Research output per year
Research output per year
Personal profile
Short presentation
Research Interests
Redox imbalance in development and disease
Living cells are constantly exposed to reactive oxygen and nitrogen species which may lead to modifications of the cellular macromolecules, mutations and eventually cell death. Increased oxidative stress - i.e. an imbalance in the cellular redox homeostasis - is observed during e.g. smoking, aging and inflammation and has been associated with several chronic diseases including atherosclerosis and cancer.
In a variety of studies ranging from primary cells, cell culture and animal models to clinical trials, we study the effects of oxidative insults on the redox homeostasis as well as the possible benefit of intervention with bioactive compounds to selected groups of animals or humans. Together with measurements of oxidative damage-an effect of oxidative stress-we investigate the link between oxidative stress and various pathological conditions. Our primary goal is to understand the role and mechanism of altered redox status in disease development and thereby pave the road for better prevention strategies and pharmacotherapy for animals and humans.
Background
Positions
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2009 to present 2008 |
Professor in experimental pharmacology and toxicology at Department of Disease Biology, Life Science Faculty, University of Copenhagen. Professor in biotechnology at Department of Disease Biology, Life Science Faculty, University of Copenhagen. |
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1998 to 2007 |
Associate professor in pharmacology at Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University. |
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1996 to 1998 |
Visiting Scientist at Department of Molecular and Cell Biology, University of California, Berkeley, USA |
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1993 to 1995 |
Post doctoral fellow at Department of Pharmacology, University of Copenhagen. |
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1990 to 1992 |
Ph.D. student at the Plant Biochemistry Laboratory, Royal Veterinary and Agricultural University. |
Academic degrees
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2005 |
D.Sc. in Medicine from the University of Copenhagen, Denmark. Title of thesis: Vitamin C as biomarker and treatment of oxidative stress caused by smoking - Methodological and clinical studies. |
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1992 |
Ph.D. in Biochemistry from the Technical University of Denmark. Title of thesis: The biosynthesis of cyanogenic glucosides and glucosinolates in higher plants. |
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1989 |
M.Sc. in Organic Chemistry and Chemistry of Natural Products from the Technical University of Denmark. Title of thesis: The synthesis of alfa,beta-unsaturated delta-lactones. |
Publications
Search Pubmed for Jens Lykkesfeldt
In vivo Pharmacology
Dr. Lykkesfeldt is head of the In Vivo Pharmacology PhD program. Read more on the homepage www.invivofarm.dk
The LIFEPHARM Centre
Dr. Lykkesfeldt is Director of the LIFEPHARM Centre for In Vivo Pharmacology. Read more on the homepage www.lifepharm.dk
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- ???Dyremodeller i biomedicinsk forskning???
- Biomedicine
- ???Farmakologi???
- ???Toksikologi???
- ???Antioxidanter???
- ???Rygning???
- Clinical nutrition
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Collaborations and top research areas from the last five years
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Malnutrition predisposes to endotoxin-induced edema and impaired inflammatory response in parenterally fed piglets
Bæk, O., Fabiansen, C., Friis, H., Ritz, C., Koch, J., Willesen, J. L., Heegaard, P. M. H., Lykkesfeldt, J., Briend, A., Golden, M. H., Sangild, P. T. & Thymann, T., 1 May 2020, In: Journal of Parenteral and Enteral Nutrition.Research output: Contribution to journal › Journal article › Research › peer-review
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Subcutaneous Administration of Insulin is Associated With Regional Differences in Injection Depot Variability and Kinetics in The Rat
Gradel, A. K. J., Porsgaard, T., Lykkesfeldt, J., Brockhoff, P. M. B., Seested, T. & Refsgaard, H. H. F., 1 May 2020, In: Experimental and Clinical Endocrinology and Diabetes. 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A role of peroxisome proliferator-activated receptor gamma in non-alcoholic fatty liver disease
Skat-Rordam, J., Ipsen, D. H., Lykkesfeldt, J. & Tveden-Nyborg, P., May 2019, In: Basic & Clinical Pharmacology & Toxicology. 124, 5, p. 528-537Research output: Contribution to journal › Review › peer-review
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Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity
Gradel, A. K. J., Porsgaard, T., Brockhoff, P. M. B., Seested, T., Lykkesfeldt, J. & Refsgaard, H. H. F., Jun 2019, In: Obesity Science & Practice. 5, 3, p. 281-288Research output: Contribution to journal › Journal article › Research › peer-review
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Determination of reduced and oxidized coenzyme Q10 in canine plasma and heart tissue by HPLC-ECD: Comparison with LC-MS/MS quantification
Schou-Pedersen, A. M. V., Schemeth, D. & Lykkesfeldt, J., 2019, In: Antioxidants. 8, 8, 253.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs
Skovsted, G. F., Tveden-Nyborg, P. & Lykkesfeldt, J., 2019, In: Placenta. 77, p. 8-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model
Ipsen, D. H., Skat-Rørdam, J., Tsamouri, M. M., Latta, M., Lykkesfeldt, J. & Tveden-Nyborg, P., 1 Jun 2019, In: Molecular Genetics and Genomics. 294, 3, p. 649–661Research output: Contribution to journal › Journal article › Research › peer-review
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Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes
Gillberg, L., Ørskov, A. D., Nasif, A., Ohtani, H., Madaj, Z., Hansen, J. W., Rapin, N., Mogensen, J. B., Liu, M., Dufva, I. H., Lykkesfeldt, J., Hajkova, P., Jones, P. A. & Grønbæk, K., 17 Oct 2019, In: Clinical Epigenetics. 11, 1, p. 143-153 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is vitamin C supplementation beneficial - lessons learned from randomized controlled trials
Jens Lykkesfeldt (Lecturer)
21 May 2010Activity: Talk or presentation types › Lecture and oral contribution
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Vitamin C as biomarker of redox imbalance: Analytical methodology and clinical significance
Jens Lykkesfeldt (Lecturer)
27 Aug 2008Activity: Talk or presentation types › Lecture and oral contribution
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Does vitamin C matter? A quest for in vivo effects of vitamin C deficiency
Jens Lykkesfeldt (Lecturer)
5 Jul 2008Activity: Talk or presentation types › Lecture and oral contribution
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Basic & Clinical Pharmacology & Toxicology (Journal)
Jens Lykkesfeldt (Editor)
1 Jul 2007 → …Activity: Publication peer-review and editorial work types › Editor of Research journal › Communication