Osman Asghar Mirza

2019

An Optimized Screen Reduces the Number of GA Transporters and Provides Insights Into Nitrate Transporter 1/Peptide Transporter Family Substrate Determinants

Wulff, N., Ernst, H. A., Jørgensen, M. E., Lambertz, S., Maierhofer, T., Belew, Z. M., Crocoll, C., Motawia, M. S., Geiger, D., Jørgensen, F. S., Mirza, O. & Nour-Eldin, H. H., 3 Oct 2019, In: Frontiers in Plant Science. 10

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase1

Petersen, A., Gram Hansen, L., Mirza, N., Crocoll, C., Mirza, O. A. & Halkier, B. A., 2 Jul 2019, In: Bioscience Reports. 39, p. 1-15 BSR20190446.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

31 Downloads (Pure)

Detection of Paracetamol as substrate of the gut microbiome

Mukhtar, I., Anwar, H., Hussain, G., Rasul, A., Naqvi, S. A. R., Faisal, M. N., Mustafa, I., Malik, S., Shaukat, A., Mirza, O. A. & Sohail, M. U., Mar 2019, In: Pakistan Journal of Pharmaceutical Sciences. 32, 2 (Supplementary), p. 751-757 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

10 Downloads (Pure)

In silico Epitope Prediction and Immunogenic Analysis for Penton base Epitope-focused Vaccine against Hydropericardium syndrome in chicken

Aziz, F., Tufail, S., Shah, M. A., Salahuddin Shah, M., Habib, M., Mirza, O., Iqbal, M. & Rahman, M., Nov 2019, In: Virus Research. p. 197750

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Molecular architecture of the Jumonji C family histone demethylase KDM5B

Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, O., Lousen, R., Bucciarelli, S., Mehta, V., Sellés-Baiget, S., Solbak, S. M. Ø., Bach, A., Mesa, P., Hernandez, P. A., Montoya, G., Nguyen, T. T. T. N., Rand, K. D., Boesen, T. & Gajhede, M., 1 Dec 2019, In: Scientific Reports. 9, 13 p., 4019.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

57 Downloads (Pure)

Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH

Aduri, N. G., Montefiori, M., Khalil, R., Gajhede, M., Jørgensen, F. S. & Mirza, O., 25 Jan 2019, In: ACS Omega. 4, 1, p. 2040-2046 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Reserpine Is the New Addition into the Repertoire of AcrB Efflux Pump Inhibitors

Translated title of the contribution: Reserpine Is the New Addition into the Repertoire of AcrB Efflux Pump InhibitorsShaheen, A., Afridi, W. A., Mahboob, S., Sana, M., Zeeshan, N., Ismat, F., Mirza, O., Iqbal, M. & Rahman, M., 1 Jul 2019, In: Molecular Biology. 53, 4, p. 674-684 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Restraining the multidrug efflux transporter STY4874 of Salmonella Typhi by reserpine and plant extracts

Tariq, A., Sana, M., Shaheen, A., Ismat, F., Mahboob, S., Rauf, W., Mirza, O., Iqbal, M. & Rahman, M., 2019, In: Letters in Applied Microbiology.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

Frydenvang, K., Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, O., Jørgensen, F. S. & Geerke, D. P., May 2019, In: PLoS ONE. 14, 5, 15 p., e0217292.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

14 Downloads (Pure)

2018

Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state

Aduri, N. G., Ernst, H. A., Prabhala, B. K., Bhatt, S., Boesen, T., Gajhede, M. & Mirza, O., 8 Jan 2018, In: Biochemical and Biophysical Research Communications. 495, 2, p. 1738-1743 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, P. R., Brasen, C., Gajhede, M., Rahman, M. & Mirza, O., 19 Jan 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

2017

Anandamide and 2-AG Are Endogenously Present within the Laterodorsal Tegmental Nucleus: Functional Implications for a role of eCBs in arousal

Soni, N., Prabhala, B. K., Mehta, V., Mirza, O. A. & Kohlmeier, K. A., 15 Jun 2017, In: Brain Research. 1665, p. 74-79 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Expression, purification and characterization of the human MTA2-RBBP7 complex

Brasen, C., Dorosz, J., Wiuf, A., Boesen, T., Mirza, O. & Gajhede, M., 1 May 2017, In: Biochimica et biophysica acta. 1865, 5, p. 531-538 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization

Hameed, U., Price, I., Ikram-Ul-Haq, Ke, A., Wilson, D. B. & Mirza, O., Oct 2017, In: B B A - Proteins and Proteomics. 1865, 10, p. 1237-1245 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Origin and evolution of transporter substrate specificity within the NPF family

Jørgensen, M. E., Xu, D., Crocoll, C., Ernst, H. A., Ramírez, D., Motawie, M. S., Olsen, C. E., Mirza, O. A., Nour-Eldin, H. H. & Halkier, B. A., 3 Mar 2017, In: eLife. 6, 30 p., e19466.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

192 Downloads (Pure)

Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, M., Hansen, P. R. & Mirza, O., Jun 2017, In: Research in Microbiology. 168, 5, p. 443-449

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Structural Biology Meets Drug Resistance: An Overview on Multidrug Resistance Transporters

Shaheen, A., Iqbal, M., Mirza, O. & Rahman, M., 1 Jun 2017, In: Journal of the Indian Institute of Science. 97, 2, p. 165-175 11 p.

