Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Tea Skaaby; Tuomas O. Kilpeläinen; Amy E Taylor; Yuvaraj Mahendran; Andrew Wong; Tarunveer S Ahluwalia; Lavinia Paternoster; Stella Trompet; David J Stott; Claudia Flexeder; Ang Zhou; Guy Brusselle; Ayesha Sajjad; Lies Lahousse; Henning Tiemeier; Christian Theil Have; Betina H Thuesen; Line Lund Kårhus; Line Tang Møllehave; Katja Biering Leth-Møller; Daniel Mønsted Shabanzadeh; Arturo Gonzalez-Quintela; Chris Power; Elina Hyppönen; Diana Kuh; Rebecca Hardy; Thomas Meitinger; J Wouter Jukema; Uwe Völker; Matthias Nauck; Henry Völzke; Nele Friedrich; Tobias N Bonten; Raymond Noordam; Dennis O Mook-Kanamori; Janne S. Tolstrup; Christian Taube; Annette Peters; Harald Grallert; Konstantin Strauch; Holger Schulz; Niels Grarup; Torben Hansen; Oluf Pedersen; Stephen Burgess; Marcus R Munafò; Allan Linneberg

doi:10.1111/add.14438

Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Tea Skaaby, Tuomas O. Kilpeläinen, Amy E Taylor, Yuvaraj Mahendran, Andrew Wong, Tarunveer S Ahluwalia, Lavinia Paternoster, Stella Trompet, David J Stott, Claudia Flexeder, Ang Zhou, Guy Brusselle, Ayesha Sajjad, Lies Lahousse, Henning Tiemeier, Christian Theil Have, Betina H Thuesen, Line Lund Kårhus, Line Tang Møllehave, Katja Biering Leth-MøllerDaniel Mønsted Shabanzadeh, Arturo Gonzalez-Quintela, Chris Power, Elina Hyppönen, Diana Kuh, Rebecca Hardy, Thomas Meitinger, J Wouter Jukema, Uwe Völker, Matthias Nauck, Henry Völzke, Nele Friedrich, Tobias N Bonten, Raymond Noordam, Dennis O Mook-Kanamori, Janne S. Tolstrup, Christian Taube, Annette Peters, Harald Grallert, Konstantin Strauch, Holger Schulz, Niels Grarup, Torben Hansen, Oluf Pedersen, Stephen Burgess, Marcus R Munafò, Allan Linneberg

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.

DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.

SETTING: Europe.

PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.

MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.

FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.

CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.

Original language	English
Journal	Addiction
Volume	114
Issue number	2
Pages (from-to)	216-225
Number of pages	10
ISSN	0965-2140
DOIs	https://doi.org/10.1111/add.14438
Publication status	Published - 1 Feb 2019

Keywords

Alcohol
allergic disease
allergic sensitization
asthma
hay fever
mendelian randomization

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10.1111/add.14438

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Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T., ... Linneberg, A. (2019). Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction, 114(2), 216-225. https://doi.org/10.1111/add.14438

Skaaby, T, Kilpeläinen, TO, Taylor, AE, Mahendran, Y, Wong, A, Ahluwalia, TS, Paternoster, L, Trompet, S, Stott, DJ, Flexeder, C, Zhou, A, Brusselle, G, Sajjad, A, Lahousse, L, Tiemeier, H, Have, CT, Thuesen, BH, Kårhus, LL, Møllehave, LT, Leth-Møller, KB, Shabanzadeh, DM, Gonzalez-Quintela, A, Power, C, Hyppönen, E, Kuh, D, Hardy, R, Meitinger, T, Jukema, JW, Völker, U, Nauck, M, Völzke, H, Friedrich, N, Bonten, TN, Noordam, R, Mook-Kanamori, DO, Tolstrup, JS, Taube, C, Peters, A, Grallert, H, Strauch, K, Schulz, H, Grarup, N , Hansen, T , Pedersen, O, Burgess, S, Munafò, MR & Linneberg, A 2019, 'Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis', Addiction, vol. 114, no. 2, pp. 216-225. https://doi.org/10.1111/add.14438

