Growth differences between North American and European children at risk for type 1 diabetes

TY - JOUR

T1 - Growth differences between North American and European children at risk for type 1 diabetes

AU - Nucci, Anita M

AU - Becker, Dorothy J

AU - Virtanen, Suvi M

AU - Cuthbertson, David

AU - Softness, Barney

AU - Huot, Celine

AU - Wasikowa, Renata

AU - Dosch, Hans Michael

AU - Akerblom, Hans K

AU - Knip, Mikael

AU - TRIGR Study Group

AU - Mandrup-Poulsen, Thomas

N1 - © 2012 John Wiley & Sons A/S.

PY - 2012/8

Y1 - 2012/8

N2 - Aim: To evaluate the relationships between early growth and regional variations in type 1 diabetes (T1D) incidence in an international cohort of children with familial and genetic risk for T1D. Methods: Anthropometric indices between birth to 5 yr of age were compared among regions and T1D proband in 2160 children participating in the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk study. Results: Children in Northern Europe had the highest weight z-score between birth to 12 months of age, while those in Southern Europe and USA had the lowest weight and length/height z-scores at most time points (p < 0.005 to p < 0.001). Few differences in z-score values for weight, height, and body mass index were found by maternal T1D status. Using International Obesity Task Force criteria, the obesity rates generally increased with age and at 5 yr were highest in males in Northern Europe (6.0%) and in females in Canada (12.8%). However, no statistically significance difference was found by geographic region. In Canada, the obesity rate for female children of mothers with and without T1D differed significantly at 4 and 5 yr (6.0 vs. 0.0% and 21.3 vs. 1.9%, respectively; p < 0.0125) but no differences by maternal T1D status were found in other regions. Conclusions: There are regional differences in early childhood growth that are consistent with the higher incidence of T1D in Northern Europe and Canada as compared to Southern Europe. Our prospective study from birth will allow evaluation of relationships between growth and the emerging development of autoimmunity and progression to T1D by region in this at-risk population of children.

AB - Aim: To evaluate the relationships between early growth and regional variations in type 1 diabetes (T1D) incidence in an international cohort of children with familial and genetic risk for T1D. Methods: Anthropometric indices between birth to 5 yr of age were compared among regions and T1D proband in 2160 children participating in the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk study. Results: Children in Northern Europe had the highest weight z-score between birth to 12 months of age, while those in Southern Europe and USA had the lowest weight and length/height z-scores at most time points (p < 0.005 to p < 0.001). Few differences in z-score values for weight, height, and body mass index were found by maternal T1D status. Using International Obesity Task Force criteria, the obesity rates generally increased with age and at 5 yr were highest in males in Northern Europe (6.0%) and in females in Canada (12.8%). However, no statistically significance difference was found by geographic region. In Canada, the obesity rate for female children of mothers with and without T1D differed significantly at 4 and 5 yr (6.0 vs. 0.0% and 21.3 vs. 1.9%, respectively; p < 0.0125) but no differences by maternal T1D status were found in other regions. Conclusions: There are regional differences in early childhood growth that are consistent with the higher incidence of T1D in Northern Europe and Canada as compared to Southern Europe. Our prospective study from birth will allow evaluation of relationships between growth and the emerging development of autoimmunity and progression to T1D by region in this at-risk population of children.

KW - Body Height

KW - Body Mass Index

KW - Body Weight

KW - Canada

KW - Child

KW - Child, Preschool

KW - Diabetes Mellitus, Type 1

KW - Europe

KW - European Continental Ancestry Group

KW - Female

KW - Growth

KW - Humans

KW - Infant

KW - Male

KW - Obesity

KW - Prospective Studies

KW - United States

U2 - 10.1111/j.1399-5448.2011.00840.x

DO - 10.1111/j.1399-5448.2011.00840.x

M3 - Journal article

C2 - 22251851

SN - 1399-543X

VL - 13

SP - 425

EP - 431

JO - Pediatric Diabetes

JF - Pediatric Diabetes

IS - 5

ER -