Research output: Contribution to journal › Review › peer-review

1 Citation (Scopus)

2016

Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production

Ullah, R., Shah, M. A., Tufail, S., Ismat, F., Imran, M., Iqbal, M., Mirza, O. & Rhaman, M., Apr 2016, In: PloS one. 11, 4, 13 p., e0153436.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

98 Downloads (Pure)

Peptide Selectivity of the Proton-Coupled Oligopeptide Transporter from Neisseria meningitidis

Sharma, N., Aduri, N. G., Iqbal, A., Prabhala, B. K. & Mirza, O., 1 Aug 2016, In: Journal of Molecular Microbiology and Biotechnology. 26, 5, p. 312-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2015

A functional EXXEK motif is essential for proton coupling and active glucosinolate transport by NPF_2.11

Jørgensen, M. E., Olsen, C. E., Geiger, D., Mirza, O. A., Halkier, B. A. & Nour-Eldin, H. H., 9 Apr 2015, In: Plant and Cell Physiology. 56, 12, p. 2340-2350 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Characterization of putative multidrug resistance transporters of the major facilitator-superfamily expressed in Salmonella Typhi

Shaheen, A., Ismat, F., Iqbal, M., Haque, A., De Zorzi, R., Mirza, O. A., Walz, T. & Rahman, M., 2015, In: Journal of Infection and Chemotherapy. 21, 5, p. 357–362 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Characterization of synthetic peptides by mass spectrometry

Prabhala, B. K., Mirza, O. A., Højrup, P. & Hansen, P. R., 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, p. 77-82

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

1 Citation (Scopus)

Investigation of the substrate specificity of the proton coupled peptide transporter PepT_So from Shewanella oneidensis

Prabhala, B. K., Aduri, N. G., Hald, H. & Mirza, O. A., Mar 2015, In: International Journal of Peptide Research and Therapeutics. 15, 21, p. 1-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-(13) C]pyruvate

Asghar Butt, S., Søgaard, L. V., Ardenkjaer-Larsen, J. H., Lauritzen, M. H., Engelholm, L. H., Paulson, O. B., Mirza, O. A., Holck, S., Magnusson, P. & Akeson, P., 1 Jan 2015, In: Magnetic Resonance in Medicine. 73, p. 51-58 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Salt-bridge Swapping in the EXXERFXYY Motif of Proton Coupled Oligopeptide Transporters

Aduri, N. G., Prabhala, B. K., Ernst, H. A., Jørgensen, F. S., Olsen, L. & Mirza, O., 11 Dec 2015, In: The Journal of Biological Chemistry. 290, 50, p. 29931-29940 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

2014

Critical role of a conserved transmembrane lysine in substrate recognition by the proton-coupled oligopeptide transporter YjdL

Jensen, J. M., Aduri, N. G., Prabhala, B. K., Jahnsen, R., Franzyk, H. & Mirza, O. A., Oct 2014, In: International Journal of Biochemistry & Cell Biology. 55, p. 311-17 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

New insights into the substrate specificities of proton-coupled oligopeptide transporters from E. coli by a pH sensitive assay

Prabhala, B. K., Aduri, N. G., Jensen, J. M., Ernst, H. A., Iram, N., Rahman, M. & Mirza, O. A., 14 Feb 2014, In: FEBS Letters. 588, 4, p. 560-565

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

2013

The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology

Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, M. & Mirza, O. A., Sept 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

2012

Biophysical characterization of the proton-coupled oligopeptide transporter YjdL

Jensen, J. M., Simonsen, F. C., Mastali, A., Hald, H., Lillebro, I., Diness, F., Olsen, L. & Mirza, O. A., Nov 2012, In: Peptides. 38, 1, p. 89-93 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Functional investigation of conserved membrane-embedded glutamate residues in the proton-coupled peptide transporter YjdL

Jensen, J. M., Ernst, H. A., Wang, X., Hald, H., Ditta, A. C., Ismat, F., Rahman, M. & Mirza, O., Mar 2012, In: Protein and Peptide Letters. 19, 3, p. 282-287

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Probing the putative active site of YjdL: an unusual proton-coupled oligopeptide transporter from E. coli

Jensen, J. M., Ismat, F., Szakonyi, G., Rahman, M. & Mirza, O. A., 22 Oct 2012, In: P L o S One. 7, 10, p. e47780

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

2010

Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, M., Kastrup, J. S. & Mirza, O. A., Jun 2010, In: Protein Expression and Purification. 71, 2, p. 179-183

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Strukturer af membranproteiner: nøglen til rationelt lægemiddeldesign

Hald, H. & Mirza, O. A., Dec 2010, In: Lægemiddelforskning. 2010, p. 13-15

Research output: Contribution to journal › Journal article › Communication

1771 Downloads (Pure)

2009

Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides

Ernst, H. A., Pham, A., Hald, H., Kastrup, J. S., Rahman, M. & Mirza, O. A., 2009, In: Biochemical and Biophysical Research Communications. 389, 1, p. 112-116

