Style 33%
  • Molecular Biology 33%
  18 Citations (Scopus)
• 2012

  (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

  Malaisse, W. J., Zhang, Y., Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., Mandrup-Poulsen, T., Waschke, D., Leshch, Y., Thimm, J., Thiem, J. & Sener, A., 15 Jan 2012, In: Archives of Biochemistry and Biophysics. 517, 2, p. 138-43 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mannoheptulose 100%
  • Insulin Derivative 59%
  • Cell Viability 28%
  • NMR Spectroscopy 19%
  • Insulin 14%
  15 Citations (Scopus)

• Association between age, IL-10, IFN¿, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

  Kaas, A., Pfleger, C. C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., Hvidoere Study Group On Childhood Diabetes & Mandrup-Poulsen, T., Jun 2012, In: Diabetic Medicine Online. 29, 6, p. 734-741 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • C-Peptide 100%
  • Interferon-gamma 77%
  • Type 1 Diabetes Mellitus 77%
  • Disease Progression 69%
  • Child 37%
  21 Citations (Scopus)

• Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis

  Hansen, J. B., Heller, S., Madsen, A. N., Holst, B., Tonnesen, M. F. & Mandrup-Poulsen, T., 2012.

  Research output: Contribution to conference › Poster › Research › peer-review

• Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

  Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F., & 1 othersMandrup-Poulsen, T., 3 Oct 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2 100%
  • Iron 51%
  • Reactive Oxygen Species 49%
  • Cytokines 38%
  • Insulin Secretion 24%
  87 Citations (Scopus)

• Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

  Cavelti-Weder, C., Babians-Brunner, A., Keller, C., Stahel, M. A., Kurz-Levin, M., Zayed, H., Solinger, A. M., Mandrup-Poulsen, T., Dinarello, C. A. & Donath, M. Y., Aug 2012, In: Diabetes Care.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • gevokizumab 100%
  • Type 2 Diabetes Mellitus 36%
  • Interleukin-1 29%
  • Placebos 20%
  • Appointments and Schedules 15%
  197 Citations (Scopus)

• Growth differences between North American and European children at risk for type 1 diabetes

  Nucci, A. M., Becker, D. J., Virtanen, S. M., Cuthbertson, D., Softness, B., Huot, C., Wasikowa, R., Dosch, H. M., Akerblom, H. K., Knip, M., TRIGR Study Group & Mandrup-Poulsen, T., Aug 2012, In: Pediatric Diabetes Online. 13, 5, p. 425-31 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Growth 56%
  • Child 48%
  • Canada 33%
  • Obesity 26%
  3 Citations (Scopus)

• Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

  Lundh, M., Christensen, D. P., Damgaard Nielsen, M., Richardson, S. J., Dahllöf, M. S., Skovgaard, T., Berthelsen, J., Dinarello, C. A., Stevenazzi, A., Mascagni, P., Grunnet, L. G., Morgan, N. G. & Mandrup-Poulsen, T., Sept 2012, In: Diabetologia. 55, 9, p. 2421-31

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Deacetylases 100%
  • Cytokines 53%
  • Apoptosis 52%
  • Child 37%
  • Type 1 Diabetes Mellitus 28%
  60 Citations (Scopus)

• Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes

  Mandrup-Poulsen, T., 2012, In: The review of diabetic studies : RDS. 9, 4, p. 338-47 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interleukin-1 100%
  • Type 1 Diabetes Mellitus 89%
  • Cytokines 62%
  • Biological Products 39%
  • Safety 35%
  13 Citations (Scopus)

• Perspective: Testing failures

  Mandrup-Poulsen, T., 16 May 2012, In: Nature Study. 485, 7398, p. S17

  Research output: Contribution to journal › Journal article › Commissioned

  3 Citations (Scopus)

• Response to Comment on: Ellervik et al. Elevated Transferrin Saturation and Risk of Diabetes: Three Population-Based Studies. Diabetes Care 2011;34:2256-2258

  Ellervik, C., Mandrup-Poulsen, T., Birgens, H. & Nordestgaard, B. G., Jun 2012, In: Diabetes Care. 35, 6, p. e48

  Research output: Contribution to journal › Journal article › Research

• RNA modifications by oxidation: a novel disease mechanism?

