The KCNQ1 potassium channel: from gene to physiological function.

TY - JOUR

T1 - The KCNQ1 potassium channel: from gene to physiological function.

AU - Jespersen, Thomas

AU - Grunnet, Morten

AU - Olesen, Søren-Peter

N1 - Keywords: Animals; Electrophysiology; Epithelium; Heart; Humans; KCNQ1 Potassium Channel

PY - 2005

Y1 - 2005

N2 - The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.

AB - The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.

U2 - 10.1152/physiol.00031.2005

DO - 10.1152/physiol.00031.2005

M3 - Journal article

C2 - 16287990

SN - 1548-9213

VL - 20

SP - 408

EP - 416

JO - Physiology

JF - Physiology

ER -