Research output per year
Research output per year
Search results
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2019
Antibiotic therapy as personalized medicine - general considerations and complicating factors
Moser, C., Lerche, C. J., Thomsen, K., Hartvig, T., Schierbeck, J., Jensen, P. O., Ciofu, O. & Hoiby, N., May 2019, In: APMIS. 127, 5, p. 361-371Research output: Contribution to journal › Review › peer-review
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Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth
Høiby, N., Henneberg, K. Å., Wang, H., Stavnsbjerg, C., Bjarnsholt, T., Ciofu, O., Johansen, U. R. & Sams, T., May 2019, In: International Journal of Antimicrobial Agents. 53, 5, p. 564-573Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients
Møller, S. A., Jensen, P. Ø., Høiby, N., Ciofu, O., Kragh, K. N., Bjarnsholt, T. & Kolpen, M., Sept 2019, In: Journal of Cystic Fibrosis.Research output: Contribution to journal › Journal article › Research › peer-review
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Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms
Ahmed, M. N., Porse, A., Abdelsamad, A., Sommer, M., Høiby, N. & Ciofu, O., 2019, In: Antimicrobial Agents and Chemotherapy. 63, 10, 12 p., e00766-19.Research output: Contribution to journal › Journal article › Research › peer-review
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P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions
Henriksen, K., Rørbo, N., Rybtke, M. L., Martinet, M. G., Tolker-Nielsen, T., Høiby, N., Middelboe, M. & Ciofu, O., 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.Research output: Contribution to journal › Journal article › Research › peer-review
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Tolerance and resistance of pseudomonas aeruginosabiofilms to antimicrobial agents-how P. aeruginosa Can escape antibiotics
Ciofu, O. & Tolker-Nielsen, T., 2019, In: Frontiers in Microbiology. 10, MAY, 15 p., 913.Research output: Contribution to journal › Review › peer-review
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2018
Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patients
Caçador, N. C., Paulino da Costa Capizzani, C., Monteiro Marin Torres, L. A. G., Galetti, R., Ciofu, O., Lúcia da Costa Darini, A. & Høiby, N., 2018, In: PLoS ONE. 13, 11, 11 p., e0208013.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin
Ahmed, M. N. A., Porse, A., Sommer, M., Høiby, N. & Ciofu, O., 1 Aug 2018, In: Antimicrobial Agents and Chemotherapy. 62, 8, 12 p., e00320-18.Research output: Contribution to journal › Journal article › Research › peer-review
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IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis
Mauch, R. M., Nørregaard, L. L., Ciofu, O., Levy, C. E. & Høiby, N., May 2018, In: Journal of Cystic Fibrosis. 17, 3, p. 356-359Research output: Contribution to journal › Journal article › Research › peer-review
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Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions
Kolpen, M., Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, K. N., Aydogan, S., Uppal, H. A., Bjarnsholt, T., Ciofu, O., Hoiby, N. & Jensen, P. Ø., 1 Feb 2018, In: Pathogens and Disease. 74, 1, 7 p., ftv086.Research output: Contribution to journal › Journal article › Research › peer-review
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2017
Antibiotic treatment of biofilm infections
Ciofu, O., Rojo-Molinero, E., Macià, M. D. & Oliver, A., Apr 2017, In: APMIS. 125, 4, p. 304-319 16 p.Research output: Contribution to journal › Review › peer-review
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Detection of multidrug-resistant bacteria in the occupied Palestinian territory: a cross-sectional study
Sjolander, I., Hansen, F., Elmanama, A., Khayyat, R., Abu-Zant, A., Hussein, A., Abu Taha, A., Hammerum, A. M. & Ciofu, O., Aug 2017, In: Lancet Oncology. 390, S1, p. S12Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Diagnosis of biofilm infections in cystic fibrosis patients
Høiby, N., Bjarnsholt, T., Moser, C., Jensen, P. Ø., Kolpen, M., Qvist, T., Aanaes, K., Pressler, T., Skov, M. & Ciofu, O., Apr 2017, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 339-343 5 p.Research output: Contribution to journal › Review › peer-review
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Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin
Kolpen, M., Lerche, C. J., Kragh, K. N., Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, T., Ciofu, O., Moser, C. E., Kühl, M., Høiby, N. & Jensen, P. Ø., Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment
Fernandez-Barat, L., Ciofu, O., Kragh, K. N., Pressler, T., Johansen, U., Motos, A., Torres, A. & Hoiby, N., 1 Mar 2017, In: Journal of Cystic Fibrosis. 16, 2, p. 222-229Research output: Contribution to journal › Journal article › Research › peer-review
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Real-Time Monitoring of nfxB Mutant Occurrence and Dynamics in Pseudomonas aeruginosa Biofilm Exposed to Subinhibitory Concentrations of Ciprofloxacin
Zaborskytė, G., Andersen, J. B., Kragh, K. N. & Ciofu, O., 1 Mar 2017, In: Antimicrobial Agents and Chemotherapy. 61, 3, 14 p., e02292-16.Research output: Contribution to journal › Journal article › Research › peer-review
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2016
