A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Ali Amin Al Olama; Zsofia Kote-Jarai; Fredrick R Schumacher; Fredrik Wiklund; Sonja I Berndt; Sara Benlloch; Graham G Giles; Gianluca Severi; David E Neal; Freddie C Hamdy; Jenny L Donovan; David J Hunter; Brian E Henderson; Michael J Thun; Michael Gaziano; Edward L Giovannucci; Afshan Siddiq; Ruth C Travis; David G Cox; Federico Canzian; Elio Riboli; Timothy J Key; Gerald Andriole; Demetrius Albanes; Richard B Hayes; Johanna Schleutker; Anssi Auvinen; Teuvo L J Tammela; Maren Weischer; Janet L Stanford; Elaine A Ostrander; Cezary Cybulski; Jan Lubinski; Stephen N Thibodeau; Daniel J Schaid; Karina D Sorensen; Jyotsna Batra; Judith A Clements; Suzanne Chambers; Joanne Aitken; Robert A Gardiner; Christiane Maier; Walther Vogel; Thilo Dörk; Hermann Brenner; Peter Klarskov; Børge G Nordestgaard; Martin Andreas Røder; Ruth Frikke-Schmidt; Stig Egil Bojesen; The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

doi:10.1093/hmg/dds425

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Ali Amin Al Olama, Zsofia Kote-Jarai, Fredrick R Schumacher, Fredrik Wiklund, Sonja I Berndt, Sara Benlloch, Graham G Giles, Gianluca Severi, David E Neal, Freddie C Hamdy, Jenny L Donovan, David J Hunter, Brian E Henderson, Michael J Thun, Michael Gaziano, Edward L Giovannucci, Afshan Siddiq, Ruth C Travis, David G Cox, Federico CanzianElio Riboli, Timothy J Key, Gerald Andriole, Demetrius Albanes, Richard B Hayes, Johanna Schleutker, Anssi Auvinen, Teuvo L J Tammela, Maren Weischer, Janet L Stanford, Elaine A Ostrander, Cezary Cybulski, Jan Lubinski, Stephen N Thibodeau, Daniel J Schaid, Karina D Sorensen, Jyotsna Batra, Judith A Clements, Suzanne Chambers, Joanne Aitken, Robert A Gardiner, Christiane Maier, Walther Vogel, Thilo Dörk, Hermann Brenner, Peter Klarskov, Børge G Nordestgaard, Martin Andreas Røder, Ruth Frikke-Schmidt, Stig Egil Bojesen, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

Department of Clinical Medicine

100 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

Original language	English
Journal	Human Molecular Genetics
Volume	22
Issue number	2
Pages (from-to)	408-415
Number of pages	8
ISSN	0964-6906
DOIs	https://doi.org/10.1093/hmg/dds425
Publication status	Published - Jan 2013

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Amin Al Olama, A., Kote-Jarai, Z., Schumacher, F. R., Wiklund, F., Berndt, S. I., Benlloch, S., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., Donovan, J. L., Hunter, D. J., Henderson, B. E., Thun, M. J., Gaziano, M., Giovannucci, E. L., Siddiq, A., Travis, R. C., Cox, D. G., ... The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology (2013). A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human Molecular Genetics, 22(2), 408-415. https://doi.org/10.1093/hmg/dds425

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. / Amin Al Olama, Ali; Kote-Jarai, Zsofia; Schumacher, Fredrick R et al.

In: Human Molecular Genetics, Vol. 22, No. 2, 01.2013, p. 408-415.

Research output: Contribution to journal › Journal article › Research › peer-review

