Thomas Jespersen

Research output

Research output per year 1997 2004 2009 2011 2015 2017 2018 2019 2021

• 114 Journal article
• 2 Article in proceedings
• 2 Review
• 1 Ph.D. thesis
• 5 More
  • 1 Book chapter
  • 1 Conference abstract for conference
  • 1 Poster
  • 1 Conference abstract in journal
  • 1 Letter

Research output per year

Research output per year

Search results

• 2015

  Synergistic antiarrhythmic effect of combining inhibition of Ca(2+)-activated K(+) (SK) channels and voltage-gated Na(+) channels in an isolated heart model of atrial fibrillation

  Kirchhoff, J. E., Goldin Diness, J., Sheykhzade, M., Grunnet, M. & Jespersen, T., 1 Feb 2015, In: Heart rhythm : the official journal of the Heart Rhythm Society. 12, 2, p. 409-18 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Voltage-Gated Potassium Channels 100%
  • Ranolazine 71%
  • Atrial Fibrillation 67%
  • Flecainide 65%
  • Heart 49%
  16 Citations (Scopus)

• The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome

  Winkel, B. G., Yuan, L., Olesen, M. S., Sadjadieh, G., Wang, Y., Risgaard, B., Jabbari, R., Haunsø, S., Holst, A. G., Hollegaard, M. V., Tfelt-Hansen, J. & Jespersen, T., 1 Jun 2015, In: Heart rhythm : the official journal of the Heart Rhythm Society. 12, 6, p. 1241-1249 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sudden Infant Death 100%
  • Sodium 67%
  • Genes 16%
  • Sodium Channels 15%
  • Neonatal Screening 15%
  14 Citations (Scopus)
• 2014

  Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome.

  Kanters, J. K., Yuan, L., Hedley, P. L., Stoevring, B., Jons, C., Bloch Thomsen, P. E., Grunnet, M., Christiansen, M. & Jespersen, T., 6 Mar 2014, In: Circulation Journal. 78, 5, p. 1136-43 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT syndrome type 3 100%
  • Flecainide 81%
  • Brugada Syndrome 78%
  • Long QT Syndrome 74%
  • Phenotype 34%
  18 Citations (Scopus)

• G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization

  Liang, B., Nissen, J. D., Laursen, M., Wang, X., Skibsbye, L., Hearing, M. C., Andersen, M. N., Rasmussen, H. B., Wickman, K., Grunnet, M., Olesen, S-P. & Jespersen, T., 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 175-84 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • tertiapin 100%
  • GTP-Binding Proteins 54%
  • Potassium 49%
  • otenzepad 35%
  • 1,3-dipropyl-8-cyclopentylxanthine 32%
  22 Citations (Scopus)

• Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada Syndrome mutant

  Yuan, L., Koivumaki, J., Liang, B., Lorentzen, L. G., Tang, C., Andersen, M. N., Svendsen, J. H., Tfelt-Hansen, J., Maleckar, M., Schmitt, N., Olesen, M. S. & Jespersen, T., 15 Apr 2014, In: American Journal of Physiology: Heart and Circulatory Physiology. 306, 8, p. H1204-12

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Sodium Channels 85%
  • Computer Simulation 34%
  • Action Potentials 32%
  • Loss of Function Mutation 20%
  17 Citations (Scopus)

• Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarisation in human atria.

  Skibsbye, L., Poulet, C., Diness, J. G., Bentzen, B. H., Yuan, L., Kappert, U., Matschke, K., Wettwer, E., Ravens, U., Grunnet, M., Christ, T. & Jespersen, T., 1 Jul 2014, In: Cardiovascular Research. 103, 1, p. 156-167 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Small-Conductance Calcium-Activated Potassium Channels 100%
  • (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine 74%
  • Action Potentials 53%
  • Atrial Fibrillation 42%
  • Muscle Cells 32%
  112 Citations (Scopus)

• Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria

  Skibsbye, L., Poulet, C., Diness, J. G., Bentzen, B. H., Yuan, L., Kappert, U., Matschke, K., Wettwer, E., Ravens, U., Grunnet, M., Christ, T. & Jespersen, T., 1 Jul 2014, In: Cardiovascular Research. 103, 1, p. 156-67 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Small-Conductance Calcium-Activated Potassium Channels 100%
  • (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine 74%
  • Action Potentials 53%
  • Atrial Fibrillation 42%
  • Muscle Cells 32%
  112 Citations (Scopus)
• 2013

  A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

  Andersen, M. N., Krzystanek, K., Petersen, F., Bomholtz, S. H., Olesen, S-P., Abriel, H., Jespersen, T. & Rasmussen, H. B., 27 Dec 2013, In: The Journal of Biological Chemistry. 288, 52, p. 36841-54 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nedd4 Ubiquitin Protein Ligases 100%
  • serum-inducible kinase 91%
  • Phosphoinositide 74%
  • Phosphatidylinositol 3-Kinase 55%
  • Glucocorticoids 49%
  20 Citations (Scopus)

• Double mutation at the putative protein kinase C phosphorylation sites Thr¹⁵¹ plus Thr³²³ in the mouse leukotrieneD₄ receptor eliminates homologous desensitization

  Jørgensen, S. T., Eriksen, H. N., Dausell, J., Jespersen, T., Lambert, I. H. & Hoffmann, E. K., Mar 2013, In: Cellular Physiology and Biochemistry. 31, 2-3, p. 366-378 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein Kinase C 100%
  • Phosphorylation 73%
  • Mutation 59%
  • Oocytes 49%
  • leukotriene D4 receptor 39%
  3 Citations (Scopus)

• GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology

  Wang, X., Liang, B., Skibsbye, L., Olesen, S-P., Grunnet, M. & Jespersen, T., Aug 2013, In: Journal of Cardiovascular Pharmacology. 62, 2, p. 192-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Purinergic P1 Receptors 100%
  • Electrophysiology 90%
  • Muscarinic Receptors 87%
  • Acetylcholine 74%
  • Membrane Potentials 58%
  17 Citations (Scopus)

• The role of CAV3 in long-QT syndrome: clinical and functional assessment of a caveolin-3/Kv11.1 double heterozygote versus caveolin-3 single heterozygote

  Hedley, P. L., Kanters, J. K., Dembic, M., Jespersen, T., Skibsbye, L., Aidt, F. H., Eschen, O., Graff, C., Behr, E. R., Schlamowitz, S., Corfield, V., McKenna, W. J. & Christiansen, M., Oct 2013, In: Circulation: Cardiovascular Genetics. 6, 5, p. 452-61 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Caveolin 3 100%
  • Long QT Syndrome 81%
  • Heterozygote 66%
  • Mutation 35%
  • Voltage-Gated Potassium Channels 9%
  16 Citations (Scopus)
• 2012

  AMP-activated protein kinase downregulates Kv7.1 cell surface expression

  Andersen, M. N., Krzystanek, K., Jespersen, T., Olesen, S-P. & Rasmussen, H. B., Jan 2012, In: Traffic. 13, 1, p. 143-56 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • AMP-Activated Protein Kinases 100%
  • Down-Regulation 58%
  • Madin Darby Canine Kidney Cells 41%
  • Polarization 35%
  • Protein 34%
  32 Citations (Scopus)

• Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure

  Nissen, J. D., Thomsen, M. B., Bentzen, B. H., Diness, J. G., Diness, T. G., Jespersen, T. & Grunnet, M., Feb 2012, In: Journal of Cardiovascular Pharmacology. 59, 2, p. 142-150 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adrenergic Agents 100%
  • Action Potentials 93%
  • Heart Failure 75%
  • Rabbits 73%
  • Atrial Remodeling 57%
  4 Citations (Scopus)

• Cardiac Arrhythmia - new considerations: The Cardiac Ion Channels

  Jespersen, T., 29 Feb 2012, Cardiac Arrhythmias - new considerations. Breijo-Marquez, F. R. (ed.). Croatia: InTech, p. 45-72 29 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

  Krzystanek, K., Rasmussen, H. B., Grunnet, M., Staub, O., Olesen, S-P., Abriel, H. & Jespersen, T., Mar 2012, In: Heart Rhythm. 9, 3, p. 440-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • KCNQ1 Potassium Channel 100%
  • Ubiquitin-Specific Proteases 84%
  • Down-Regulation 39%
  • Enzymes 30%
  • Protein Isoforms 9%
  23 Citations (Scopus)