  Poulsen, H. E., Specht, E., Broedbaek, K., Henriksen, T., Ellervik, C., Mandrup-Poulsen, T., Tonnesen, M., Nielsen, P. E., Andersen, H. U. & Weimann, A., 15 Apr 2012, In: Free Radical Biology & Medicine. 52, 8, p. 1353-61 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA 100%
  • Modification 80%
  • Oxidation Reaction 64%
  • Hemochromatosis 32%
  • Protein 18%
  121 Citations (Scopus)

• Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

  Ablamunits, V., Henegariu, O., Hansen, J. B., Opare-Addo, L., Preston-Hurlburt, P., Santamaria, P., Mandrup-Poulsen, T. & Herold, K. C., Jan 2012, In: Diabetes. 61, 1, p. 145-54 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inbred NOD Mouse 100%
  • Interleukin-1 80%
  • Type 1 Diabetes Mellitus 72%
  • Monoclonal Antibodies 59%
  • Interleukins 44%
  90 Citations (Scopus)

• The lysine deacetylase inhibitor givinostat inhibits ß-cell IL-1ß induced IL-1ß transcription and processing

  Dahllöf, M. S., Christensen, D. P., Lundh, M., Dinarello, C. A., Mascagni, P., Grunnet, L. G. & Mandrup-Poulsen, T., 1 Nov 2012, In: Islets. 4, 6, p. 417-22 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • givinostat 100%
  • Interleukin-1 49%
  • Lysine 48%
  • Messenger RNA 8%
  • Chemokines 5%
  8 Citations (Scopus)

• TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

  Engholm-Keller, K., Birck, P., Størling, J., Pociot, F., Mandrup-Poulsen, T. & Larsen, M. R., 22 Oct 2012, In: International Journal of Proteomics. 75, 18, p. 5749-61 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • imidazoleacetic acid 100%
  • Phosphopeptides 78%
  • Hydrophobic and Hydrophilic Interactions 64%
  • Liquid Chromatography 61%
  • Hydrophilicity 52%
  137 Citations (Scopus)

• Transcriptional and translational regulation of cytokine signaling in inflammatory ß-cell dysfunction and apoptosis

  Novotny, G. W., Lundh, M., Backe, M. B., Christensen, D. P., Hansen, J. B., Dahllöf, M. S., Pallesen, E. & Mandrup-Poulsen, T., 15 Dec 2012, In: Archives of Biochemistry and Biophysics. 528, 2, p. 171-84

  Research output: Contribution to journal › Review › peer-review

  • Protein Biosynthesis 100%
  • Cytokines 85%
  • Apoptosis 83%
  • Cope Reaction 59%
  • Protein 56%
  25 Citations (Scopus)
• 2011

  16 SKELETAL-MUSCLE LIPOPROTEIN EXPRESSION IS REGULATED BY TRAINING AND TYPE 2 DIABETES IN HUMANS AND IMPROVES INSULIN SENSITIVITY IN OBESE MICE

  Bartels, E. M., Mandrup-Poulsen, T. & Nielsen, L. B., Jun 2011, In: Atherosclerosis. Supplement. 12, 1, p. 4 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Apolipoprotein CIII Reduces Proinflammatory Cytokine-Induced Apoptosis in Rat Pancreatic Islets via the Akt Prosurvival Pathway

  Størling, J., Juntti-Berggren, L., Olivecrona, G., Prause, M. C., Berggren, P-O. & Mandrup-Poulsen, T., Aug 2011, In: Endocrinology. 152, 8, p. 3040-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoprotein C-III 100%
  • Apolipoprotein 82%
  • Islets of Langerhans 67%
  • Cytokines 41%
  • Apoptosis 41%
  15 Citations (Scopus)

• Cytokines and type 1 diabetes: a numbers game

  Grunnet, L. G. & Mandrup-Poulsen, T., Mar 2011, In: Diabetes. 60, 3, p. 697-9 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  13 Citations (Scopus)

• Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

  Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, N., Berezin, V., Bock, E. & Mandrup-Poulsen, T., 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Palmitoylation 100%
  • Lipoylation 87%
  • Neural Cell Adhesion Molecules 81%
  • Dimerization 69%
  • Energy Transfer 16%
  9 Citations (Scopus)

• Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)

  Knip, M., Virtanen, S. M., Becker, D., Dupré, J., Krischer, J. P., Åkerblom, H. K., TRIGR Study Group & Mandrup-Poulsen, T., 1 Dec 2011, In: American Journal of Clinical Nutrition. 94, 6 Suppl, p. 1814S-1820S 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Weaning 90%
  • Fruit 52%
  • Milk Proteins 37%
  • Guideline Adherence 35%
  44 Citations (Scopus)

• Elevated transferrin saturation and risk of diabetes: Three population-based studies