Genome sequence of Pseudomonas aeruginosa strain DK1-NH57388A, a stable mucoid cystic fibrosis isolate
Norman, A., Ciofu, O., Amador, C. I., Høiby, N. & Jelsbak, L., 2016, In: Genome Announcements. 4, 1, e00008-16.Research output: Contribution to journal › Journal article › Research
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OligoG CF-5/20 disruption of mucoid Pseudomonas aeruginosa biofilm in a murine lung infection model
Wang, H., Song, Z., Ciofu, O., Onsøyen, E., Rye, P. D. & Høiby, N., 2016, In: Antimicrobial Agents and Chemotherapy. 60, 5, p. 2620-2626 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide antigen discovery of novel protective vaccine candidates against Staphylococcus aureus infection
Rasmussen, K. J., Mattsson, A. H., Pilely, K., Asferg, C. A., Ciofu, O., Vitved, L., Koch, C. & Kemp, M., 31 Aug 2016, In: Vaccine. 34, 38, p. 4602-4609 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment
Kolpen, M., Mousavi, N., Sams, T., Bjarnsholt, T., Ciofu, O., Moser, C. E., Kühl, M., Høiby, N. & Jensen, P. Ø., 1 Feb 2016, In: International Journal of Antimicrobial Agents. 47, 2, p. 163–167 5 p.Research output: Contribution to journal › Letter › peer-review
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The phenotypic evolution of pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin
Wassermann, T., Jørgensen, K. M., Ivanyshyn, K., Bjarnsholt, T., Hossein Khademi, S. M., Jelsbak, L., Høiby, N. & Ciofu, O., 1 May 2016, In: Microbiology. 162, 5, p. 865-875 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2015
Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients
Ciofu, O., Tolker-Nielsen, T., Jensen, P. Ø., Wang, H. & Høiby, N., 1 May 2015, In: Advanced Drug Delivery Reviews. 85, p. 7-23 17 p.Research output: Contribution to journal › Review › peer-review
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Chronic Infection with Pseudomonas aeruginosa in an animal model of oxidative stress: lessons for patients with cystic fibrosis
Ciofu, O., 2015, Diet and Exercise in Cystic Fibrosis. Ross Watson, R. (ed.). London: Academic Press, p. 171-176Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Diversity of metabolic profiles of cystic fibrosis Pseudomonas aeruginosa during the early stages of lung infection
Jorgensen, K. M., Wassermann, T., Johansen, H. K., Christiansen, L. E., Molin, S., Hoiby, N. & Ciofu, O., 1 Jul 2015, In: Microbiology. 161, 7, p. 1447-1462 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Kompendium i mikrobiologi og infektionsmedicin
Høiby, N., Skinhøj, P., Andersen, Å. B., Andersen, L. P., Arendrup, M. C., Christiansen, C. B., Ciofu, O., Gerstoft, J., Johansen, H. K., Kemp, M., Kurtzhals, J. A. L., Nielsen, L. P., Lyngsøe Svejgaard, E., Theander, T. G. & Thomsen, A. R., 2015, 1. ed. FADL's Forlag.Research output: Book/Report › Book › Education
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RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT
Kolpen, M., Mousavi, N., Sams, T., Kragh, K. N., Bjarnsholt, T., Ciofu, O., Hoiby, N. & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection: a pilot study
Skov, M., Pressler, T., Lykkesfeldt, J., Poulsen, H. E., Jensen, P. Ø., Johansen, H. K., Qvist, T., Kræmer, D., Høiby, N. & Ciofu, O., 1 Mar 2015, In: Journal of Cystic Fibrosis. 14, 2, p. 211-218 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients
Marvig, R. L., Dolce, D., Sommer, L. M., Petersen, B., Ciofu, O., Campana, S., Molin, S., Taccetti, G. & Johansen, H. K., Dec 2015, In: B M C Microbiology. 15, 13 p., 218.Research output: Contribution to journal › Journal article › Research › peer-review
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2014
Antioxidant supplementation for lung disease in cystic fibrosis
Ciofu, O. & Lykkesfeldt, J., 7 Aug 2014, In: The Cochrane library. 2014, 8, 87 p., CD007020.Research output: Contribution to journal › Journal article › Research › peer-review
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Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation
Brochmann, R. P., Toft, A., Ciofu, O., Briales, A., Kolpen, M., Hempel, C., Bjarnsholt, T., Høiby, N. & Jensen, P. Ø., Feb 2014, In: International Journal of Antimicrobial Agents. 43, 2, p. 140-147 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms
Jensen, P. Ø., Briales, A., Brochmann, R. P., Wang, H., Kragh, K. N., Kolpen, M., Hempel, C., Bjarnsholt, T., Høiby, N. & Ciofu, O., 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo
Hengzhuang, W., Høiby, N. & Ciofu, O., 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 239-54 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Line, L., Alhede, M., Kolpen, M., Kühl, M., Ciofu, O., Bjarnsholt, T., Moser, C. E., Toyofuku, M., Nomura, N., Høiby, N. & Jensen, P. Ø., 2014, In: Frontiers in Microbiology. 5, 11 p., 554.Research output: Contribution to journal › Journal article › Research › peer-review
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2013
Anvendelse af antibiotika i tandlæge
Larsen, T., Ciofu, O., Moesby, L., Kirkevang, L-L. & Poulsen, A. H., 2013, In: Tandlaegebladet. 117, 9, p. 718-729 12 p.Research output: Contribution to journal › Journal article › Communication
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Applying insights from biofilm biology to drug development - can a new approach be developed?