• Functionally Selective AT(1) Receptor Activation Reduces Ischemia Reperfusion Injury

  Hostrup, A., Christensen, G. L., Bentzen, B. H., Liang, B., Aplin, M., Grunnet, M., Hansen, J. L. & Jespersen, T., Aug 2012, In: Cellular Physiology and Biochemistry. 30, 3, p. 642-652 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Reperfusion Injury 100%
  • Angiotensin II 99%
  • GTP-Binding Proteins 34%
  • seven-transmembrane G-protein-coupled receptor 18%
  • Arrestin 16%
  13 Citations (Scopus)

• High Prevalence of Long QT Syndrome Associated SCN5A Variants in Patients with Early-Onset Lone Atrial Fibrillation

  Olesen, M. S., Yuan, L., Liang, B., Holst, A. G., Nielsen, N., Nielsen, J. B., Hedley, P. L., Christiansen, M., Olesen, S-P., Haunsø, S., Schmitt, N., Jespersen, T. & Svendsen, J. H., Aug 2012, In: Circulation: Cardiovascular Genetics. 5, 4, p. 450-459 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT syndrome type 3 100%
  • Long QT Syndrome 88%
  • Atrial Fibrillation 60%
  • Mutation 38%
  • Exome 13%
  96 Citations (Scopus)
• 2011

  A Novel Nonsense Variant in Nav1.5 Cofactor MOG1 Eliminates Its Sodium Current Increasing Effect and May Increase the Risk of Arrhythmias

  Olesen, M. S., Jensen, N. F., Holst, A. G., Nielsen, J. B., Tfelt-Hansen, J., Jespersen, T., Sajadieh, A., Haunsø, S., Lund, J. T., Calloe, K., Schmitt, N. & Svendsen, J. H., 26 May 2011, In: Canadian Journal of Cardiology. 27, 4, p. 523.e17-23

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cardiac Arrhythmias 100%
  • Sodium 98%
  • Brugada Syndrome 40%
  • Genes 35%
  • CHO Cells 35%
  42 Citations (Scopus)

• Atrieflimmer og elektrofysiologi hos heste

  Haugaard, M. M., Buhl, R. & Jespersen, T., 2011, In: Dansk Veterinaertidsskrift. 12, p. 28-31 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Cardiac channelopathies and sudden infant death syndrome

  Tfelt-Hansen, J., Winkel, B. G., Grunnet, M. & Jespersen, T., Aug 2011, In: The Cardiology. 119, 1, p. 21-33 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Channelopathies 100%
  • Sudden Infant Death 87%
  • Ion Channels 40%
  • Genes 20%
  • Polymorphic catecholergic ventricular tachycardia 16%
  26 Citations (Scopus)

• Characterization of cardiac repolarization in the Göttingen minipig

  Laursen, M., Olesen, S-P., Grunnet, M., Mow, T., Jespersen, T. & Jespersen, T., Mar 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Miniature Swine 100%
  • Dofetilide 92%
  • Action Potentials 67%
  • HMR1556 59%
  • Endocardium 48%
  18 Citations (Scopus)

• Comparison of the Effects of a Transient Outward Potassium Channel Activator on Currents Recorded from Atrial and Ventricular Cardiomyocytes.

  Callø, K., Nof, E., Jespersen, T., Di Diego, J. M., Chlus, N., Olesen, S-P., Antzelevitch, C. & Cordeiro, J. M., Sept 2011, In: Journal of Cardiovascular Electrophysiology. 22, 9, p. 1057-1066 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea 100%
  • Potassium Channels 53%
  • Cardiac Myocytes 43%
  • Muscle Cells 23%
  • Endocardium 11%
  25 Citations (Scopus)

• Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition

  Diness, J. G., Skibsbye, L., Jespersen, T., Bartels, E. D., Sørensen, U. S., Hansen, R. S. & Grunnet, M., Jun 2011, In: Hypertension. 57, 6, p. 1129-35 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine 100%
  • Atrial Fibrillation 85%
  • Inbred SHR Rats 39%
  • Atrial Remodeling 33%
  • Hypertension 23%
  83 Citations (Scopus)

• Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts

  Laursen, M., Grunnet, M., Olesen, S-P., Jespersen, T. & Mow, T., Sept 2011, In: Journal of Pharmacological and Toxicological Methods. 64, 2, p. 134-44 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proarrhythmic 100%
  • Arrhythmic 96%
  • QT Interval 96%
  • Miniature Swine 66%
  • Lethal 59%
  8 Citations (Scopus)

• Mutations in sodium channel {beta}-subunit SCN3B are associated with early-onset lone atrial fibrillation

  Olesen, M. S., Jespersen, T., Nielsen, J. B., Liang, B., Møller, D. V., Hedley, P., Christiansen, M., Varro, A., Olesen, S-P., Haunsø, S., Schmitt, N. & Svendsen, J. H., 1 Mar 2011, In: Cardiovascular Research. 89, 4, p. 786-793 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Voltage-Gated Sodium Channel beta-3 Subunit 100%
  • Atrial Fibrillation 37%
  • Mutation 23%
  • Sodium Channels 14%
  • Sodium 10%
  91 Citations (Scopus)

• Regulation and physiological function of Na(v) 1.5 and KCNQ1 channels

  Jespersen, T., May 2011, In: Acta Physiologica (Print). 202 Suppl 683, p. 1-26 26 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  2 Citations (Scopus)

• Screening of KCNN3 in patients with early-onset lone atrial fibrillation

  Olesen, M. S., Jabbari, J., Holst, A. G., Nielsen, J. B., Steinbrüchel, D. A., Jespersen, T., Haunsø, S., Svendsen, J. H. & Jespersen, T., Jul 2011, In: Europace. 13, 7, p. 963-967 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Atrial Fibrillation 100%
  • Single Nucleotide Polymorphism 41%
  • Alleles 18%
  • Calcium-Activated Potassium Channels 16%
  • Mutation 13%
  38 Citations (Scopus)
• 2010

  Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

  Yang, Y., Yang, Y., Liang, B., Liu, J., Li, J., Grunnet, M., Olesen, S-P., Rasmussen, H. B., Ellinor, P. T., Gao, L., Lin, X., Li, L., Wang, L., Xiao, J., Liu, Y., Liu, Y., Zhang, S., Liang, D., Peng, L., Jespersen, T., & 1 othersChen, Y-H., 11 Jul 2010, In: American Journal of Human Genetics. 86, 6, p. 872-80 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT Syndrome 100%
  • Mutation 43%
  • Genetic Loci 37%
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels 26%
  • Genes 24%
  147 Citations (Scopus)

• Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

  Diness, J. G., Sørensen, U. S., Nissen, J. D., Al-Shahib, B., Jespersen, T., Grunnet, M., Hansen, R. S. & Jespersen, T., Aug 2010, In: Circulation. Arrhythmia and electrophysiology. 3, 4, p. 380-90 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Calcium-Activated Potassium Channels 100%
  • Atrial Fibrillation 68%
  • (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine 56%
  • Heart 26%
  • Acetylcholine 12%
  140 Citations (Scopus)

• Sick sinus syndrome, progressive cardiac conduction disease, atrial flutter and ventricular tachycardia caused by a novel SCN5A mutation

  Holst, A. G., Liang, B., Jespersen, T., Bundgaard, H., Haunso, S., Svendsen, J. H. & Tfelt-Hansen, J., Apr 2010, In: Cardiology. 115, 4, p. 311-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sick Sinus Syndrome 100%
  • Atrial Flutter 92%
  • Ventricular Tachycardia 78%
  • Heart Diseases 60%
  • Mutation 41%
  15 Citations (Scopus)
• 2009

  Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury

  Bentzen, B. H., Osadchii, O., Jespersen, T., Hansen, R. S., Olesen, S-P. & Grunnet, M., 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)thiourea 100%
  • Cardioprotective 81%
  • Large-Conductance Calcium-Activated Potassium Channels 75%
  • Reperfusion Injury 52%
  • Conductance 51%
  72 Citations (Scopus)