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove

Champion, E., Remaud-Simeon, M., Skov, L. K., Kastrup, J. S., Gajhede, M. & Mirza, O. A., 2009, In: Acta Crystallographica. Section D: Biological Crystallography. 65, 12, p. 1309-1314

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

2008

Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter

Weyand, S., Shimamura, T., Yajima, S., Suzuki, S., Mirza, O. A., Krusong, K., Carpenter, E. P., Rutherford, N. G., Hadden, J. M., O'Reilly, J., Ma, P., Saidijam, M., Patching, S. G., Hope, R. J., Norbertczak, H. T., Roach, P. C. J., Iwata, S., Henderson, P. J. F. & Cameron, A. D., 2008, In: Science. 322, 5902, p. 709-713

Research output: Contribution to journal › Journal article › Research › peer-review

275 Citations (Scopus)

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency

Beich-Frandsen, M., Pickering, D. S., Mirza, O., Johansen, T. N., Greenwood, J., Vestergaard, B., Schousboe, A., Gajhede, M., Liljefors, T. & Kastrup, J. S., 2008, In: Journal of Medicinal Chemistry. 51, 5, p. 1459-63

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit

Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, J. S., Gajhede, M. & Mirza, O., 2008, In: Biochemistry. 47, 28, p. 7441-7451

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

2007

Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells

Yu, J., Lubinsky, D., Tsomaia, N., Huang, Z., Taylor, L., Mierke, D., Navarro, J., Mirza, O. A. & Polgar, P., 2007, In: Journal of Cellular Biochemistry. 101, 1, p. 192-204

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Structural determination of wild-type lactose permease

Guan, L., Mirza, O. A., Verner, G., Iwata, S. & Kaback, H. R., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 39, p. 15294-15298

Research output: Contribution to journal › Journal article › Research › peer-review

179 Citations (Scopus)

Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains

Tanabe, M., Mirza, O., Bertrand, T., Atkins, H. S., Titball, R. W., Iwata, S., Brown, K. A. & Byrne, B., 2007, In: Acta Crystallographica. Section D: Biological Crystallography. 63, 11, p. 1185-1193

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

2006

Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose

Skov, L. K., Mirza, O., Sprogøe, D., van der Veen, B., Remaud-Simeon, M., Albenne, C., Monsan, P. & Gajhede, M., 1 Jan 2006, In: Biocatalysis and Biotransformation. 24, 1-2, p. 99-105 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domain

Maklashina, E., Iverson, T. M., Sher, Y., Kotlyar, V., Andréll, J., Mirza, O. A., Hudson, J. M., Armstrong, F. A., Rothery, R. A., Weiner, J. H. & Cecchini, G., 21 Apr 2006, In: Journal of Biological Chemistry. 281, 16, p. 11357-65 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY

Mirza, O. A., Guan, L., Verner, G., Iwata, S. & Kaback, H. R., 22 Mar 2006, In: E M B O Journal. 25, 6, p. 1177-83 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

151 Citations (Scopus)

Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion

Mirza, O., Henriksen, L. S., Sprogøe, D., van den Broek, L. A. M., Beldman, G., Kastrup, J. S. & Gajhede, M., 2006, In: Journal of Biological Chemistry. 281, 46, p. 35576-84 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection

Tanabe, M., Atkins, H. S., Harland, D. N., Elvin, S. J., Stagg, A. J., Mirza, O. A., Titball, R. W., Byrne, B. & Brown, K. A., Jun 2006, In: Infection and Immunity. 74, 6, p. 3687-91 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

56 Citations (Scopus)

The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209

Kasper, C., Pickering, D. S., Mirza, O., Olsen, L., Kristensen, A. S., Greenwood, J. R., Liljefors, T., Schousboe, A., Wätjen, F., Gajhede, M., Sigurskjold, B. W. & Kastrup, J. S., 2006, In: Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

2004

Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

Sprogøe, D., van den Broek, L. A. M., Mirza, O., Kastrup, J. S. J., Voragen, A. G. J., Gajhede, M. & Skov, L., 10 Feb 2004, In: Biochemistry. 43, 5, p. 1156-62 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

72 Citations (Scopus)

Crystal structure of the covalent intermediate of amylosucrase from Neisseria polysaccharea

Jensen, M. H., Mirza, O. A., Albenne, C., Remaud-Simeon, M., Monsan, P., Gajhede, M. & Skov, L., 23 Mar 2004, In: Biochemistry. 43, 11, p. 3104-10 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

Molecular basis of the amylose-like polymer formation catalyzed by Neisseria polysaccharea amylosucrase

Albenne, C., Skov, L., Mirza, O. A., Gajhede, M., Feller, G., D'Amico, S., André, G., Potocki-Véronèse, G., van der Veen, B. A., Monsan, P. & Remaud-Simeon, M., 2 Jan 2004, In: Journal of Biological Chemistry. 279, 1, p. 726-34 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

86 Citations (Scopus)

Osman Asghar Mirza

Research output

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