  Ellervik, C., Mandrup-Poulsen, T., Andersen, H. U., Tybjærg-Hansen, A., Frandsen, M., Birgens, H. & Nordestgaard, B. G., Oct 2011, In: Diabetes Care. 34, 10, p. 2256-8 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transferrin 100%
  • Population 36%
  • Case-Control Studies 24%
  • Research Design 24%
  • Type 2 Diabetes Mellitus 23%
  42 Citations (Scopus)

• Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

  Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, N., Mandrup-Poulsen, T., Parving, H-H. & Rossing, P., Jun 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Endothelial Progenitor Cells 100%
  • Diabetic Nephropathies 86%
  • Cardiovascular Diseases 48%
  • Cell Count 38%
  • Asymptomatic Diseases 9%
  8 Citations (Scopus)

• Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

  Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, N., Grunnet, L. G. & Mandrup-Poulsen, T., May 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 99%
  • Insulin Resistance 69%
  • Diabetes Mellitus 67%
  • Immunologic Factors 46%
  167 Citations (Scopus)

• The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ß cells in vivo and in vitro

  Lewis, E. C., Blaabjerg, L., Størling, J., Ronn, S. G., Mascagni, P., Dinarello, C. A. & Mandrup-Poulsen, T., May 2011, In: Molecular Medicine. 17, 5-6, p. 369-377 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • givinostat hydrochloride 100%
  • Histone Deacetylase Inhibitors 58%
  • Islets of Langerhans 49%
  • Cytokines 30%
  • Histone Deacetylases 28%
  83 Citations (Scopus)

• The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up

  Akerblom, H. K., Krischer, J., Virtanen, V. S., Berseth, C., Becker, D., Dupré, J., Ilonen, J., Trucco, M., Savilahti, E., Koski, K., Pajakkala, E., Fransiscus, M., Lough, G., Bradley, B., Koski, M., Knip, M., TRIGR Study Group & Mandrup-Poulsen, T., 1 Mar 2011, In: Diabetologica. 54, 3, p. 627-633 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Weaning 30%
  • National Institutes of Health (U.S.) 29%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 22%
  • Data Management 18%
  68 Citations (Scopus)
• 2010

  Blockade of Interleukin 1 in Type 1 diabetes mellitus

  Mandrup-Poulsen, T., Pickersgill, L. M. S. & Donath, M. Y., Mar 2010, In: Nature Reviews Endocrinology. 6, p. 158-166 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Interleukin-1 100%
  • Type 1 Diabetes Mellitus 89%
  • Fever 15%
  • Inflammation Mediators 12%
  • Acute-Phase Reaction 12%
  172 Citations (Scopus)

• DIFFERENTIAL TRANSCRIPTIONAL REGULATION OF EXTRA CELLULAR MATRIX MODULATING GENES BY PROINFLAMMATORY CYTOKINES IN INS-1 CELLS

  Hansen, J. B., Tonnesen, M. F., Friberg, J., Brunner, N. & Mandrup-Poulsen, T., 2010.

  Research output: Contribution to conference › Conference abstract for conference › Research

• Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.

  Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, N., Brunner, N. & Mandrup-Poulsen, T., 2010, (Accepted/In press).

  Research output: Contribution to conference › Conference abstract for conference › Research

• High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

  Fred, R. G., Bang-Berthelsen, C. H., Mandrup-Poulsen, T., Grunnet, L. G. & Welsh, N., 2010, In: PLoS ONE. 5, 5, p. e10843

  Research output: Contribution to journal › Journal article › Research › peer-review

  • polypyrimidine tract-binding proteins 100%
  • Polypyrimidine Tract-Binding Protein 88%
  • Biosynthesis 88%
  • Carrier Proteins 86%
  • Insulin 77%
  65 Citations (Scopus)

• IAPP boosts islet macrophage IL-1 in type 2 diabetes

  Mandrup-Poulsen, T., 1 Oct 2010, In: Nature Immunology. 11, 10, p. 881-3 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  31 Citations (Scopus)

• IL-1 family nomenclature

  Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., Mantovani, A., Garlanda, C., Boraschi, D., Rubartelli, A., Netea, M., van der Meer, J., Joosten, L., Mandrup-Poulsen, T., & 14 othersDonath, M., Lewis, E., Pfeilschifter, J., Martin, M., Kracht, M., Muehl, H., Novick, D., Lukic, M., Conti, B., Solinger, A., Kelk, P., Peyman, K., van de Veerdonk, F. & Gabel, C., 1 Nov 2010, In: Nature Immunology. 11, 11, p. 973 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  213 Citations (Scopus)