• A Novel SCN5A Mutation in a Patient with Coexistence of Brugada Syndrome Traits and Ischaemic Heart Disease

  Holst, A. G., Calloe, K., Jespersen, T., Cedergreen, P., Winkel, B. G., Jensen, H. K., Leren, T. P., Haunso, S., Svendsen, J. H. & Tfelt-Hansen, J., 2009, In: Case Reports in Medicine. 2009, p. 963645

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Myocardial Ischemia 64%
  • Sudden Cardiac Death 59%
  • Mutation 40%
  • Sodium Channels 21%

• Arvelige hjertesygdomme forårsaget af natriumkanalmutationer

  Translated title of the contribution: Inherited cardiac diseases caused by Nav1.5 sodium channel mutationsTfelt-Hansen, J., Olesen, S-P., Svendsen, J. H. & Jespersen, T., 2009, In: Ugeskrift for læger. 171, 15, p. 1261-5 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle

  Calloe, K., Soltysinska, E., Jespersen, T., Lundby, A., Antzelevitch, C., Olesen, S-P. & Cordeiro, J. M., 2009, In: Journal of Molecular and Cellular Cardiology. 48, 1, p. 191-200 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea 100%
  • Heart Ventricles 41%
  • Canidae 40%
  • CHO Cells 14%
  • Muscle Cells 10%
  37 Citations (Scopus)

• Inherited Cardiac Diseases Caused by Mutations in the Nav1.5 Sodium Channel

  Tfelt-Hansen, J., Winkel, B. G., Grunnet, M. & Jespersen, T., 2009, In: Cardiovascular Electrophysiology.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sodium Channels 100%
  • Heart Diseases 68%
  • Atrial Fibrillation 50%
  • Cardiac Arrhythmias 47%
  • Mutation 47%
  62 Citations (Scopus)

• Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes

  Nissen, J. D., Diness, J. G., Diness, T. G., Hansen, R. S., Grunnet, M. & Jespersen, T., 2009, In: Journal of Cardiovascular Pharmacology. 54, 2, p. 169-77 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Benzodiazepines 100%
  • Cardiac Myocytes 91%
  • Action Potentials 88%
  • Guinea Pigs 86%
  • L 364373 76%
  19 Citations (Scopus)

• Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts

  Soltysinska, E., Olesen, S-P., Christ, T., Wettwer, E., Varró, A., Grunnet, M. & Jespersen, T., 2009, In: Pflügers Archiv: European Journal of Physiology. 459, 1, p. 11-23 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ion Channels 100%
  • Heart Failure 74%
  • Heart 65%
  • Cardiac Arrhythmias 51%
  • Western Blotting 42%
  72 Citations (Scopus)

• Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A

  Tfelt-Hansen, J., Jespersen, T., Hofman-Bang, J., Rasmussen, H. B., Cedergreen, P., Skovby, F., Abriel, H., Svendsen, J. H., Olesen, S-P., Christiansen, M. & Haunso, S., 2009, In: Canadian Journal of Cardiology. 25, 3, p. 156-60 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Ventricular Tachycardia 76%
  • Cardiac Arrhythmias 40%
  • Haploinsufficiency 30%
  • Frameshift Mutation 29%
  11 Citations (Scopus)
• 2008

  Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome.

  Petitprez, S., Jespersen, T., Pruvot, E., Keller, D. I., Corbaz, C., Schläpfer, J., Abriel, H. & Kucera, J. P., 2008, In: Cardiovascular Research. 78, 3, p. 494-504 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Mutation 40%
  • HEK293 Cells 22%
  • Sodium Channels 12%
  • Sudden Cardiac Death 11%
  32 Citations (Scopus)

• Antiarrhythmic effect of IKr activation in a cellular model of LQT3

  Diness, J. G., Hansen, R. S., Nissen, J. D., Jespersen, T. & Grunnet, M., 2008, In: Heart Rhythm. 6, 1, p. 100-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • NS 3623 100%
  • Long QT syndrome type 3 79%
  • toxin II (Anemonia sulcata) 42%
  • Action Potentials 30%
  • rottlerin 17%
  18 Citations (Scopus)

• Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.

