A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

Martin Nybo Andersen; Katarzyna Krzystanek; Frederic Petersen; Sofia Hammami Bomholtz; Søren-Peter Olesen; Hugues Abriel; Thomas Jespersen; Hanne Borger Rasmussen

doi:10.1074/jbc.M113.525931

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

Martin Nybo Andersen, Katarzyna Krzystanek, Frederic Petersen, Sofia Hammami Bomholtz, Søren-Peter Olesen, Hugues Abriel, Thomas Jespersen, Hanne Borger Rasmussen

20 Citations (Scopus)

Abstract

Background: PI3K regulates the surface expression of Kv7.1. Results: Kv7.1 surface expression depends on PI3K activity in polarized epithelial cells. SGK1 is the primary downstream target of PI3K in this process, which involves inhibition of Nedd4-2-dependent endocytosis of the channel. Conclusion: The surface expression of Kv7.1 is regulated by a PI3K-SGK1-Nedd4-2-mediated pathway. Significance: This pathway could regulate Kv7.1 cell surface expression levels in epithelial cells and cardiac myocytes.

Original language	English
Journal	The Journal of Biological Chemistry
Volume	288
Issue number	52
Pages (from-to)	36841-54
Number of pages	14
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M113.525931
Publication status	Published - 27 Dec 2013

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Andersen, M. N., Krzystanek, K., Petersen, F., Bomholtz, S. H., Olesen, S-P., Abriel, H., Jespersen, T., & Rasmussen, H. B. (2013). A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. The Journal of Biological Chemistry, 288(52), 36841-54. https://doi.org/10.1074/jbc.M113.525931

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. / Andersen, Martin Nybo; Krzystanek, Katarzyna; Petersen, Frederic et al.

In: The Journal of Biological Chemistry, Vol. 288, No. 52, 27.12.2013, p. 36841-54.

Research output: Contribution to journal › Journal article › Research › peer-review

Andersen, MN, Krzystanek, K, Petersen, F, Bomholtz, SH, Olesen, S-P, Abriel, H, Jespersen, T & Rasmussen, HB 2013, 'A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein', The Journal of Biological Chemistry, vol. 288, no. 52, pp. 36841-54. https://doi.org/10.1074/jbc.M113.525931

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title = "A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein",

abstract = "Background: PI3K regulates the surface expression of Kv7.1. Results: Kv7.1 surface expression depends on PI3K activity in polarized epithelial cells. SGK1 is the primary downstream target of PI3K in this process, which involves inhibition of Nedd4-2-dependent endocytosis of the channel. Conclusion: The surface expression of Kv7.1 is regulated by a PI3K-SGK1-Nedd4-2-mediated pathway. Significance: This pathway could regulate Kv7.1 cell surface expression levels in epithelial cells and cardiac myocytes.",

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AU - Andersen, Martin Nybo

AU - Krzystanek, Katarzyna

AU - Petersen, Frederic

AU - Bomholtz, Sofia Hammami

AU - Olesen, Søren-Peter

AU - Abriel, Hugues

AU - Jespersen, Thomas

AU - Rasmussen, Hanne Borger

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AB - Background: PI3K regulates the surface expression of Kv7.1. Results: Kv7.1 surface expression depends on PI3K activity in polarized epithelial cells. SGK1 is the primary downstream target of PI3K in this process, which involves inhibition of Nedd4-2-dependent endocytosis of the channel. Conclusion: The surface expression of Kv7.1 is regulated by a PI3K-SGK1-Nedd4-2-mediated pathway. Significance: This pathway could regulate Kv7.1 cell surface expression levels in epithelial cells and cardiac myocytes.

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JO - Journal of Biological Chemistry

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A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

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