Niels Grarup

Publikationer pr. år

Aktuel forskning

Type 2 diabetes is a disorder caused by a subtle combination of heritable factors and environmental and lifestyle risk factors. Also intermediary diabetes-related physiological traits such as obesity, insulin resistance and disturbed insulin secretion have been shown to be partly modulated by genetic factors. My research interests are focused on identification genetic variation associated with type 2 diabetes (diabetes genomics discovery) and on performing detailed physiological characterization of these variants in relation to diabetes phenotype (genetic-epidemiology and genetic-physiology studies). Genetic variation is explored by both next generation nucleotide sequencing and by large-scale genotyping array-based genotyping. The long term goals are to gain a deeper understanding of the genetic architecture of type 2 diabetes, to expand our insights into diabetes pathogenesis and pathophysiology and possibly thereby derive novel drug targets for diabetes and in the longer term cause advances in clinical diabetes management and prevention.

CV

Education

2003 MD, University of Copenhagen

2009 PhD, Aarhus University (Title: Genetic aspects of type 2 diabetes and related traits – The past, present and future)

Previous positions

1999-2000 Research assistant at Steno Diabetes Center

2003-2005 Resident at Department of Endocrinology, Herlev University Hospital Department of Orthopedic Surgery and Department and internal medicine at Storstrømmens Sygehus Nykøbing Falster and at General Practitioner Christian Schlütter, Nykøbing Falster

2005-2009 PhD-student at Steno Diabetes Center, Copenhagen enrolled at Aarhus University

2009-2010 Post.doc at Hagedorn Research Institute, Gentofte

2010-2012 Post.doc at University of Copenhagen

Educational activities and lecturing experience

Supervised five graduate students

Pre- and postgraduate teacher at University of Copenhagen, Aarhus University and University of Southern Denmark

Teacher at Steno Diabetes Center, STAR Education Programme

Multiple oral and poster presentations at international scientific meetings and several invited lectures

Awards

Winner of Lecture Competition at the annual meeting of the Danish Society for Internal Medicine (2007), Award for basic research at the annual meeting of the Danish Society of Endocrinology (2008), Bagger-Sørensen Foundation Talent Award (2010), Schwartz-Sørensen Award (2011)

Other scientific activities

Reviewer for Diabetes, Diabetologia, Clinical Endocrinology, Obesity, PLoS One among others

Board member of the Scandinavian Society for the Study of Diabetes (SSSD) and organizer of the 47^th Annual Meeting of SSSD in 2012.

Work package leader and member of Consultative Council of Danish Diabetes Academy

Software skills

Microsoft Office, SPSS, R, PLINK, METAL, EPACTS and various web-based genetics tools.

Publications

Pubmed: http://www.ncbi.nlm.nih.gov/pubmed?term=grarup-n[au]

58 peer-reviewed original papers

2 peer-reviewed reviews

2 textbook chapters

H-index: 19

Ekspertise relateret til FN’s Verdensmål

I 2015 blev FN-landende enige om 17 Verdensmål til at standse fattigdom, beskytte planeten og sikre velstand for alle. Denne persons arbejde bidrager til følgende verdensmål:

Emneord

Det Sundhedsvidenskabelige Fakultet

Fingeraftryk

Dyk ned i forskningsemnerne, hvor Niels Grarup er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.

12 Lignende profiler

179 Tidsskriftartikel
4 Letter
3 Review
1 Konferenceabstrakt i tidsskrift
Mere
- 1 Konferenceartikel

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis
Viitasalo, A., Schnurr, T. M., Pitkänen, N., Hollensted, M., Nielsen, T. R. H., Pahkala, K., Atalay, M., Lind, M. V., Heikkinen, S., Frithioff-Bøjsøe, C., Fonvig, C. E., Grarup, N., Kähönen, M., Carrasquilla, G. D., Larnkjær, A., Pedersen, O., Michaelsen, K. F., Lakka, T. A., Holm, J.-C. & Lehtimäki, T. & 3 flere, Raitakari, O., Hansen, T. & Kilpeläinen, T. O., 1 nov. 2019, I: American Journal of Clinical Nutrition. 110, 5, s. 1079-1087 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
8 Citationer (Scopus)
ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations
Graae, A.-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjølby, M. F., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K. L., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A. & Kiens, B. & 10 flere, Wojtaszewski, J., Larsen, S., Apte, S. S., Häring, H.-U., Vaag, A., Zethelius, B., Pedersen, O. B., Treebak, J. T., Hansen, T. & Holst, B., 1 mar. 2019, I: Diabetes. 68, 3, s. 502-514
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
8 Citationer (Scopus)
A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria
Ahluwalia, T. S., Schulz, C.-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P.-H., Hadjadj, S., Tregouet, D.-A., Jorgensen, M. E. & Grarup, N. & 9 flere, Pedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpelainen, T. O. & Hansen, T., 1 feb. 2019, I: Diabetologia. 62, 2, s. 292-305
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
12 Citationer (Scopus)

19 Downloads (Pure)
Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis
Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T. & Leth-Møller, K. B. & 27 flere, Shabanzadeh, D. M., Gonzalez-Quintela, A., Power, C., Hyppönen, E., Kuh, D., Hardy, R., Meitinger, T., Jukema, J. W., Völker, U., Nauck, M., Völzke, H., Friedrich, N., Bonten, T. N., Noordam, R., Mook-Kanamori, D. O., Tolstrup, J. S., Taube, C., Peters, A., Grallert, H., Strauch, K., Schulz, H., Grarup, N., Hansen, T., Pedersen, O., Burgess, S., Munafò, M. R. & Linneberg, A., 1 feb. 2019, I: Addiction. 114, 2, s. 216-225 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
4 Citationer (Scopus)
Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations
Andersson, C., Krogager, M. L., Skals, R. K., Appel, E. V. R., Have, C. T., Grarup, N., Pedersen, O., Jeppesen, J. L., Pedersen, O. D., Dominguez, H., Dixen, U., Engstrøm, T., Tønder, N., Roden, D. M., Stender, S., Gislason, G. H., Enghusen-Poulsen, H., Hansen, T., Køber, L. & Torp-Pedersen, C. & 1 flere, Weeke, P. E., 2019, I: P L o S One. 14, 2, 12 s., e0211690.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit
Rønn, P. F., Jørgensen, M. E., Smith, L. S., Bjerregaard, P., Dahl-Petersen, I. K., Larsen, C. V. L., Grarup, N. & Andersen, G. S., apr. 2019, I: Diabetes Research and Clinical Practice. 150, s. 129-137 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
3 Citationer (Scopus)
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J. & Wang, L. & 132 flere, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W.-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kernson, N. D., Larson, N. B., Lin, K.-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W.H.-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpelainen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sorensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y.-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3 jan. 2019, I: American Journal of Human Genetics. 104, 1, s. 112-138 27 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
35 Citationer (Scopus)
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y.-H., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, T. O., Grarup, N., Linneberg, A., Zhang, Y., Vaughan, R., Loos, R. J. F., Lazar, M. A. & Friedman, J. M., 1 mar. 2019, I: Nature Medicine. 25, 3, s. 507-530 24 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
36 Citationer (Scopus)

Niels Grarup

Personlig profil

Aktuel forskning

CV

Ekspertise relateret til FN’s Verdensmål

Emneord

Fingeraftryk

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: A Mendelian randomization analysis

ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations

Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity