Research output per year
Research output per year
Personal profile
CV
Education and employment record
2011- : Industrial postdoc at Uni. Copenhagen/Acesion Pharma,
Co-founder Acesion Pharma
2008-2011: Industrial Ph.D. student at Uni. Copenhagen (Medicine) and NeuroSearch
2008-2008: Research assistant at Uni. Copenhagen (3 months)
2008 : Completes master thesis with top grade (12). MSc. Pharm
Primary scientific focus
- Electrical arrhythmias such as atrial fibrillation and LQT-syndromes 1-3.
- Strong knowledge of biostatistics, cardiovascular physiology, and pharmacology.
Techniques
- Advanced models of atrial fibrillation in large animals with long-term tachypacing of the atria.
- Invented, set up and worked extensively with several new in vivo methods for screening possible anti-AF candidates.
- Langendorff perfused hearts: Isolation of and data acquisition from langendorff hearts from rat, guinea pig and rabbit.
- Patch clamping on isolated cardiomyocytes and heterologous expression systems.
- Isolation of cardiomyocytes from rat and guinea pig.
- Two-electrode voltage clamp on Xenopus oocytes.
Other Activities
Member of the board: The Industrial PhD Association (since 2011)
Member of the board: The Industrial Postdoc Association (since 2013)
Ad hoc reviewer for the following peer reviewed papers:
Circulation, Circulation Arrhythmia and Electrophysiology, Hypertension,
Heart Rhythm, and Reviews of Physiology, Biochemistry & Pharmacology
Fingerprint
Dive into the research topics where Jonas Goldin Diness is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Research output
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The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, S. H., Abildgaard, L., Jespersen, T., Sørensen, U. S., Grunnet, M., Bentzen, B. H. & Diness, J. G., 19 Jun 2019, In: Frontiers in Pharmacology. 10, 668.Research output: Contribution to journal › Journal article › Research › peer-review
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A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels
Simo Vicens, R., Kirchhoff, J. E., Dolce , B., Abildgaard, L., Speerschneider, T., Sørensen, U. S., Grunnet, M., Diness, J. G. & Bentzen, B. H., 5 Dec 2017, In: British Journal of Pharmacology. 174, 23, p. 4396-4408 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels
Simo Vicens, R., Sauter, D. R. P., Grunnet, M., Diness, J. G. & Bentzen, B. H., 15 May 2017, In: European Journal of Pharmacology. 803, p. 118-123 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel negative allosteric modulator inhibits small conductance calcium-activated potassium channels and selectively prolongs atrial refractoriness in conscious pigs
Simó-Vicens, R., Citerni, C., Edvardsson, N. G., Sørensen, U. S., Grunnet, M., Diness, J. G. & Bentzen, B. H., 11 May 2017, In: Heart Rhythm. 14, 5 suppl., p. S149-S150 P-PO02-15.Research output: Contribution to journal › Conference abstract in journal › Research
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Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Diness, J. G., Skibsbye, L., Simó-Vicens, R., Louro Larupa dos Santos, J., Lundegaard, P. R., Citerni, C., Sauter, D. R. P., Bomholtz, S. H., Svendsen, J. H., Olesen, S.-P., Sørensen, U. S., Jespersen, T., Grunnet, M. & Bentzen, B. H., 1 Oct 2017, In: Circulation: Arrhythmia and Electrophysiology. 10, 19 p., e005125.Research output: Contribution to journal › Journal article › Research › peer-review
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Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation
Kirchhoff, J. E., Diness, J. G., Abildgaard, L., Sheykhzade, M., Grunnet, M. & Jespersen, T., 1 Nov 2016, In: Pfluegers Archiv. 468, 11, p. 1853–1863 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy
Diness, J. G., Bentzen, B. H., S. Sørensen, U. & Grunnet, M., 1 Nov 2015, In: Journal of Cardiovascular Pharmacology. 66, 5, p. 441-448 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarisation in human atria.
Skibsbye, L., Poulet, C., Diness, J. G., Bentzen, B. H., Yuan, L., Kappert, U., Matschke, K., Wettwer, E., Ravens, U., Grunnet, M., Christ, T. & Jespersen, T., 1 Jul 2014, In: Cardiovascular Research. 103, 1, p. 156-167 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Press/Media
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Højteknologifonden vilde med erhvervspostdoc'er
05/12/2011
1 Media contribution
Press/Media: Press / Media
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