Bjarnsholt, T., Ciofu, O., Molin, S., Givskov, M. & Høiby, N., 1 Oct 2013, In: Nature Reviews. Drug Discovery. 12, 10, p. 791-808 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J., & 2 others, 22 Jul 2013, In: P L o S One. 8, 7, 17 p., e68484.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of long-term voluntary exercise wheel running on susceptibility to bacterial pulmonary infections in a mouse model
van de Weert-van Leeuwen, P. B., de Vrankrijker, A. M. M., Fentz, J., Ciofu, O., Wojtaszewski, J., Arets, H. G. M., Hulzebos, H. J., van der Ent, C. K., Beekman, J. M. & Johansen, H. K., 23 Feb 2013, In: P L o S One. 8, 12, 7 p., e82869.Research output: Contribution to journal › Journal article › Research › peer-review
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High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms
Hengzhuang, W., Ciofu, O., Yang, L., Wu, H., Song, Z., Oliver, A. & Høiby, N., Jan 2013, In: Antimicrobial Agents and Chemotherapy. 57, 1, p. 196-204 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs
Ciofu, O., Johansen, H. K., Aanaes, K., Wassermann, T., Alhede, M., von Buchwald, C. & Høiby, N., Dec 2013, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 12, 6, p. 729-736 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Respiratory bacterial infections in cystic fibrosis
Ciofu, O., Hansen, C. R. & Høiby, N., May 2013, In: Current Opinion in Pulmonary Medicine. 19, 3, p. 251-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa
Jørgensen, K. M., Wassermann, T., Jensen, P. Ø., Hengzuang, W., Molin, S., Høiby, N. & Ciofu, O., Sept 2013, In: Antimicrobial Agents and Chemotherapy. 57, 9, p. 4215-21 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2012
A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production
Sautter, R., Ramos, D., Schneper, L., Ciofu, O., Wassermann, T., Koh, C-L., Heydorn, A., Hentzer, M., Høiby, N., Kharazmi, A., Molin, S., Devries, C. A., Ohman, D. E. & Mathee, K., 1 May 2012, In: Gene. 498, 2, p. 242-253 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
Folkesson, A., Jelsbak, L., Yang, L., Johansen, H. K., Ciofu, O., Høiby, N. & Molin, S., Dec 2012, In: Nature Reviews. Microbiology. 10, 12, p. 841-851 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
Hansen, S. K., Rau, M. H., Johansen, H. K., Ciofu, O., Jelsbak, L., Yang, L., Folkesson, A., Jarmer, H. Ø., Aanæs, K., von Buchwald, C., Høiby, N. & Molin, S., Jan 2012, In: I S M E Journal. 6, 1, p. 31-45Research output: Contribution to journal › Journal article › Research › peer-review
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Initial Pseudomonas aeruginosa infection in patients with cystic fibrosis: characteristics of eradicated and persistent isolates
Tramper-Stranders, G. A., van der Ent, C. K., Molin, S., Yang, L., Hansen, S. K., Rau, M. H., Ciofu, O., Johansen, H. K. & Wolfs, T. F. W., Jun 2012, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 18, 6, p. 567-74 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection
Hengzhuang, W., Wu, H., Ciofu, O., Song, Z. & Høiby, N., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2683-2690 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis
Cramer, N., Wiehlmann, L., Ciofu, O., Tamm, S., Høiby, N. & Tümmler, B., 28 Nov 2012, In: PLOS ONE. 7, 11, e50731.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections
Ciofu, O., Mandsberg, L. F., Wang, H. & Høiby, N., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 215-225 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in Guinea Pigs
Jensen, P. Ø., Lykkesfeldt, J., Bjarnsholt, T., Hougen, H. P., Høiby, N. & Ciofu, O., Apr 2012, In: Basic & Clinical Pharmacology & Toxicology. 110, 4, p. 353-358 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2011
Antibiotic tolerance and resistance in biofilms
Ciofu, O. & Tolker-Nielsen, T., 1 Dec 2011, Biofilm Infections. Springer New York, p. 215-229 15 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review