Ruth Frikke-Schmidt

Research output

Research output per year 2008 2010 2011 2014 2015 2017 2018 2019

• 66 Journal article
• 7 Conference abstract in journal
• 1 Ph.D. thesis
• 1 Letter
• 1 More
  • 1 Review

Research output per year

Research output per year

Search results

• 2019

  Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals

  Juul Rasmussen, I., Tybjærg-Hansen, A., Rasmussen, K. L., Nordestgaard, B. G. & Frikke-Schmidt, R., 2019, In: European Journal of Epidemiology. 34, 6, p. 579-590 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transcytosis 100%
  • Vascular Dementia 68%
  • Dementia 62%
  • Alleles 54%
  • Stroke 51%
  11 Citations (Scopus)

  20 Downloads (Pure)

• Early Life Exposures to Perfluoroalkyl Substances in Relation to Adipokine Hormone Levels at Birth and During Childhood

  Shelly, C., Grandjean, P., Oulhote, Y., Plomgaard, P., Frikke-Schmidt, R., Nielsen, F., Zmirou-Navier, D., Weihe, P. & Valvi, D., 1 Nov 2019, In: The Journal of clinical endocrinology and metabolism. 104, 11, p. 5338-5348

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Resistin 100%
  • Adiponectin 80%
  • Leptin 76%
  • Adipokines 68%
  • Hormone 59%
  7 Citations (Scopus)

• Lactate is a Prognostic Factor in Patients Admitted With Suspected ST-Elevation Myocardial Infarction

  Frydland, M., Møller, J. E., Wiberg, S., Lindholm, M. G., Hansen, R., Henriques, J. P. S., Møller-Helgestad, O. K., Bang, L. E., Frikke-Schmidt, R., Goetze, J. P., Udesen, N. L. J., Thomsen, J. H., Ouweneel, D. M., Obling, L., Ravn, H. B., Holmvang, L., Jensen, L. O., Kjaergaard, J. & Hassager, C., 1 Mar 2019, In: Shock. 51, 3, p. 321-327

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ST Elevation Myocardial Infarction 100%
  • Lactic Acid 80%
  • Blood Pressure 42%
  • Cardiogenic Shock 39%
  • Stroke Volume 30%
  6 Citations (Scopus)

• Metabolic syndrome, inflammation and oxidative stress as potential risk factors for affective disorders: a twin study

  Ottesen, N. M., Meluken, I., Frikke-Schmidt, R., Plomgaard, P., Henrik, E. P., Scheike, T., Fernandes, B., Dodd, S., Berk, M., Kessing, L. V., Miskowiak, K. & Vinberg, M., 2019, In: European Neuropsychopharmacology. 29, Supplement 2, p. S706-S707 2 p., P.4.08 .

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2018

  ABCA7 and risk of dementia and vascular disease in the Danish population

  Kjeldsen, E. W., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 2018, In: Annals of Clinical and Translational Neurology. 5, 1, p. 41-51 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ATP-Binding Cassette Transporters 100%
  • Vascular Diseases 81%
  • Dementia 70%
  • Apolipoproteins E 35%
  • Population 32%
  6 Citations (Scopus)

  104 Downloads (Pure)

• Absolute 10-year risk of dementia by age, sex and APOE genotype: A population-based cohort study

  Rasmussen, K. L., Tybjarg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 2018, In: CMAJ. 190, 35, p. E1033-E1041

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins E 100%
  • Dementia 78%
  • Genotype 67%
  • Cohort Studies 64%
  • Population 36%
  26 Citations (Scopus)

• An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease-A cohort study of 95,442 individuals

  Rasmussen, K. L., Nordestgaard, B. G., Frikke-Schmidt, R. & Nielsen, S. F., Dec 2018, In: Alzheimer's & Dementia. 14, 12, p. 1589-1601 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Complement C3 100%
  • dementia 80%
  • Alzheimer Disease 62%
  • Cohort Studies 54%
  • Random Allocation 39%
  9 Citations (Scopus)

• Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism

  Mandrup, C. M., Egelund, J., Nyberg, M. P., Enevoldsen, L. H., Kjær, A., Clemmensen, A. E., Nymark Christensen, A., Suetta, C., Frikke-Schmidt, R., Enggaard Steenberg, D., Wojtaszewski, J., Hellsten, Y. & Stallknecht, B. M., 1 Feb 2018, In: Menopause . 25, 2, p. 165-175 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Menopause 100%
  • Insulin Resistance 79%
  • Glucose 61%
  • Muscles 58%
  • Thigh 44%
  6 Citations (Scopus)

• Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease

  Qayyum, F., Lauridsen, B. K., Frikke-Schmidt, R., Kofoed, K. F., Nordestgaard, B. G. & Tybjærg-Hansen, A., 2018, In: European Heart Journal. 39, 22, p. 2106-2116 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gallstones 100%
  • Myocardial Infarction 65%
  • LDL Cholesterol 53%
  • Alleles 43%
  • Cholesterol 7-alpha-Hydroxylase 22%
  14 Citations (Scopus)

• Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: Cohort studies and meta-analyses of 362,338 individuals

  Nordestgaard, L. T., Tybjærg-Hansen, A., Rasmussen, K. L., Nordestgaard, B. G. & Frikke-Schmidt, R., 2018, In: BMC Medicine. 16, 11 p., 39.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Clusterin 100%
  • Vascular Diseases 69%
  • Genetic Variation 68%
  • Dementia 59%
  • Meta-Analysis 53%
  12 Citations (Scopus)

• Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans

  Oldoni, F., van Capelleveen, J. C., Dalila, N., Wolters, J. C., Heeren, J., Sinke, R. J., Hui, D. Y., Dallinga-Thie, G. M., Frikke-Schmidt, R., Hovingh, K. G., van de Sluis, B., Tybjærg-Hansen, A. & Kuivenhoven, J. A., 1 Jul 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 7, p. 1440-1453 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Low Density Lipoprotein Receptor-Related Protein-1 100%
  • CD36 Antigens 98%
  • HDL Lipoproteins 72%
  • Adenosine Triphosphate 53%
  • human LRP1 protein 27%
  7 Citations (Scopus)

• Osteoporosis is associated with deteriorating clinical status in adults with cystic fibrosis

  Mathiesen, I. H., Pressler, T., Oturai, P., Katzenstein, T. L., Skov, M., Frikke-Schmidt, R. & Hitz, M. F., 2018, In: International Journal of Endocrinology. 2018, 10 p., 4803974.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cystic Fibrosis 100%
  • Osteoporosis 90%
  • Forced Expiratory Volume 43%
  • Calcium 28%
  • Photon Absorptiometry 21%
  4 Citations (Scopus)

  26 Downloads (Pure)

• Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals

  Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., Jan 2018, In: Alzheimer's & Dementia. 14, 1, p. 71-80

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins E 100%
  • dementia 94%
  • Random Allocation 92%
  • Dementia 78%
  • Alzheimer Disease 29%
  27 Citations (Scopus)

• Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

  Turcot, V., Lu, Y., Highland, H. M., Bang, L. E., Benn, M., Kamstrup, P. R., Bork-Jensen, J., Frikke-Schmidt, R., Gjesing, A. P., Grarup, N., Hansen, T., Have, C. T., Jørgensen, T., Nielsen, S. F., Linneberg, A. R., Pedersen, O., Pers, T. H., Vestergaard, H., Nordestgaard, B., Tybjærg-Hansen, A., & 15 othersVarbo, A., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetics Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., 1 Jan 2018, In: Nature Genetics. 50, p. 26-41 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Energy Intake 100%
  • Energy Metabolism 89%
  • Body Mass Index 71%
  • Obesity 69%
  • Genome-Wide Association Study 41%
  128 Citations (Scopus)

• The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people

  EuroSIDA in EuroCoord, Feb 2018, In: HIV Medicine. 19, 2, p. 90-101 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • activation 100%
  • Lymphoma 85%
  • B-Lymphocytes 78%
  • HIV 70%
  • confidence 64%
  5 Citations (Scopus)

• U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies

  Madsen, C. M., Varbo, A., Tybjærg-Hansen, A., Frikke-Schmidt, R. & Nordestgaard, B. G., 7 Apr 2018, In: European Heart Journal. 39, 14, p. 1181-1190 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • HDL Cholesterol 100%
  • Communicable Diseases 95%
  • Cohort Studies 75%
  • Population 43%
  • Immune System 29%
  58 Citations (Scopus)
• 2017

  Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort

  Grunnet, L. G., Hansen, S., Hjort, L., Madsen, C. M., Kampmann, F. B., Thuesen, A. C. B., Granstrømi, C., Strøm, M., Maslova, E., Frikke-Schmidt, R., Damm, P., Chavarro, J. E., Hu, F. B., Olsen, S. F. & Vaag, A., 1 Dec 2017, In: Diabetes Care. 40, 12, p. 1746-1755 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gestational Diabetes 100%
  • Puberty 94%
  • Adiposity 93%
  • Parturition 62%
  • Clinical Studies 61%
  40 Citations (Scopus)

  53 Downloads (Pure)

• Aerobic exercise training lowers platelet reactivity and improves platelet sensitivity to prostacyclin in pre- and postmenopausal women

  Lundberg Slingsby, M. H., Nyberg, M. P., Egelund, J., Mandrup, C. M., Frikke-Schmidt, R., Kirkby, N. S. & Hellsten, Y., Dec 2017, In: Journal of Thrombosis and Haemostasis. 15, 12, p. 2419-2431 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Epoprostenol 100%
  • Blood Platelets 69%
  • Exercise 57%
  • Menopause 30%
  • Platelet Aggregation 14%
  9 Citations (Scopus)

• Body mass index and risk of Alzheimer's disease: A mendelian randomization study of 399,536 individuals

  Nordestgaard, L. T., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., Jul 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2310-2320 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Random Allocation 100%
  • Alzheimer Disease 79%
  • Body Mass Index 73%
  • Confidence Intervals 34%
  • Genomics 29%
  15 Citations (Scopus)

• Exome-wide association study of plasma lipids in >300,000 individuals

  Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C., & 207 othersBoehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, R., Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, J. M., Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, A., Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, B. G., Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, O., Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjaerg-Hansen, A., Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J. & Kathiresan, S., 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.

  Research output: Contribution to journal › Letter › peer-review

  • Exome 100%
  • Lipids 54%
  • Cholesterol 49%
  • Coronary Artery Disease 41%
  • Triglycerides 40%
  209 Citations (Scopus)

  50 Downloads (Pure)

• Genetic variation in WRN and ischemic stroke: General population studies and meta-analyses

  Christoffersen, M., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjærg-Hansen, A., Mar 2017, In: Experimental Gerontology. 89, p. 69-77 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genetic Variation 100%
  • Meta-Analysis 77%
  • Stroke 70%
  • Heart 57%
  • Vascular Diseases 57%
  6 Citations (Scopus)

• Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

  Zhao, W., Rasheed, A., Tikkanen, E., Lee, J-J., Butterworth, A. S., Howson, J. M. M., Assimes, T. L., Chowdhury, R., Orho-Melander, M., Damrauer, S., Small, A., Asma, S., Imamura, M., Yamauch, T., Chambers, J. C., Chen, P., Sapkota, B. R., Shah, N., Jabeen, S., Surendran, P., & 31 othersLu, Y., Zhang, W., Imran, A., Abbas, S., Majeed, F., Trindade, K., Qamar, N., Mallick, N. H., Yaqoob, Z., Saghir, T., Rizvi, S. N. H., Memon, A., Rasheed, S. Z., Memon, F-U-R., Mehmood, K., Ahmed, N., Qureshi, I. H., Tanveer-Us-Salam, Iqbal, W., Malik, U., Mehra, N., Kuo, J. Z., Sheu, W. H-H., Guo, X., Hsiung, C. A., Juang, J-M. J., Nordestgaard, B. G., Tybjaerg-Hansen, A., Benn, M., Frikke-Schmidt, R. & CHD Exome+ Consortium, 1 Oct 2017, In: Nature Genetics. 49, 10, p. 1450-1457 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coronary Disease 100%
  • Type 2 Diabetes Mellitus 84%
  • HLA-DRB5 Chains 23%
  • eicosapentaenoic acid ethyl ester 22%
  • Joints 17%
  91 Citations (Scopus)

• Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase

  Nyberg, M. P., Egelund, J., Mandrup Jensen, C. M., Andersen, C. B., Hansen, K. M. B. E., Hergel, I-M. F., Valbak-Andersen, N., Frikke-Schmidt, R., Stallknecht, B. M., Bangsbo, J. & Hellsten, Y., 1 May 2017, In: Journal of Physiology. 595, 9, p. 2969-2983 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Leg 100%
  • Skeletal Muscle 97%
  • Exercise 79%
  • Blood Vessels 72%
  • Nitric Oxide Synthase Type III 18%
  18 Citations (Scopus)

• Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study

  Benn, M., Nordestgaard, B. G., Frikke-Schmidt, R. & Tybjærg-Hansen, A., 24 Apr 2017, In: B M J. 357, 11 p., j1648.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hydroxymethylglutaryl CoA Reductases 100%
  • Random Allocation 71%
  • Genetic Variation 70%
  • LDL Cholesterol 65%
  • Parkinson Disease 60%
  67 Citations (Scopus)

  68 Downloads (Pure)

• Rare and low-frequency coding variants alter human adult height

  Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T., & 31 othersLocke, A. E., Masca, N. G. D., Ng, M. C. Y., Mudgal, P., Rivas, M. A., Vedantam, S., Mahajan, A., Guo, X., Abecasis, G., Aben, K. K., Allin, K. H., Appel, E. V., Bang, L. E., Benn, M., Bork-Jensen, J., Frikke-Schmidt, R., Grarup, N., Hansen, T., Hollensted, M., Jensen, G. B., Jørgensen, M. E., Jørgensen, T., Kamstrup, P. R., Linneberg, A., Nielsen, S. F., Nordestgaard, B. G., Pedersen, O., Tybjaerg-Hansen, A., Vestergaard, H., Pers, T. H. & EPIC-InterAct Consortium, 9 Feb 2017, In: Nature. 542, 7640, p. 186-190 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Alleles 100%
  • Insulin-Like Growth Factor Binding Protein 4 70%
  • Pregnancy-Associated Plasma Protein-A 65%
  • Growth Disorders 56%
  • Multifactorial Inheritance 56%
  277 Citations (Scopus)

• The Bipolar Illness Onset study: research protocol for the BIO cohort study

  Kessing, L. V., Munkholm, K., Faurholt-Jepsen, M., Miskowiak, K. W., Nielsen, L. B., Frikke-Schmidt, R., Ekstrøm, C. T., Winther, O., Pedersen, B. K., Poulsen, H. E., McIntyre, R. S., Kapczinski, F., Gattaz, W. F., Bardram, J., Frost, M., Mayora, O., Knudsen, G. M., Phillips, M. & Vinberg, M., 2017, In: BMJ Open. 7, 6, 12 p., e015462.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Bipolar Disorder 100%
  • Cohort Studies 70%
  • Smartphone 27%
  • Congresses 22%
  • Biomarkers 22%
  55 Citations (Scopus)

  165 Downloads (Pure)

• Using genetics to explore whether the cholesterol-lowering drug ezetimibe may cause an increased risk of cancer

  Kobberø Lauridsen, B., Stender, S., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjærg-Hansen, A., 1 Dec 2017, In: International Journal of Epidemiology. 46, 6, p. 1777-1785

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ezetimibe 100%
  • Cholesterol 53%
  • Pharmaceutical Preparations 30%
  • Alleles 24%
  • Neoplasms 23%
  2 Citations (Scopus)
• 2016

  Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease

  Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 1 Mar 2016, In: Data in Brief. 6, p. 923-932 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins E 100%
  • Lipoproteins 89%
  • Myocardial Ischemia 83%
  • Genotype 67%
  • Lipids 61%
  7 Citations (Scopus)

  89 Downloads (Pure)

• Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population

  Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 1 Mar 2016, In: Atherosclerosis. 246, p. 63-70 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins E 100%
  • Myocardial Ischemia 83%
  • Population 36%
  • Triglycerides 32%
  • Myocardial Infarction 29%
  16 Citations (Scopus)

• Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

  CHD Exome+ Consortium, CARDIoGRAM Exome Consortium & Global Lipids Genetics Consortium, 11 Mar 2016, In: Science (New York, N.Y.). 351, 6278, p. 1166-71 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Scavenger Receptors 100%
  • HDL Lipoproteins 81%
  • HDL Cholesterol 69%
  • Coronary Disease 68%
  • Induced Pluripotent Stem Cells 14%
  278 Citations (Scopus)

• Relation between plasma and brain lipids

  Wellington, C. L. & Frikke-Schmidt, R., 1 Jun 2016, In: Current Opinion in Lipidology. 27, 3, p. 225-232 8 p.