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title = "Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis",

abstract = "AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.",

keywords = "Alcohol, allergic disease, allergic sensitization, asthma, hay fever, mendelian randomization",

author = "Tea Skaaby and Kilpel{\"a}inen, {Tuomas O.} and Taylor, {Amy E} and Yuvaraj Mahendran and Andrew Wong and Ahluwalia, {Tarunveer S} and Lavinia Paternoster and Stella Trompet and Stott, {David J} and Claudia Flexeder and Ang Zhou and Guy Brusselle and Ayesha Sajjad and Lies Lahousse and Henning Tiemeier and Have, {Christian Theil} and Thuesen, {Betina H} and K{\aa}rhus, {Line Lund} and M{\o}llehave, {Line Tang} and Leth-M{\o}ller, {Katja Biering} and Shabanzadeh, {Daniel M{\o}nsted} and Arturo Gonzalez-Quintela and Chris Power and Elina Hypp{\"o}nen and Diana Kuh and Rebecca Hardy and Thomas Meitinger and Jukema, {J Wouter} and Uwe V{\"o}lker and Matthias Nauck and Henry V{\"o}lzke and Nele Friedrich and Bonten, {Tobias N} and Raymond Noordam and Mook-Kanamori, {Dennis O} and Tolstrup, {Janne S.} and Christian Taube and Annette Peters and Harald Grallert and Konstantin Strauch and Holger Schulz and Niels Grarup and Torben Hansen and Oluf Pedersen and Stephen Burgess and Munaf{\`o}, {Marcus R} and Allan Linneberg",

note = "{\textcopyright} 2018 Society for the Study of Addiction.",

year = "2019",

month = feb,

day = "1",

doi = "10.1111/add.14438",

language = "English",

volume = "114",

pages = "216--225",

journal = "Addiction",

issn = "0965-2140",

publisher = "Wiley-Blackwell",

number = "2",

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TY - JOUR

T1 - Association of alcohol consumption with allergic disease and asthma

T2 - a multi-centre Mendelian randomization analysis

AU - Skaaby, Tea

AU - Kilpeläinen, Tuomas O.

AU - Taylor, Amy E

AU - Mahendran, Yuvaraj

AU - Wong, Andrew

AU - Ahluwalia, Tarunveer S

AU - Paternoster, Lavinia

AU - Trompet, Stella

AU - Stott, David J

AU - Flexeder, Claudia

AU - Zhou, Ang

AU - Brusselle, Guy

AU - Sajjad, Ayesha

AU - Lahousse, Lies

AU - Tiemeier, Henning

AU - Have, Christian Theil

AU - Thuesen, Betina H

AU - Kårhus, Line Lund

AU - Møllehave, Line Tang

AU - Leth-Møller, Katja Biering

AU - Shabanzadeh, Daniel Mønsted

AU - Gonzalez-Quintela, Arturo

AU - Power, Chris

AU - Hyppönen, Elina

AU - Kuh, Diana

AU - Hardy, Rebecca

AU - Meitinger, Thomas

AU - Jukema, J Wouter

AU - Völker, Uwe

AU - Nauck, Matthias

AU - Völzke, Henry

AU - Friedrich, Nele

AU - Bonten, Tobias N

AU - Noordam, Raymond

AU - Mook-Kanamori, Dennis O

AU - Tolstrup, Janne S.

AU - Taube, Christian

AU - Peters, Annette

AU - Grallert, Harald

AU - Strauch, Konstantin

AU - Schulz, Holger

AU - Grarup, Niels

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Burgess, Stephen

AU - Munafò, Marcus R

AU - Linneberg, Allan

PY - 2019/2/1

Y1 - 2019/2/1

N2 - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.

AB - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.

KW - Alcohol

KW - allergic disease

KW - allergic sensitization

KW - asthma

KW - hay fever

KW - mendelian randomization

U2 - 10.1111/add.14438

DO - 10.1111/add.14438

M3 - Journal article

C2 - 30209858

SN - 0965-2140

VL - 114

SP - 216

EP - 225

JO - Addiction

JF - Addiction

IS - 2

ER -

Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Abstract

Keywords

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