Amin Al Olama, A, Kote-Jarai, Z, Schumacher, FR, Wiklund, F, Berndt, SI, Benlloch, S, Giles, GG, Severi, G, Neal, DE, Hamdy, FC, Donovan, JL, Hunter, DJ, Henderson, BE, Thun, MJ, Gaziano, M, Giovannucci, EL, Siddiq, A, Travis, RC, Cox, DG, Canzian, F, Riboli, E, Key, TJ, Andriole, G, Albanes, D, Hayes, RB, Schleutker, J, Auvinen, A, Tammela, TLJ, Weischer, M, Stanford, JL, Ostrander, EA, Cybulski, C, Lubinski, J, Thibodeau, SN, Schaid, DJ, Sorensen, KD, Batra, J, Clements, JA, Chambers, S, Aitken, J, Gardiner, RA, Maier, C, Vogel, W, Dörk, T, Brenner, H, Klarskov, P, Nordestgaard, BG , Røder, MA , Frikke-Schmidt, R , Bojesen, SE & The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2013, 'A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease', Human Molecular Genetics, vol. 22, no. 2, pp. 408-415. https://doi.org/10.1093/hmg/dds425

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title = "A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease",

abstract = "Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.",

author = "{Amin Al Olama}, Ali and Zsofia Kote-Jarai and Schumacher, {Fredrick R} and Fredrik Wiklund and Berndt, {Sonja I} and Sara Benlloch and Giles, {Graham G} and Gianluca Severi and Neal, {David E} and Hamdy, {Freddie C} and Donovan, {Jenny L} and Hunter, {David J} and Henderson, {Brian E} and Thun, {Michael J} and Michael Gaziano and Giovannucci, {Edward L} and Afshan Siddiq and Travis, {Ruth C} and Cox, {David G} and Federico Canzian and Elio Riboli and Key, {Timothy J} and Gerald Andriole and Demetrius Albanes and Hayes, {Richard B} and Johanna Schleutker and Anssi Auvinen and Tammela, {Teuvo L J} and Maren Weischer and Stanford, {Janet L} and Ostrander, {Elaine A} and Cezary Cybulski and Jan Lubinski and Thibodeau, {Stephen N} and Schaid, {Daniel J} and Sorensen, {Karina D} and Jyotsna Batra and Clements, {Judith A} and Suzanne Chambers and Joanne Aitken and Gardiner, {Robert A} and Christiane Maier and Walther Vogel and Thilo D{\"o}rk and Hermann Brenner and Peter Klarskov and Nordestgaard, {B{\o}rge G} and R{\o}der, {Martin Andreas} and Ruth Frikke-Schmidt and Bojesen, {Stig Egil} and B{\o}rge Nordestgaard",

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doi = "10.1093/hmg/dds425",

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T1 - A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

AU - Amin Al Olama, Ali

AU - Kote-Jarai, Zsofia

AU - Schumacher, Fredrick R

AU - Wiklund, Fredrik

AU - Berndt, Sonja I

AU - Benlloch, Sara

AU - Giles, Graham G

AU - Severi, Gianluca

AU - Neal, David E

AU - Hamdy, Freddie C

AU - Donovan, Jenny L

AU - Hunter, David J

AU - Henderson, Brian E

AU - Thun, Michael J

AU - Gaziano, Michael

AU - Giovannucci, Edward L

AU - Siddiq, Afshan

AU - Travis, Ruth C

AU - Cox, David G

AU - Canzian, Federico

AU - Riboli, Elio

AU - Key, Timothy J

AU - Andriole, Gerald

AU - Albanes, Demetrius

AU - Hayes, Richard B

AU - Schleutker, Johanna

AU - Auvinen, Anssi

AU - Tammela, Teuvo L J

AU - Weischer, Maren

AU - Stanford, Janet L

AU - Ostrander, Elaine A

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Thibodeau, Stephen N

AU - Schaid, Daniel J

AU - Sorensen, Karina D

AU - Batra, Jyotsna

AU - Clements, Judith A

AU - Chambers, Suzanne

AU - Aitken, Joanne

AU - Gardiner, Robert A

AU - Maier, Christiane

AU - Vogel, Walther

AU - Dörk, Thilo

AU - Brenner, Hermann

AU - Klarskov, Peter

AU - Nordestgaard, Børge G

AU - Røder, Martin Andreas

AU - Frikke-Schmidt, Ruth

AU - Bojesen, Stig Egil

AU - The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

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N2 - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

AB - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

U2 - 10.1093/hmg/dds425

DO - 10.1093/hmg/dds425

M3 - Journal article

C2 - 23065704

SN - 0964-6906

VL - 22

SP - 408

EP - 415

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 2

ER -

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Abstract

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