Osteoporosis is associated with deteriorating clinical status in adults with cystic fibrosis

TY - JOUR

T1 - Osteoporosis is associated with deteriorating clinical status in adults with cystic fibrosis

AU - Mathiesen, Inger Hee

AU - Pressler, Tacjana

AU - Oturai, Peter

AU - Katzenstein, Terese Lea

AU - Skov, Marianne

AU - Frikke-Schmidt, Ruth

AU - Hitz, Mette Friberg

PY - 2018

Y1 - 2018

N2 - Background. Cystic fibrosis (CF) patients are in increased risk of osteoporosis. We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status' association with bone mineral density evaluated by dual X-ray absorptiometry scan. Methods. We performed a cross section database study of adults at a tertiary CF Center. Z scores were applied for patients < 50 years of age and T scores for patients > 50 years of age. Results. One hundred twenty-five patients were included. Compared to nonosteoporotic patients, osteoporotic patients (15%) had significantly lower percent predicted forced expiratory volume in 1 second (pp FEV1 ), lower body mass index, higher frequency of CF-related diabetes and chronic lung infection, and higher high-sensitive C-reactive protein and glycated hemoglobin levels. Vitamin D was not associated with any outcome. In multivariate analyses, only pp FEV1 and female gender were independently associated with Z scores. Conclusions. Osteoporosis in CF occurs with deteriorating clinical status while the role of calcium metabolism seems minor. Gender specific and dysglycemic impact on bone status should be investigated further.

AB - Background. Cystic fibrosis (CF) patients are in increased risk of osteoporosis. We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status' association with bone mineral density evaluated by dual X-ray absorptiometry scan. Methods. We performed a cross section database study of adults at a tertiary CF Center. Z scores were applied for patients < 50 years of age and T scores for patients > 50 years of age. Results. One hundred twenty-five patients were included. Compared to nonosteoporotic patients, osteoporotic patients (15%) had significantly lower percent predicted forced expiratory volume in 1 second (pp FEV1 ), lower body mass index, higher frequency of CF-related diabetes and chronic lung infection, and higher high-sensitive C-reactive protein and glycated hemoglobin levels. Vitamin D was not associated with any outcome. In multivariate analyses, only pp FEV1 and female gender were independently associated with Z scores. Conclusions. Osteoporosis in CF occurs with deteriorating clinical status while the role of calcium metabolism seems minor. Gender specific and dysglycemic impact on bone status should be investigated further.

U2 - 10.1155/2018/4803974

DO - 10.1155/2018/4803974

M3 - Journal article

C2 - 29780417

AN - SCOPUS:85056099000

SN - 1687-8337

VL - 2018

JO - International Journal of Endocrinology

JF - International Journal of Endocrinology

M1 - 4803974

ER -