  Research output: Contribution to journal › Review › peer-review

  • Apolipoproteins 100%
  • Lipids 55%
  • Lipoproteins 48%
  • Dementia 42%
  • Brain 41%
  12 Citations (Scopus)
• 2015

  Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

  Laursen, J. H., Søndergaard, H. B., Albrechtsen, A., Frikke-Schmidt, R., Koch-Henriksen, N., Sørensen, P. S., Sellebjerg, F. T. & Oturai, A. B., 1 Oct 2015, In: Multiple Sclerosis Journal. 21, 11, p. 1414-1422 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 25-hydroxyvitamin D 100%
  • Multiple Sclerosis 75%
  • Single Nucleotide Polymorphism 71%
  • Vitamin D 47%
  • Genome-Wide Association Study 35%
  12 Citations (Scopus)

• Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease

  Lauridsen, B. K., Stender, S., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjærg-Hansen, A., 1 Jul 2015, In: European Heart Journal. 36, 25, p. 1601-8 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Niemann-Pick C1 Protein 100%
  • Gallstones 64%
  • Vascular Diseases 55%
  • Genetic Variation 55%
  • Ezetimibe 52%
  38 Citations (Scopus)

• HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study

  Haase, C. L., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., Sept 2015, In: Diabetes. 64, 9, p. 3328-33 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Random Allocation 100%
  • HDL Cholesterol 91%
  • Type 2 Diabetes Mellitus 76%
  • Alleles 14%
  • Causality 9%
  75 Citations (Scopus)

• Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

  Nordestgaard, L. T., Tybjærg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 1 Dec 2015, In: Alzheimer's & Dementia. 11, 12, p. 1430-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • loss of function 100%
  • sound storage medium 79%
  • Loss of Function Mutation 67%
  • Apolipoproteins E 63%
  • Cerebrovascular Disorders 61%
  61 Citations (Scopus)

• Plasma levels of apolipoprotein E and risk of dementia in the general population

  Rasmussen, K. L., Tybjaerg-Hansen, A., Nordestgaard, B. G. & Frikke-Schmidt, R., 1 Feb 2015, In: Annals of Neurology. 77, 2, p. 301-11 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins E 100%
  • Apolipoprotein E4 85%
  • Dementia 78%
  • Alzheimer Disease 73%
  • Apolipoprotein E3 69%
  89 Citations (Scopus)

• Subgroups at high risk for ischaemic heart disease:identification and validation in 67 000 individuals from the general population

  Frikke-Schmidt, R., Tybjærg-Hansen, A., Dyson, G., Haase, C. L., Benn, M., Nordestgaard, B. G. & Sing, C. F., 1 Feb 2015, In: International Journal of Epidemiology. 44, 1, p. 117-128 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Myocardial Ischemia 100%
  • Incidence 54%
  • Population 44%
  • Heart 44%
  • lipoprotein triglyceride 30%
  5 Citations (Scopus)
• 2014

  A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease

  Holmes, M. V., Frikke-Schmidt, R., Melis, D., Luben, R., Asselbergs, F. W., Boer, J. M. A., Cooper, J., Palmen, J., Horvat, P., Engmann, J., Li, K-W., Onland-Moret, N. C., Hofker, M. H., Kumari, M., Keating, B. J., Hubacek, J. A., Adamkova, V., Kubinova, R., Bobak, M., Khaw, K-T., & 6 othersNordestgaard, B. G., Wareham, N., Humphries, S. E., Langenberg, C., Tybjaerg-Hansen, A. & Talmud, P. J., 1 Dec 2014, In: Atherosclerosis. 237, 1, p. 5-12 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coronary Disease 100%
  • Meta-Analysis 84%
  • Systematic Reviews 83%
  • Smoking 81%
  • Genotype 80%
  19 Citations (Scopus)

• Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease

  Jørgensen, A. B., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjærg-Hansen, A., Jul 2014, In: New England Journal of Medicine. 371, 1, p. 32-41 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins 100%
  • Loss of Function Mutation 95%
  • Vascular Diseases 82%
  • Triglycerides 67%
  • Myocardial Ischemia 53%
  525 Citations (Scopus)

• Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2

  Christiansen, M., Hedley, P. L., Theilade, J., Stoevring, B., Leren, T. P., Eschen, O., Sørensen, K. M., Tybjærg-Hansen, A., Ousager, L. B., Pedersen, L. N., Frikke-Schmidt, R., Aidt, F. H., Hansen, M. G., Hansen, J., Bloch Thomsen, P. E., Toft, E., Henriksen, F. L., Bundgaard, H., Jensen, H. K. & Kanters, J. K., 7 Mar 2014, In: BMC Medical Genetics. 15, 11 p., 31.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT Syndrome 100%
  • Mutation 43%
  • Channelopathies 15%
  • Genes 13%
  • Exome 13%
  9 Citations (Scopus)

• The ABCG5/8 Cholesterol Transporter and Myocardial Infarction Versus Gallstone Disease

  Stender, S., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjaerg-Hansen, A., 27 May 2014, In: Journal of the American College of Cardiology. 63, 20, p. 2121-2128 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gallstones 100%
  • Cholesterol 65%
  • Myocardial Infarction 65%
  • LDL Cholesterol 48%
  • Genetic Variation 34%
  29 Citations (Scopus)

• Validated context-dependent associations of coronary heart disease risk with genotype variation in the chromosome 9p21 region: the Atherosclerosis Risk in Communities study

  Lusk, C. M., Dyson, G., Clark, A. G., Ballantyne, C. M., Frikke-Schmidt, R., Tybjærg-Hansen, A., Boerwinkle, E. & Sing, C. F., 1 Sept 2014, In: Human Genetics. 133, 9, p. 1105-1116 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coronary Disease 100%
  • Atherosclerosis 91%
  • Chromosomes 89%
  • Genotype 80%
  • Single Nucleotide Polymorphism 67%
  13 Citations (Scopus)

• Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population: A Prospective Cohort Study

  Christoffersen, M., Frikke-Schmidt, R., Schnohr, P., Jensen, G. B., Nordestgaard, B. G. & Tybjærg-Hansen, A., 4 Mar 2014, In: Circulation Research. 129, 9, p. 990-998 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Myocardial Ischemia 100%
  • Cohort Studies 77%
  • Prospective Studies 72%
  • Myocardial Infarction 71%
  • Alopecia 45%
  51 Citations (Scopus)
• 2013

  A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

  Amin Al Olama, A., Kote-Jarai, Z., Schumacher, F. R., Wiklund, F., Berndt, S. I., Benlloch, S., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., Donovan, J. L., Hunter, D. J., Henderson, B. E., Thun, M. J., Gaziano, M., Giovannucci, E. L., Siddiq, A., Travis, R. C., Cox, D. G., Canzian, F., & 31 othersRiboli, E., Key, T. J., Andriole, G., Albanes, D., Hayes, R. B., Schleutker, J., Auvinen, A., Tammela, T. L. J., Weischer, M., Stanford, J. L., Ostrander, E. A., Cybulski, C., Lubinski, J., Thibodeau, S. N., Schaid, D. J., Sorensen, K. D., Batra, J., Clements, J. A., Chambers, S., Aitken, J., Gardiner, R. A., Maier, C., Vogel, W., Dörk, T., Brenner, H., Klarskov, P., Nordestgaard, B. G., Røder, M. A., Frikke-Schmidt, R., Bojesen, S. E. & The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, Jan 2013, In: Human Molecular Genetics. 22, 2, p. 408-415 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genome-Wide Association Study 100%
  • Prostatic Neoplasms 75%
  • Meta-Analysis 71%
  • Single Nucleotide Polymorphism 22%
  • Chromosomes, Human, Pair 19 18%
  100 Citations (Scopus)

• Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals

  Khan, T. A., Shah, T., Prieto, D., Zhang, W., Price, J., Fowkes, G. R., Cooper, J., Talmud, P. J., Humphries, S. E., Sundstrom, J., Hubacek, J. A., Ebrahim, S., Lawlor, D. A., Ben-Shlomo, Y., Abdollahi, M. R., Slooter, A. J. C., Szolnoki, Z., Sandhu, M., Wareham, N., Frikke-Schmidt, R., & 29 othersTybjærg-Hansen, A., Fillenbaum, G., Heijmans, B. T., Katsuya, T., Gromadzka, G., Singleton, A., Ferrucci, L., Hardy, J., Worrall, B., Rich, S. S., Matarin, M., Whittaker, J., Gaunt, T. R., Whincup, P., Morris, R., Deanfield, J., Donald, A., Davey Smith, G., Kivimaki, M., Kumari, M., Smeeth, L., Khaw, K-T., Nalls, M., Meschia, J., Sun, K., Hui, R., Day, I., Hingorani, A. D. & Casas, J. P., Apr 2013, In: International Journal of Epidemiology. 42, 2, p. 475-492 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins E 100%
  • Meta-Analysis 70%
  • Systematic Reviews 69%
  • Genotype 67%
  • Stroke 64%
  90 Citations (Scopus)

• Extreme Bilirubin Levels as a Causal Risk Factor for Symptomatic Gallstone Disease

  Stender, S., Frikke-Schmidt, R., Nordestgaard, B. G. & Tybjærg-Hansen, A., 8 Jul 2013, In: Annals of Internal Medicine. 173, 13, p. 1222-1228 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gallstones 100%
  • Bilirubin 87%
  • Homozygote 30%
  • Heterozygote 14%
  • UGT1A1 enzyme 11%
  31 Citations (Scopus)

• Lipoprotein Subclass Profiling Reveals Pleiotropy in the Genetic Variants of Lipid Risk Factors for Coronary Heart Disease: A Note on Mendelian Randomization Studies

  Würtz, P., Kangas, A. J., Soininen, P., Lehtimäki, T., Kähönen, M., Viikari, J. S., Raitakari, O. T., Järvelin, M-R., Davey Smith, G., Ala-Korpela, M., Tybjærg-Hansen, A. & Frikke-Schmidt, R., 12 Nov 2013, In: Journal of the American College of Cardiology. 62, 20, p. 1906-8 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  29 Citations (Scopus)

• The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis

  Singh, G. M., Danaei, G., Farzadfar, F., Stevens, G. A., Woodward, M., Wormser, D., Kaptoge, S., Whitlock, G., Qiao, Q., Lewington, S., Di Angelantonio, E., Vander Hoorn, S., Lawes, C. M. M., Ali, M. K., Mozaffarian, D., Ezzati, M., Tybjærg-Hansen, A., Frikke-Schmidt, R., Benn, M. & Nordestgaard, B. G., 30 Jul 2013, In: P L o S One. 8, 7, p. 1-10 10 p., e65174.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cardiovascular Disease 100%
  • Diabetes 89%
  • diabetes 83%
  • Risk Factors 82%
  • cardiovascular disease 77%
  280 Citations (Scopus)
• 2012

  The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles

  Christoffersen, C., Benn, M., Christensen, P. M., Gordts, P. L. S. M., Roebroek, A. J. M., Frikke-Schmidt, R., Tybjaerg-Hansen, A., Dahlback, B. & Nielsen, L. B., Oct 2012, In: Journal of Lipid Research.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apolipoproteins M 100%
  • Apolipoprotein 68%
  • LDL Receptors 65%
  • Plasma Concentration 65%
  • Apolipoproteins B 62%
  26 Citations (Scopus)
• 2011

  Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses

  Nørskov, M. S., Frikke-Schmidt, R., Loft, S., Sillesen, H., Grande, P., Nordestgaard, B. G. & Tybjaerg-Hansen, A., Aug 2011, In: Circulation: Cardiovascular Genetics. 4, 4, p. 418-28 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • glutathione S-transferase M1 100%
  • glutathione S-transferase T1 99%
  • Vascular Diseases 63%
  • Meta-Analysis 48%
  • Myocardial Ischemia 34%
  35 Citations (Scopus)