  Larsen, A. P., Olesen, S-P., Grunnet, M. & Jespersen, T., 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Messenger RNA 100%
  • Potassium Channels 86%
  • Xenopus laevis 44%
  • Time Constant of Recovery 38%
  • Time Constant of Inactivation 37%
  52 Citations (Scopus)
• 2007

  Brugada syndrome unmasked by accidental inhalation of gasoline vapors.

  Kranjcec, D., Bergovec, M., Rougier, J-S., Raguz, M., Pavlovic, S., Jespersen, T., Castella, V., Keller, D. I. & Abriel, H., 2007, In: Pacing and Clinical Electrophysiology. 30, 10, p. 1294-8 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gasoline 100%
  • Brugada Syndrome 96%
  • Inhalation 65%
  • Paroxysmal ventricular fibrillation 57%
  • Defibrillators 42%
  6 Citations (Scopus)

• The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

  Jespersen, T., Membrez, M., Nicolas, C. S., Pitard, B., Staub, O., Olesen, S-P., Baró, I. & Abriel, H., 2007, In: Cardiovascular Research. 74, 1, p. 64-74 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • KCNQ1 Potassium Channel 100%
  • Nedd4 Ubiquitin Protein Ligases 68%
  • Ubiquitination 60%
  • HEK293 Cells 40%
  • Cardiac Myocytes 34%
  107 Citations (Scopus)
• 2006

  Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1.

  Jespersen, T., Gavillet, B., van Bemmelen, M. X., Cordonier, S., Thomas, M. A., Staub, O. & Abriel, H., 2006, In: Biochemical and Biophysical Research Communications. 348, 4, p. 1455-62 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein Tyrosine Phosphatases 100%
  • Sodium Channels 95%
  • Tyrosine 74%
  • Proto-Oncogene Proteins c-fyn 68%
  • PDZ Domains 56%
  43 Citations (Scopus)

• Kondo physics in tunable semicondouctor nanowire quantum dots

  Jespersen, T., Aagesen, M., Sørensen, C. B., Lindelof, P. E. & Nygård, J., 2006, In: Physical Review B. Condensed Matter and Materials Physics. 74, 23, p. 233304

  Research output: Contribution to journal › Journal article › Research › peer-review

  59 Citations (Scopus)

• Subtype-specific, bi-component inhibition of SK channels by low internal pH.

  Peitersen, T., Jespersen, T., Jorgensen, N. K., Olesen, S-P. & Grunnet, M., 2006, In: Biochemical and Biophysical Research Communications. 343, 3, p. 943-9 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • pH Value 100%
  • 1-ethyl-2-benzimidazolinone 73%
  • Calcium-Activated Potassium Channels 51%
  • Calmodulin 43%
  • Patch-Clamp Techniques 43%
  4 Citations (Scopus)

• The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?

  Jespersen, T., Grunnet, M., Rasmussen, H. B., Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, S-P. & Klaerke, D. A., 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • corticosteroid hormone-induced factor 100%
  • Adrenal Cortex Hormone 62%
  • Xenopus laevis 8%
  • Ion Channels 6%
  • Oocytes 6%
  10 Citations (Scopus)
• 2005

  hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.

  Grunnet, M., Olesen, S-P., Klaerke, D. A. & Jespersen, T., 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium 100%
  • Kinetics 80%
  • Xenopus laevis 64%
  • Oocytes 51%
  28 Citations (Scopus)

• The KCNQ1 potassium channel: from gene to physiological function.

  Jespersen, T., Grunnet, M. & Olesen, S-P., 2005, In: Physiology. 20, p. 408-16 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • KCNQ1 Potassium Channel 100%
  • Action Potentials 25%
  • Salts 24%
  • Genes 22%
  • Epithelium 21%
  189 Citations (Scopus)

• The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.

  Jensen, H. S., Callø, K., Jespersen, T., Jensen, B. S. & Olesen, S-P., 2005, In: Brain Research. 139, 1, p. 52-62 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • mouse KCNQ5 channel 100%
  • Potassium Channels 44%
  • Zinc 37%
  • 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone 25%
  • Organism Cloning 23%
  51 Citations (Scopus)